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Mr. Peter Cooke
Icahn School of Medicine at Mount Sinai

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0 Hepatocellular carcinoma
0 Thyroid
0 Thyroid Cancer
0 Radiomics
0 otolaryngology

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Oncology
Published: 25 March 2021 in Cureus
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Patients with hepatocellular carcinoma (HCC) involving the inferior vena cava (IVC) and/or right atrium (RA) often experience debilitating symptoms, including lower extremity edema, dyspnea on exertion, shortness of breath at rest, chest pain, and ascites, that impact quality of life. The efficacy of external beam radiation therapy (EBRT) in palliating these symptoms is unclear. Thus, we sought to assess the effectiveness of EBRT in the palliation of symptoms and treatment outcomes in this patient population. All patients with HCC that compressed or invaded the IVC, received EBRT, and had a two-month follow-up visit to assess clinical response at our institution between 2010 and 2018 were analyzed. Patient demographics and clinical features were retrieved from the electronic medical record. Local control, local progression-free survival, and overall survival (OS) were measured from the last day of EBRT and calculated using the Kaplan-Meier method. Twenty-six patients with invasion or compression of the IVC were identified, 11 of whom (42%) had involvement of the RA. The median follow-up was 3.6 months. Five patients (19%) were treated with stereotactic body radiation therapy (SBRT) (all with five fractions) and 21 patients (81%) were treated with fractionated radiation therapy (range 10-16 fractions), both to a median dose of 3,000 cGy (range 2500-4000 cGy for SBRT, 2500-3750 cGy for fractionated radiation therapy). Significant proportions of patients experienced symptomatic relief from peripheral edema (54%), dyspnea on exertion (57%), shortness of breath (83%), chest pain (67%), and ascites (25%) after receiving EBRT. Additionally, they experienced few toxicities, with zero experiencing grade three or higher toxicities. One-year and two-year local control rates were 11.5% and 7.7%, respectively, and the median local progression-free survival was 4.8 months. One-year and two-year OS rates were 38.4% and 38.4%, respectively. Our results suggest that EBRT should be considered as a potential treatment option for patients with HCC invading or compressing the IVC with or without involvement of the RA. EBRT was very well-tolerated and effectively palliated a variety of symptoms in patients with advanced disease.

ACS Style

Peter Cooke; Kunal K. Sindhu; Eric J. Lehrer; Samuel Z. Maron; Kenneth E. Rosenzweig; Michael Buckstein. Palliating Symptoms in Patients With Hepatocellular Carcinoma Involving the Inferior Vena Cava With External Beam Radiation Therapy. Cureus 2021, 13, 1 .

AMA Style

Peter Cooke, Kunal K. Sindhu, Eric J. Lehrer, Samuel Z. Maron, Kenneth E. Rosenzweig, Michael Buckstein. Palliating Symptoms in Patients With Hepatocellular Carcinoma Involving the Inferior Vena Cava With External Beam Radiation Therapy. Cureus. 2021; 13 (3):1.

Chicago/Turabian Style

Peter Cooke; Kunal K. Sindhu; Eric J. Lehrer; Samuel Z. Maron; Kenneth E. Rosenzweig; Michael Buckstein. 2021. "Palliating Symptoms in Patients With Hepatocellular Carcinoma Involving the Inferior Vena Cava With External Beam Radiation Therapy." Cureus 13, no. 3: 1.

Review
Published: 19 January 2021 in Toxics
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Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.

ACS Style

Mathilda Alsen; Catherine Sinclair; Peter Cooke; Kimia Ziadkhanpour; Eric Genden; Maaike van Gerwen. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics 2021, 9, 14 .

AMA Style

Mathilda Alsen, Catherine Sinclair, Peter Cooke, Kimia Ziadkhanpour, Eric Genden, Maaike van Gerwen. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics. 2021; 9 (1):14.

Chicago/Turabian Style

Mathilda Alsen; Catherine Sinclair; Peter Cooke; Kimia Ziadkhanpour; Eric Genden; Maaike van Gerwen. 2021. "Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview." Toxics 9, no. 1: 14.

Journal article
Published: 12 January 2021 in American Journal of Otolaryngology
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To present the results of our implementation of a four-dimensional computed tomography- (4DCT) based parathyroid localization protocol for primary hyperparathyroidism at a safety net hospital. We performed a retrospective review of all patients who underwent parathyroidectomy for primary hyperparathyroidism at Elmhurst Hospital Center from June 2016 – September 2019. Patients treated prior to the implementation of 4DCT during October 2018 served as historical controls for comparison. Imaging-related costs and hospital charges were obtained from the Radiology Department for each patient. Forty-two patients underwent parathyroid surgery during the study period. Twenty patients had undergone 4DCT while 22 had nuclear medicine studies with or without ultrasonography. The sensitivity and specificity of 4DCT was 90.4% and 100% respectively, compared to 63% and 93.7% for nuclear imaging studies and 41% and 95% for ultrasound. The mean number of glands explored was significantly less in the 4DCT group, 1.8 ± 1.19 versus 2.77 ± 1.26 (p = 0.01). There was no increase in infrastructure or personnel costs associated with 4DCT implementation. 4DCT represents an increasingly common imaging modality for pre-operative parathyroid localization. Here we demonstrate that 4DCT is associated with a reduction in the number of glands explored and enables minimally invasive parathyroid surgery. 4DCT is a cost-effective and clinically sound localization study for parathyroid localization in an urban safety-net hospital.

ACS Style

Ameya A. Jategaonkar; David K. Lerner; Peter Cooke; Diana Kirke; Eric M. Genden; Samuel J. Trosman. Implementation of a 4-dimensional computed tomography protocol for parathyroid adenoma localization. American Journal of Otolaryngology 2021, 42, 102907 .

AMA Style

Ameya A. Jategaonkar, David K. Lerner, Peter Cooke, Diana Kirke, Eric M. Genden, Samuel J. Trosman. Implementation of a 4-dimensional computed tomography protocol for parathyroid adenoma localization. American Journal of Otolaryngology. 2021; 42 (3):102907.

Chicago/Turabian Style

Ameya A. Jategaonkar; David K. Lerner; Peter Cooke; Diana Kirke; Eric M. Genden; Samuel J. Trosman. 2021. "Implementation of a 4-dimensional computed tomography protocol for parathyroid adenoma localization." American Journal of Otolaryngology 42, no. 3: 102907.

Journal article
Published: 14 February 2020 in World Neurosurgery
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The predictive ability of Elixhauser Comorbidity Index (ECI) and Charlson Comorbidity Index (CCI) have been compared in orthopedic and gastrointestinal surgery; however, their predictive ability for complications secondary to spine surgery and posterior cervical decompression and fusion (PCDF) specifically is understudied. This study examines the predictive ability of the ECI and CCI for complications and morbidity following PCDF. ECI and CCI were retrospectively computed for all PCDF cases in the National Inpatient Sample database from 2013 to 2014 and complications or morbidity were identified. C-statistics were used to analyze ECI and CCI predictive ability in a range of complications and compared with a base comorbidity model that included age, sex, race, and primary payer. PCDF was performed in 46,700 hospitalizations between 2013 and 2014. The complications for which ECI was found to be a significantly better predictor included airway complications (69.16% superior to CCI), hemorrhagic anemia (79.04% superior), cardiac arrest (72.39% superior), pulmonary embolism (83.01% superior), sepsis (62.44% superior), septic shock (78.90% superior), urinary tract infection (63.53% superior), death (74.28% superior), any minor complication (75% superior), any major complication (133% superior), and any complication at all (63.72% superior). The complications for which neither the ECI Index nor the CCI proved superior were acute kidney injury, myocardial infarction, cerebrovascular accident, deep vein thrombosis, pneumonia, wound dehiscence, and superficial surgical-site infection following PCDF. ECI showed superior predictive ability to the CCI in predicting 8 of the 18 complications that were analyzed and inferior in none.

ACS Style

Samuel Z. Maron; Sean N. Neifert; William A. Ranson; Dominic A. Nistal; Robert J. Rothrock; Peter Cooke; Colin D. Lamb; Samuel K. Cho; John M. Caridi. Elixhauser Comorbidity Measure is Superior to Charlson Comorbidity Index In-Predicting Hospital Complications Following Elective Posterior Cervical Decompression and Fusion. World Neurosurgery 2020, 138, e26 -e34.

AMA Style

Samuel Z. Maron, Sean N. Neifert, William A. Ranson, Dominic A. Nistal, Robert J. Rothrock, Peter Cooke, Colin D. Lamb, Samuel K. Cho, John M. Caridi. Elixhauser Comorbidity Measure is Superior to Charlson Comorbidity Index In-Predicting Hospital Complications Following Elective Posterior Cervical Decompression and Fusion. World Neurosurgery. 2020; 138 ():e26-e34.

Chicago/Turabian Style

Samuel Z. Maron; Sean N. Neifert; William A. Ranson; Dominic A. Nistal; Robert J. Rothrock; Peter Cooke; Colin D. Lamb; Samuel K. Cho; John M. Caridi. 2020. "Elixhauser Comorbidity Measure is Superior to Charlson Comorbidity Index In-Predicting Hospital Complications Following Elective Posterior Cervical Decompression and Fusion." World Neurosurgery 138, no. : e26-e34.

Journal article
Published: 22 January 2020 in International Journal of Environmental Research and Public Health
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Besides specific, incidental radiation exposure, which has been associated with increased thyroid cancer risk, the effects of exposure to background radiation from uranium, a naturally occurring, radioactive, and ubiquitous element, on the thyroid gland has not been widely studied. We therefore investigated the association between uranium exposure and thyroid health in the US. Using the National Health and Nutrition Examination Survey (NHANES), we assessed the association between urinary uranium levels and thyroid-related antibodies, including thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase (anti-TPO), in the general population. Secondly, we performed an ecological study of age-adjusted thyroid cancer incidence rates per state and sources of uranium exposure. We included 3125 eligible participants from the NHANES and found a significant association between increased TgAb and increased urinary uranium levels when analyzed as quartiles (p = 0.0105), while no association was found with anti-TPO. In addition, although no significant correlation was found in the ecological study, certain states had high age-adjusted thyroid cancer incidence rates and a high number of uranium activity locations and high uranium concentrations in water. The present study suggests that uranium exposure may affect thyroid health, which warrants increased sampling of soil and water in high-risk states.

ACS Style

Maaike Van Gerwen; Naomi Alpert; Wil Lieberman-Cribbin; Peter Cooke; Kimia Ziadkhanpour; Bian Liu; Eric Genden. Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study. International Journal of Environmental Research and Public Health 2020, 17, 712 .

AMA Style

Maaike Van Gerwen, Naomi Alpert, Wil Lieberman-Cribbin, Peter Cooke, Kimia Ziadkhanpour, Bian Liu, Eric Genden. Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study. International Journal of Environmental Research and Public Health. 2020; 17 (3):712.

Chicago/Turabian Style

Maaike Van Gerwen; Naomi Alpert; Wil Lieberman-Cribbin; Peter Cooke; Kimia Ziadkhanpour; Bian Liu; Eric Genden. 2020. "Association between Uranium Exposure and Thyroid Health: A National Health and Nutrition Examination Survey Analysis and Ecological Study." International Journal of Environmental Research and Public Health 17, no. 3: 712.

Case report
Published: 31 August 2019 in Head and Neck Pathology
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Intravascular papillary endothelial hyperplasia (IPEH) is a benign, highly vascularized, endothelial growth that can be mischaracterized as a malignancy. While hundreds of IPEH cases are reported, only four occurred in the maxillary sinus. We present the case of a 28-year-old male who underwent surgical resection of IPEH of the right maxillary sinus. An additional consideration was the patient’s condition of univentricular tricuspid atresia which contributed to chronic hypoxemia and polycythemia. After complete resection from the maxillary sinus, post-operational workup determined the lesion to be IPEH. Given the potential for misdiagnosis of IPEH, careful histopathologic evaluation is required in order to avoid improper treatment.

ACS Style

Peter Cooke; David Goldrich; Alfred Marc Iloreta; Abeer Salama; Raj Shrivastava. Intravascular Papillary Endothelial Hyperplasia of the Maxillary Sinus in Patient with Tricuspid Atresia. Head and Neck Pathology 2019, 14, 803 -807.

AMA Style

Peter Cooke, David Goldrich, Alfred Marc Iloreta, Abeer Salama, Raj Shrivastava. Intravascular Papillary Endothelial Hyperplasia of the Maxillary Sinus in Patient with Tricuspid Atresia. Head and Neck Pathology. 2019; 14 (3):803-807.

Chicago/Turabian Style

Peter Cooke; David Goldrich; Alfred Marc Iloreta; Abeer Salama; Raj Shrivastava. 2019. "Intravascular Papillary Endothelial Hyperplasia of the Maxillary Sinus in Patient with Tricuspid Atresia." Head and Neck Pathology 14, no. 3: 803-807.