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Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD), particularly in cases of early atherosclerosis and myocardial infarction. IBD most frequently begins at an early age, patients usually present normal weight and remain under constant care of a physician, as well as of a nutritionist. Therefore, the classical risk factors of CVD are not reflected in the higher prevalence of CVD in the IBD population. Still, both groups are characterised by chronic inflammation and display similar physiopathological mechanisms. In the course of IBD, increased concentrations of pro-inflammatory cytokines, such as C-reactive protein (CRP) and homocysteine, may lead to endothelial dysfunctions and the development of CVD. Furthermore, gut microbiota dysbiosis in patients with IBD also constitutes a risk factor for an increased susceptibility to cardiovascular disease and atherosclerosis. Additionally, diet is an essential factor affecting both positively and negatively the course of the aforementioned diseases, whereas several dietary patterns may also influence the association between IBD and CVD. Thus, it is essential to investigate the factors responsible for the increased cardiovascular (CV) risk in this group of patients. Our paper attempts to review the role of potential inflammatory and nutritional factors, as well as intestinal dysbiosis and pharmacotherapy, in the increased risk of CVD in IBD patients.
Liliana Łykowska-Szuber; Anna Maria Rychter; Magdalena Dudek; Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Piotr Eder; Maciej Lesiak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review. Nutrients 2021, 13, 2661 .
AMA StyleLiliana Łykowska-Szuber, Anna Maria Rychter, Magdalena Dudek, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Piotr Eder, Maciej Lesiak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review. Nutrients. 2021; 13 (8):2661.
Chicago/Turabian StyleLiliana Łykowska-Szuber; Anna Maria Rychter; Magdalena Dudek; Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Piotr Eder; Maciej Lesiak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review." Nutrients 13, no. 8: 2661.
Atherosclerosis—considered the major cause of cardiovascular diseases (CVDs)—is strongly associated with obesity, to which it strongly contributes. Moreover, atherosclerosis is characterised by a long asymptomatic phase, and its progression can lead to serious cardiovascular (CV) events. The carotid intima-media thickness (cIMT) has been determined as a predictor of CV events, as well as a marker of subclinical atherosclerosis, and has been used in clinical trials as an alternative assessment method or a surrogate endpoint. It should be noted that several behavioural approaches can directly influence the cIMT values, and decrease or increase the CV risk. In our paper, we aimed to summarize the current knowledge regarding IMT measurement among patients with obesity as a risk group—also in terms of the obesity paradox where the diagnosis of subclinical atherosclerosis is especially essential and implements the early therapeutic approach. We also summarized behavioural, modifiable factors, such as the Mediterranean diet, the Dietary Approach to Stop Hypertension Diets, body weight reduction or the intake of micro- and macronutrients, with a particular focus on the studies where the cIMT values were one of the outcomes. In order to collect the literature data related to the presented topic, the PubMed database was explored.
Anna Rychter; Dariusz Naskręt; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity? Journal of Personalized Medicine 2021, 11, 505 .
AMA StyleAnna Rychter, Dariusz Naskręt, Agnieszka Zawada, Alicja Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity? Journal of Personalized Medicine. 2021; 11 (6):505.
Chicago/Turabian StyleAnna Rychter; Dariusz Naskręt; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity?" Journal of Personalized Medicine 11, no. 6: 505.
Osteoporosis affects women twice as often as men. Additionally, it is estimated that 0.3 million and 1.7 million people have hip fractures in the USA and Europe, respectively. Having a proper peak bone mass and keeping it as long as possible is especially important for osteoporosis prevention. One of the most important calcium sources is milk and dairy products. Breast milk is the best infant food, but milk should not be avoided later in life to prevent losing bone mass. On the other hand, more and more people limit their milk consumption and consume other dairy or non-dairy products. For example, they are usually replaced with plant beverages, which should be consumed carefully in several age groups. Additionally, an important element of milk and dairy products, as well as plant beverages, are probiotics and prebiotics, which may modulate bone turnover. Dietary recommendations focused on milk, and dairy products are an important element for the prevention of osteoporosis.
Alicja Ratajczak; Agnieszka Zawada; Anna Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis. Nutrients 2021, 13, 1329 .
AMA StyleAlicja Ratajczak, Agnieszka Zawada, Anna Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis. Nutrients. 2021; 13 (4):1329.
Chicago/Turabian StyleAlicja Ratajczak; Agnieszka Zawada; Anna Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis." Nutrients 13, no. 4: 1329.
Cigarette smoking constitutes one of the most important modifiable factors of osteoporosis, as well as contributes to an early death, tumors, and numerous chronic diseases. The group with an increased risk of a lower bone mineral density are patients suffering from inflammatory bowel diseases. In fact, tobacco smoke, which contains more than 7000 chemical compounds, affects bone mineral density (BMD) both directly and indirectly, as it has an impact on the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium–phosphate balance. Constant cigarette use interferes with the production of protective mucus and inhibits the repair processes in the intestinal mucus. Nicotine as well as the other compounds of the cigarette smoke are important risk factors of the inflammatory bowel disease and osteoporosis. Additionally, cigarette smoking may decrease BMD in the IBD patients. Interestingly, it affects patients with Crohn’s disease and ulcerative colitis in different ways—on the one hand it protects against ulcerative colitis, whereas on the other it increases the risk of Crohn’s disease development. Nevertheless, all patients should be encouraged to cease smoking in order to decrease the risk of developing other disorders.
Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases. Journal of Clinical Medicine 2021, 10, 1515 .
AMA StyleAlicja Ratajczak, Aleksandra Szymczak-Tomczak, Anna Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2021; 10 (7):1515.
Chicago/Turabian StyleAlicja Ratajczak; Aleksandra Szymczak-Tomczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases." Journal of Clinical Medicine 10, no. 7: 1515.
Introduction: Protein profiling allows the determination of the presence of proteins marking various stages of the disease, and differentiates between people at risk of various diseases. In type 1 diabetes, protein profiling had been previously used to find blood markers other than islet autoantibodies to indicate the pancreatic beta cell destruction process and to reflect the progression of type 1 diabetes mellitus (T1DM). However, T1DM is an auto-immune disease and its clinical presentation changes in time of its duration. The aim of the study: To find differences in protein profiles in patients with type 1 diabetes according to diabetes control (HbA1c > 7%) and with presence of diabetic complications or obesity. It may help to identify subgroups of patients who may need a better clinical supervision and individualized treatment. Material and methods: A group of 103 patients with auto-immunologically confirmed T1DM, and meeting the following inclusion criteria: Caucasian race, duration of diabetes >5 years, were used in the study. Criteria of exclusion: past or present cancer (treated with chemo-/radiotherapy), diseases of the liver (ALT > 3 × ULN) except for people with simple hepatic steatosis, chronic renal disease (eGFR < 30 mL/1.73 m2/min), and acute inflammation (CRP > 5 mg/dL). The study group was divided in terms of the presence of chronic complications, obesity, or poor metabolic control (HbA1c > 7%). Protein profiling was completed by using the MALDI-TOF MS (matrix-assisted laser desorption/ionization-time of flight mass spectrometry) analyzer. Results: Differentiating proteins were identified in all of the groups. The groups burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Conclusion: The groups of type 1 diabetes patients burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Further detailed studies are necessary to determine more subtle changes in the proteomic profile of patients with type 1 diabetes.
Agnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health 2021, 18, 2263 .
AMA StyleAgnieszka Zawada, Dariusz Naskręt, Eliza Matuszewska, Zenon Kokot, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska, Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health. 2021; 18 (5):2263.
Chicago/Turabian StyleAgnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. 2021. "MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications." International Journal of Environmental Research and Public Health 18, no. 5: 2263.
Osteoporosis is one of the most common extraintestinal complications among patients suffering from inflammatory bowel diseases. The role of vitamin D and calcium in the prevention of a decreased bone mineral density is well known, although other nutrients, including micronutrients, are also of extreme importance. Despite the fact that zinc, copper, selenium, iron, cadmium, silicon and fluorine have not been frequently discussed with regard to the prevention of osteoporosis, it is possible that a deficiency or excess of the abovementioned elements may affect bone mineralization. Additionally, the risk of malnutrition, which is common in patients with ulcerative colitis or Crohn’s disease, as well as the composition of gut microbiota, may be associated with micronutrients status.
Alicja Ratajczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis. Nutrients 2021, 13, 525 .
AMA StyleAlicja Ratajczak, Anna Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis. Nutrients. 2021; 13 (2):525.
Chicago/Turabian StyleAlicja Ratajczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis." Nutrients 13, no. 2: 525.
The endocannabinoid system (ECS) is an endogenous signaling system formed by specific receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands (endocannabinoids), and enzymes involved in their synthesis and degradation. The ECS, centrally and peripherally, is involved in various physiological processes, including regulation of energy balance, promotion of metabolic process, food intake, weight gain, promotion of fat accumulation in adipocytes, and regulation of body homeostasis; thus, its overactivity may be related to obesity. In this review, we try to explain the role of the ECS and the impact of genetic factors on endocannabinoid system modulation in the pathogenesis of obesity, which is a global and civilizational problem affecting the entire world population regardless of age. We also emphasize that the search for potential new targets for health assessment, treatment, and the development of possible therapies in obesity is of great importance.
Piotr Schulz; Szymon Hryhorowicz; Anna Maria Rychter; Agnieszka Zawada; Ryszard Słomski; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity? Nutrients 2021, 13, 373 .
AMA StylePiotr Schulz, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity? Nutrients. 2021; 13 (2):373.
Chicago/Turabian StylePiotr Schulz; Szymon Hryhorowicz; Anna Maria Rychter; Agnieszka Zawada; Ryszard Słomski; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?" Nutrients 13, no. 2: 373.
Patients suffering from Crohn’s disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimulants. Coffee and tea contain numerous compounds affecting bone metabolism. Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory.
Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Anna Maria Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases? Nutrients 2021, 13, 216 .
AMA StyleAlicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases? Nutrients. 2021; 13 (1):216.
Chicago/Turabian StyleAlicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Anna Maria Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?" Nutrients 13, no. 1: 216.
More research has recently focused on the role of the gut microbiota in the development or course of numerous diseases, including non-communicable diseases. As obesity remains prevalent, the question arises as to what microbial changes are associated with increased obesity prevalence and what kind of prevention and treatment approaches it could provide. Moreover, the influence of the gut-brain axis on obesity is also crucial, since it can affect metabolism and food intake. The quantitative and qualitative changes in the microbiota composition are called dysbiosis; however, in view of the current knowledge, it is difficult to conclude which microbial imbalances are adverse or beneficial. Increased numbers of pathological microorganisms were observed among patients with obesity and comorbidities associated with it, such as diabetes, cardiovascular disease, and insulin resistance. Our review provides current knowledge regarding changes in the intestinal microbiota associated with obesity and obesity-associated comorbidities. Nevertheless, given that dietary patterns and nutrients are two of the factors affecting the intestinal microbiota, we also discuss the role of different dietary approaches, vitamins, and minerals in the shaping of the intestinal microbiota.
Agnieszka Zawada; Anna Maria Rychter; Alicja Ewa Ratajczak; Agata Lisiecka-Masian; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders? Microorganisms 2020, 9, 18 .
AMA StyleAgnieszka Zawada, Anna Maria Rychter, Alicja Ewa Ratajczak, Agata Lisiecka-Masian, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders? Microorganisms. 2020; 9 (1):18.
Chicago/Turabian StyleAgnieszka Zawada; Anna Maria Rychter; Alicja Ewa Ratajczak; Agata Lisiecka-Masian; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders?" Microorganisms 9, no. 1: 18.
The process of protein glycation described by Brownlee et al. is a crucial pathogenic mechanism in the development of chronic complications of diabetes. To assess advanced glycation end products (AGEs) in the skin of patients with type 1 diabetes (DM1) and excess body fat (EBF) accumulation. The study group consisted of 227 DM1 patients (121 women and 106 men) whose mean age was 31 ±9.2 years; the mean duration of diabetes was 12 ±7.7 years; and the mean HbA1c was 8.9 ±1.8%. The inclusion criteria were as follows: age 18-65 years, DM1, and lack of acute inflammations and uncontrolled chronic diseases. The exclusion criteria were: anemia (hemoglobin (Hb) <11 g/dL), chronic kidney disease (CKD) (glomerular filtration rate (eGFR) <30 mL/min/1.73 m2) and elevated aminotransferase levels (more than twice the upper normal limits). Total adipose tissue content was assessed using the electrical bioimpedance method, with the Tanita BC-418 MA analyzer (Tanita Corp., Tokyo, Japan). The Tanita ViScan AB 140 (Tanita Corp.) was used to evaluate visceral fat tissue (VTF). The content of glycation end products in the skin was assessed using a DiagnOptics AGE Reader device (type 214D00102; DiagnOptics, Groningen, the Netherlands). The group with normal body fat (NBF) consisted of 123 subjects, whereas 104 subjects had EBF. No significant statistical differences were found between the NBF and EBF groups with regard to age, duration of diabetes, current HbA1C value, and tobacco use. A significantly higher AGE score was observed in the EBF group. Increased body fat affects the amount of AGE in the skin, which correlates with a higher risk of developing chronic diabetes complications.
Agnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine 2020, 29, 1193 -1199.
AMA StyleAgnieszka Ewa Zawada, Dariusz Naskret, Paweł Niedźwiecki, Marian Grzymisławski, Dorota Anna Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine. 2020; 29 (10):1193-1199.
Chicago/Turabian StyleAgnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. 2020. "Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes." Advances in Clinical and Experimental Medicine 29, no. 10: 1193-1199.
Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group.
Anna Maria Rychter; Marzena Skrzypczak-Zielinska; Aleksandra Zielińska; Piotr Eder; Eliana B. Souto; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Retinol-binding protein 4 in obesity. 2020, 1 .
AMA StyleAnna Maria Rychter, Marzena Skrzypczak-Zielinska, Aleksandra Zielińska, Piotr Eder, Eliana B. Souto, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Retinol-binding protein 4 in obesity. . 2020; ():1.
Chicago/Turabian StyleAnna Maria Rychter; Marzena Skrzypczak-Zielinska; Aleksandra Zielińska; Piotr Eder; Eliana B. Souto; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Retinol-binding protein 4 in obesity." , no. : 1.
Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn’s disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. Moreover, serum vitamin C level also is dependent on genetic factors, such as SLC23A1 and SLC23A2 genes, encoding sodium-dependent vitamin C transporters and GSTM1, GSTP1 and GSTT1 genes which encode glutathione S-transferases. Furthermore, ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.
Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Marzena Skrzypczak-Zielińska; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease. Nutrients 2020, 12, 2263 .
AMA StyleAlicja Ratajczak, Aleksandra Szymczak-Tomczak, Marzena Skrzypczak-Zielińska, Anna Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease. Nutrients. 2020; 12 (8):2263.
Chicago/Turabian StyleAlicja Ratajczak; Aleksandra Szymczak-Tomczak; Marzena Skrzypczak-Zielińska; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease." Nutrients 12, no. 8: 2263.
Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group. In our review, we summarized the current knowledge about RBP4 and its association with essential aspects of cardiovascular disease—lipid profile, intima-media thickness, atherosclerotic process, and diet. We also discussed the RBP4 gene polymorphisms essential from a cardiovascular perspective.
Anna Rychter; Marzena Skrzypczak-Zielińska; Aleksandra Zielińska; Piotr Eder; Eliana Souto; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? International Journal of Molecular Sciences 2020, 21, 5229 .
AMA StyleAnna Rychter, Marzena Skrzypczak-Zielińska, Aleksandra Zielińska, Piotr Eder, Eliana Souto, Agnieszka Zawada, Alicja Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity? International Journal of Molecular Sciences. 2020; 21 (15):5229.
Chicago/Turabian StyleAnna Rychter; Marzena Skrzypczak-Zielińska; Aleksandra Zielińska; Piotr Eder; Eliana Souto; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Is the Retinol-Binding Protein 4 a Possible Risk Factor for Cardiovascular Diseases in Obesity?" International Journal of Molecular Sciences 21, no. 15: 5229.
COVID‐19 crisis has lasted since the late 2019 to the present day. The severity of the disease is positively correlated with several factors, such as age and coexisting diseases. Furthermore, obesity is increasingly considered as a yet another risk factor, particularly, because it has been observed that people suffering from excessive body weight may experience a more severe course of COVID‐19 infection. On the basis of current research, in our nonsystematic review, we have investigated the extent to which obesity can affect the SARS‐CoV‐2 course and identify the potential mechanisms of the disease. We have also described the role of proper nutrition, physical activity and other aspects relevant to the management of obesity.
Anna Maria Rychter; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela‐Kaźmierczak. Should patients with obesity be more afraid of COVID‐19? Obesity Reviews 2020, 21, 1 .
AMA StyleAnna Maria Rychter, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela‐Kaźmierczak. Should patients with obesity be more afraid of COVID‐19? Obesity Reviews. 2020; 21 (9):1.
Chicago/Turabian StyleAnna Maria Rychter; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela‐Kaźmierczak. 2020. "Should patients with obesity be more afraid of COVID‐19?" Obesity Reviews 21, no. 9: 1.
The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral density is multifactorial and includes both diet and nutritional status. Calcium is the most often discussed minerals with regard to bone mineral density. Moreover, phosphorus; magnesium and sodium are also involved in the formation of bone mass. Patients suffering from inflammatory bowel diseases frequently consume inadequate amounts of the aforementioned minerals or their absorption is disturbed, resulting innutritional deficiency and an increased risk of osteoporosis.
Alicja Ewa Ratajczak; Anna Maria Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Minerals and Bone Mineral Density in Inflammatory Bowel Diseases. 2020, 1 .
AMA StyleAlicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Minerals and Bone Mineral Density in Inflammatory Bowel Diseases. . 2020; ():1.
Chicago/Turabian StyleAlicja Ewa Ratajczak; Anna Maria Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Minerals and Bone Mineral Density in Inflammatory Bowel Diseases." , no. : 1.
The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral density is multifactorial and includes both diet and nutritional status. Calcium and vitamin D are the most often discussed nutrients with regard to bone mineral density. Moreover, vitamins A, K, C, B12; folic acid; calcium; phosphorus; magnesium; sodium; zinc; copper; and selenium are also involved in the formation of bone mass. Patients suffering from inflammatory bowel diseases frequently consume inadequate amounts of the aforementioned minerals and vitamins or their absorption is disturbed, resulting innutritional deficiency and an increased risk of osteoporosis. Thus, nutritional guidelines for inflammatory bowel disease patients should comprise information concerning the prevention of osteoporosis.
Alicja Ewa Ratajczak; Anna Maria Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases. Nutrients 2020, 12, 1702 .
AMA StyleAlicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases. Nutrients. 2020; 12 (6):1702.
Chicago/Turabian StyleAlicja Ewa Ratajczak; Anna Maria Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases." Nutrients 12, no. 6: 1702.
Although cardiovascular disease and its risk factors have been widely studied and new methods of diagnosis and treatment have been developed and implemented, the morbidity and mortality levels are still rising—cardiovascular disease is responsible for more than four million deaths each year in Europe alone. Even though nutrition is classified as one of the main and changeable risk factors, the quality of the diet in the majority of people does not follow the recommendations essential for prevention of obesity and cardiovascular disease. It demonstrates the need for better nutritional education in cardiovascular disease prevention and treatment, and the need to emphasize dietary components most relevant in cardiovascular disease. In our non-systematic review, we summarize the most recent knowledge about nutritional risk and prevention in cardiovascular disease and obesity.
Anna Maria Rychter; Alicja Ewa Ratajczak; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity. Nutrients 2020, 12, 814 .
AMA StyleAnna Maria Rychter, Alicja Ewa Ratajczak, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity. Nutrients. 2020; 12 (3):814.
Chicago/Turabian StyleAnna Maria Rychter; Alicja Ewa Ratajczak; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity." Nutrients 12, no. 3: 814.
Conventional knowledge, resulting from observations and experience, maintains the conviction that there are gender differences in the acquisition, preparation and consumption of food. This review shows differences between the sexes in eating behavior, food choice and nutritional strategy which were conditioned by evolution and by intra-individual (biological or psychological) and extra-individual (socioeconomic and cultural) factors. Women manifest a more pronounced trust in healthy nutrition, greater engagement in controlling body weight, a higher tendency to eat in a group and in stressful situations, and they frequently experience frustration due to their own nutritional behaviors, which reflects higher social pressure and their attempts to reduce eating-related pleasure. On the other hand, men prefer fatty meals with a strong taste, and are directed mainly by the pleasure of consumption; they more frequently furtively eat sweet foods while watching television, use more dietary supplements and more frequently visit fast food restaurants. Nutritional behavior, styles of nutrition, dietary profiles, approach to nourishment, approach to the place of meal consumption, and the sources of nutritional knowledge all demonstrate associations with gender. Reciprocal interactions between gender and diet are conditioned by physiological, psychological and sociocultural factors. This system of reciprocal interactions includes feedback: biological sex and cultural gender shape one's diet and, reciprocally, one's diet affects the deepening or flattening of gender differences. The analysis of reciprocally interacting factors entangled in the formation of a nutritional model may also represent an important element of pro-health prophylaxis and should be used in medical and dietary practice. Males in particular should be informed and educated about health-promoting diets.
Małgorzata Grzymisławska; Elżbieta Alicja Puch; Agnieszka Zawada; Marian Grzymisławski. Do nutritional behaviors depend on biological sex and cultural gender? Advances in Clinical and Experimental Medicine 2020, 29, 165 -172.
AMA StyleMałgorzata Grzymisławska, Elżbieta Alicja Puch, Agnieszka Zawada, Marian Grzymisławski. Do nutritional behaviors depend on biological sex and cultural gender? Advances in Clinical and Experimental Medicine. 2020; 29 (1):165-172.
Chicago/Turabian StyleMałgorzata Grzymisławska; Elżbieta Alicja Puch; Agnieszka Zawada; Marian Grzymisławski. 2020. "Do nutritional behaviors depend on biological sex and cultural gender?" Advances in Clinical and Experimental Medicine 29, no. 1: 165-172.
Context: Amaranth and canola oils have been used traditionally. Amaranth has been identified as being of interest because of its outstanding nutritive value. Amaranth oil is a rich source of highly unsaturated fats and so could be a valuable dietary alternative for individuals affected with obesity. Reactive oxygen species (ROS) are postulated to be involved in systemic inflammation and oxidative stress. Activated polymorphonuclear neutrophils (PMNs) generate high amounts of reactive oxygen species. Objective: Our study investigates the impact of amaranth and canola oils supplementation on oxidative metabolism in patients with obesity. We hypothesized that, due to its lipid-lowering and antioxidant properties, amaranth and canola oil would protect against oxidative stress. Materials and methods: We tested 19 obese patients [body mass index (BMI) = 41.1 ± 7.8 kg/m2, (mean ± SD)]. The protocol consisted of two stages: a run-in phase of 2 weeks and an experimental stage – canola or amaranth oil supplementation (20 mL/d) with calorie restriction diet for 3 weeks. The neutrophil oxidative burst was expressed by fluorescence intensity (IF). Results: The oxidative burst had increased significantly at the end of treatment in both groups IF: (21.4 ± 11.15 vs. 35.9 ± 20.3; mean ± SD) p < 0.05. The levels of IF were significantly higher in neutrophils of patients who received canola oil (41.05 ± 25.3) compared to those who received amaranth oil (28.4 ± 11.8) p < 0.05. Conclusions: Canola oil exerts possible effects on oxidative burst activity in neutrophils in vivo conditions.
Dominika Kanikowska; Alina Kanikowska; Rafał Rutkowski; Małgorzata Włochal; Zofia Orzechowska; Aldona Juchacz; Agnieszka Zawada; Marian Grzymisławski; Magdalena Roszak; Maki Sato; Andrzej Bręborowicz; Janusz Witowski. Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*. Pharmaceutical Biology 2019, 57, 140 -144.
AMA StyleDominika Kanikowska, Alina Kanikowska, Rafał Rutkowski, Małgorzata Włochal, Zofia Orzechowska, Aldona Juchacz, Agnieszka Zawada, Marian Grzymisławski, Magdalena Roszak, Maki Sato, Andrzej Bręborowicz, Janusz Witowski. Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*. Pharmaceutical Biology. 2019; 57 (1):140-144.
Chicago/Turabian StyleDominika Kanikowska; Alina Kanikowska; Rafał Rutkowski; Małgorzata Włochal; Zofia Orzechowska; Aldona Juchacz; Agnieszka Zawada; Marian Grzymisławski; Magdalena Roszak; Maki Sato; Andrzej Bręborowicz; Janusz Witowski. 2019. "Amaranth (Amaranthus cruentus L.) and canola (Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*." Pharmaceutical Biology 57, no. 1: 140-144.
Małgorzata Moszak; Agnieszka Klupczynska; Alina Kanikowska; Zenon Kokot; Agnieszka Zawada; Małgorzata Grzymisławska; Marian Grzymisławski. The influence of a 3-week body mass reduction program on the metabolic parameters and free amino acid profiles in adult Polish people with obesity. Advances in Clinical and Experimental Medicine 2018, 27, 749 -757.
AMA StyleMałgorzata Moszak, Agnieszka Klupczynska, Alina Kanikowska, Zenon Kokot, Agnieszka Zawada, Małgorzata Grzymisławska, Marian Grzymisławski. The influence of a 3-week body mass reduction program on the metabolic parameters and free amino acid profiles in adult Polish people with obesity. Advances in Clinical and Experimental Medicine. 2018; 27 (6):749-757.
Chicago/Turabian StyleMałgorzata Moszak; Agnieszka Klupczynska; Alina Kanikowska; Zenon Kokot; Agnieszka Zawada; Małgorzata Grzymisławska; Marian Grzymisławski. 2018. "The influence of a 3-week body mass reduction program on the metabolic parameters and free amino acid profiles in adult Polish people with obesity." Advances in Clinical and Experimental Medicine 27, no. 6: 749-757.