This page has only limited features, please log in for full access.

Unclaimed
Sven-Christian Pawelzik
Theme Heart and Vessels, Division of Valvular and Coronary Disease, Karolinska University Hospital, 171 77 Stockholm, Sweden

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 16 July 2020 in Cells
Reads 0
Downloads 0

Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by active calcification of the leaflets of the aortic valve. How innate immune cells are involved in disease pathogenesis is not clear. In this study we investigate the role of the pattern recognition receptor Toll-like receptor 7 (TLR7) in CAVS, especially in relation to macrophage subtype. Human aortic valves were used for mRNA expression analysis, immunofluorescence staining, or ex vivo tissue assays. Response to TLR7 agonist in primary macrophages and valvular interstitial cells (VICs) were investigated in vitro. In the aortic valve, TLR7 correlated with M2 macrophage markers on mRNA levels. Expression was higher in the calcified part compared with the intermediate and healthy parts. TLR7+ cells were co-stained with M2-type macrophage receptors CD163 and CD206. Ex vivo stimulation of valve tissue with the TLR7 ligand imiquimod significantly increased secretion of IL-10, TNF-α, and GM-CSF. Primary macrophages responded to imiquimod with increased secretion of IL-10 while isolated VICs did not respond. In summary, in human aortic valves TLR7 expression is associated with M2 macrophages markers. Ex vivo tissue challenge with TLR7 ligand led to secretion of immunomodulatory cytokine IL-10. These results connect TLR7 activation in CAVS to reduced inflammation and improved clearance.

ACS Style

Glykeria Karadimou; Oscar Plunde; Sven-Christian Pawelzik; Miguel Carracedo; Per Eriksson; Anders Franco-Cereceda; Gabrielle Paulsson-Berne; Magnus Bäck. TLR7 Expression is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis. Cells 2020, 9, 1710 .

AMA Style

Glykeria Karadimou, Oscar Plunde, Sven-Christian Pawelzik, Miguel Carracedo, Per Eriksson, Anders Franco-Cereceda, Gabrielle Paulsson-Berne, Magnus Bäck. TLR7 Expression is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis. Cells. 2020; 9 (7):1710.

Chicago/Turabian Style

Glykeria Karadimou; Oscar Plunde; Sven-Christian Pawelzik; Miguel Carracedo; Per Eriksson; Anders Franco-Cereceda; Gabrielle Paulsson-Berne; Magnus Bäck. 2020. "TLR7 Expression is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis." Cells 9, no. 7: 1710.

Review
Published: 04 April 2020 in Toxins
Reads 0
Downloads 0

Persistent low-grade inflammation and premature ageing are hallmarks of the uremic phenotype and contribute to impaired health status, reduced quality of life, and premature mortality in chronic kidney disease (CKD). Because there is a huge global burden of disease due to CKD, treatment strategies targeting inflammation and premature ageing in CKD are of particular interest. Several distinct features of the uremic phenotype may represent potential treatment options to attenuate the risk of progression and poor outcome in CKD. The nuclear factor erythroid 2-related factor 2 (NRF2)–kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein 1 (KEAP1) signaling pathway, the endocrine phosphate-fibroblast growth factor-23–klotho axis, increased cellular senescence, and impaired mitochondrial biogenesis are currently the most promising candidates, and different pharmaceutical compounds are already under evaluation. If studies in humans show beneficial effects, carefully phenotyped patients with CKD can benefit from them.

ACS Style

Thomas Ebert; Sven-Christian Pawelzik; Anna Witasp; Samsul Arefin; Sam Hobson; Karolina Kublickiene; Paul G. Shiels; Magnus Bäck; Peter Stenvinkel. Inflammation and Premature Ageing in Chronic Kidney Disease. Toxins 2020, 12, 227 .

AMA Style

Thomas Ebert, Sven-Christian Pawelzik, Anna Witasp, Samsul Arefin, Sam Hobson, Karolina Kublickiene, Paul G. Shiels, Magnus Bäck, Peter Stenvinkel. Inflammation and Premature Ageing in Chronic Kidney Disease. Toxins. 2020; 12 (4):227.

Chicago/Turabian Style

Thomas Ebert; Sven-Christian Pawelzik; Anna Witasp; Samsul Arefin; Sam Hobson; Karolina Kublickiene; Paul G. Shiels; Magnus Bäck; Peter Stenvinkel. 2020. "Inflammation and Premature Ageing in Chronic Kidney Disease." Toxins 12, no. 4: 227.

Editorial
Published: 01 March 2020 in Annals of Translational Medicine
Reads 0
Downloads 0

Eastern Remedies for Western-type diet induced atherosclerosis

ACS Style

Sven-Christian Pawelzik; Magnus Bäck. Eastern Remedies for Western-type diet induced atherosclerosis. Annals of Translational Medicine 2020, 8, 258 -258.

AMA Style

Sven-Christian Pawelzik, Magnus Bäck. Eastern Remedies for Western-type diet induced atherosclerosis. Annals of Translational Medicine. 2020; 8 (6):258-258.

Chicago/Turabian Style

Sven-Christian Pawelzik; Magnus Bäck. 2020. "Eastern Remedies for Western-type diet induced atherosclerosis." Annals of Translational Medicine 8, no. 6: 258-258.

Journal article
Published: 01 December 2019 in Prostaglandins & Other Lipid Mediators
Reads 0
Downloads 0

Obesity is associated with low-grade chronic inflammation, which contributes to the development of the metabolic syndrome and its associated complications, such as insulin resistance and type-2 diabetes. Limited data from animal and human studies support local generation of pro-inflammatory prostanoid lipid mediators in white adipose tissue. However, the link between systemic prostanoid levels and parameters characterizing the metabolic syndrome is missing in human obesity. Therefore, we performed a targeted lipidomic analysis using urine samples from obese human subjects (n = 45) and show for the first time in humans that urinary prostanoid levels correlate with metabolic parameters that indicate a dysregulated glucose and triglyceride metabolism. We identified tetranor-PGDM and tetranor-PGEM as the two major urinary prostanoid metabolites in obese subjects with levels of 247 ± 31 and 23.3 ± 4.0 pmol/mg creatinine, respectively. Tetranor-PGDM was significantly associated with serum triglycerides, while tetranor-PGEM was associated with abdominal obesity as defined by an increased waist-to-hip ratio (WHR), with glycated hemoglobin (HbA1c), and with impaired oral glucose tolerance. These results confirm the previously established notion of low-grade chronic inflammation in obesity and further identify an association of the prostanoid pathway with obesity-associated dyslipidemia, abdominal obesity, and insulin resistance.

ACS Style

Sven-Christian Pawelzik; Antoine Avignon; Helena Idborg; Catherine Boegner; Françoise Stanke-Labesque; Per-Johan Jakobsson; Ariane Sultan; Magnus Bäck. Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects. Prostaglandins & Other Lipid Mediators 2019, 145, 106361 .

AMA Style

Sven-Christian Pawelzik, Antoine Avignon, Helena Idborg, Catherine Boegner, Françoise Stanke-Labesque, Per-Johan Jakobsson, Ariane Sultan, Magnus Bäck. Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects. Prostaglandins & Other Lipid Mediators. 2019; 145 ():106361.

Chicago/Turabian Style

Sven-Christian Pawelzik; Antoine Avignon; Helena Idborg; Catherine Boegner; Françoise Stanke-Labesque; Per-Johan Jakobsson; Ariane Sultan; Magnus Bäck. 2019. "Urinary prostaglandin D2 and E2 metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects." Prostaglandins & Other Lipid Mediators 145, no. : 106361.