Vaginal drug delivery systems can provide a long-term and constant liberation of the active pharmaceutical ingredient even for months. For our experiment, FDM 3D printing was used to manufacture the vaginal ring samples from thermoplastic polyurethane filament, which enables fast manufacturing of complex, personalized medications. 3D printing can be an excellent alternative instead of industrial manufacturing, which is complicated and time-consuming. In our work, the 3D printed vaginal rings were filled manually with jellified metronidazole or chloramphenicol for the treatment of bacterial vaginosis. The need for manual filling was certified by the thermogravimetric and heatflow assay results. The manufactured samples were analyzed by an Erweka USP type II Dissolution Apparatus, and the dissolution profile can be distinguished based on the applied jellifying agents and the API’s. All samples were considered non-similar based on the pairwise comparison. The biocompatibility properties were determined by prolonged MTT assay on HeLa cells, and the polymer could be considered non-toxic. Based on the microbiological assay on E. coli metronidazole and chitosan containing samples had bactericidal effects while just metronidazole or just chitosan containing samples bacteriostatic effect. None of these samples showed a fungistatic or fungicide effect against C. albicans. Based on our results, we successfully manufactured 3D printed vaginal rings filled with jellified metronidazole.

The appearance of online map services and frameworks (e.g., KML, QGIS) has increased the possibilities to easily, quickly and—in many cases—cost-effectively publish spatial data stored in databases. The aim of this study is to present the geovisualization of spatial databases of a Hungarian settlement on the web, using the open source webGIS system and Google application programming interfaces (APIs). The interactive point and interpolated distribution maps available online provide a detailed picture of the level of contamination, the spatial distribution of the ground water supply of the investigated settlement, and the changes which have occurred following the establishment of the sewage system. In the case of PO₄³⁻ we determined that in the year before the sewage system was constructed, most of the area of the settlement could be considered contaminated, with the highest level of contamination measured in the central area of the settlement. Five years after the construction of the sewage system, the ratio of the contaminated areas had significantly decreased. In the case of NO₃⁻ we found a high level of contamination before the construction of the sewage system with a concentration increase in a North–West direction. After the establishment of the sewage system, the increase in concentration was the most intense in the central parts of the settlement, while the characteristic spatial distribution could no longer be observed. The geovisualization techniques developed are able to provide information about the different spatial data for users in a visual way, and also help to understand better the spatial information using a cognitive approach. The advantage of interactive web maps created with the technologies applied over traditional static maps is a new approach, which allows the user to manipulate the temporal and spatial data directly in the most appropriate way.

The provision of webGIS-based water quality data services has become a priority area for both the public and administrative sectors in the context of the pandemic emergency associated with the global spread of COVID-19. Current geographic, monitoring and decision supporting systems, typically based on web-based geospatial information, greatly facilitate the sharing of spatial and temporal data from environmental databases and real-time analyses. In the present study, different water quality indices are determined, compared and geovisualized, during which the changes in the quality of the shallow groundwater resources of a settlement are examined in the period (2011–2019) in an eastern Hungarian settlement. Another objective of the research is to determine three water quality indices (Water Quality Index, CCME Water Quality Index, Contamination degree) and categorize water samples based on the same input spatial and temporal data using self-developed freely available geovisualization tools. Groundwater quality was assessed by using different water quality indices. Significant pollution of the groundwater in the time period before the installation of a sewage network was shown. Regarding water quality, significant positive changes were shown based on all three water quality indices in the years after installing a sewage network (2015–2019). The presence of pollution apart from the positive changes suggests that the purification processes will last for a long time.

Currently, several devices (such as laser scanners, Kinect, time of flight cameras, medical imaging equipment (CT, MRI, intraoral scanners)), and technologies (e.g., photogrammetry) are capable of generating 3D point clouds. Each point cloud type has its unique structure or characteristics, but they have a common point: they may be loaded with errors. Before further data processing, these unwanted portions of the data must be removed with filtering and outlier detection. There are several algorithms for detecting outliers, but their performances decrease when the size of the point cloud increases. The industry has a high demand for efficient algorithms to deal with large point clouds. The most commonly used algorithm is the radius outlier filter (ROL or ROR), which has several improvements (e.g., statistical outlier removal, SOR). Unfortunately, this algorithm is also limited since it is slow on a large number of points. This paper introduces a novel algorithm, based on the idea of the ROL filter, that finds outliers in huge point clouds while its time complexity is not exponential. As a result of the linear complexity, the algorithm can handle extra large point clouds, and the effectiveness of this is demonstrated in several tests.

One of the most promising emerging innovations in personalized medication is based on 3D printing technology. For use as authorized medications, 3D-printed products require different in vitro tests, including dissolution and biocompatibility investigations. Our objective was to manufacture implantable drug delivery systems using fused deposition modeling, and in vitro tests were performed for the assessment of these products. Polylactic acid, antibacterial polylactic acid, polyethylene terephthalate glycol, and poly(methyl methacrylate) filaments were selected, and samples with 16, 19, or 22 mm diameters and 0%, 5%, 10%, or 15% infill percentages were produced. The dissolution test was performed by a USP dissolution apparatus 1. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide dye (MTT)-based prolonged cytotoxicity test was performed on Caco-2 cells to certify the cytocompatibility properties. The implantable drug delivery systems were characterized by thermogravimetric and heatflow assay, contact angle measurement, scanning electron microscopy, microcomputed tomography, and Raman spectroscopy. Based on our results, it can be stated that the samples are considered nontoxic. The dissolution profiles are influenced by the material properties of the polymers, the diameter, and the infill percentage. Our results confirm the potential of fused deposition modeling (FDM) 3D printing for the manufacturing of different implantable drug delivery systems in personalized medicine and may be applied during surgical interventions.

There are many options for open access publishing of location-related information, thanks to the development of technology in the webGIS field. At the same time, geovizualization makes the interpretation of spatial data much easier. The aim of this study is to present the geovizualization of a Central-European forest reserve on the web, using open source databases (ASTER GDEM v2, CORINE CLC50) and the archive genetic soil map. We used the open source QGIS software for the geoinformatics processing and publishing on the web. The results showed us that we can represent not only the data in the geoinformatics system on web, but also complex information from the map elements, (for example: soil type, area, perimeter, categories of land cover, altitude), which help users not only to orientate, but also to understand the spatial information better.