Zhu-yun Yan

Dr. Zhu-yun Yan

Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2020 in Fitoterapia
Verified
Journal Article
Closed access
YWYan-Hong Wu
Yan-Hong Wu
YWYu-Rui Wu
Yu-Rui Wu
BLBo Li
Bo Li
ZYZhu-yun Yan
Zhu-yun Yan

27 November 2019 in Food Science & Nutrition
Verified
Journal Article
Open access
PDF file
LPLian-Xin Peng
Lian-Xin Peng
QZQu Zhang
Qu Zhang
YZYanhong Zhang
Yanhong Zhang
ZYZhendong Yao
Zhendong Yao
PSPanpan Song
Panpan Song
ZYZhu-yun Yan
Zhu-yun Yan
Tartary buckwheat is rich in flavonoids. However, the health‐promoting effect of these flavonoids has not been adequately studied. In the present study, we investigated the impact of rutin, quercetin, and Tartary buckwheat on the lipid metabolism of rats on a high‐fat diet. Quercetin could significantly reduce body weight, serum triacylglycerol, low‐density lipoprotein cholesterol, TNF‐α, insulin, and ameliorate glucose tolerance. It was surprising that Tartary buckwheat significantly increased the weight of the rats. Rutin, quercetin, and Tartary buckwheat tended to decreased fat deposition in the liver of rats but have little effect on short‐chain fatty acid production. The changes in the structure and diversity of the microbiota were found to be modulated by these diets. It was concluded that quercetin could attenuate high‐fat diet‐induced obesity, rutin, quercetin, and Tartary buckwheat can shape the specific structure of gut microbiota. Mechanism of Tartary buckwheat on lipid metabolism needs further systematic research.

1 January 2020 in Evidence-Based Complementary and Alternative Medicine
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Journal Article
Open access
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TCTing Chen
Ting Chen
FZFurong Zhong
Furong Zhong
CYCheng Yao
Cheng Yao
JCJia Chen
Jia Chen
YXYiqing Xiang
Yiqing Xiang
YMYuntong Ma
Yuntong Ma
Fritillariae Cirrhosae Bulbus (known as chuanbeimu in Chinese, FCB) is a famous folk medicine which has been widely used to relieve cough and eliminate phlegm for thousands of years in China. The medicine originates from dried bulbs of six species of Fritillaria which are distributed in the temperate zone of the Northern Hemisphere. Increasing attention has been paid to FCB because of its excellent medicinal value such as being antitussive, expectorant, analgesic, anticancer, anti‐inflammatory, and antioxidative. During the past years, a large number of research studies have been conducted to investigate the phytochemistry, pharmacology, and pharmacokinetics of FCB. A range of compounds have been isolated and identified from FCB, including alkaloids, saponins, nucleosides, organic acids, terpenoids, and sterols. Among them, alkaloids as the main active ingredient have been illustrated to exert significant therapeutic effects on many diseases such as cancer, acute lung injury, chronic obstructive pulmonary disease, asthma, Parkinson’s disease, and diabetes. Due to the excellent medical value and low toxicity, FCB has a huge market all over the world and triggers a growing enthusiasm among researchers. However, there is still a lack of systematic review. Hence, in this work, we reviewed the FCB‐based articles published in Sci Finder, Web of Science, PubMed, Google Scholar, CNKI, and other databases in the recent years. The traditional uses, sources, phytochemistry, pharmacology, pharmacokinetics, and toxicity of FCB were discussed in the review, which aims to provide a reference for further development and utilization of FCB.

2 February 2021 in Frontiers in Plant Science
Verified
Journal Article
Open access
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YWYan-Hong Wu
Yan-Hong Wu
HWHai Wang
Hai Wang
MLMin Liu
Min Liu
BLBo Li
Bo Li
XCXin Chen
Xin Chen
ZYZhu-yun Yan
Zhu-yun Yan
Arbuscular mycorrhiza fungi (AMFs) are a group of soil-dwelling fungi that form symbiotic associations with plants, to mediate the secondary metabolism and production of active ingredients in aromatic and medicinal plants. Currently, there is little research on Salvia miltiorrhiza Bge. inoculation with native AMFs and the concomitant effects on growth and secondary metabolites. In this study, S. miltiorrhiza was treated with eight AMFs, i.e., Glomus formosanum; Gl. tenebrosum; Septoglomus constrictum; Funneliformis geosporum; Rhizophagus manihotis; Ambispora gerdemanii; Acaulospora laevis; Ac. tuberculata, to investigate the influence of AMF inoculation on biomass and secondary production under greenhouse conditions in S. miltiorrhiza roots. The results showed that mycorrhiza formation rates were between 54.83 and 86.10%. Apart from Ac. laevis and Gl. tenebrosum treatment, the roots biomass of the other treatment groups was effectively increased, and the fresh and dry weight of the plant inoculated with Fu. geosporum were increased by 86.76 and 86.95%, respectively. Specifically, AMF treatments also impacted on phenolic acids production; inoculation with both Fu. geosporum or Ac. laevis significantly reduced total phenolic acids, whereas the other treatments effectively increased these levels, of which Gl. formosanum generated significant levels. Most AMF-plant symbiotic experiments facilitated phenolic acid accumulation in the secondary metabolites of S. miltiorrhiza (except Ac. laevis). This study showed that most native AMFs inoculation with S. miltiorrhiza promoted roots growth and increased secondary metabolites production (especially phenolic acids). Going forward, inoculation of native AMF is a promising method to improve the quality and yield of S. miltiorrhiza and should be considered during production.

1 December 2020 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
KZKui Zhao
Kui Zhao
BLBo Li
Bo Li
DHDongmei He
Dongmei He
CZCan Zhao
Can Zhao
SZShi Zhengjun
Shi Zhengjun
ZGZhanhu Guo
Zhanhu Guo

15 March 2021 in Food Science & Nutrition
Verified
Journal Article
Open access
PDF file
BMBujin Ma
Bujin Ma
JMJing Ma
Jing Ma
BLBo Li
Bo Li
QTQian Tao
Qian Tao
JGJiaxia Gan
Jiaxia Gan
ZYZhu-yun Yan
Zhu-yun Yan
Fritillaria cirrhosa D. Don is the major source plants of traditional Chinese medicine Fritillariae Cirrhosae Bulbus (FCB). Domestication, introduction, and cultivation is an important strategy to alleviate the shortage of endangered medicinal plants of F. cirrhosa. However, until now, the yield and quality changes of FCB in different harvest periods and drying treatments after harvest were not well understood. Therefore, in this paper, we investigated the yield and quality of cultivated F. cirrhosa at different harvest periods and postharvest processing methods. The results showed that dry weight per bulb ranged from 0.8913 to 1.4681 g and reached the highest at the wilting stage. The soluble sugar content ranged from 0.075% to 0.127% and reached the highest at the wilting stage. The content of total alkaloids ranged from 0.088% to 0.218% and reached the highest at the late‐flowering stage. The contents of peimisine, sipeimine, peimine, and peiminine were 0.01178%‐0.02615%, 0%–0.01713%, 0%–0.00745%, and 0%–0.00621% and reached the highest at the late‐flowering period, wilting period, young fruit period, and initial flowering period, respectively. For the two different postharvest processing methods, the contents of total alkaloids and the 16 main characteristic peaks did not exhibit significant differences. Still, the alkaloid contents of the oven drying after washing were slightly higher than the sun drying. In conclusion, the best harvest period is the wilting period of F. cirrhosa, and oven drying after washing is more beneficial to ensure the quality of FCB and improve productivity.