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Dr. Maria-Elena Cocuz
Transilvania University of Brasov, 29 Eroilor Bld. 500016, Brasov, Romania

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Research Keywords & Expertise

0 COVID 19
0 Hepatitis B prophylaxis
0 Clostridioides difficile infection
0 Hepatitis B and C viruses
0 SARS CoV 2

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Journal article
Published: 27 May 2021 in Medicina
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Background and Objectives: The COVID-19 pandemic has globally affected health systems and services. Non-melanoma skin cancers (NMSCs) are the most common malignancies around the world. This study aimed to analyze the differences in the benign and malignant histopathological diagnoses performed on radical excision skin tumors and skin biopsies in the dermatopathology ward in Mures Clinical County Hospital, Targu Mures, Romania, 1 year prior to and during the COVID-19 pandemic, to emphasize the changes in the diagnostic process as per the new regulations. Materials and Methods: A total of 1168 histopathological diagnoses were included in the study—302 from the COVID-19 period and 866 from the non-COVID-19 period—considering the number, type, and frequency of the histopathological diagnoses as variables to be analyzed. Results: In the COVID-19 period, out of the 55 NMSC and melanoma histopathological diagnoses, 50.9% (n = 28) were BCCs, 20% (n = 11) were SCCs, 10.9% (n = 6) were basosquamous cell carcinomas, and 18.18% (n = 10) were melanoma cases. Regarding the non-COVID-19 period, out of the 173 NMSC and melanoma histopathological diagnoses, 46.82% (n = 81) were BCCs, 22.54% (n = 39) were SCCs, 7.51% (n = 13) were basosquamous cell carcinomas, and 23.12% (n = 40) were melanoma cases. Conclusions: During the COVID-19 pandemic, a decrease in histopathological diagnoses at the dermatopathology ward in our hospital was observed, for both benign and malignant pathologies, especially for NMSCs and melanomas, compared to the same period 1 year prior to the pandemic.

ACS Style

Iuliu-Gabriel Cocuz; Maria-Elena Cocuz; Raluca Niculescu; Mihaela Șincu; Andreea Tinca; Adrian-Horațiu Sabău; Diana Chiorean; Silviu Morariu; Ovidiu Cotoi. The Impact of and Adaptations Due to the COVID-19 Pandemic on the Histopathological Diagnosis of Skin Pathologies, Including Non-Melanocyte and Melanoma Skin Cancers—A Single-Center Study in Romania. Medicina 2021, 57, 533 .

AMA Style

Iuliu-Gabriel Cocuz, Maria-Elena Cocuz, Raluca Niculescu, Mihaela Șincu, Andreea Tinca, Adrian-Horațiu Sabău, Diana Chiorean, Silviu Morariu, Ovidiu Cotoi. The Impact of and Adaptations Due to the COVID-19 Pandemic on the Histopathological Diagnosis of Skin Pathologies, Including Non-Melanocyte and Melanoma Skin Cancers—A Single-Center Study in Romania. Medicina. 2021; 57 (6):533.

Chicago/Turabian Style

Iuliu-Gabriel Cocuz; Maria-Elena Cocuz; Raluca Niculescu; Mihaela Șincu; Andreea Tinca; Adrian-Horațiu Sabău; Diana Chiorean; Silviu Morariu; Ovidiu Cotoi. 2021. "The Impact of and Adaptations Due to the COVID-19 Pandemic on the Histopathological Diagnosis of Skin Pathologies, Including Non-Melanocyte and Melanoma Skin Cancers—A Single-Center Study in Romania." Medicina 57, no. 6: 533.

Journal article
Published: 25 May 2021 in Toxics
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Toxicity studies were conducted to provide safety data of potential drug candidates by determining lethal and toxic doses. This study was designed for pre-clinical evaluation of novel cyclohexenone derivative with respect to the acute and sub-acute toxicity along with the diabetogenic potential. Acute and sub-acute toxicity were assessed after intraperitoneal (i.p) injection of the investigational compound through selected doses for 21 days. This was followed by assessment of isolated body organs (liver, kidney, heart and pancreas) via biochemical indicators and histopathological techniques. No signs of toxicity were revealed in the study of acute toxicity. Similarly, a sub-acute toxicity study showed no significant difference in biochemical indicators on 11th and 21st days between treated and control groups. However, in blood urea nitrogen (BUN) and random blood glucose/sugar (RBS) values, significant differences were recorded. Histopathological evaluation of liver, kidney, pancreas and heart tissues revealed mild to severe changes in the form of steatosis, inflammation, fibrosis, necrosis and myofibrillary damages on 11th and 21st days of treatment. In conclusion, the median lethal dose of the tested compound was expected to be greater than 500 mg/kg. No significant change occurred in selected biomarkers, except BUN and RBS levels, but a histopathological study showed moderate toxic effect on liver, kidney, pancreas and heart tissues by the cyclohexenone derivative.

ACS Style

Muhammad Kamil; Arifa Fatima; Sami Ullah; Gowhar Ali; Rasool Khan; Naila Ismail; Mughal Qayum; Marius Irimie; Catalina Dinu; Hanadi Ahmedah; Maria Cocuz. Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques. Toxics 2021, 9, 119 .

AMA Style

Muhammad Kamil, Arifa Fatima, Sami Ullah, Gowhar Ali, Rasool Khan, Naila Ismail, Mughal Qayum, Marius Irimie, Catalina Dinu, Hanadi Ahmedah, Maria Cocuz. Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques. Toxics. 2021; 9 (6):119.

Chicago/Turabian Style

Muhammad Kamil; Arifa Fatima; Sami Ullah; Gowhar Ali; Rasool Khan; Naila Ismail; Mughal Qayum; Marius Irimie; Catalina Dinu; Hanadi Ahmedah; Maria Cocuz. 2021. "Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques." Toxics 9, no. 6: 119.

Review
Published: 17 March 2021 in Sustainability
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The sustainable development of humanity imposes precise norms regarding the management of natural resources, their extraction, use, and the introduction in a complex, innovative circuit of the waste resulting from exploitation. The paper deals with some aspects related to the sustainable management of general medical waste on the one hand and the medical waste specific to the COVID-19 pandemic, on the other hand. Medical waste requires special treatment given its impact on the environment and on humanity. The management of activities related to its storage, transport, destruction is an important point in the sustainable development of mankind, especially in the current context of the pandemic. Medical waste is in a continuous increase in quantity and involves many effects in various activity fields. Through a scientometric study in the Web of Science—WOS database, the authors identify clusters of keywords, analyze the articles identified in the WOS and identify the main research directions and existing concepts. Corroborating and interpreting the results obtained, three significant trends of approach to medical waste are identified: M—management (1); E—exposure (2); and D—distribution (3). An extensive map of the concepts is made, a narrow map of the concepts used, and a theoretical map of the concepts. The link between medical waste and the development of a sustainable society is demonstrated, and it is possible to open new research directions. The scientometric research undertaken on 1192 WOS articles that were published in 2020 led to the selection of 32, focused on issues related to hazardous medical waste, especially of COVID-19 patients. Following this approach, the authors were able to see, by comparison, the different forms of management of this waste in different countries, thus being able to contribute to the creation of procedures for the collection, storage, and destruction of this hazardous waste, with direct influence on the environment.

ACS Style

Costel Bucătaru; Dan Săvescu; Angela Repanovici; Larisa Blaga; Ecaterina Coman; Maria-Elena Cocuz. The Implications and Effects of Medical Waste on Development of Sustainable Society—A Brief Review of the Literature. Sustainability 2021, 13, 3300 .

AMA Style

Costel Bucătaru, Dan Săvescu, Angela Repanovici, Larisa Blaga, Ecaterina Coman, Maria-Elena Cocuz. The Implications and Effects of Medical Waste on Development of Sustainable Society—A Brief Review of the Literature. Sustainability. 2021; 13 (6):3300.

Chicago/Turabian Style

Costel Bucătaru; Dan Săvescu; Angela Repanovici; Larisa Blaga; Ecaterina Coman; Maria-Elena Cocuz. 2021. "The Implications and Effects of Medical Waste on Development of Sustainable Society—A Brief Review of the Literature." Sustainability 13, no. 6: 3300.

Journal article
Published: 04 February 2021 in Microorganisms
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Dengue fever is among the most common vector-borne diseases. Dengue virus (DENV), responsible for dengue fever as well as dengue hemorrhagic fever, belongs to the genus flavivirus and family Flaviviridae. Flaviviruses infect various vertebrate species and arthropods and are also responsible for diseases in birds, wild animals, and primates. DENV consists of a single-stranded, positive-sense RNA genome ~11 kb in size. Complete genome and partial gene sequences of geographically distinct DENV-3 strains were retrieved from the GenBank database. The evolutionary divergence of the 33 whole-genome and individual gene sequences of the nucleotides and amino acids of DENV-3 strains were generated with the maximum likelihood (ML) and Bayesian phylogenetic study (BEAST) methods using the MEGA 7 software. The genome size varied from 10,484 to 10,724 nucleotides among the strains with distinct geographical backgrounds belonging to Central America, South-Central Asia, and Eastern Asia. A phylogenetic analysis of the nucleotide and amino acid sequences of these DENV-3 isolates revealed extensive differences in the topologies due to PrM/M, NS1, NS2B, and NS3 genes. These results suggest substantial variation in the evolutionary pathways of the studied genes and genomes.

ACS Style

Muhammad Amir; Abrar Hussain; Muhammad Asif; Sagheer Ahmed; Hina Alam; Marius Moga; Maria Cocuz; Luigi Marceanu; Alexandru Blidaru. Full-Length Genome and Partial Viral Genes Phylogenetic and Geographical Analysis of Dengue Serotype 3 Isolates. Microorganisms 2021, 9, 323 .

AMA Style

Muhammad Amir, Abrar Hussain, Muhammad Asif, Sagheer Ahmed, Hina Alam, Marius Moga, Maria Cocuz, Luigi Marceanu, Alexandru Blidaru. Full-Length Genome and Partial Viral Genes Phylogenetic and Geographical Analysis of Dengue Serotype 3 Isolates. Microorganisms. 2021; 9 (2):323.

Chicago/Turabian Style

Muhammad Amir; Abrar Hussain; Muhammad Asif; Sagheer Ahmed; Hina Alam; Marius Moga; Maria Cocuz; Luigi Marceanu; Alexandru Blidaru. 2021. "Full-Length Genome and Partial Viral Genes Phylogenetic and Geographical Analysis of Dengue Serotype 3 Isolates." Microorganisms 9, no. 2: 323.

Review
Published: 28 February 2019 in World Journal of Emergency Surgery
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In the last three decades, Clostridium difficile infection (CDI) has increased in incidence and severity in many countries worldwide. The increase in CDI incidence has been particularly apparent among surgical patients. Therefore, prevention of CDI and optimization of management in the surgical patient are paramount. An international multidisciplinary panel of experts from the World Society of Emergency Surgery (WSES) updated its guidelines for management of CDI in surgical patients according to the most recent available literature. The update includes recent changes introduced in the management of this infection.

ACS Style

Massimo Sartelli; Stefano Di Bella; Lynne V. McFarland; Sahil Khanna; Luis Furuya-Kanamori; Nadir Abuzeid; Fikri M. Abu-Zidan; Luca Ansaloni; Goran Augustin; Miklosh Bala; Offir Ben-Ishay; Walter L. Biffl; Stephen M. Brecher; Adrián Camacho-Ortiz; Miguel A. Caínzos; Shirley Chan; Jill R. Cherry-Bukowiec; Jesse Clanton; Federico Coccolini; Maria E. Cocuz; Raul Coimbra; Francesco Cortese; Yunfeng Cui; Jacek Czepiel; Zaza Demetrashvili; Isidoro Di Carlo; Salomone Di Saverio; Irina M. Dumitru; Christian Eckmann; Edward H. Eiland; Joseph D. Forrester; Gustavo P. Fraga; Jean L. Frossard; Donald E. Fry; Rita Galeiras; Wagih Ghnnam; Carlos A. Gomes; Ewen A. Griffiths; Xavier Guirao; Mohamed H. Ahmed; Torsten Herzog; Jae Il Kim; Tariq Iqbal; Arda Isik; Kamal M. F. Itani; Francesco M. Labricciosa; Yeong Y. Lee; Paul Juang; Aleksandar Karamarkovic; Peter K. Kim; Yoram Kluger; Ari Leppaniemi; Varut Lohsiriwat; Gustavo M. Machain; Sanjay Marwah; John E. Mazuski; Gokhan Metan; Ernest E. Moore; Frederick A. Moore; Carlos A. Ordoñez; Leonardo Pagani; Nicola Petrosillo; Francisco Portela; Kemal Rasa; Miran Rems; Boris E. Sakakushev; Helmut Segovia-Lohse; Gabriele Sganga; Vishal G. Shelat; Patrizia Spigaglia; Pierre Tattevin; Cristian Tranà; Libor Urbánek; Jan Ulrych; Pierluigi Viale; Gian L. Baiocchi; Fausto Catena. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients. World Journal of Emergency Surgery 2019, 14, 8 .

AMA Style

Massimo Sartelli, Stefano Di Bella, Lynne V. McFarland, Sahil Khanna, Luis Furuya-Kanamori, Nadir Abuzeid, Fikri M. Abu-Zidan, Luca Ansaloni, Goran Augustin, Miklosh Bala, Offir Ben-Ishay, Walter L. Biffl, Stephen M. Brecher, Adrián Camacho-Ortiz, Miguel A. Caínzos, Shirley Chan, Jill R. Cherry-Bukowiec, Jesse Clanton, Federico Coccolini, Maria E. Cocuz, Raul Coimbra, Francesco Cortese, Yunfeng Cui, Jacek Czepiel, Zaza Demetrashvili, Isidoro Di Carlo, Salomone Di Saverio, Irina M. Dumitru, Christian Eckmann, Edward H. Eiland, Joseph D. Forrester, Gustavo P. Fraga, Jean L. Frossard, Donald E. Fry, Rita Galeiras, Wagih Ghnnam, Carlos A. Gomes, Ewen A. Griffiths, Xavier Guirao, Mohamed H. Ahmed, Torsten Herzog, Jae Il Kim, Tariq Iqbal, Arda Isik, Kamal M. F. Itani, Francesco M. Labricciosa, Yeong Y. Lee, Paul Juang, Aleksandar Karamarkovic, Peter K. Kim, Yoram Kluger, Ari Leppaniemi, Varut Lohsiriwat, Gustavo M. Machain, Sanjay Marwah, John E. Mazuski, Gokhan Metan, Ernest E. Moore, Frederick A. Moore, Carlos A. Ordoñez, Leonardo Pagani, Nicola Petrosillo, Francisco Portela, Kemal Rasa, Miran Rems, Boris E. Sakakushev, Helmut Segovia-Lohse, Gabriele Sganga, Vishal G. Shelat, Patrizia Spigaglia, Pierre Tattevin, Cristian Tranà, Libor Urbánek, Jan Ulrych, Pierluigi Viale, Gian L. Baiocchi, Fausto Catena. 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients. World Journal of Emergency Surgery. 2019; 14 (1):8.

Chicago/Turabian Style

Massimo Sartelli; Stefano Di Bella; Lynne V. McFarland; Sahil Khanna; Luis Furuya-Kanamori; Nadir Abuzeid; Fikri M. Abu-Zidan; Luca Ansaloni; Goran Augustin; Miklosh Bala; Offir Ben-Ishay; Walter L. Biffl; Stephen M. Brecher; Adrián Camacho-Ortiz; Miguel A. Caínzos; Shirley Chan; Jill R. Cherry-Bukowiec; Jesse Clanton; Federico Coccolini; Maria E. Cocuz; Raul Coimbra; Francesco Cortese; Yunfeng Cui; Jacek Czepiel; Zaza Demetrashvili; Isidoro Di Carlo; Salomone Di Saverio; Irina M. Dumitru; Christian Eckmann; Edward H. Eiland; Joseph D. Forrester; Gustavo P. Fraga; Jean L. Frossard; Donald E. Fry; Rita Galeiras; Wagih Ghnnam; Carlos A. Gomes; Ewen A. Griffiths; Xavier Guirao; Mohamed H. Ahmed; Torsten Herzog; Jae Il Kim; Tariq Iqbal; Arda Isik; Kamal M. F. Itani; Francesco M. Labricciosa; Yeong Y. Lee; Paul Juang; Aleksandar Karamarkovic; Peter K. Kim; Yoram Kluger; Ari Leppaniemi; Varut Lohsiriwat; Gustavo M. Machain; Sanjay Marwah; John E. Mazuski; Gokhan Metan; Ernest E. Moore; Frederick A. Moore; Carlos A. Ordoñez; Leonardo Pagani; Nicola Petrosillo; Francisco Portela; Kemal Rasa; Miran Rems; Boris E. Sakakushev; Helmut Segovia-Lohse; Gabriele Sganga; Vishal G. Shelat; Patrizia Spigaglia; Pierre Tattevin; Cristian Tranà; Libor Urbánek; Jan Ulrych; Pierluigi Viale; Gian L. Baiocchi; Fausto Catena. 2019. "2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients." World Journal of Emergency Surgery 14, no. 1: 8.