Sepsis-induced myocardial dysfunction (SIMD) is a fatal disease with no specific treatment worldwide to this day. As a biological product, platelet-rich plasma (PRP) has attracted much attention due to its diverse and potential biological effects. However, its role in lipopolysaccharide (LPS)-induced cardiac injury has not been fully investigated. This study aimed to explore the mechanism of PRP in SIMD. PRP (30 µL) was injectedin situinto the heart, and LPS (10 mg/kg) was injected intraperitoneally into mice. Neonatal rat cardiomyocytes were treated with LPS (1 μg/ml) for 24 h. The results showed that, compared with the LPS group, PRP significantly decreased the levels of Lactate dehydrogenase (LDH) and Creatine Kinase MB (CK-MB), and improved cardiac function. In addition, PRP markedly decreased the Malonic dialdehyde (MDA) content, and increased the Superoxide dismutase (SOD) activity and Glutathione (GSH) level, demonstrating that PRP alleviated LPS-induced oxidative stress. The Western blot and qPCR results showed that LPS-induced ferroptosis and inflammation effectsin vivoandin vitrowere ameliorated after PRP treatment. Moreover, PRP can alleviate erastin-induced ferroptosis and improve cell viability. Mechanistically, p-AKT and p-mTOR expressions were down-regulated after treatment with LPS, while PRP pretreatment could reverse this effect. In summary, our study demonstrated that PRP could play a unique role in reducing LPS-induced cardiac injury through regulation of AKT/mTOR signaling pathways. These findings provide a new therapeutic direction for treating SIMD.

The energy management strategy of hybrid electric vehicles is of significant importance to improve the fuel economy. In this regard, two energy management strategies are designed for power-split hybrid electric city bus (HECB), which are based on the linear time-varying stochastic model predictive control (LTV-SMPC) and stochastic model predictive control based on Pontriagin’s minimum principle (PMP-SMPC). In the present study, the Markov chain and long short-term memory (LSTM) forecast demand torque and velocity respectively are applied to establish a combination forecast model. Then several processes, including linear approximation, processing simplified control model, the proposed nonlinear vehicle model is converted into a linear time-varying model. Meanwhile, the energy management problem in a linear quadratic programming problem is solved. Considering linearization error and limitations of the quadratic optimization, Pontriagin’s minimum principle (PMP) is applied to optimize the nonlinear model predictive control. Based on the reference theory, the range of coordinated variables is derived, and the optimal coordination variable is searched by dichotomy to realize the rolling optimization of the model predictive control (MPC). Finally, the effectiveness of the proposed energy management strategy is verified by simulating several case studies. Obtained results show that compared with the rule-based (RB) control strategy, the fuel economy of LTV-SMPC and PMP-SMPC increases by 8.79% and 14.42%, respectively. Meanwhile, it is concluded that the two strategies have real-time computing potential.

This article examines the fundamental meaning of 20th-century architectural heritage by reviewing the formation of the concept by the International Council on Monuments and Sites (ICOMOS). It analyses the current state of conservation and potential threats to China’s built heritage, built environment, and cultural landscapes that are less than 50 years old. The article presents a thorough review of the facilitating process of the regulative infrastructure of Chinese modern architecture conservation. It makes a comparative study of several cities’ urban heritage assessment criteria as well as the first and second inventories of China’s 20th-century architectural heritage. The article argues that conserving China’s 20th-century heritage calls for a theoretical framework, which integrates value assessment and advancing the conservation mechanism for built heritage. In doing so, the transition may be facilitated from focusing on World Heritage towards heritage of the everyday, which embodies collective memories, and from preserving iconic monuments towards comprehensively conserving the built heritage.

Grid enterprises started late in data management, development, and applications, due to the constraints of the industry, business structure and technical means. As an innovative application of both technical solutions and management means, blockchain is highly compatible with data asset management. This paper designs a directory blockchain system based on blockchain technology and power grid data resource directory, which records the source, use, sharing and other operations of power grid business data, so as to ensure that the ownership, location, content and other information cannot be tampered with. Three stages of application scenarios are designed to gradually expand the directory blockchain nodes and application scope from the inside to the outside, so as to upgrade the data governance level and promote open data sharing.

Introduction: Incontinentia Pigmenti (IP) is a rare X-linked dominant neurocutaneous disorder characterized by cutaneous, ocular, and neurological manifestations. We present a fatal case of IP with atypical neuroimaging findings. Case Presentation: A 4-month-old female infant presented with generalized hyperpigmentation, palatal cleft, and acute encephalopathy. Initial non-contrast cranial Computed Tomography (CT) demonstrated cerebellar hypoattenuation with punctate calcifications and ventriculomegaly. Subsequent Magnetic Resonance Imaging (MRI) demonstrated extensive ischemia, edema, and hemorrhagic lesions in the brainstem, cerebellum, and cervical spinal cord. Trio-based whole-exome sequencing did not detect pathogenic variants in the Inhibitor of Nuclear Factor Kappa-B Kinase Regulatory Subunit Gamma (IKBKG) gene (NM_003639.3). Conclusion: This case highlights the critical role of neuroimaging in diagnosing IP-related neurological complications and emphasizes the need for early multimodal imaging evaluation. The discordance between clinical phenotype and genetic findings warrants further investigation into novel pathogenic mechanisms.