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Prof. Agnieszka Dobrowolska
Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences

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Research Keywords & Expertise

0 Inflammatory Bowel Disease
0 Medical sciences
0 Microbiota, ibd, ibs, celiac disease, hepatitis, helicobacter pylori, pancreatic diseases, gastric diseases, liver diseases, esophageal diseases, colonic diverticulosis
0 Genetic
0 Digestive diseases

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Journal article
Published: 24 August 2021 in Journal of Clinical Medicine
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The genetic background and the determinants influencing the disease form, course, and onset of inflammatory bowel disease (IBD) remain unresolved. We aimed to determine the NOD2 gene haplotypes and their relationship with IBD occurrence, clinical presentation, and onset, analyzing a cohort of 578 patients with IBD, including children, and 888 controls. Imaging or endoscopy with a histopathological confirmation was used to diagnose IBD. Genotyping was performed to assess the differences in genotypic and allelic frequencies. Linkage disequilibrium was analyzed, and associations between haplotypes and clinical data were evaluated. We emphasized the prevalence of risk alleles in all analyzed loci in patients with Crohn disease (CD). Interestingly, c.2722G>C and c.3019_3020insC alleles were also overrepresented in ulcerative colitis (UC). T-C-G-C-insC, T-C-G-T-insC, and T-T-G-T-wt haplotypes were correlated with the late-onset form of CD (OR = 23.01, 5.09, and 17.71, respectively), while T-T-G-T-wt and C-C-G-T-wt were prevalent only in CD children (OR = 29.36, and 12.93, respectively; p-value = 0.001). In conclusion, the presence of c.3019_3020insC along with c.802C>T occurred as the most fundamental contributing diplotype in late-onset CD form, while in CD children, the mutual allele in all predisposing haplotypes was the c.2798 + 158T. Identifying the unique, high-impact haplotypes supports further studies of the NOD2 gene, including haplotypic backgrounds.

ACS Style

Marta Kaczmarek-Ryś; Szymon Tytus Hryhorowicz; Emilia Lis; Tomasz Banasiewicz; Jacek Paszkowski; Maciej Borejsza-Wysocki; Jarosław Walkowiak; Wojciech Cichy; Piotr Krokowicz; Elżbieta Czkwianianc; Andrzej Hnatyszyn; Iwona Krela-Kaźmierczak; Agnieszka Dobrowolska; Ryszard Słomski; Andrzej Pławski. Crohn’s Disease Susceptibility and Onset Are Strongly Related to Three NOD2 Gene Haplotypes. Journal of Clinical Medicine 2021, 10, 3777 .

AMA Style

Marta Kaczmarek-Ryś, Szymon Tytus Hryhorowicz, Emilia Lis, Tomasz Banasiewicz, Jacek Paszkowski, Maciej Borejsza-Wysocki, Jarosław Walkowiak, Wojciech Cichy, Piotr Krokowicz, Elżbieta Czkwianianc, Andrzej Hnatyszyn, Iwona Krela-Kaźmierczak, Agnieszka Dobrowolska, Ryszard Słomski, Andrzej Pławski. Crohn’s Disease Susceptibility and Onset Are Strongly Related to Three NOD2 Gene Haplotypes. Journal of Clinical Medicine. 2021; 10 (17):3777.

Chicago/Turabian Style

Marta Kaczmarek-Ryś; Szymon Tytus Hryhorowicz; Emilia Lis; Tomasz Banasiewicz; Jacek Paszkowski; Maciej Borejsza-Wysocki; Jarosław Walkowiak; Wojciech Cichy; Piotr Krokowicz; Elżbieta Czkwianianc; Andrzej Hnatyszyn; Iwona Krela-Kaźmierczak; Agnieszka Dobrowolska; Ryszard Słomski; Andrzej Pławski. 2021. "Crohn’s Disease Susceptibility and Onset Are Strongly Related to Three NOD2 Gene Haplotypes." Journal of Clinical Medicine 10, no. 17: 3777.

Journal article
Published: 20 August 2021 in Journal of Clinical Medicine
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(1) Background: Social distancing rules have been widely introduced in the fight against the coronavirus disease 2019 (COVID-19) pandemic. So far, the effectiveness of these methods has not been assessed in the group of inflammatory bowel disease (IBD) patients. (2) Methods: The study included 473 patients with IBD who made 1180 hospital visits from 1 May to 30 September 2020. During each visit, the patients completed a five-step, progressive scale that was developed to assess the degree of social isolation. In parallel, other demographic data were collected and the concentrations of anti-severe acute respiratory coronavirus 2 (SARS-CoV-2) IgG and IgM+IgA antibodies were measured using the ELISA method. (3) Results: The study found a significant correlation between the degree of social distancing and the presence of anti-SARS-CoV-2 antibodies in the groups with the lowest degree of isolation (3 to 5). (4) Conclusions: Maintaining social distancing is an effective method for reducing the spread of SARS-CoV-2 virus among IBD patients.

ACS Style

Michał Łodyga; Katarzyna Maciejewska; Piotr Eder; Katarzyna Waszak; Kamila Stawczyk-Eder; Agnieszka Dobrowolska; Aleksandra Kaczka; Anita Gąsiorowska; Beata Stępień-Wrochna; Małgorzata Cicha; Grażyna Rydzewska. Social Distancing during COVID-19 Pandemic among Inflammatory Bowel Disease Patients. Journal of Clinical Medicine 2021, 10, 3689 .

AMA Style

Michał Łodyga, Katarzyna Maciejewska, Piotr Eder, Katarzyna Waszak, Kamila Stawczyk-Eder, Agnieszka Dobrowolska, Aleksandra Kaczka, Anita Gąsiorowska, Beata Stępień-Wrochna, Małgorzata Cicha, Grażyna Rydzewska. Social Distancing during COVID-19 Pandemic among Inflammatory Bowel Disease Patients. Journal of Clinical Medicine. 2021; 10 (16):3689.

Chicago/Turabian Style

Michał Łodyga; Katarzyna Maciejewska; Piotr Eder; Katarzyna Waszak; Kamila Stawczyk-Eder; Agnieszka Dobrowolska; Aleksandra Kaczka; Anita Gąsiorowska; Beata Stępień-Wrochna; Małgorzata Cicha; Grażyna Rydzewska. 2021. "Social Distancing during COVID-19 Pandemic among Inflammatory Bowel Disease Patients." Journal of Clinical Medicine 10, no. 16: 3689.

Review
Published: 30 July 2021 in Nutrients
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Several studies have shown increased rates of cardiovascular disease (CVD) in patients suffering from inflammatory bowel disease (IBD), particularly in cases of early atherosclerosis and myocardial infarction. IBD most frequently begins at an early age, patients usually present normal weight and remain under constant care of a physician, as well as of a nutritionist. Therefore, the classical risk factors of CVD are not reflected in the higher prevalence of CVD in the IBD population. Still, both groups are characterised by chronic inflammation and display similar physiopathological mechanisms. In the course of IBD, increased concentrations of pro-inflammatory cytokines, such as C-reactive protein (CRP) and homocysteine, may lead to endothelial dysfunctions and the development of CVD. Furthermore, gut microbiota dysbiosis in patients with IBD also constitutes a risk factor for an increased susceptibility to cardiovascular disease and atherosclerosis. Additionally, diet is an essential factor affecting both positively and negatively the course of the aforementioned diseases, whereas several dietary patterns may also influence the association between IBD and CVD. Thus, it is essential to investigate the factors responsible for the increased cardiovascular (CV) risk in this group of patients. Our paper attempts to review the role of potential inflammatory and nutritional factors, as well as intestinal dysbiosis and pharmacotherapy, in the increased risk of CVD in IBD patients.

ACS Style

Liliana Łykowska-Szuber; Anna Maria Rychter; Magdalena Dudek; Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Piotr Eder; Maciej Lesiak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review. Nutrients 2021, 13, 2661 .

AMA Style

Liliana Łykowska-Szuber, Anna Maria Rychter, Magdalena Dudek, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Piotr Eder, Maciej Lesiak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review. Nutrients. 2021; 13 (8):2661.

Chicago/Turabian Style

Liliana Łykowska-Szuber; Anna Maria Rychter; Magdalena Dudek; Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Piotr Eder; Maciej Lesiak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review." Nutrients 13, no. 8: 2661.

Review
Published: 03 June 2021 in Journal of Personalized Medicine
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Atherosclerosis—considered the major cause of cardiovascular diseases (CVDs)—is strongly associated with obesity, to which it strongly contributes. Moreover, atherosclerosis is characterised by a long asymptomatic phase, and its progression can lead to serious cardiovascular (CV) events. The carotid intima-media thickness (cIMT) has been determined as a predictor of CV events, as well as a marker of subclinical atherosclerosis, and has been used in clinical trials as an alternative assessment method or a surrogate endpoint. It should be noted that several behavioural approaches can directly influence the cIMT values, and decrease or increase the CV risk. In our paper, we aimed to summarize the current knowledge regarding IMT measurement among patients with obesity as a risk group—also in terms of the obesity paradox where the diagnosis of subclinical atherosclerosis is especially essential and implements the early therapeutic approach. We also summarized behavioural, modifiable factors, such as the Mediterranean diet, the Dietary Approach to Stop Hypertension Diets, body weight reduction or the intake of micro- and macronutrients, with a particular focus on the studies where the cIMT values were one of the outcomes. In order to collect the literature data related to the presented topic, the PubMed database was explored.

ACS Style

Anna Rychter; Dariusz Naskręt; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity? Journal of Personalized Medicine 2021, 11, 505 .

AMA Style

Anna Rychter, Dariusz Naskręt, Agnieszka Zawada, Alicja Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity? Journal of Personalized Medicine. 2021; 11 (6):505.

Chicago/Turabian Style

Anna Rychter; Dariusz Naskręt; Agnieszka Zawada; Alicja Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Can We Change in Diet and Behaviour in Order to Decrease Carotid Intima-Media Thickness in Patients with Obesity?" Journal of Personalized Medicine 11, no. 6: 505.

Journal article
Published: 30 May 2021 in Nutrients
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Reduced physical activity (PA), smoking, and coffee and alcohol drinking constitute risk factors of osteoporosis in patients with inflammatory bowel disease (IBD). The aim of the study was to measure the bone mineral density (BMD) and frequency of osteopenia and osteoporosis in patients with IBD and their correlation with PA, smoking, coffee, and alcohol. The study group consisted of 208 patients with IBD-103 with Crohn’s disease (CD), 105 suffering from ulcerative colitis (UC). Densitometric measurements were performed using the DXA. All patients completed a questionnaire concerning PA, smoking, and coffee and alcohol consumption. The prevalence of osteopenia and osteoporosis (L2–L4) in the IBD group was 48.1%; in the CD group, it amounted to 48.6%, and in the UC group, the prevalence was equal to 33.3%. Patients with CD who were diagnosed with osteopenia and osteoporosis demonstrated reduced PA compared to patients with a normal BMD who exercised regularly (p = 0.0335). A similar observation was made in the group of women with IBD. Women with a normal BMD exercised significantly more often than women suffering from osteopenia and osteoporosis (p = 0.0146). However, no differences in BMD were observed with regard to coffee use, alcohol consumption, or smoking. Thus, since the incidence of osteoporosis in IBD patients is high, it may be dependent on PA.

ACS Style

Anna Rychter; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Michał Michalak; Piotr Eder; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Associations of Lifestyle Factors with Osteopenia and Osteoporosis in Polish Patients with Inflammatory Bowel Disease. Nutrients 2021, 13, 1863 .

AMA Style

Anna Rychter, Alicja Ratajczak, Aleksandra Szymczak-Tomczak, Michał Michalak, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Associations of Lifestyle Factors with Osteopenia and Osteoporosis in Polish Patients with Inflammatory Bowel Disease. Nutrients. 2021; 13 (6):1863.

Chicago/Turabian Style

Anna Rychter; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Michał Michalak; Piotr Eder; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Associations of Lifestyle Factors with Osteopenia and Osteoporosis in Polish Patients with Inflammatory Bowel Disease." Nutrients 13, no. 6: 1863.

Review
Published: 17 April 2021 in Nutrients
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Osteoporosis affects women twice as often as men. Additionally, it is estimated that 0.3 million and 1.7 million people have hip fractures in the USA and Europe, respectively. Having a proper peak bone mass and keeping it as long as possible is especially important for osteoporosis prevention. One of the most important calcium sources is milk and dairy products. Breast milk is the best infant food, but milk should not be avoided later in life to prevent losing bone mass. On the other hand, more and more people limit their milk consumption and consume other dairy or non-dairy products. For example, they are usually replaced with plant beverages, which should be consumed carefully in several age groups. Additionally, an important element of milk and dairy products, as well as plant beverages, are probiotics and prebiotics, which may modulate bone turnover. Dietary recommendations focused on milk, and dairy products are an important element for the prevention of osteoporosis.

ACS Style

Alicja Ratajczak; Agnieszka Zawada; Anna Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis. Nutrients 2021, 13, 1329 .

AMA Style

Alicja Ratajczak, Agnieszka Zawada, Anna Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis. Nutrients. 2021; 13 (4):1329.

Chicago/Turabian Style

Alicja Ratajczak; Agnieszka Zawada; Anna Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Milk and Dairy Products: Good or Bad for Human Bone? Practical Dietary Recommendations for the Prevention and Management of Osteoporosis." Nutrients 13, no. 4: 1329.

Review
Published: 05 April 2021 in Journal of Clinical Medicine
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Cigarette smoking constitutes one of the most important modifiable factors of osteoporosis, as well as contributes to an early death, tumors, and numerous chronic diseases. The group with an increased risk of a lower bone mineral density are patients suffering from inflammatory bowel diseases. In fact, tobacco smoke, which contains more than 7000 chemical compounds, affects bone mineral density (BMD) both directly and indirectly, as it has an impact on the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium–phosphate balance. Constant cigarette use interferes with the production of protective mucus and inhibits the repair processes in the intestinal mucus. Nicotine as well as the other compounds of the cigarette smoke are important risk factors of the inflammatory bowel disease and osteoporosis. Additionally, cigarette smoking may decrease BMD in the IBD patients. Interestingly, it affects patients with Crohn’s disease and ulcerative colitis in different ways—on the one hand it protects against ulcerative colitis, whereas on the other it increases the risk of Crohn’s disease development. Nevertheless, all patients should be encouraged to cease smoking in order to decrease the risk of developing other disorders.

ACS Style

Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases. Journal of Clinical Medicine 2021, 10, 1515 .

AMA Style

Alicja Ratajczak, Aleksandra Szymczak-Tomczak, Anna Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases. Journal of Clinical Medicine. 2021; 10 (7):1515.

Chicago/Turabian Style

Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases." Journal of Clinical Medicine 10, no. 7: 1515.

Journal article
Published: 25 February 2021 in International Journal of Environmental Research and Public Health
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Introduction: Protein profiling allows the determination of the presence of proteins marking various stages of the disease, and differentiates between people at risk of various diseases. In type 1 diabetes, protein profiling had been previously used to find blood markers other than islet autoantibodies to indicate the pancreatic beta cell destruction process and to reflect the progression of type 1 diabetes mellitus (T1DM). However, T1DM is an auto-immune disease and its clinical presentation changes in time of its duration. The aim of the study: To find differences in protein profiles in patients with type 1 diabetes according to diabetes control (HbA1c > 7%) and with presence of diabetic complications or obesity. It may help to identify subgroups of patients who may need a better clinical supervision and individualized treatment. Material and methods: A group of 103 patients with auto-immunologically confirmed T1DM, and meeting the following inclusion criteria: Caucasian race, duration of diabetes >5 years, were used in the study. Criteria of exclusion: past or present cancer (treated with chemo-/radiotherapy), diseases of the liver (ALT > 3 × ULN) except for people with simple hepatic steatosis, chronic renal disease (eGFR < 30 mL/1.73 m2/min), and acute inflammation (CRP > 5 mg/dL). The study group was divided in terms of the presence of chronic complications, obesity, or poor metabolic control (HbA1c > 7%). Protein profiling was completed by using the MALDI-TOF MS (matrix-assisted laser desorption/ionization-time of flight mass spectrometry) analyzer. Results: Differentiating proteins were identified in all of the groups. The groups burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Conclusion: The groups of type 1 diabetes patients burdened with complications, obesity, and poor metabolic control were characterized by increased levels of fibrinogen, complement C4 and C3. Further detailed studies are necessary to determine more subtle changes in the proteomic profile of patients with type 1 diabetes.

ACS Style

Agnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health 2021, 18, 2263 .

AMA Style

Agnieszka Zawada, Dariusz Naskręt, Eliza Matuszewska, Zenon Kokot, Marian Grzymisławski, Dorota Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska, Jan Matysiak. MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications. International Journal of Environmental Research and Public Health. 2021; 18 (5):2263.

Chicago/Turabian Style

Agnieszka Zawada; Dariusz Naskręt; Eliza Matuszewska; Zenon Kokot; Marian Grzymisławski; Dorota Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska; Jan Matysiak. 2021. "MALDI-TOF Protein Profiling Reflects Changes in Type 1 Diabetes Patients Depending on the Increased Amount of Adipose Tissue, Poor Control of Diabetes and the Presence of Chronic Complications." International Journal of Environmental Research and Public Health 18, no. 5: 2263.

Review
Published: 16 February 2021 in Nutrients
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A gluten-free diet is the mainstay method of treatment and the prevention of celiac disease complications. However, an inadequately balanced gluten-free diet can increase the risk of obesity, negatively affect glucose and lipid metabolism, and increase the risk of the metabolic syndrome. Therefore, an adequate nutritional counselling is necessary for patients diagnosed with celiac disease in order to prevent and treat the components of the metabolic syndrome.

ACS Style

Martyna Marciniak; Aleksandra Szymczak-Tomczak; Dagmara Mahadea; Piotr Eder; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review. Nutrients 2021, 13, 643 .

AMA Style

Martyna Marciniak, Aleksandra Szymczak-Tomczak, Dagmara Mahadea, Piotr Eder, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review. Nutrients. 2021; 13 (2):643.

Chicago/Turabian Style

Martyna Marciniak; Aleksandra Szymczak-Tomczak; Dagmara Mahadea; Piotr Eder; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Multidimensional Disadvantages of a Gluten-Free Diet in Celiac Disease: A Narrative Review." Nutrients 13, no. 2: 643.

Review
Published: 05 February 2021 in Nutrients
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Osteoporosis is one of the most common extraintestinal complications among patients suffering from inflammatory bowel diseases. The role of vitamin D and calcium in the prevention of a decreased bone mineral density is well known, although other nutrients, including micronutrients, are also of extreme importance. Despite the fact that zinc, copper, selenium, iron, cadmium, silicon and fluorine have not been frequently discussed with regard to the prevention of osteoporosis, it is possible that a deficiency or excess of the abovementioned elements may affect bone mineralization. Additionally, the risk of malnutrition, which is common in patients with ulcerative colitis or Crohn’s disease, as well as the composition of gut microbiota, may be associated with micronutrients status.

ACS Style

Alicja Ratajczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis. Nutrients 2021, 13, 525 .

AMA Style

Alicja Ratajczak, Anna Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis. Nutrients. 2021; 13 (2):525.

Chicago/Turabian Style

Alicja Ratajczak; Anna Rychter; Agnieszka Zawada; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis." Nutrients 13, no. 2: 525.

Review
Published: 04 February 2021 in Nutrients
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Iodine deficiency is a global issue and affects around 2 billion people worldwide, with pregnant women as a high-risk group. Iodine-deficiency prevention began in the 20th century and started with global salt iodination programmes, which aimed to improve the iodine intake status globally. Although it resulted in the effective eradication of the endemic goitre, it seems that salt iodination did not resolve all the issues. Currently, it is recommended to limit the consumption of salt, which is the main source of iodine, as a preventive measure of non-communicable diseases, such as hypertension or cancer the prevalence of which is increasing. In spite of the fact that there are other sources of iodine, such as fish, seafood, dairy products, water, and vegetables, the high consumption of processed food with a high content of unionised salt, alternative diets or limited salt intake can still lead to iodine deficiency. Thus, iodine deficiency remains a relevant issue, with new, preventive solutions necessary. However, it appears that there is no diet which would fully cover the iodine requirements, and iodine food supplementation is still required.

ACS Style

Iwona Krela-Kaźmierczak; Agata Czarnywojtek; Kinga Skoracka; Anna Rychter; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Marek Ruchała; Agnieszka Dobrowolska. Is There an Ideal Diet to Protect against Iodine Deficiency? Nutrients 2021, 13, 513 .

AMA Style

Iwona Krela-Kaźmierczak, Agata Czarnywojtek, Kinga Skoracka, Anna Rychter, Alicja Ratajczak, Aleksandra Szymczak-Tomczak, Marek Ruchała, Agnieszka Dobrowolska. Is There an Ideal Diet to Protect against Iodine Deficiency? Nutrients. 2021; 13 (2):513.

Chicago/Turabian Style

Iwona Krela-Kaźmierczak; Agata Czarnywojtek; Kinga Skoracka; Anna Rychter; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Marek Ruchała; Agnieszka Dobrowolska. 2021. "Is There an Ideal Diet to Protect against Iodine Deficiency?" Nutrients 13, no. 2: 513.

Review
Published: 26 January 2021 in Nutrients
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The endocannabinoid system (ECS) is an endogenous signaling system formed by specific receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands (endocannabinoids), and enzymes involved in their synthesis and degradation. The ECS, centrally and peripherally, is involved in various physiological processes, including regulation of energy balance, promotion of metabolic process, food intake, weight gain, promotion of fat accumulation in adipocytes, and regulation of body homeostasis; thus, its overactivity may be related to obesity. In this review, we try to explain the role of the ECS and the impact of genetic factors on endocannabinoid system modulation in the pathogenesis of obesity, which is a global and civilizational problem affecting the entire world population regardless of age. We also emphasize that the search for potential new targets for health assessment, treatment, and the development of possible therapies in obesity is of great importance.

ACS Style

Piotr Schulz; Szymon Hryhorowicz; Anna Maria Rychter; Agnieszka Zawada; Ryszard Słomski; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity? Nutrients 2021, 13, 373 .

AMA Style

Piotr Schulz, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Słomski, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity? Nutrients. 2021; 13 (2):373.

Chicago/Turabian Style

Piotr Schulz; Szymon Hryhorowicz; Anna Maria Rychter; Agnieszka Zawada; Ryszard Słomski; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?" Nutrients 13, no. 2: 373.

Review
Published: 20 January 2021 in Nutrients
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Sarcopenia is a disorder characterized by a loss of muscle mass which leads to the reduction of muscle strength and a decrease in the quality and quantity of muscle. It was previously thought that sarcopenia was specific to ageing. However, sarcopenia may affect patients suffering from chronic diseases throughout their entire lives. A decreased mass of muscle and bone is common among patients with inflammatory bowel disease (IBD). Since sarcopenia and osteoporosis are closely linked, they should be diagnosed as mutual consequences of IBD. Additionally, multidirectional treatment of sarcopenia and osteoporosis including nutrition, physical activity, and pharmacotherapy should include both disorders, referred to as osteosarcopenia.

ACS Style

Dorota Skrzypczak; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Dobrowolska; Piotr Eder; Iwona Krela-Kaźmierczak. A Vicious Cycle of Osteosarcopeniain Inflammatory Bowel Diseases—Aetiology, Clinical Implications and Therapeutic Perspectives. Nutrients 2021, 13, 293 .

AMA Style

Dorota Skrzypczak, Alicja Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Dobrowolska, Piotr Eder, Iwona Krela-Kaźmierczak. A Vicious Cycle of Osteosarcopeniain Inflammatory Bowel Diseases—Aetiology, Clinical Implications and Therapeutic Perspectives. Nutrients. 2021; 13 (2):293.

Chicago/Turabian Style

Dorota Skrzypczak; Alicja Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Dobrowolska; Piotr Eder; Iwona Krela-Kaźmierczak. 2021. "A Vicious Cycle of Osteosarcopeniain Inflammatory Bowel Diseases—Aetiology, Clinical Implications and Therapeutic Perspectives." Nutrients 13, no. 2: 293.

Review
Published: 13 January 2021 in Nutrients
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Patients suffering from Crohn’s disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimulants. Coffee and tea contain numerous compounds affecting bone metabolism. Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory.

ACS Style

Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Anna Maria Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases? Nutrients 2021, 13, 216 .

AMA Style

Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases? Nutrients. 2021; 13 (1):216.

Chicago/Turabian Style

Alicja Ewa Ratajczak; Aleksandra Szymczak-Tomczak; Agnieszka Zawada; Anna Maria Rychter; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2021. "Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?" Nutrients 13, no. 1: 216.

Proceedings
Published: 11 January 2021 in Proceedings
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Various products coded by genes recognized in microbiota are involved in many biochemical pathways in thehuman body. Bacteria composition in the gastrointestinal tract may be an important aspect of selected diseases’ pathogenesis, including irritable bowel syndrome (IBS). Traditional research methods based on classical microbiology, using selective media for bacterial growth, have proven to be ineffective. The use of genetic methods allows the identification of unidentified microbiota, including anaerobes. Roseburia hominis is a flagellated gut anaerobic commensal bacterium, producing short-fatty acids. The knowledge about the microbial components of the intestinal ecosystem is still very limited, including Roseburia hominis. This study aimed to identify Roseburia hominis in the faeces samples obtained from IBS patients and healthy individuals, using PCR techniques. The differences between studied groups were observed, and it was concluded that R. hominis may play a role in IBS etiology.

ACS Style

Paulina Pecyna; Zuzanna Babalska; Klaudia Szymendera; Dorota Nowak Malczewska; Monika Górna; Maria Jaworska Marcelina; Marcin Gabryel; Dorota Mańkowska-Wierzbicka; Marian Grzymisławski; Agnieszka Dobrowolska; Hanna Tomczak; Małgorzata Chmielewska; Marzena Gajęcka. Qualitative Identification of Roseburia hominis in Faeces Samples Obtained from Patients with Irritable Bowel Syndrome and Healthy Individuals. Proceedings 2021, 66, 28 .

AMA Style

Paulina Pecyna, Zuzanna Babalska, Klaudia Szymendera, Dorota Nowak Malczewska, Monika Górna, Maria Jaworska Marcelina, Marcin Gabryel, Dorota Mańkowska-Wierzbicka, Marian Grzymisławski, Agnieszka Dobrowolska, Hanna Tomczak, Małgorzata Chmielewska, Marzena Gajęcka. Qualitative Identification of Roseburia hominis in Faeces Samples Obtained from Patients with Irritable Bowel Syndrome and Healthy Individuals. Proceedings. 2021; 66 (1):28.

Chicago/Turabian Style

Paulina Pecyna; Zuzanna Babalska; Klaudia Szymendera; Dorota Nowak Malczewska; Monika Górna; Maria Jaworska Marcelina; Marcin Gabryel; Dorota Mańkowska-Wierzbicka; Marian Grzymisławski; Agnieszka Dobrowolska; Hanna Tomczak; Małgorzata Chmielewska; Marzena Gajęcka. 2021. "Qualitative Identification of Roseburia hominis in Faeces Samples Obtained from Patients with Irritable Bowel Syndrome and Healthy Individuals." Proceedings 66, no. 1: 28.

Review
Published: 23 December 2020 in Microorganisms
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More research has recently focused on the role of the gut microbiota in the development or course of numerous diseases, including non-communicable diseases. As obesity remains prevalent, the question arises as to what microbial changes are associated with increased obesity prevalence and what kind of prevention and treatment approaches it could provide. Moreover, the influence of the gut-brain axis on obesity is also crucial, since it can affect metabolism and food intake. The quantitative and qualitative changes in the microbiota composition are called dysbiosis; however, in view of the current knowledge, it is difficult to conclude which microbial imbalances are adverse or beneficial. Increased numbers of pathological microorganisms were observed among patients with obesity and comorbidities associated with it, such as diabetes, cardiovascular disease, and insulin resistance. Our review provides current knowledge regarding changes in the intestinal microbiota associated with obesity and obesity-associated comorbidities. Nevertheless, given that dietary patterns and nutrients are two of the factors affecting the intestinal microbiota, we also discuss the role of different dietary approaches, vitamins, and minerals in the shaping of the intestinal microbiota.

ACS Style

Agnieszka Zawada; Anna Maria Rychter; Alicja Ewa Ratajczak; Agata Lisiecka-Masian; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders? Microorganisms 2020, 9, 18 .

AMA Style

Agnieszka Zawada, Anna Maria Rychter, Alicja Ewa Ratajczak, Agata Lisiecka-Masian, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders? Microorganisms. 2020; 9 (1):18.

Chicago/Turabian Style

Agnieszka Zawada; Anna Maria Rychter; Alicja Ewa Ratajczak; Agata Lisiecka-Masian; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Does Gut-Microbiome Interaction Protect against Obesity and Obesity-Associated Metabolic Disorders?" Microorganisms 9, no. 1: 18.

Journal article
Published: 16 October 2020 in Advances in Clinical and Experimental Medicine
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The process of protein glycation described by Brownlee et al. is a crucial pathogenic mechanism in the development of chronic complications of diabetes. To assess advanced glycation end products (AGEs) in the skin of patients with type 1 diabetes (DM1) and excess body fat (EBF) accumulation. The study group consisted of 227 DM1 patients (121 women and 106 men) whose mean age was 31 ±9.2 years; the mean duration of diabetes was 12 ±7.7 years; and the mean HbA1c was 8.9 ±1.8%. The inclusion criteria were as follows: age 18-65 years, DM1, and lack of acute inflammations and uncontrolled chronic diseases. The exclusion criteria were: anemia (hemoglobin (Hb) <11 g/dL), chronic kidney disease (CKD) (glomerular filtration rate (eGFR) <30 mL/min/1.73 m2) and elevated aminotransferase levels (more than twice the upper normal limits). Total adipose tissue content was assessed using the electrical bioimpedance method, with the Tanita BC-418 MA analyzer (Tanita Corp., Tokyo, Japan). The Tanita ViScan AB 140 (Tanita Corp.) was used to evaluate visceral fat tissue (VTF). The content of glycation end products in the skin was assessed using a DiagnOptics AGE Reader device (type 214D00102; DiagnOptics, Groningen, the Netherlands). The group with normal body fat (NBF) consisted of 123 subjects, whereas 104 subjects had EBF. No significant statistical differences were found between the NBF and EBF groups with regard to age, duration of diabetes, current HbA1C value, and tobacco use. A significantly higher AGE score was observed in the EBF group. Increased body fat affects the amount of AGE in the skin, which correlates with a higher risk of developing chronic diabetes complications.

ACS Style

Agnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine 2020, 29, 1193 -1199.

AMA Style

Agnieszka Ewa Zawada, Dariusz Naskret, Paweł Niedźwiecki, Marian Grzymisławski, Dorota Anna Zozulińska-Ziółkiewicz, Agnieszka Dobrowolska. Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes. Advances in Clinical and Experimental Medicine. 2020; 29 (10):1193-1199.

Chicago/Turabian Style

Agnieszka Ewa Zawada; Dariusz Naskret; Paweł Niedźwiecki; Marian Grzymisławski; Dorota Anna Zozulińska-Ziółkiewicz; Agnieszka Dobrowolska. 2020. "Excess body fat increases the accumulation of advanced glycation end products in the skin of patients with type 1 diabetes." Advances in Clinical and Experimental Medicine 29, no. 10: 1193-1199.

Preprint content
Published: 08 August 2020
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Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management. Excessive accumulation of adipose tissue among patients suffering from obesity not only constitutes one of the main risk factors of CVD development but also alters adipokines. Increased attention is devoted to bioactive adipokines, which are also produced by the adipose tissue. The retinol-binding protein 4 (RBP4) has been associated with numerous CVDs and is presumably associated with an increased cardiovascular risk. With this in mind, exploring the role of RBP4, particularly among patients with obesity, could be a promising direction and could lead to better CVD prevention and management in this patient group.

ACS Style

Anna Maria Rychter; Marzena Skrzypczak-Zielinska; Aleksandra Zielińska; Piotr Eder; Eliana B. Souto; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. Retinol-binding protein 4 in obesity. 2020, 1 .

AMA Style

Anna Maria Rychter, Marzena Skrzypczak-Zielinska, Aleksandra Zielińska, Piotr Eder, Eliana B. Souto, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak. Retinol-binding protein 4 in obesity. . 2020; ():1.

Chicago/Turabian Style

Anna Maria Rychter; Marzena Skrzypczak-Zielinska; Aleksandra Zielińska; Piotr Eder; Eliana B. Souto; Agnieszka Zawada; Alicja Ewa Ratajczak; Agnieszka Dobrowolska; Iwona Krela-Kaźmierczak. 2020. "Retinol-binding protein 4 in obesity." , no. : 1.

Preprint content
Published: 03 August 2020
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In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory bowel disease (IBD), is increasingly growing worldwide. It is well established that primary immunodeficiencies (PIDs) exhibit gastrointestinal manifestations and mimic other diseases, including CeD and IBD. The most common PIDs in adults are the selective immunoglobulin A deficiency (SIgAD) and the common variable immunodeficiency (CVID). However, some differences concerning diagnostics and management between enteropathy/colitis in PIDs, as compared to idiopathic forms of CeD/IBD, have been described. There is an ongoing discussion whether CeD and IBD in CVID patients should be considered a true CeD and IBD or just CeD-like and IBD-like diseases. This review addresses the current state of the art of the most common primary immunodeficiencies in adults and co-occurring CeD and IBD.

ACS Style

Michał Malesza; Ida Malesza; Iwona Krela-Kaźmierczak; Aleksandra Zielińska; Eliana B. Souto; Agnieszka Dobrowolska; Piotr Eder. Gastrointestinal Diseases in Primary Immunodeficiencies. 2020, 1 .

AMA Style

Michał Malesza, Ida Malesza, Iwona Krela-Kaźmierczak, Aleksandra Zielińska, Eliana B. Souto, Agnieszka Dobrowolska, Piotr Eder. Gastrointestinal Diseases in Primary Immunodeficiencies. . 2020; ():1.

Chicago/Turabian Style

Michał Malesza; Ida Malesza; Iwona Krela-Kaźmierczak; Aleksandra Zielińska; Eliana B. Souto; Agnieszka Dobrowolska; Piotr Eder. 2020. "Gastrointestinal Diseases in Primary Immunodeficiencies." , no. : 1.

Preprint content
Published: 02 August 2020
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In recent years, the incidence of immune-mediated gastrointestinal disorders, including celiac disease (CeD) and inflammatory bowel disease (IBD), is increasingly growing worldwide. It is well established that primary immunodeficiencies (PIDs) exhibit gastrointestinal manifestations and mimic other diseases, including CeD and IBD. The most common PIDs in adults are the selective immunoglobulin A deficiency (SIgAD) and the common variable immunodeficiency (CVID). However, some differences concerning diagnostics and management between enteropathy/colitis in PIDs, as compared to idiopathic forms of CeD/IBD, have been described. There is an ongoing discussion whether CeD and IBD in CVID patients should be considered a true CeD and IBD or just CeD-like and IBD-like diseases. This review addresses the current state of the art of the most common primary immunodeficiencies in adults and co-occurring CeD and IBD.

ACS Style

Michał Malesza; Ida Malesza; Iwona Krela-Kaźmierczak; Aleksandra Zielińska; Eliana B. Souto; Agnieszka Dobrowolska; Piotr Eder. Gastrointestinal Diseases in Primary Immunodeficiencies. 2020, 1 .

AMA Style

Michał Malesza, Ida Malesza, Iwona Krela-Kaźmierczak, Aleksandra Zielińska, Eliana B. Souto, Agnieszka Dobrowolska, Piotr Eder. Gastrointestinal Diseases in Primary Immunodeficiencies. . 2020; ():1.

Chicago/Turabian Style

Michał Malesza; Ida Malesza; Iwona Krela-Kaźmierczak; Aleksandra Zielińska; Eliana B. Souto; Agnieszka Dobrowolska; Piotr Eder. 2020. "Gastrointestinal Diseases in Primary Immunodeficiencies." , no. : 1.