Kit-San Yuen earned his Bachelor's degree in Applied Biology with Biotechnology from the Hong Kong Polytechnic University. He pursued his PhD in Molecular Virology at the University of Hong Kong, concentrating on research related to the Epstein–Barr virus in nasopharyngeal carcinoma, virus and innate immunity, and CRISPR/Cas-mediated genome editing. In 2020, Sam became a senior lecturer in the School of Medical and Health Sciences at Tung Wah College, and in 2022, he was promoted to assistant professor in the School of Nursing. He continues to focus his research on virology and microbial detection.