Fibromyalgia is a prevalent multidimensional disorder with complex symptoms and relatively poor treatment outcomes.
1-3 Fibromyalgia is characterized by diffuse chronic pain for more than 3 months and bilateral sites of focal tenderness.
4 It is associated with fatigue, sleep dysfunction, stiffness, depression, cognitive disruption, and exercise intolerance.
3 The prevalence of fibromyalgia in the United States is estimated to be 3.4% in women and 0.5% in men
5 and is reported to be greater in individuals with other rheumatic conditions.
6 The causes and pathologic mechanisms of fibromyalgia are unknown. Current hypotheses center on atypical sensory processing in the central nervous system and dysfunction of skeletal muscle nociception and the hypothalamic-pituitary-adrenal axis.
7-9 Even with the recent approval of pregabalin by the Food and Drug Administration to treat fibromyalgia symptoms, pharmacotherapy is often insufficient to resolve persistent symptoms or improve functional limitations and quality of life.
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