Predictive modeling is becoming increasingly popular in the context of early disease detection. The use of machine learning approaches for predictive modeling can help early detection of diseases thereby enabling medical experts to appropriate medical treatments. Stillbirth prediction is a similar domain where artificial intelligence-based predictive modeling can alleviate this significant global health challenge. Despite advancements in prenatal care, the prevention of stillbirths remains a complex issue requiring further research and interventions. The cardiotocography (CTG) dataset is used in this research work from the UCI machine learning (ML) repository to investigate the efficiency of the proposed approach regarding stillbirth prediction. This research work adopts the Tabular Prior Data Fitted Network (TabPFN) model which was originally designed to solve small tabular classification. TabPFN is used to predict the still or live birth during pregnancy with 97.91% accuracy. To address this life-saving problem with more accurate results and in-depth analysis of ML models, this research work makes use of 13 renowned ML models for performance comparison with the proposed model. The proposed model is evaluated using precision, recall, F-score, Mathews Correlation Coefficient (MCC), and the area under the curve evaluation parameters and the results are 97.87%, 98.26%, 98.05%, 96.42%, and 98.88%, respectively. The results of the proposed model are further evaluated using k-fold cross-validation and its performance comparison with other state-of-the-art studies indicating the superior performance of TabPFN model.

Background and Objectives: Breast cancer accounts for 12.5% of all new cancer cases in women worldwide. Early detection significantly improves survival rates, but traditional biomarkers like CA 15-3 and HER2 lack sensitivity and specificity, particularly for early-stage disease. Advances in metabolomics and machine learning, particularly explainable artificial intelligence (XAI), offer new opportunities for identifying robust biomarkers and improving diagnostic accuracy. This study aimed to identify and validate serum-based metabolic biomarkers for breast cancer using advanced metabolomic profiling techniques and a Light Gradient Boosting Machine (LightGBM) model. Additionally, SHapley Additive exPlanations (SHAP) were applied to enhance model interpretability and biological insight. Materials and Methods: The study included 103 breast cancer patients and 31 healthy controls. Serum samples underwent liquid and gas chromatography–time-of-flight mass spectrometry (LC-TOFMS and GC-TOFMS). Mutual Information (MI), Sparse Partial Least Squares (sPLS), Boruta, and Multi-Objective Feature Selection (MOFS) approaches were applied to the data for biomarker discovery. LightGBM, AdaBoost, and Random Forest were employed for classification and to identify class imbalance with the Synthetic Minority Oversampling Technique (SMOTE). SHAP analysis ranked metabolites based on their contribution to model predictions. Results: Compared to other feature selection approaches, the MOFS approach was more robust in terms of predictive performance, and metabolites identified by this method were used in subsequent analyses for biomarker discovery. LightGBM outperformed the AdaBoost and Random Forest models, achieving 86.6% accuracy, 89.1% sensitivity, 84.2% specificity, and an F1-score of 87.0%. SHAP analysis identified 2-Aminobutyric acid, choline, and coproporphyrin as the most influential metabolites, with dysregulation of these markers associated with breast cancer risk. Conclusions: This study is among the first to integrate SHAP explainability with metabolomic profiling, bridging computational predictions and biological insights for improved clinical adoption. This study demonstrates the effectiveness of combining metabolomics with XAI-driven machine learning for breast cancer diagnostics. The identified biomarkers not only improve diagnostic accuracy but also reveal critical metabolic dysregulations associated with disease progression.

Background/Objectives: Early and accurate detection of breast cancer is essential for reducing mortality and improving patient outcomes. However, the manual interpretation of breast ultrasound images is challenging due to image variability, noise, and inter-observer subjectivity. This study aims to address these limitations by developing an automated and interpretable computer-aided diagnosis (CAD) system. Methods: We propose an automated and interpretable computer-aided diagnosis (CAD) system that integrates ensemble transfer learning with Vision Transformer architectures. The system combines the Data-Efficient Image Transformer (Deit) and Vision Transformer (ViT) through concatenation-based feature fusion to exploit their complementary representations. Preprocessing, normalization, and targeted data augmentation enhance robustness, while Gradient-weighted Class Activation Mapping (Grad-CAM) provides visual explanations to support clinical interpretability. The proposed model is benchmarked against state-of-the-art CNNs (VGG16, ResNet50, DenseNet201) and Transformer models (ViT, DeiT, Swin, Beit) using the Breast Ultrasound Images (BUSI) dataset. Results: The ensemble achieved 96.92% accuracy and 97.10% AUC for binary classification, and 94.27% accuracy with 94.81% AUC for three-class classification. External validation on independent datasets demonstrated strong generalizability, with 87.76%/88.07% accuracy/AUC on BrEaST, 86.77%/85.90% on BUS-BRA, and 86.99%/86.99% on BUSI_WHU. Performance decreased for fine-grained BI-RADS classification—76.68%/84.59% accuracy/AUC on BUS-BRA and 68.75%/81.10% on BrEaST—reflecting the inherent complexity and subjectivity of clinical subclassification. Conclusions: The proposed Vision Transformer-based ensemble demonstrates high diagnostic accuracy, strong cross-dataset generalization, and clinically meaningful explainability. These findings highlight its potential as a reliable second-opinion CAD tool for breast cancer diagnosis, particularly in resource-limited clinical environments.

More than 85% of the world’s cervical cancer fatalities occur in less-developed nations, causing early mortality among women. In this paper, we propose a novel approach for the early classification of cervical cancer based on a new feature selection algorithm and classification method. The new feature selection algorithm is based on a hybrid of the Waterwheel Plant Algorithm and Particle Swarm Optimization algorithms, and bWWPAPSO denotes it. Meanwhile, the new classification method is based on optimizing the parameters of a multilayer perceptron neural network (WWPAPSO+MLP). A publicly available dataset is employed to verify the effectiveness of the proposed approach. Due to this dataset’s imbalance and missing values, it is preprocessed and balanced using SMOTETomek, where undersampling and oversampling were utilized. The usefulness of class imbalance and feature selection based on the classifier’s specificity, sensitivity, and accuracy has been demonstrated by way of a comparative study of the proposed methodology that has been carried out. WWPAPSO+MLP achieves superior performance, with an accuracy of 97.3% and a sensitivity of 98.8%. On the other hand, several statistical tests were conducted, including the Wilcoxon signed rank test and analysis of variance (ANOVA) to confirm the effectiveness and superiority of the proposed approach.

Background: Sepsis poses a significant threat in emergency settings, necessitating tools for early and interpretable risk assessment. This study aimed to develop a robust explainable boosting machine (EBM) model, one of the explainable artificial intelligence (XAI) technologies, to construct a predictive model that balances high accuracy and clinical interpretability for use in emergency departments (EDs) and to examine candidate biomarkers. Methods: The study identified a significant class imbalance problem in the sepsis distribution among 560 sepsis and 1012 non-sepsis patients. To address the imbalance issue, SMOTE-NC was applied in the training data. The data was divided into two parts, 80% training and 20% testing. To ensure the reliability of the models and to report unbiased results, this process was repeated 100 times and the average performance was reported. To determine the best model for sepsis prediction, five different models (AdaBoost, Gradient Boosting, CatBoost, LightGBM, and EBM) were trained, and their performances were evaluated. In the last stage, we presented local and global explanations of EBM. Results: The EBM model achieved the highest success by reaching 79.1% F1-score, 80.9% sensitivity, and 84.8% AUC after resampling. In the global explanations, the variables with the highest weights in the model’s decision process were identified as positive blood culture, oxygen saturation, and procalcitonin, respectively. Conclusion: The EBM model accurately predicts sepsis risk based on clinically relevant biomarkers. The model’s high performance and inherent transparency can foster trust among clinicians and facilitate its integration into emergency department workflows for real-time decision support.