The University of Texas at San Antonio

Amitrajeet A. Batabyal; Hamid Beladi. Consumption Spillovers, Pollution Cleanup in the Ganges, and Welfare in Kanpur and Varanasi. 2024, 21 -33.

Amitrajeet A. Batabyal, Hamid Beladi. Consumption Spillovers, Pollution Cleanup in the Ganges, and Welfare in Kanpur and Varanasi. . 2024; ():21-33.

Amitrajeet A. Batabyal; Hamid Beladi. 2024. "Consumption Spillovers, Pollution Cleanup in the Ganges, and Welfare in Kanpur and Varanasi." , no. : 21-33.

Objectives: Mandated by the Affordable Care Act of 2010, hospices were required to provide information regarding the Hospice Quality Reporting Program, with a reduced reimbursement tied to hospices if they fail to submit data to the Centers for Medicare and Medicaid Services. The purpose of this study was to examine the association between hospice organizational and community factors and quality of hospice care as measured by patient experience through Hospice Consumer Assessment of Healthcare Providers & Systems (CAHPS®) survey. Methods: We used secondary data from Hospice Compare, Healthcare Cost Report Information System Dataset, Rural–urban commuting area codes, and the American Community Survey to examine the relationship between hospice patient/family experience and hospice organizational-level and community-level factors for the period 2017–2020. The unit of analysis was hospice-year observations. Results: For-profit and chain-affiliated hospices were negatively associated with CAHPS® scores. Organizational longevity and Medicare payer mix were positively associated with CAHPS® scores. Hospice community factors including competition, per capita income, and the racial/ethnic minorities’ percentage were negatively associated with CAHPS® scores. Significance of results: Hospice organizational and community factors were related to hospice quality of care. Interventions that account for organizational and community factors may be needed to improve patient/family experience of hospice care.

Mengying He; Ganisher Davlyatov; Gregory Orewa; Haiyan Qu; Robert Weech-Maldonado. Facility- and community-level factors associated with hospice patient experience. Palliative & Supportive Care 2024, 1 -6.

Mengying He, Ganisher Davlyatov, Gregory Orewa, Haiyan Qu, Robert Weech-Maldonado. Facility- and community-level factors associated with hospice patient experience. Palliative & Supportive Care. 2024; ():1-6.

Mengying He; Ganisher Davlyatov; Gregory Orewa; Haiyan Qu; Robert Weech-Maldonado. 2024. "Facility- and community-level factors associated with hospice patient experience." Palliative & Supportive Care , no. : 1-6.

Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+ signaling in melanosome biology remains unknown. Here, we show that pigmentation requires mitochondrial Ca2+ uptake. In vitro gain and loss of function studies demonstrate that mitochondrial Ca2+ uniporter (MCU) is crucial for melanogenesis while MCU rheostat, MCUb negatively control melanogenesis. Zebrafish, MCU+/- and MCUb-/- mice models show that MCU complex drives pigmentation in vivo. Mechanistically, MCU silencing activates transcription factor NFAT2 to induce expression of keratin (5, 7, and 8) filaments. Interestingly, keratin5 in turn augments mitochondrial Ca2+ uptake and potentiates melanogenesis by regulating melanosome biogenesis and maturation. Hence this signaling module acts as a negative feedback loop that fine-tunes both mitochondrial Ca2+ signaling and pigmentation. Notably, mitoxantrone, an FDA approved drug that inhibits MCU, reduces pigmentation thereby highlighting therapeutic potential of targeting mitochondrial Ca2+ uptake for clinical management of pigmentary disorders. Taken together, we reveal an MCU-NFAT2-Keratin5 driven signaling axis that acts as a critical determinant of mitochondrial Ca2+ uptake and pigmentation. Given the vital role of mitochondrial Ca2+ signaling and keratin filaments in cellular physiology, this feedback loop could be operational in a variety of other patho-physiological processes.

Jyoti Tanwar; Kriti Ahuja; Akshay Sharma; Paras Sehgal; Gyan Ranjan; Farina Sultan; Anushka Agrawal; Donato D'ANgelo; Anshu Priya; Vamsi K Yenamandra; Archana Singh; Anna Raffaello; Muniswamy Madesh; Rosario Rizzuto; Sridhar Sivasubbu; Rajender K Motiani. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. 2024, 22, e3002895 .

Jyoti Tanwar, Kriti Ahuja, Akshay Sharma, Paras Sehgal, Gyan Ranjan, Farina Sultan, Anushka Agrawal, Donato D'ANgelo, Anshu Priya, Vamsi K Yenamandra, Archana Singh, Anna Raffaello, Muniswamy Madesh, Rosario Rizzuto, Sridhar Sivasubbu, Rajender K Motiani. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. . 2024; 22 (11):e3002895.

Jyoti Tanwar; Kriti Ahuja; Akshay Sharma; Paras Sehgal; Gyan Ranjan; Farina Sultan; Anushka Agrawal; Donato D'ANgelo; Anshu Priya; Vamsi K Yenamandra; Archana Singh; Anna Raffaello; Muniswamy Madesh; Rosario Rizzuto; Sridhar Sivasubbu; Rajender K Motiani. 2024. "Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments." 22, no. 11: e3002895.