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Patient-reported outcomes are important in the surgical decision-making process for low-risk, differentiated thyroid cancer. Current study aimed to assess patient-reported outcomes in thyroid cancer survivors comparing total thyroidectomy (TT) and lobectomy (LT) using the Patient Reported Outcomes Following Initial treatment and Long term Evaluation of Survivorship (PROFILES) registry. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scales, illness perception questions, Beliefs about Medicines Questionnaire (BMQ) scales and questions about thyroid surgery–related medication use were compared between thyroid cancer patients who underwent TT versus LT using descriptive analyses. In total, 58 thyroid cancer patients who underwent TT or LT were included in this study. None of the EORTC QLQ-C30 scales or questions regarding illness perception were significantly different between the surgical groups. Patients in the TT group had significantly higher belief in the necessity of their medication (21.0 vs 15.4; p = 0.003) and greater concerns about taking their medicines (14.7 vs 11.1; p = 0.008) versus patients in the LT group. Concerns about post-surgical medication use specifically in the TT group may indicate that clinicians should consider LT in patients with low-risk, differentiated thyroid cancer when LT and TT are viable surgical options. Clinicians should be aware of the impact of post-surgical medication use in particular following TT and use this knowledge to align goals of treatment with the extent of surgery, allowing for a better-informed decision-making process.
Maaike van Gerwen; Peter V. Cooke; Naomi Alpert; Floortje Mols; Eric Genden; Rebecca M. Schwartz. Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data. Supportive Care in Cancer 2021, 1 -7.
AMA StyleMaaike van Gerwen, Peter V. Cooke, Naomi Alpert, Floortje Mols, Eric Genden, Rebecca M. Schwartz. Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data. Supportive Care in Cancer. 2021; ():1-7.
Chicago/Turabian StyleMaaike van Gerwen; Peter V. Cooke; Naomi Alpert; Floortje Mols; Eric Genden; Rebecca M. Schwartz. 2021. "Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data." Supportive Care in Cancer , no. : 1-7.
An excess risk of thyroid cancer has been reported in different World Trade Center (WTC)-dust exposed cohorts. Increased surveillance of these cohorts has been suggested as a potential explanation of this reported excess thyroid cancer risk leading to an increased diagnosis of earlier-stage thyroid cancers. However, the uncertainty to what extent surveillance or physician bias may be contributing to the reported incidence of thyroid cancer in WTC-dust exposed populations remains, highlighting the need to investigate a potential causal link between WTC dust exposure and thyroid cancer. Future studies are therefore indicated to investigate potential consequences of WTC dust exposure on the thyroid gland. Studies of the heavily exposed populations offer the possibility to better understand the mechanisms behind the exposure to a variety of environmental contaminants, and may provide useful insights into exposures harmful to the thyroid. These can be used in risk stratification when implementing screening in high-risk populations and may inform shared decision-making regarding the extent of thyroid cancer treatment.
Maaike Gerwen; Janete M. Cerutti; Joseph Rapp; Eric Genden; Gregory J. Riggins Md; Emanuela Taioli Md. Post‐9/11 excess risk of thyroid cancer: Surveillance or exposure? American Journal of Industrial Medicine 2021, 1 .
AMA StyleMaaike Gerwen, Janete M. Cerutti, Joseph Rapp, Eric Genden, Gregory J. Riggins Md, Emanuela Taioli Md. Post‐9/11 excess risk of thyroid cancer: Surveillance or exposure? American Journal of Industrial Medicine. 2021; ():1.
Chicago/Turabian StyleMaaike Gerwen; Janete M. Cerutti; Joseph Rapp; Eric Genden; Gregory J. Riggins Md; Emanuela Taioli Md. 2021. "Post‐9/11 excess risk of thyroid cancer: Surveillance or exposure?" American Journal of Industrial Medicine , no. : 1.
Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.
Mathilda Alsen; Catherine Sinclair; Peter Cooke; Kimia Ziadkhanpour; Eric Genden; Maaike van Gerwen. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics 2021, 9, 14 .
AMA StyleMathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics. 2021; 9 (1):14.
Chicago/Turabian StyleMathilda Alsen; Catherine Sinclair; Peter Cooke; Kimia Ziadkhanpour; Eric Genden; Maaike van Gerwen. 2021. "Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview." Toxics 9, no. 1: 14.
There have been limited data assessing the influence of disadvantaged socioeconomic status (SES) on the incidence and clinical outcomes of COVID-19 patients within the diverse communities of the United States. Here, we aim to investigate the association between poverty level, as an indicator of SES, and COVID-19 related clinical outcomes including hospitalization and all-cause mortality. This retrospective cohort study included 3528 patients with laboratory confirmed COVID-19 seen at a large New York City health system between March 1, 2020 and April 1, 2020. Data for neighborhood level poverty was acquired from the American Community Survey 2014–2018 and defined as the percent of residents in each ZIP code whose household income was below the federal poverty threshold (FPT): 0% to < 20% below FPT (low poverty) and > 20% below FPT (high poverty). COVID-19 positive patients who resided in high poverty areas were significantly younger, had a higher prevalence of comorbidities and were more likely to be of female gender or a racial minority when compared to individuals living in low poverty areas. Residence in a high poverty area was not associated with an increased risk of COVID-19 related hospitalization and was found to be associated with a decreased risk of in-hospital mortality. This study suggests the existence of an unequal socioeconomic gradient in the demographic and clinical presentation of COVID-19 patients including differences in age, gender and race between poverty groups. Further studies are needed to fully assess the intersectionality of SES with the COVID-19 pandemic.
Christine Little; Mathilda Alsen; Joshua Barlow; Leonard Naymagon; Douglas Tremblay; Eric Genden; Samuel Trosman; Laura Iavicoli; Maaike van Gerwen. The Impact of Socioeconomic Status on the Clinical Outcomes of COVID-19; a Retrospective Cohort Study. Journal of Community Health 2021, 46, 794 -802.
AMA StyleChristine Little, Mathilda Alsen, Joshua Barlow, Leonard Naymagon, Douglas Tremblay, Eric Genden, Samuel Trosman, Laura Iavicoli, Maaike van Gerwen. The Impact of Socioeconomic Status on the Clinical Outcomes of COVID-19; a Retrospective Cohort Study. Journal of Community Health. 2021; 46 (4):794-802.
Chicago/Turabian StyleChristine Little; Mathilda Alsen; Joshua Barlow; Leonard Naymagon; Douglas Tremblay; Eric Genden; Samuel Trosman; Laura Iavicoli; Maaike van Gerwen. 2021. "The Impact of Socioeconomic Status on the Clinical Outcomes of COVID-19; a Retrospective Cohort Study." Journal of Community Health 46, no. 4: 794-802.
Perfluoroalkyl acids (PFAS) are known endocrine disrupting chemicals, potentially affecting thyroid function. Smoking has been associated with PFAS levels as well as with thyroid function. The impact of smoking on the association between PFAS and thyroid function remains to be elucidated, so the objective was to assess the effect of PFAS exposure on thyroid function in the general population, stratified by smoking status, using the National Health and Nutrition Examination Survey (NHANES). NHANES adult participants who were part of the 2011–2012 laboratory subsample and had PFAS and thyroid function measured were included (n = 1325). Adjusted linear regression models and stratified analyses were performed. There was a significant positive association between perfluorooctanesulfonic acid (PFOS) (p = 0.003), perfluorononanoic acid (PFNA) (p = 0.014), total PFAS (p = 0.004) concentrations and free T4 (FT4). No significant associations were found between perfluorooctanoic acid (PFOA), PFOS, perfluorohexane sulfonate (PFHxS), PFNA, total PFAS and total T4 (TT4) or thyroid stimulating hormone (TSH). In non-smokers, a significant positive association was found between PFOS (p = 0.003), PFHxS (p = 0.034), PFNA (p = 0.012), total PFAS (p = 0.003) and FT4 while no significant associations were found in smokers. The present study showed that increased PFAS exposure was associated with increased FT4 in non-smokers, while no association was found in smokers. These results confirm that smoking modifies the association between PFAS exposure and thyroid function.
Maaike Van Gerwen; Naomi Alpert; Mathilda Alsen; Kimia Ziadkhanpour; Emanuela Taioli; Eric Genden. The Impact of Smoking on the Association between Perfluoroalkyl Acids (PFAS) and Thyroid Hormones: A National Health and Nutrition Examination Survey Analysis. Toxics 2020, 8, 116 .
AMA StyleMaaike Van Gerwen, Naomi Alpert, Mathilda Alsen, Kimia Ziadkhanpour, Emanuela Taioli, Eric Genden. The Impact of Smoking on the Association between Perfluoroalkyl Acids (PFAS) and Thyroid Hormones: A National Health and Nutrition Examination Survey Analysis. Toxics. 2020; 8 (4):116.
Chicago/Turabian StyleMaaike Van Gerwen; Naomi Alpert; Mathilda Alsen; Kimia Ziadkhanpour; Emanuela Taioli; Eric Genden. 2020. "The Impact of Smoking on the Association between Perfluoroalkyl Acids (PFAS) and Thyroid Hormones: A National Health and Nutrition Examination Survey Analysis." Toxics 8, no. 4: 116.
Coronavirus diseases (COVID-19) is associated with high rates of morbidity and mortality and worse outcomes have been reported for various morbidities. The impact of pre-existing hypothyroidism on COVID-19 outcomes remains unknown. The aim of the present study was to identify a possible association between hypothyroidism and outcomes related to COVID-19 including hospitalization, need for mechanical ventilation, and all-cause mortality. All patients with a laboratory confirmed COVID-19 diagnosis in March 2020 in a large New York City health system were reviewed. Of the 3703 COVID-19 positive patients included in present study, 251 patients (6.8%) had pre-existing hypothyroidism and received thyroid hormone therapy. Hypothyroidism was not associated with increased risk of hospitalization [Adjusted Odds Ratio (ORadj): 1.23 (95% Confidence Interval (CI): 0.88- 1.70)], mechanical ventilation [ORadj: 1.17 (95% CI: 0.81–1.69)] nor death [ORadj: 1.07 (95% CI: 0.75–1.54)]. This study provides insight into the role of hypothyroidism on the outcomes of COVID-19 positive patients, indicating that no additional precautions or consultations are needed. However, future research into the potential complications of COVID-19 on the thyroid gland and function is warranted.
Maaike Van Gerwen; Mathilda Alsen; Christine Little; Joshua Barlow; Leonard Naymagon; Douglas Tremblay; Catherine F. Sinclair; Eric Genden. Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study. Frontiers in Endocrinology 2020, 11, 1 .
AMA StyleMaaike Van Gerwen, Mathilda Alsen, Christine Little, Joshua Barlow, Leonard Naymagon, Douglas Tremblay, Catherine F. Sinclair, Eric Genden. Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study. Frontiers in Endocrinology. 2020; 11 ():1.
Chicago/Turabian StyleMaaike Van Gerwen; Mathilda Alsen; Christine Little; Joshua Barlow; Leonard Naymagon; Douglas Tremblay; Catherine F. Sinclair; Eric Genden. 2020. "Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study." Frontiers in Endocrinology 11, no. : 1.
Background Coronavirus disease 2019 (COVID‐19) is a global pandemic and information on risk factors for worse prognosis is needed to accurately identify patients at risk and potentially provide insight into therapeutic options. Methods In this retrospective cohort study, including 3703 patients with laboratory confirmed COVID‐19, we identified risk factors associated with all‐cause mortality, need for hospitalization and mechanical ventilation. Results Male gender was independently associated with increased risk of hospitalization (Adjusted Odds Ratio (ORadj: 1.62 (95% Confidence Interval (95% CI): 1.38‐ 1.91)), mechanical ventilation (ORadj: 1.35 (95% CI: 1.08‐ 1.69)) and death (ORadj: 1.46 (95% CI: 1.17‐ 1.82)). Patients > 60 years had higher risk of hospitalization (ORadj: 5.47 (95% CI: 4.29‐ 6.96)), mechanical ventilation (ORadj: 3.26 (95% CI: 2.08‐ 5.11)) and death (ORadj: 13.04 (95% CI: 6.25‐ 27.24)). Congestive heart failure (ORadj: 1.47 (95% CI: 1.06‐ 2.02)) and dementia (ORadj: 2.03 (95% CI: 1.46‐ 2.83)) were associated with increased odds of death, as well as the presence of more than two comorbidities (ORadj: 1.90 (95% CI: 1.35‐ 2.68)). Conclusion COVID‐19 patients of older age, male gender or having more than two comorbidities are at higher risk of hospitalization, mechanical ventilation and death, and should therefore be closely monitored. This article is protected by copyright. All rights reserved.
Maaike Van Gerwen; Mathilda Alsen; Christine Little; Joshua Barlow; Eric Genden; Leonard Naymagon; Douglas Tremblay. Risk factors and outcomes of COVID‐19 in New York City; a retrospective cohort study. Journal of Medical Virology 2020, 93, 907 -915.
AMA StyleMaaike Van Gerwen, Mathilda Alsen, Christine Little, Joshua Barlow, Eric Genden, Leonard Naymagon, Douglas Tremblay. Risk factors and outcomes of COVID‐19 in New York City; a retrospective cohort study. Journal of Medical Virology. 2020; 93 (2):907-915.
Chicago/Turabian StyleMaaike Van Gerwen; Mathilda Alsen; Christine Little; Joshua Barlow; Eric Genden; Leonard Naymagon; Douglas Tremblay. 2020. "Risk factors and outcomes of COVID‐19 in New York City; a retrospective cohort study." Journal of Medical Virology 93, no. 2: 907-915.
The incidence of papillary thyroid microcarcinoma is increasing. We evaluated the recurrence-free survival following total thyroidectomy and lobectomy to identify the optimal surgical choice. A meta-analysis was performed using the National Library of Medicine and the National Institutes of Health PubMed database to identify eligible studies. Summary 5- and 10-year RFS estimates after TT versus LT were calculated using random effects models. The literature search yielded 1117 studies (1990–2019). Nine studies met the inclusion criteria comprising 10,186 total thyroidectomy and 11,408 lobectomy patients. The 5-year recurrence-free survival was 98% [95% confidence interval (CI) 97–99%] after total thyroidectomy and 97% (95% CI 96–99%) after lobectomy, based on eight studies (9421 total thyroidectomy and 11,283 lobectomy patients); the 10-year recurrence-free survival was 95% (95% CI 92–98%) after total thyroidectomy and 92% (95% CI 86–96%) after lobectomy, based on eight studies (total thyroidectomy = 10,100, lobectomy = 11,389 patients). The present meta-analysis demonstrates excellent, long-term recurrence-free survival following both total thyroidectomy and lobectomy surgery in patients with papillary thyroid microcarcinoma. The analysis also suggests that patients undergoing total thyroidectomy trended toward a slightly better long-term 10-year recurrence-free survival in comparison to patients undergoing lobectomy, a finding of potential, clinical significance in the management decision-making process.
M. van Gerwen; M. Alsen; E. Lee; C. Sinclair; E. Genden; E. Taioli. Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma. Journal of Endocrinological Investigation 2020, 44, 725 -734.
AMA StyleM. van Gerwen, M. Alsen, E. Lee, C. Sinclair, E. Genden, E. Taioli. Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma. Journal of Endocrinological Investigation. 2020; 44 (4):725-734.
Chicago/Turabian StyleM. van Gerwen; M. Alsen; E. Lee; C. Sinclair; E. Genden; E. Taioli. 2020. "Recurrence-free survival after total thyroidectomy and lobectomy in patients with papillary thyroid microcarcinoma." Journal of Endocrinological Investigation 44, no. 4: 725-734.
Tremblay and colleagues asked whether patients receiving either routine anticoagulation or antiplatelet therapy for existing conditions prior to becoming ill with COVID-19 have different outcomes from patients receiving neither therapy. After matching for existing comorbidities, this retrospective observational study finds no evidence for an effect of prediagnosis anticoagulation on mortality.
Douglas Tremblay; Maaike Van Gerwen; Mathilda Alsen; Santiago Thibaud; Alaina Justine Kessler; Sangeetha Venugopal; Iman Makki; Qian Qin; Sirish Dharmapuri; Tomi Jun; Sheena Bhalla; Shana Berwick; Jonathan Feld; John Mascarenhas; Kevin Troy; Caroline Cromwell; Andrew Dunn; William K. Oh; Leonard Naymagon. Impact of anticoagulation prior to COVID-19 infection: a propensity score–matched cohort study. Blood 2020, 136, 144 -147.
AMA StyleDouglas Tremblay, Maaike Van Gerwen, Mathilda Alsen, Santiago Thibaud, Alaina Justine Kessler, Sangeetha Venugopal, Iman Makki, Qian Qin, Sirish Dharmapuri, Tomi Jun, Sheena Bhalla, Shana Berwick, Jonathan Feld, John Mascarenhas, Kevin Troy, Caroline Cromwell, Andrew Dunn, William K. Oh, Leonard Naymagon. Impact of anticoagulation prior to COVID-19 infection: a propensity score–matched cohort study. Blood. 2020; 136 (1):144-147.
Chicago/Turabian StyleDouglas Tremblay; Maaike Van Gerwen; Mathilda Alsen; Santiago Thibaud; Alaina Justine Kessler; Sangeetha Venugopal; Iman Makki; Qian Qin; Sirish Dharmapuri; Tomi Jun; Sheena Bhalla; Shana Berwick; Jonathan Feld; John Mascarenhas; Kevin Troy; Caroline Cromwell; Andrew Dunn; William K. Oh; Leonard Naymagon. 2020. "Impact of anticoagulation prior to COVID-19 infection: a propensity score–matched cohort study." Blood 136, no. 1: 144-147.
With a steadily increasing thyroid cancer incidence, information regarding cancer aggressiveness is essential to determine which patients may be suitable for active surveillance. This study assessed the extent of non-aggressiveness of untreated, local and regional stage, papillary thyroid cancer. We used the Surveillance, Epidemiology, and End Results (SEER) registry and included 1423 local stage and 337 regional stage papillary thyroid cancer cases. Thyroid cancer specific survival was estimated conditional on the absence of death due to competing causes using competing risk methods. Stratified analyses were done to determine non-aggressiveness among different patient and tumor characteristics. The overall rate of non-aggressiveness for local stage thyroid cancer was 99.34% (95% CI: 99.33–99.35%), with a rate of non-aggressiveness of 98.85% (95% CI: 98.77–98.93%) for males and 99.48% (95% CI: 99.46–99.49%) for females (p = 0.055). Rate of non-aggressiveness was significantly lower in patients >60 years compared to patients ≤60 years (p < 0.001). Although the rate of non-aggressiveness was the same for tumors ≤10 mm and tumors of 11–20 mm, tumors measuring >20 mm had a significantly lower rate of non-aggressiveness (p = 0.002). The overall rate of non-aggressiveness for regional stage thyroid cancer was 72.58% (95% CI: 70.61–74.56%). We found high rates of non-aggressiveness in untreated, local stage, papillary thyroid cancer, particularly in younger patients with small (≤2 cm) thyroid cancer, suggesting that these patients may be good candidates for active surveillance.
Maaike van Gerwen; Naomi Alpert; Catherine Sinclair; Minal Kale; Eric Genden; Emanuela Taioli. Assessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer. Oral Oncology 2020, 105, 104674 .
AMA StyleMaaike van Gerwen, Naomi Alpert, Catherine Sinclair, Minal Kale, Eric Genden, Emanuela Taioli. Assessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer. Oral Oncology. 2020; 105 ():104674.
Chicago/Turabian StyleMaaike van Gerwen; Naomi Alpert; Catherine Sinclair; Minal Kale; Eric Genden; Emanuela Taioli. 2020. "Assessing non-aggressiveness of untreated, local and regional, papillary thyroid cancer." Oral Oncology 105, no. : 104674.
Besides specific, incidental radiation exposure, which has been associated with increased thyroid cancer risk, the effects of exposure to background radiation from uranium, a naturally occurring, radioactive, and ubiquitous element, on the thyroid gland has not been widely studied. We therefore investigated the association between uranium exposure and thyroid health in the US. Using the National Health and Nutrition Examination Survey (NHANES), we assessed the association between urinary uranium levels and thyroid-related antibodies, including thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase (anti-TPO), in the general population. Secondly, we performed an ecological study of age-adjusted thyroid cancer incidence rates per state and sources of uranium exposure. We included 3125 eligible participants from the NHANES and found a significant association between increased TgAb and increased urinary uranium levels when analyzed as quartiles (p = 0.0105), while no association was found with anti-TPO. In addition, although no significant correlation was found in the ecological study, certain states had high age-adjusted thyroid cancer incidence rates and a high number of uranium activity locations and high uranium concentrations in water. The present study suggests that uranium exposure may affect thyroid health, which warrants increased sampling of soil and water in high-risk states.
Maaike Van Gerwen; Naomi Alpert; Wil Lieberman-Cribbin; Peter Cooke; Kimia Ziadkhanpour; Bian Liu; Eric Genden. Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study. International Journal of Environmental Research and Public Health 2020, 17, 712 .
AMA StyleMaaike Van Gerwen, Naomi Alpert, Wil Lieberman-Cribbin, Peter Cooke, Kimia Ziadkhanpour, Bian Liu, Eric Genden. Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study. International Journal of Environmental Research and Public Health. 2020; 17 (3):712.
Chicago/Turabian StyleMaaike Van Gerwen; Naomi Alpert; Wil Lieberman-Cribbin; Peter Cooke; Kimia Ziadkhanpour; Bian Liu; Eric Genden. 2020. "Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study." International Journal of Environmental Research and Public Health 17, no. 3: 712.
The association between asbestos exposure, mainly in occupational settings, and malignant mesothelioma has been well established; this has prompted several countries to establish mesothelioma epidemiologic surveillance programs often at the request of national agencies. This review compares currently existing mesothelioma registries worldwide to develop a concept model for a US real‐time case capture mesothelioma registry. Five countries were identified with a mesothelioma specific registry, including Italy, France, UK, Australia, and South Korea. All, except the UK, used interviews to collect exposure data. Linkage with the national death index was available or was in future plans for all registries. The registries have limited information on treatment, quality of life, and other patient‐centered outcomes such as symptoms and pain management. To thoroughly collect exposure data, “real‐time” enrollment is preferable; to maximize the capture of mesothelioma cases, optimal coverage, and a simplified consent process are needed.
Maaike Van Gerwen; Naomi Alpert; Raja Flores; Emanuela Taioli Md. An overview of existing mesothelioma registries worldwide, and the need for a US Registry. American Journal of Industrial Medicine 2019, 63, 115 -120.
AMA StyleMaaike Van Gerwen, Naomi Alpert, Raja Flores, Emanuela Taioli Md. An overview of existing mesothelioma registries worldwide, and the need for a US Registry. American Journal of Industrial Medicine. 2019; 63 (2):115-120.
Chicago/Turabian StyleMaaike Van Gerwen; Naomi Alpert; Raja Flores; Emanuela Taioli Md. 2019. "An overview of existing mesothelioma registries worldwide, and the need for a US Registry." American Journal of Industrial Medicine 63, no. 2: 115-120.
Thyroid cancer incidence is higher in World Trade Center (WTC) responders compared with the general population. It is unclear whether this excess in thyroid cancer is associated with WTC-related exposures or if instead there is an over-diagnosis of malignant thyroid cancer among WTC first responders due to enhanced surveillance and physician bias. To maximize diagnostic yield and determine the false positive rate for malignancy, the histological diagnoses of thyroid cancer tumors from WTC responders and age, gender, and histology matched non-WTC thyroid cancer cases were evaluated using biomarkers of malignancy. Using a highly accurate panel of four biomarkers that are able to distinguish benign from malignant thyroid cancer, our results suggest that over-diagnosis by virtue of misdiagnosis of a benign tumor as malignant does not explain the increased incidence of thyroid cancer observed in WTC responders. Therefore, rather than over-diagnosis due to physician bias, the yearly screening visits by the World Trade Center Health Program are identifying true cases of thyroid cancer. Continuing regular screening of this cohort is thus warranted.
Maaike A. G. Van Gerwen; Stephanie Tuminello; Gregory J. Riggins; Thais B. Mendes; Michael Donovan; Emma K.T. Benn; Eric Genden; Janete M. Cerutti; Emanuela Taioli. Molecular Study of Thyroid Cancer in World Trade Center Responders. International Journal of Environmental Research and Public Health 2019, 16, 1600 .
AMA StyleMaaike A. G. Van Gerwen, Stephanie Tuminello, Gregory J. Riggins, Thais B. Mendes, Michael Donovan, Emma K.T. Benn, Eric Genden, Janete M. Cerutti, Emanuela Taioli. Molecular Study of Thyroid Cancer in World Trade Center Responders. International Journal of Environmental Research and Public Health. 2019; 16 (9):1600.
Chicago/Turabian StyleMaaike A. G. Van Gerwen; Stephanie Tuminello; Gregory J. Riggins; Thais B. Mendes; Michael Donovan; Emma K.T. Benn; Eric Genden; Janete M. Cerutti; Emanuela Taioli. 2019. "Molecular Study of Thyroid Cancer in World Trade Center Responders." International Journal of Environmental Research and Public Health 16, no. 9: 1600.
An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = 0.2) compared to a subset of thyroid cancer cases treated at Mount Sinai without WTC exposure. These results do not support the surveillance bias hypothesis, under which smaller tumors are expected to be diagnosed at earlier ages. WTCHP thyroid cancer cases also reported a past history of radiation exposure and a family history of thyroid conditions at lower rates than expected, with higher than expected rates of previous cancer diagnoses, family histories of other cancers, and high Body Mass Indexes (BMIs). Further research is needed to better understand the underlying risk factors that may play a role in the development of thyroid cancer in this group.
Stephanie Tuminello; Maaike A. G. Van Gerwen; Eric Genden; Michael Crane; Wil Lieberman-Cribbin; Emanuela Taioli. Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment. International Journal of Environmental Research and Public Health 2019, 16, 1258 .
AMA StyleStephanie Tuminello, Maaike A. G. Van Gerwen, Eric Genden, Michael Crane, Wil Lieberman-Cribbin, Emanuela Taioli. Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment. International Journal of Environmental Research and Public Health. 2019; 16 (7):1258.
Chicago/Turabian StyleStephanie Tuminello; Maaike A. G. Van Gerwen; Eric Genden; Michael Crane; Wil Lieberman-Cribbin; Emanuela Taioli. 2019. "Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment." International Journal of Environmental Research and Public Health 16, no. 7: 1258.
Despite the growing and widespread use of glyphosate, a broad-spectrum herbicide and desiccant, very few studies have evaluated the extent and amount of human exposure. We review documented levels of human exposure among workers in occupational settings and the general population. We conducted a review of scientific publications on glyphosate levels in humans; 19 studies were identified, of which five investigated occupational exposure to glyphosate, 11 documented the exposure in general populations, and three reported on both. Eight studies reported urinary levels in 423 occupationally and para-occupationally exposed subjects; 14 studies reported glyphosate levels in various biofluids on 3298 subjects from the general population. Average urinary levels in occupationally exposed subjects varied from 0.26 to 73.5 μg/L; environmental exposure urinary levels ranged from 0.16 to 7.6 μg/L. Only two studies measured temporal trends in exposure, both of which show increasing proportions of individuals with detectable levels of glyphosate in their urine over time. The current review highlights the paucity of data on glyphosate levels among individuals exposed occupationally, para-occupationally, or environmentally to the herbicide. As such, it is challenging to fully understand the extent of exposure overall and in vulnerable populations such as children. We recommend further work to evaluate exposure across populations and geographic regions, apportion the exposure sources (e.g., occupational, household use, food residues), and understand temporal trends.
Christina Gillezeau; Maaike Van Gerwen; Rachel M. Shaffer; Iemaan Rana; Luoping Zhang; Lianne Sheppard; Emanuela Taioli. The evidence of human exposure to glyphosate: a review. Environmental Health 2019, 18, 1 -14.
AMA StyleChristina Gillezeau, Maaike Van Gerwen, Rachel M. Shaffer, Iemaan Rana, Luoping Zhang, Lianne Sheppard, Emanuela Taioli. The evidence of human exposure to glyphosate: a review. Environmental Health. 2019; 18 (1):1-14.
Chicago/Turabian StyleChristina Gillezeau; Maaike Van Gerwen; Rachel M. Shaffer; Iemaan Rana; Luoping Zhang; Lianne Sheppard; Emanuela Taioli. 2019. "The evidence of human exposure to glyphosate: a review." Environmental Health 18, no. 1: 1-14.
World Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this population have reported elevated risks of cancer compared to the general population. There is a need to supplement current epidemiologic cancer follow-up with a cancer tissue bank in order to better elucidate a possible connection between each cancer and past WTC exposure. This work describes the implementation of a tissue bank system for the WTC newly diagnosed cancers, focused on advancing the understanding of the biology of these tumors. This will ultimately impact the modalities of treatment, and the probability of success and survival of these patients. WTC Responders who participated (as employees or volunteers) in the rescue, recovery and cleanup efforts at the WTC sites have been enrolled at Mount Sinai in the World Trade Center Health Program. Responders with cancer identified and validated through linkages with New York, New Jersey, Pennsylvania, and Connecticut cancer registries were eligible to participate in this biobank. Potential participants were contacted through letters, phone calls, and emails to explain the research study, consent process, and to obtain the location where their cancer procedure was performed. Pathology departments were contacted to identify and request tissue samples. All the 866 solid cancer cases confirmed by the Data Center at Mount Sinai have been contacted and consent was requested for retrieval and storage of the tissue samples from their cancer. Hospitals and doctors' offices were then contacted to locate and identify the correct tissue block for each patient. The majority of these cases consist of archival paraffin blocks from surgical patients treated from 2002 to 2015. At the time of manuscript writing, this resulted in 280 cancer samples stored in the biobank. A biobank of cancer tissue from WTC responders has been compiled with 280 specimens in storage to date. This tissue bank represents an important resource for the scientific community allowing for high impact studies on environmental exposures and cancer etiology, cancer outcome, and gene-environment interaction in the unique population of WTC responders.
Wil Lieberman-Cribbin; Stephanie Tuminello; Christina Gillezeau; Maaike Van Gerwen; Rachel Brody; Michael Donovan; Emanuela Taioli. The development of a Biobank of cancer tissue samples from World Trade Center responders. Journal of Translational Medicine 2018, 16, 280 .
AMA StyleWil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike Van Gerwen, Rachel Brody, Michael Donovan, Emanuela Taioli. The development of a Biobank of cancer tissue samples from World Trade Center responders. Journal of Translational Medicine. 2018; 16 (1):280.
Chicago/Turabian StyleWil Lieberman-Cribbin; Stephanie Tuminello; Christina Gillezeau; Maaike Van Gerwen; Rachel Brody; Michael Donovan; Emanuela Taioli. 2018. "The development of a Biobank of cancer tissue samples from World Trade Center responders." Journal of Translational Medicine 16, no. 1: 280.
Background/Objectives We evaluated postoperative mortality and complications after extrapleural pneumonectomy (EPP) and pleurectomy decortication (P/D) to better understand their effectiveness in malignant pleural mesothelioma (MPM). Methods A meta‐analysis was done to evaluate 30‐day mortality and postoperative complications. In addition, in‐patients data of 500 eligible patients with MPM who underwent EPP or P/D was extracted from the New York Statewide Planning and Research Cooperative System (SPARCS). Multivariate analyses and propensity matching were used to compare in‐hospital mortality and postoperative complications in EPP vs P/D. Results The meta‐analysis showed a statistically significant difference in 30‐day mortality (5% [95% CI: 4‐6] vs P/D 2% [95% CI: 1‐3]), proportion of complications (46% [95% CI: 36‐56] vs 24% [95% CI: 15‐34]) and postoperative arrhythmias (20% [95% CI: 12‐31] vs 5% [95% CI: 2‐8]) for EPP vs P/D. In‐hospital mortality (OR adj: 2.6; 95% CI: 0.86‐7.75) and postoperative complications (OR adj: 1.1; 95% CI: 0.68‐1.86) were not different in EPP compared with P/D while supraventricular arrhythmia was significantly more frequent after EPP vs P/D (OR adj: 5.2; 95% CI: 2.34‐11.33). Conclusions Postoperative mortality, postoperative complications, and particularly supraventricular arrhythmia are less frequent after P/D vs EPP. P/D, a less invasive surgery, may provide a better option when technically feasible for patients with MPM.
Maaike Van Gerwen; Andrea Wolf; Bian Liu; Raja Flores; Emanuela Taioli. Short-term outcomes of pleurectomy decortication and extrapleural pneumonectomy in mesothelioma. Journal of Surgical Oncology 2018, 118, 1178 -1187.
AMA StyleMaaike Van Gerwen, Andrea Wolf, Bian Liu, Raja Flores, Emanuela Taioli. Short-term outcomes of pleurectomy decortication and extrapleural pneumonectomy in mesothelioma. Journal of Surgical Oncology. 2018; 118 (7):1178-1187.
Chicago/Turabian StyleMaaike Van Gerwen; Andrea Wolf; Bian Liu; Raja Flores; Emanuela Taioli. 2018. "Short-term outcomes of pleurectomy decortication and extrapleural pneumonectomy in mesothelioma." Journal of Surgical Oncology 118, no. 7: 1178-1187.