Sebastian Grillo

Dr. Sebastian Grillo

orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 October 2021 in Applied Sciences
Verified
Journal Article
Open access
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Julio César Mello RománJulio César Mello Román
Julio César Mello Román
Jose Luis Vázquez NogueraJose Luis Vázquez Noguera
Jose Luis Vázquez Noguera
Horacio Legal AyalaHoracio Legal Ayala
Horacio Legal Ayala
Miguel Garcia TorresMiguel Garcia Torres
Miguel Garcia Torres
JFjacques facon
jacques facon
JMJorge Mello-Román
Jorge Mello-Román
Skin dermoscopy images frequently lack contrast caused by varying light conditions. Indeed, often low contrast is seen in dermoscopy images of melanoma, causing the lesion to blend in with the surrounding skin. In addition, the low contrast prevents certain details from being seen in the image. Therefore, it is necessary to design an approach that can enhance the contrast and details of dermoscopic images. In this work, we propose a multi-scale morphological approach to reduce the impacts of lack of contrast and to enhance the quality of the images. By top-hat reconstruction, the local bright and dark features are extracted from the image. The local bright features are added and the dark features are subtracted from the image. In this way, images with higher contrast and detail are obtained. The proposed approach was applied to a database of 236 color images of benign and malignant melanocytic lesions. The results show that the multi-scale morphological approach by reconstruction is a competitive algorithm since it achieved a very satisfactory level of contrast enhancement and detail enhancement in dermoscopy images.

18 October 2021 in Applied Sciences
Verified
Journal Article
Open access
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HSHyun Ho Shin
Hyun Ho Shin
CACarlos Sauer Ayala
Carlos Sauer Ayala
PEPastor Enmanuel Pérez Estigarribia
Pastor Enmanuel Pérez Estigarribia
SGSebastian Grillo
Sebastian Grillo
LSLeticia Segovia-Cabrera
Leticia Segovia-Cabrera
ESEduardo De Los Santos
Eduardo De Los Santos
Forecasting the dynamics of the number of cases with coronavirus disease 2019 (COVID-19) in a given population is a challenging task due to behavioural changes which occur over short periods. Planning of hospital resources and containment measures in the near term require a scenario analysis and the use of predictive models to gain insight into possible outcomes for each scenario. In this paper, we present the SEIR-H epidemiological model for the spread dynamics in a given population and the impact of COVID-19 in the local health system. It was developed as an extension of the classic SEIR model to account for required hospital resources and behavioural changes of the population in response to containment measures. Time-varying parameters such as transmissibility are estimated using Bayesian methods, based on the database of reported cases with a moving time-window strategy. The assessment of the model offers reasonable results with estimated parameters and simulations, reflecting the observed dynamics in Paraguay. The proposed model can be used to simulate future scenarios and possible effects of containment strategies, to guide the public institution response based on the available resources in the local health system.

15 November 2021 in Mathematics
Verified
Journal Article
Open access
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SGSebastian Grillo
Sebastian Grillo
Jose Luis Vázquez NogueraJose Luis Vázquez Noguera
Jose Luis Vázquez Noguera
Julio César Mello RománJulio César Mello Román
Julio César Mello Román
Miguel Garcia TorresMiguel Garcia Torres
Miguel Garcia Torres
JFjacques facon
jacques facon
DCDeysi Natalia Leguizamon Correa
Deysi Natalia Leguizamon Correa
In feature selection, redundancy is one of the major concerns since the removal of redundancy in data is connected with dimensionality reduction. Despite the evidence of such a connection, few works present theoretical studies regarding redundancy. In this work, we analyze the effect of redundant features on the performance of classification models. We can summarize the contribution of this work as follows: (i) develop a theoretical framework to analyze feature construction and selection, (ii) show that certain properly defined features are redundant but make the data linearly separable, and (iii) propose a formal criterion to validate feature construction methods. The results of experiments suggest that a large number of redundant features can reduce the classification error. The results imply that it is not enough to analyze features solely using criteria that measure the amount of information provided by such features.

27 November 2025 in Symmetry
Verified
Journal Article
Open access
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EHEdher Herrera
Edher Herrera
Julio César Mello RománJulio César Mello Román
Julio César Mello Román
JFJoel Florentin
Joel Florentin
JPJosé Palacios
José Palacios
GMGustavo Eduardo Mereles Menesse
Gustavo Eduardo Mereles Menesse
Horacio Legal AyalaHoracio Legal Ayala
Horacio Legal Ayala
Laser Speckle Imaging (LSI) is a non-invasive optical technique used to assess biological activity by detecting dynamic variations in speckle patterns. These patterns exhibit statistical symmetry in static regions, while biological activity induces symmetry breaking that can be captured through the Graphic Absolute Value of Differences (GAVD), producing the activity map IGAVD. This work evaluates the effect of four contrast enhancement algorithms: Histogram Equalization (HE), Contrast Limited Adaptive Histogram Equalization (CLAHE), Multiscale Morphological Contrast Enhancement (MMCE), and Multiscale Top-Hat Transform with an Open-Close Close-Open (OCCO) filter, applied to intermediate LSI images, with the final activity map used for quantitative evaluation. Each method represents a distinct enhancement paradigm: HE and CLAHE are histogram-based techniques for global and local contrast adjustment, whereas MMCE and OCCO-MTH are morphological approaches that emphasize structural preservation and local detail enhancement. The dataset consisted of images of Phaseolus vulgaris (SP) and Lactuca sativa (SL) seeds. Evaluation was conducted through expert visual inspection and quantitative analysis using contrast, entropy, spatial frequency (SF), structural similarity index (SSIM), peak signal-to-noise ratio (PSNR), and contrast improvement ratio (CIR). All metrics were computed on IGAVD activity maps, which reflect bioactivity through the disruption of statistical symmetry. Non-parametric statistical tests (Friedman, aligned Friedman, and Quade) revealed that CLAHE and MMCE significantly improved image quality compared to the original images (p<0.05). Among the evaluated algorithms, CLAHE increased global contrast by approximately 25% and entropy by 6% relative to the original speckle frames, enhancing the visibility of bioactive regions. MMCE achieved the highest bioactivity contrast ratio (CIR = 0.64), while OCCO-MTH provided the best structural fidelity (SSIM = 0.91) and noise suppression (PSNR = 30.7 dB). These results demonstrate that suitable contrast enhancement can substantially improve the interpretability of LSI activity maps without altering acquisition hardware. This finding is particularly relevant for experimental applications aiming to maximize information quality without modifying acquisition hardware.

24 November 2025 in International Journal of Energy and Water Resources
Verified
Journal Article
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CLCelia Ortigoza Larroza
Celia Ortigoza Larroza
GRGustavo Rivas
Gustavo Rivas
SGSebastian Grillo
Sebastian Grillo
EBEdgar Benítez
Edgar Benítez

16 June 2020 in Symmetry
Verified
Journal Article
Open access
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AAAlejandro Marcelo Arce
Alejandro Marcelo Arce
GCGabriel Giovanni Caroni
Gabriel Giovanni Caroni
Jose Luis Vázquez NogueraJose Luis Vázquez Noguera
Jose Luis Vázquez Noguera
DPDiego P. Pinto-Roa
Diego P. Pinto-Roa
Horacio Legal AyalaHoracio Legal Ayala
Horacio Legal Ayala
SGSebastian Grillo
Sebastian Grillo
The superformula generates curves called Gielis curves, which depend on a small number of input parameters. Recovering parameters generating a curve that adapts to a set of points is a non-trivial task, thus methods to accomplish it are still being developed. These curves can represent a great variety of forms, such as living organisms, objects and geometric shapes. In this work we propose a method that uses a genetic algorithm to minimize a combination of three objectives functions: Euclidean distances from the sample points to the curve, from the curve to the sample points and the curve length. Curves generated with the parameters obtained by this method adjust better to real curves in relation to the state of art, according to observational and numeric comparisons.