This page has only limited features, please log in for full access.

Prof. Angelo Peli
1. Department of Veterinary Sciences, Alma Mater Studiorum Università di Bologna, Bologna, Italy

Basic Info


Research Keywords & Expertise

0 Animal Welfare
0 Ethics
0 Veterinary legislation
0 Animal used for experimental purposes
0 Animal health (ruminants)

Fingerprints

Animal Welfare

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 12 May 2021 in Animals
Reads 0
Downloads 0

Severe equine asthma (EA) syndrome is a chronic obstructive disease characterized by exaggerated contraction, inflammation, and structural alteration of the airways in adult horses, when exposed to airborne molds and particulate material. However, little is known about the relationship between the degree and type of inflammation on one hand, and the severity of the disease and the response to treatment on the other. Furthermore, to date, very few studies evaluate the diagnostic value of histology and immunohistochemical features of endoscopic biopsies on subjects with severe equine asthma. To investigate the expression of two inflammatory markers (NKA and IL-8) before, during, and after the exacerbation of severe EA, a histological and immunohistochemical study was carried out on a series of biopsy samples collected by bronchoscopy from six EA-affected horses subjected to process exacerbation through environmental stimuli and then to pharmacological treatment. The application of a histological biopsy scoring system revealed a significant difference between control cases and the EA-affected horses in all experimental phases (asymptomatic, early exacerbation phase, late exacerbation phase, and remission phase). For immunohistochemistry (IHC), only the intensity of NKA positivity increases significantly between control horses and the EA horses at late exacerbation and remission phases. In EA-affected horses, a difference was detected by comparing histology between asymptomatic and remission phase, meanwhile, NKA and IL-8 showed no differences between the experimental phases. Based on these results we can assert that: (1) The endoscopic biopsies generate reliable and homogeneous samples in the entire bronchial tree; (2) the clinical improvement associated with treatment is characterized by a significant worsening of the histological findings; and (3) the NKA immunopositivity seems to increase significantly rather than decrease, as one would have expected, after pharmacological treatment. Further studies are necessary both to implement the number of samples and to use other markers of inflammation to characterize the potential role of cytokines in the diagnosis and therapeutic approach of severe equine asthma.

ACS Style

Maria Morini; Angelo Peli; Riccardo Rinnovati; Giuseppe Magazzù; Noemi Romagnoli; Alessandro Spadari; Marco Pietra. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase. Animals 2021, 11, 1376 .

AMA Style

Maria Morini, Angelo Peli, Riccardo Rinnovati, Giuseppe Magazzù, Noemi Romagnoli, Alessandro Spadari, Marco Pietra. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase. Animals. 2021; 11 (5):1376.

Chicago/Turabian Style

Maria Morini; Angelo Peli; Riccardo Rinnovati; Giuseppe Magazzù; Noemi Romagnoli; Alessandro Spadari; Marco Pietra. 2021. "Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase." Animals 11, no. 5: 1376.

Journal article
Published: 01 December 2020 in Toxins
Reads 0
Downloads 0

An assessment of the natural ochratoxin A (OTA) exposure of seven Martina Franca jennies was carried out by analyzing blood and milk samples collected close to and after delivery. A total of 41 and 34 blood samples were collected from jennies and foals, respectively, and analyzed by ELISA. A total of 33 milk samples were collected from jennies and analyzed by the HPLC/FLD method based on IAC clean-up. Furthermore, 53 feed samples were collected from January to September and analyzed by a reference method (AOAC Official Method No. 2000.03) for OTA content. Feed samples showed OTA levels up to 2.7 ng/g with an incidence of 32%, while the OTA incidence rate in jennies’ blood samples was 73%, with a median value of 97 ng/L and concentrations ranging from

ACS Style

Vincenzo Lippolis; Shafaq Asif; Michelangelo Pascale; Salvatore Cervellieri; Erminia Mancini; Angelo Peli; Ippolito De Amicis; Domenico Robbe; Fiorenza Minervini. Natural Occurrence of Ochratoxin A in Blood and Milk Samples from Jennies and Their Foals after Delivery. Toxins 2020, 12, 758 .

AMA Style

Vincenzo Lippolis, Shafaq Asif, Michelangelo Pascale, Salvatore Cervellieri, Erminia Mancini, Angelo Peli, Ippolito De Amicis, Domenico Robbe, Fiorenza Minervini. Natural Occurrence of Ochratoxin A in Blood and Milk Samples from Jennies and Their Foals after Delivery. Toxins. 2020; 12 (12):758.

Chicago/Turabian Style

Vincenzo Lippolis; Shafaq Asif; Michelangelo Pascale; Salvatore Cervellieri; Erminia Mancini; Angelo Peli; Ippolito De Amicis; Domenico Robbe; Fiorenza Minervini. 2020. "Natural Occurrence of Ochratoxin A in Blood and Milk Samples from Jennies and Their Foals after Delivery." Toxins 12, no. 12: 758.

Journal article
Published: 20 August 2020 in Biology
Reads 0
Downloads 0

Traumatic brain injury (TBI) is a shocking disease frequently followed by behavioral disabilities, including risk of cerebral atrophy and dementia. N-formylpeptide receptor 1 (FPR1) is expressed in cells and neurons in the central nervous system. It is involved in inflammatory processes and during the differentiation process in the neural stem cells. We investigate the effect of the absence of Fpr1 gene expression in mice subjected to TBI from the early stage of acute inflammation to neurogenesis and systematic behavioral testing four weeks after injury. C57BL/6 animals and Fpr1 KO mice were subjected to TBI and sacrificed 24 h or four weeks after injury. Twenty-four hours after injury, TBI Fpr1 KO mice showed reduced histological impairment, tissue damage and acute inflammation (MAPK activation, NF-κB signaling induction, NRLP3 inflammasome pathway activation and oxidative stress increase). Conversely, four weeks after TBI, the Fpr1 KO mice showed reduced survival of the proliferated cells in the Dentate Gyrus compared to the WT group. Behavioral analysis confirmed this trend. Moreover, TBI Fpr1 KO animals displayed reduced neural differentiation (evaluated by beta-III tubulin expression) and upregulation of astrocyte differentiation (evaluated by GFAP expression). Collectively, our study reports that, immediately after TBI, Fpr1 increased acute inflammation, while after four weeks, Fpr1 promoted neurogenesis.

ACS Style

Roberta Fusco; Enrico Gugliandolo; Rosalba Siracusa; Maria Scuto; Marika Cordaro; Ramona D’Amico; Maurizio Evangelista; Angelo Peli; Alessio Filippo Peritore; Daniela Impellizzeri; Rosalia Crupi; Salvatore Cuzzocrea; Rosanna Di Paola. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology 2020, 9, 238 .

AMA Style

Roberta Fusco, Enrico Gugliandolo, Rosalba Siracusa, Maria Scuto, Marika Cordaro, Ramona D’Amico, Maurizio Evangelista, Angelo Peli, Alessio Filippo Peritore, Daniela Impellizzeri, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola. Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury. Biology. 2020; 9 (9):238.

Chicago/Turabian Style

Roberta Fusco; Enrico Gugliandolo; Rosalba Siracusa; Maria Scuto; Marika Cordaro; Ramona D’Amico; Maurizio Evangelista; Angelo Peli; Alessio Filippo Peritore; Daniela Impellizzeri; Rosalia Crupi; Salvatore Cuzzocrea; Rosanna Di Paola. 2020. "Formyl Peptide Receptor 1 Signaling in Acute Inflammation and Neural Differentiation Induced by Traumatic Brain Injury." Biology 9, no. 9: 238.

Case report
Published: 11 August 2020 in International Journal of Legal Medicine
Reads 0
Downloads 0

Genetic testing of animal biological material has become a valuable tool in forensic investigations, and it is successfully used to identify unknown crime perpetrators, to unmask food frauds, or to clarify cases of animal attacks on humans or other animals. When DNA profiling is not possible due to inadequate amounts of nuclear DNA, mitochondrial DNA (mtDNA) testing is the only viable alternative, as in the case of shed hair samples. In this case, a dog was allegedly killed by wild animals while being hosted in a boarding house. Extraneous hair fragments recovered from the dog’s mouth and paws were subjected to genetic analysis: the cytochrome b gene located on mtDNA was amplified and sequenced in order to determine the species responsible for the killing. The mtDNA analysis provided evidence that the dog was killed by other dogs, thus unmasking a false wild animal attack and putting the case in an entirely different perspective.

ACS Style

Mariana Roccaro; Carla Bini; Paolo Fais; Giuseppe Merialdi; Susi Pelotti; Angelo Peli. Who killed my dog? Use of forensic genetics to investigate an enigmatic case. International Journal of Legal Medicine 2020, 135, 387 -392.

AMA Style

Mariana Roccaro, Carla Bini, Paolo Fais, Giuseppe Merialdi, Susi Pelotti, Angelo Peli. Who killed my dog? Use of forensic genetics to investigate an enigmatic case. International Journal of Legal Medicine. 2020; 135 (2):387-392.

Chicago/Turabian Style

Mariana Roccaro; Carla Bini; Paolo Fais; Giuseppe Merialdi; Susi Pelotti; Angelo Peli. 2020. "Who killed my dog? Use of forensic genetics to investigate an enigmatic case." International Journal of Legal Medicine 135, no. 2: 387-392.

Journal article
Published: 14 July 2020
Reads 0
Downloads 0
ACS Style

Mariana Roccaro; Angelo Peli. Age determination in dog puppies by teeth examination: legal, health and welfare implications, review of the literature and practical considerations. 2020, 56, 149 -162.

AMA Style

Mariana Roccaro, Angelo Peli. Age determination in dog puppies by teeth examination: legal, health and welfare implications, review of the literature and practical considerations. . 2020; 56 (3):149-162.

Chicago/Turabian Style

Mariana Roccaro; Angelo Peli. 2020. "Age determination in dog puppies by teeth examination: legal, health and welfare implications, review of the literature and practical considerations." 56, no. 3: 149-162.

Journal article
Published: 14 June 2019 in Animals
Reads 0
Downloads 0

Calves reared for the production of white veal are subjected to stressful events due to the type of liquid diet they receive. Stress responses are mediated by three main stress-responsive cerebral regions: the prefrontal cortex, the paraventricular nucleus of the hypothalamus, and the nucleus of the solitary tract of the brainstem. In the present study, we have investigated the effects of different diets on these brain regions of ruminants using immunohistochemical methods. In this study, 15 calves were used and kept in group housing systems of five calves each. They were fed with three different diets: a control diet, a milk diet, and a weaned diet. Brain sections were immunostained to evaluate the distribution of neuronal nitric oxide synthase and myelin oligodendrocyte glycoprotein immunoreactivity in the prefrontal cortex; the expression of oxytocin in the paraventricular nucleus; and the presence of c-Fos in the A2 group of the nucleus of the solitary tract. The main results obtained indicate that in weaned diet group the oxytocin activity is lower than in control diet and milk diet groups. In addition, weaning appears to stimulate myelination in the prefrontal cortex. In summary, this study supports the importance of maintaining a nutritional lifestyle similar to that occurring in natural conditions.

ACS Style

Angelo Peli; Annamaria Grandis; Marco Tassinari; Paolo Famigli Bergamini; Claudio Tagliavia; Mariana Roccaro; Cristiano Bombardi. Environment and Behavior: Neurochemical Effects of Different Diets in the Calf Brain. Animals 2019, 9, 358 .

AMA Style

Angelo Peli, Annamaria Grandis, Marco Tassinari, Paolo Famigli Bergamini, Claudio Tagliavia, Mariana Roccaro, Cristiano Bombardi. Environment and Behavior: Neurochemical Effects of Different Diets in the Calf Brain. Animals. 2019; 9 (6):358.

Chicago/Turabian Style

Angelo Peli; Annamaria Grandis; Marco Tassinari; Paolo Famigli Bergamini; Claudio Tagliavia; Mariana Roccaro; Cristiano Bombardi. 2019. "Environment and Behavior: Neurochemical Effects of Different Diets in the Calf Brain." Animals 9, no. 6: 358.

Journal article
Published: 31 December 2018 in Vet. Ital.
Reads 0
Downloads 0
ACS Style

Angelo Peli; Mariana Roccaro. The reliability and forensic soundness of the equine shin circumference measurement in living animals versus post‑mortem examination. Vet. Ital. 2018, 54, 281 -286.

AMA Style

Angelo Peli, Mariana Roccaro. The reliability and forensic soundness of the equine shin circumference measurement in living animals versus post‑mortem examination. Vet. Ital.. 2018; 54 (4):281-286.

Chicago/Turabian Style

Angelo Peli; Mariana Roccaro. 2018. "The reliability and forensic soundness of the equine shin circumference measurement in living animals versus post‑mortem examination." Vet. Ital. 54, no. 4: 281-286.

Journal article
Published: 18 January 2016 in Italian Journal of Food Safety
Reads 0
Downloads 0

The final results of a survey on welfare of dairy cows in 7 Italian Regions are presented. The study has been performed on 943 farms in southern and central Italy to highlight critical and strong points concerning animal welfare in dairy systems, by using direct and indirect criteria. To assess animal welfare, a check-list based on 303 parameters has been used; indirect criteria have been organized in 5 general areas concerning “Farm management”, “Farming and housing systems”, “Environment”, “Feeding”, “Health and hygiene”; other resource-based criteria were considered in 5 specific areasfor the different productive categories (lactating cows, dry cows, pregnant heifers, cows comeback, calves up to 8 weeks and calves between 8 weeks and 6 months); finally, an “Indicators” section focusedon animal based criteria. Parameters have been valued as “conforming” or “not conforming” on the basis of the current lesgislation on animal welfare, and in the other cases by the use of a semi-quantitative scale such as “poor”, “satisfactory”, “good” or “very good”, referring to scientific literature and reports by the European Food Safety Authority (EFSA) Animal Health and Animal Welfare (AHAW) panel. Among the 249 examined parameters (54 criteria have been valued as “descriptive”), 15 showed a failure prevalence inferior to 1%; for the remaining parameters, the overall noncompliance prevalence on the whole sample ranged from a maximum of 67% to a minimum of 2%, showing an inverse proportionality correlation with the herd size. 110 parameters were judged as “poor” (96) or “not in compliance” with the rules in force (14) in more than 10% of the examined herds. The most common non-compliance aspects detected in the different areas concern calves management, staff training and prophylaxis programs; staff training levels were inversely related to failure prevalences in almost all areas. The combination of direct and indirect criteria has allowed to fully embrace recommendations on the use of animal based measures for the assessment of animal welfare, as accepted into the strategic Plan for the EU animal welfare for 2012-2015.

ACS Style

Angelo Peli; Marco Pietra; Federica Giacometti; Antonella Mazzi; Gianluca Scacco; Andrea Serraino; Lorenzo Scagliarini. Survey on animal welfare in 943 Italian dairy farms. Italian Journal of Food Safety 2016, 5, 5832 .

AMA Style

Angelo Peli, Marco Pietra, Federica Giacometti, Antonella Mazzi, Gianluca Scacco, Andrea Serraino, Lorenzo Scagliarini. Survey on animal welfare in 943 Italian dairy farms. Italian Journal of Food Safety. 2016; 5 (1):5832.

Chicago/Turabian Style

Angelo Peli; Marco Pietra; Federica Giacometti; Antonella Mazzi; Gianluca Scacco; Andrea Serraino; Lorenzo Scagliarini. 2016. "Survey on animal welfare in 943 Italian dairy farms." Italian Journal of Food Safety 5, no. 1: 5832.

Case report
Published: 01 December 2015 in Irish Veterinary Journal
Reads 0
Downloads 0

The authors report the first case of feline gastric actinomycosis associated with infection by Actinomyces hordeovulneris. A 4-year-old, neutered male, semi-feral European cat, with a 1 year history of chronic vomiting, was referred to the clinic. Abdominal ultrasound examination identified a hypoechoic focal transmural thickening with loss of normal wall layering and hyperechoic speckles at the gastric body. Initial gastroscopic examination showed a tumour-like gastric mass with an ulcerated depression at the level of the greater curvature. Histologic examination of endoscopic biopsy specimens was consistent with a severe lymphoplasmacytic gastritis. After 2 months, due to persistence of abdominal discomfort, surgical exploration and intraoperative sampling of gross abnormalities was recommended. Full thickness gastric wall biopsies, and fine needle aspiration of the gastric thickening and gastric lymph node, were performed. Histopathological examination identified a transmural pyogranulomatous gastritis. Aspirate samples of the gastric wall cultured positive, with colony morphology, biochemical testing and PCR of the 16 s rRNA gene compatible with Actinomyces hordeovulneris. After 4 months of treatment with cefovecin (8 mg/kg subcutaneously every 14 days), the vomiting completely resolved, as well as the ultrasonographic gastric alteration. This case report of feline gastric actinomycosis, caused by Actinomyces hordeovulneris, suggests that gastric bacterial infection should be considered in cases of focal gastric wall thickening associated with chronic vomiting in the cat, which may otherwise closely resemble neoplastic disease. Once a diagnosis of actinomycosis was obtained, a correct treatment with antibiotic therapy can resolve it.

ACS Style

Marco Pietra; Renato Giulio Zanoni; Angelo Peli; Barbara Brunetti; Nikolina Linta; Ombretta Capitani; Giuseppe Spinella. Gastric inflammatory pseudotumour secondary to Actinomyces hordeovulneris infection in a cat. Irish Veterinary Journal 2015, 69, 12 .

AMA Style

Marco Pietra, Renato Giulio Zanoni, Angelo Peli, Barbara Brunetti, Nikolina Linta, Ombretta Capitani, Giuseppe Spinella. Gastric inflammatory pseudotumour secondary to Actinomyces hordeovulneris infection in a cat. Irish Veterinary Journal. 2015; 69 (1):12.

Chicago/Turabian Style

Marco Pietra; Renato Giulio Zanoni; Angelo Peli; Barbara Brunetti; Nikolina Linta; Ombretta Capitani; Giuseppe Spinella. 2015. "Gastric inflammatory pseudotumour secondary to Actinomyces hordeovulneris infection in a cat." Irish Veterinary Journal 69, no. 1: 12.

Journal article
Published: 18 November 2013 in Arthritis Research & Therapy
Reads 0
Downloads 0

N-palmitoylethanolamine (PEA) is an endogenous fatty acid amide belonging to the family of the N-acylethanolamines (NAEs). Recently, several studies demonstrated that PEA is an important analgesic, antiinflammatory, and neuroprotective mediator. The aim of this study was to investigate the effect of co-ultramicronized PEA + luteolin formulation on the modulation of the inflammatory response in mice subjected to collagen-induced arthritis (CIA). CIA was induced by an intradermally injection of 100 μl of the emulsion (containing 100 μg of bovine type II collagen (CII)) and complete Freund adjuvant (CFA) at the base of the tail. On day 21, a second injection of CII in CFA was administered. Mice subjected to CIA were administered PEA (10 mg/kg 10% ethanol, intraperitoneally (i.p.)) or co-ultramicronized PEA + luteolin (1 mg/kg, i.p.) every 24 hours, starting from day 25 to 35. Mice developed erosive hind-paw arthritis when immunized with CII in CFA. Macroscopic clinical evidence of CIA first appeared as periarticular erythema and edema in the hindpaws. The incidence of CIA was 100% by day 28 in the CII-challenged mice, and the severity of CIA progressed over a 35-day period with a resorption of bone. The histopathology of CIA included erosion of the cartilage at the joint. Treatment with PEA or PEA + luteolin ameliorated the clinical signs at days 26 to 35 and improved histologic status in the joint and paw. The degree of oxidative and nitrosative damage was significantly reduced in PEA + luteolin-treated mice, as indicated by nitrotyrosine and malondialdehyde (MDA) levels. Plasma levels of the proinflammatory cytokines and chemokines were significantly reduced by PEA + luteolin treatment. We demonstrated that PEA co-ultramicronized with luteolin exerts an antiinflammatory effect during chronic inflammation and ameliorates CIA.

ACS Style

Daniela Impellizzeri; Emanuela Esposito; Rosanna Di Paola; Akbar Ahmad; Michela Campolo; Angelo Peli; Valeria Maria Morittu; Domenico Britti; Salvatore Cuzzocrea. Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice. Arthritis Research & Therapy 2013, 15, 4055 -R192.

AMA Style

Daniela Impellizzeri, Emanuela Esposito, Rosanna Di Paola, Akbar Ahmad, Michela Campolo, Angelo Peli, Valeria Maria Morittu, Domenico Britti, Salvatore Cuzzocrea. Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice. Arthritis Research & Therapy. 2013; 15 (6):4055-R192.

Chicago/Turabian Style

Daniela Impellizzeri; Emanuela Esposito; Rosanna Di Paola; Akbar Ahmad; Michela Campolo; Angelo Peli; Valeria Maria Morittu; Domenico Britti; Salvatore Cuzzocrea. 2013. "Palmitoylethanolamide and luteolin ameliorate development of arthritis caused by injection of collagen type II in mice." Arthritis Research & Therapy 15, no. 6: 4055-R192.

Review
Published: 02 January 2013 in Veterinaria italiana
Reads 0
Downloads 0
ACS Style

Angelo Peli; Lorenzo Scagliarini; Stefano Calbucci; Giuseppe Diegoli. Considerations on the sphere of application of European Union animal protection legislation for horses. Veterinaria italiana 2013, 48, 1 .

AMA Style

Angelo Peli, Lorenzo Scagliarini, Stefano Calbucci, Giuseppe Diegoli. Considerations on the sphere of application of European Union animal protection legislation for horses. Veterinaria italiana. 2013; 48 (4):1.

Chicago/Turabian Style

Angelo Peli; Lorenzo Scagliarini; Stefano Calbucci; Giuseppe Diegoli. 2013. "Considerations on the sphere of application of European Union animal protection legislation for horses." Veterinaria italiana 48, no. 4: 1.

Journal article
Published: 11 December 2012 in Journal of Leukocyte Biology
Reads 0
Downloads 0

Dietary olive oil supplementation and more recently, olive oil phenols have been recommended as important therapeutic interventions in preventive medicine. Ole has several pharmacological properties, including antioxidant, anti‐inflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral and for these reasons, is becoming an important subject of study in recent years. The aim of this study was to investigate the effects of Ole aglycone on the modulation of the secondary events in mice subjected to intestinal IRI. This was induced in mice by clamping the superior mesenteric artery and the celiac trunk for 30 min, followed by release of the clamp, allowing reperfusion for 1 h. After 60 min of reperfusion, animals were killed for histological examination of the ileum tissue and immunohistochemical localization of proinflammatory cytokines (TNF‐α and IL‐1β) and adhesion molecules (ICAM‐1 and P‐sel); moreover, by Western blot analysis, we investigated the activation of NF‐κB and IκBα. In addition, we evaluated the apoptosis process, as shown by TUNEL staining and Bax/Bcl‐2 expressions. The results obtained by the histological and molecular examinations showed in Ole aglycone‐treated mice, a decrease of inflammation and apoptosis pathway versus SAO‐shocked mice. In conclusion, we propose that the olive oil compounds, in particular, the Ole aglycone, could represent a possible treatment against secondary events of intestinal IRI.

ACS Style

Michela Campolo; Rosanna Di Paola; Daniela Impellizzeri; Rosalia Crupi; Valeria Maria Morittu; Antonio Procopio; Enzo Perri; Domenico Britti; Angelo Peli; Emanuela Esposito; Salvatore Cuzzocrea. Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. Journal of Leukocyte Biology 2012, 93, 277 -287.

AMA Style

Michela Campolo, Rosanna Di Paola, Daniela Impellizzeri, Rosalia Crupi, Valeria Maria Morittu, Antonio Procopio, Enzo Perri, Domenico Britti, Angelo Peli, Emanuela Esposito, Salvatore Cuzzocrea. Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. Journal of Leukocyte Biology. 2012; 93 (2):277-287.

Chicago/Turabian Style

Michela Campolo; Rosanna Di Paola; Daniela Impellizzeri; Rosalia Crupi; Valeria Maria Morittu; Antonio Procopio; Enzo Perri; Domenico Britti; Angelo Peli; Emanuela Esposito; Salvatore Cuzzocrea. 2012. "Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury." Journal of Leukocyte Biology 93, no. 2: 277-287.

Journal article
Published: 01 April 2006 in American Journal of Veterinary Research
Reads 0
Downloads 0

Objective-To compare 4 assay procedures for prediction of passive transfer status in lambs. Animals-Thirty-one 1-day-old Sardinian lambs. Procedure-Serum IgG concentration was determined by use of single radial immunodiffusion, The following were determined: serum total protein concentration as measured by refractometry (ie, refractometry serum total protein concentration), serum total protein concentration as determined by the biuret method (ie, biuret method serum total protein concentration), serum gamma-globulin concentration as determined by serum protein electrophoresis, and serum gamma-glutamyltransferase (GGT) activity as measured by spectrophotometry. Accuracy of these assays for estimation of serum IgG concentration in 1-day-old lambs was established by use of linear regression analysis. Results-Refractometry serum total protein concentration, biuret method serum total protein concentration, and serum gamma-globulin concentration were closely and linearly correlated with serum IgG concentration. The natural logarithm (In) of serum GGT activity was closely and linearly correlated with serum IgG concentration (In) Refractometry serum total protein concentration, biuret method serum total protein concentration, and gamma-globulin concentration accounted for approximately 85%, 91%, and 95% of the variation in serum IgG concentration, respectively. Serum GGT activity (In) accounted for approximately 92% of the variation in serum IgG concentration (In). Conclusions and Clinical Relevance-For prediction of passive transfer status in 1-day-old lambs, serum GGT activity or biuret method serum total protein concentration determination will allow for passive transfer monitoring program development. Immediate refractometry serum total protein concentration determination is beneficial in making timely management and treatment decisions. Serum gamma-globulin concentration determination can be used as a confirmatory test.[...

ACS Style

Genesio Massimini; Angelo Peli; Andrea Boari; Domenico Britti. Evaluation of assay procedures for prediction of passive transfer status in lambs. American Journal of Veterinary Research 2006, 67, 593 -598.

AMA Style

Genesio Massimini, Angelo Peli, Andrea Boari, Domenico Britti. Evaluation of assay procedures for prediction of passive transfer status in lambs. American Journal of Veterinary Research. 2006; 67 (4):593-598.

Chicago/Turabian Style

Genesio Massimini; Angelo Peli; Andrea Boari; Domenico Britti. 2006. "Evaluation of assay procedures for prediction of passive transfer status in lambs." American Journal of Veterinary Research 67, no. 4: 593-598.

Original paper
Published: 24 August 2004 in Planta Medica
Reads 0
Downloads 0

Anthocyanins are a group of naturally occurring phenolic compounds related to the colouring of plants, flowers and fruits. These pigments are important as quality indicators, chemotaxonomic markers and for their antioxidant activities. Here we have investigated the therapeutic efficacy of anthocyanins contained in a blackberry extract on (i) circulatory failure, (ii) multiple organ dysfunction and (iii) activity of the inducible isoforms of nitric oxide (NO) synthase (iNOS) and cyclooxygenase (COX-2) in anaesthetised rats with endotoxic shock. In a model of endotoxic shock induced by lipopolysaccharide (LPS, E. coli, 10 mg/kg, i. v.) in the rat, pretreatment with anthocyanins present in the blackberry extract (5 mg/kg, i. v. 30 min before LPS) prevented the hypotension induced by LPS. Endotoxaemia also caused rises in the serum levels of (i) glutamyl oxaloacetic transaminase (GOT), glutamyl pyruvic transaminase (GPT), alkaline phosphates and bilirubin (hepatic dysfunction) (ii) creatinine (renal dysfunction), (iii) amylase and lipase (pancreatic injury), (iiii) NOx and 6-keto-PGF1 α. Anthocyanins attenuated the hepatic and pancreatic injury, the renal dysfunction and decreased NOx and 6-keto-PGF1 α levels. Endotoxaemia for 6 h resulted in a substantial increase in iNOS and COX activity in rat lung, which was attenuated in rats pretreated with anthocyanins. Moreover, anthocyanins (0.02 - 0.32 mg/mL) inhibited in vitro iNOS and COX activity from lung of LPS-treated rats. Polymorphonuclear (PMN) infiltration (myeloperoxidase activity), lipid peroxidation (malondialdehyde levels) as well as tissue injury (histological examination) induced by LPS in rat lung and ileum was reduced by anthocyanins (5 mg/kg, i. v. 30 min before LPS). Furthermore, endotoxaemia induced the formation of nitrotyrosine and poly(ADP-ribose) synthetase (PARS) activation as determined by immunohistochemical analysis of lung and ileum tissues. The degree of staining was lowered by anthocyanin treatment. These results indicate that the anthocyanins contained in the blackberry extract exert multiple protective effects in endotoxic shock. NOx:nitrite/nitrate LPS:lipopolysaccharide NO:nitric oxide iNOS:inducible nitric oxide synthase COX-2:cyclooxygenase-2 PMN:polymorphonuclear PARS:poly(ADP-ribose) synthetase PG:prostaglandin ROS:reactive oxygen species MODS:multiple organ dysfunction syndrome MAP:mean arterial blood pressure GOT:glutamyl oxaloacetic transaminase GPT:glutamyl pyruvic transaminase DEX:dexamethasone MPO:myeloperoxidase MDA:malondialdehyde

ACS Style

Lidia Sautebin; Antonietta Rossi; Ivana Serraino; Paola Dugo; Rosanna Di Paola; Luigi Mondello; Tiziana Genovese; Domenico Britti; Angelo Peli; Giovanni Dugo; Achille P. Caputi; Salvatore Cuzzocrea. Effect of Anthocyanins Contained in a Blackberry Extract on the Circulatory Failure and Multiple Organ Dysfunction Caused by Endotoxin in the Rat. Planta Medica 2004, 70, 745 -752.

AMA Style

Lidia Sautebin, Antonietta Rossi, Ivana Serraino, Paola Dugo, Rosanna Di Paola, Luigi Mondello, Tiziana Genovese, Domenico Britti, Angelo Peli, Giovanni Dugo, Achille P. Caputi, Salvatore Cuzzocrea. Effect of Anthocyanins Contained in a Blackberry Extract on the Circulatory Failure and Multiple Organ Dysfunction Caused by Endotoxin in the Rat. Planta Medica. 2004; 70 (8):745-752.

Chicago/Turabian Style

Lidia Sautebin; Antonietta Rossi; Ivana Serraino; Paola Dugo; Rosanna Di Paola; Luigi Mondello; Tiziana Genovese; Domenico Britti; Angelo Peli; Giovanni Dugo; Achille P. Caputi; Salvatore Cuzzocrea. 2004. "Effect of Anthocyanins Contained in a Blackberry Extract on the Circulatory Failure and Multiple Organ Dysfunction Caused by Endotoxin in the Rat." Planta Medica 70, no. 8: 745-752.