Junkai Yan is a researcher at Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. His research focuses on metabolic diseases and health effects associated with environmental pollutant exposure. In particular, he investigates how environmental chemicals—such as organophosphate esters (OPEs)—perturb endocrine and metabolic homeostasis and contribute to conditions including cardiometabolic diseases and premature ovarian insufficiency. In parallel, he applies targeted metabolomics to characterize metabolic dysregulation in disorders such as parenteral nutrition-associated liver disease (PNALD), with recent work highlighting the role of altered phenylalanine catabolism in promoting hepatic steatosis and lipid accumulation. Overall, his work bridges environmental toxicology and metabolic pathophysiology, aiming to elucidate disease mechanisms and identify potential preventive and therapeutic strategies for metabolic disorders linked to chemical exposures.