Institut de Neurophysiopathologie

Corticosteroids (CSs), widely used in oncology for their anti-inflammatory and immunosuppressive properties, help manage cancer-related symptoms and side effects. However, their long-term use may negatively affect patient survival and exacerbate tumor progression. Elevated glucose and glutamine metabolism, disruption of vitamin D levels, and alterations in the microbiome are some of the key factors contributing to these adverse outcomes. Approaches such as ketogenic diets, fasting, sartans, and vitamin D supplementation have shown promise in providing similar benefits to CSs while mitigating the risks associated with the mechanisms identified as contributing to tumor progression. This perspective underscores the necessity for a reevaluation of CSs use in cancer care and advocates for further research into safer, more effective therapeutic strategies.

Pierrick Martinez; Jean-Marc Sabatier. Rethinking corticosteroids use in oncology. Frontiers in Pharmacology 2025, 16, 1551111 .

Pierrick Martinez, Jean-Marc Sabatier. Rethinking corticosteroids use in oncology. Frontiers in Pharmacology. 2025; 16 ():1551111.

Pierrick Martinez; Jean-Marc Sabatier. 2025. "Rethinking corticosteroids use in oncology." Frontiers in Pharmacology 16, no. : 1551111.

Louisa Mezache; Christophe Leterrier. Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments. 2025, 31 .

Louisa Mezache, Christophe Leterrier. Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments. . 2025; 31 (2):.

Louisa Mezache; Christophe Leterrier. 2025. "Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments." 31, no. 2: .

Among epigenetic modifiers, telomeres represent attractive modulators of the genome in part through position effects. Telomere Position Effect‐Over Long Distances (TPE‐OLD) modulates gene expression by changes in telomere‐dependent long‐distance loops. To gain insights into the molecular mechanisms of TPE‐OLD, we performed a genome‐wide transcriptome and methylome analysis in proliferative fibroblasts and myoblasts or differentiated myotubes with controlled telomere lengths. By integrating omics data, we identified a common TPE‐OLD dependent cis‐acting motif that behaves as an insulator or enhancer. Next, we uncovered trans partners that regulate these activities and observed the consistent depletion of one candidate factor, RBPJ, at TPE‐OLD associated loci upon telomere shortening. Importantly, we confirmed our findings by unbiased comparisons to recent Human transcriptomic studies, including those from the Genotype‐Tissue Expression (GTEx) project. We concluded that TPE‐OLD acts at the genome‐wide level and can be relayed by RBPJ bridging Alu‐like elements to telomeres. In response to physiological (i.e., aging) or pathological cues, TPE‐OLD might coordinate the genome‐wide impact of telomeres through recently evolved Alu elements acting as enhancers in association with RBPJ.

Raphaël Chevalier; Victor Murcia Pienkowski; Nicolas Jullien; Pascal Verdier Pinard; Frédérique Magdinier; Jérôme D. Robin. Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element. Aging Cell 2025, e70027 .

Raphaël Chevalier, Victor Murcia Pienkowski, Nicolas Jullien, Pascal Verdier Pinard, Frédérique Magdinier, Jérôme D. Robin. Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element. Aging Cell. 2025; ():e70027.

Raphaël Chevalier; Victor Murcia Pienkowski; Nicolas Jullien; Pascal Verdier Pinard; Frédérique Magdinier; Jérôme D. Robin. 2025. "Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element." Aging Cell , no. : e70027.