Human natural killer (NK) cells express low‐affinity Fc immunoglobulin G (IgG) receptor (FcγRIIIA/CD16). The binding of monomeric IgG (mIgG) and F(ab′)₂ fragments of 3G8 anti‐CD16 monoclonal antibody (mAb) to FcγRIIIA was investigated by flow cytometry. Over 90% of NK cells bound endogenous IgG, and during incubation at 37 °C, the FcγRIIIA occupancy decreased slowly. Approximately 90% of NK cells bind mIgG or F(ab′)₂ fragments of 3G8 anti‐CD16 mAb. The calculated half‐time (T_1/2) of in vitro mIgG dissociation from FcγRIIIA was 130 min. By cross‐linking the mIgG ligand with F(ab′)₂ fragments of anti‐human IgG antibody, the T_1/2 decreases to 85 min. In kinetics study, it has been shown that ¹²⁵I‐mIgG bound to FcγRIIIA is slowly released in the culture supernatant, maybe eluted at acid pH, or partially internalized and degraded. The binding of IgG to FcγRIIIA was increased by 53.8% on cells cultured in the presence of RU36156, a matrix metalloproteinase (MMP) inhibitor. Furthermore, an increase in phosphorylation of Lyn tyrosine kinase, after cross‐linking of mIgG‐FcγRIIIA complex, was observed on NK cells treated with RU36156. When the FcγRIIIA was occupied by mIgG, the capacity of NK cells to kill K562 target cells was decreased by RU36156, because the MMP inhibitor protects CD16 from proteolysis. Our data demonstrate that binding of mIgG to human NK cells is followed by ligand dissociation and/or internalization, enzymatic degradation and exocytosis. The RU36156 MMP inhibitor protects FcγRIIIA from cleavage, augments NK‐cell activation and may interfere in their killing capacity.

McMahon Hall, an iconic Brutalist dormitory at the University of Washington, has become the site of an interdisciplinary experiment in cultural memory and machine-assisted storytelling. This article presents a method that combines remote sensing with AI-generated voices to produce a polyvocal narrative of architecture through the perspective of the building itself, its material (concrete), an architect, a journalist, and a bird. Drone photogrammetry and generated 3D models were combined with generative AI (text, image, and voice) to reconstruct the site digitally and imaginatively (AI-driven speculative narratives). Through speculative storytelling, the article and the project explore how cultural memory and perception of built heritage can be augmented by machines, offering plural perspectives that challenge singular historical narratives. The Introduction situates the work at the intersection of digital heritage documentation, AI storytelling, epistemology in machine learning, and spatial computing, emphasizing the perception of heritage through different actors. The Theoretical Framework draws on literature in photogrammetry for heritage preservation, polyvocal narrative, and knowledge frameworks of AI. The Materials and Methods detail the workflow: capturing McMahon Hall via UAV photogrammetry, producing a 3D model, and generating character-driven narratives with large language models and voice synthesis. The resulting multi-voiced narrative and its thematic insights are described. In the Discussion, the implications of this approach for architectural heritage interpretation are considered, including its capacity to amplify diverse voices and the risks of bias or hyperreality in AI-generated narratives. The study argues that this polyvocal, machine-augmented storytelling expands the toolkit of remote sensing and digital heritage by not only documenting the tangible form of the built environment but also speculating on its intangible cultural memory. The Conclusions reflect on how merging spatial computing techniques with AI narratives can support new modes of engagement with architecture, positioning this work as a building block toward richer human-machine co-created heritage experiences.

This paper explores the value of imperfections and curated decay in the conservation of architecture and public art as vehicles of cultural memory. While conventional heritage practice treats physical degradation as a threat, newer conservation ethics argue for embracing material impermanence within an aesthetics of care. We examine how acknowledging patina, weathering, and even structural decline can become an act of care, maintaining the “spirit” and authenticity of a place. The theoretical framework integrated the aesthetics of imperfection, including concepts like the Japanese wabi-sabi, which finds beauty in the incomplete and impermanent, critical heritage theory (which questions whose memories and values are preserved or excluded) and cultural memory studies (notably Nora’s notion of lieux de mémoire, where material sites become symbolic elements of communal memory). Methodologically, the article is grounded by two case-study video essays, Imperfections (Genoa) and Scars (Nicosia), as instruments of research, which provide visual analyses of decayed architectural environments. These examples illustrate how curated decay can transform abandoned buildings and war-scarred urban zones into powerful mnemonic devices, provoking reflection on history, identity and the ethics of preservation. Despite extensive theorisation of patina/age-value and curated decay, recent heritage debates offer limited operational criteria for distinguishing intentional curated decay from unmanaged neglect in lived urban conservation contexts. Drawing on ethics and aesthetics of care, this article asks if and how care can be operationalised into a decision framework for urban conservation and tests this framework through two selected buildings: Albergo dei Poveri (Genoa) and Home for Cooperation (Nicosia). The authors argue that caring for heritage does not always mean restoring it to an as-new state; curating ageing and traces of time can support remembrance, resilience, and reconciliation, enriching heritage’s role in future urban imaginaries.

This paper aims to present the reinvention of rural underground and half buried houses in the context of the 21^st century's raising cost for energy, environmental concerns and landscape alteration by the growing population, together with today's urban-rural migration. Rural homes, ‘bordei’ type, had an extensive occurrence in Europe and beyond, found in various forms in different geographic regions throughout the history of manmade dwellings. Unfortunately, the construction of this housing typology in Romania, found mostly in the southern part, has stopped instead of evolving because of the failure to understand its benefits and degree of self-sufficiency in terms of energy consumption, protection, environmentally friendly approach, and so on. The main cause of the disappearance or scarce presence of the underground or half buried houses is their association with the early typologies of homes built by less fortunate people and therefore related to poverty and misery. Different global crisis led people to re-design underground homes or even restore vernacular ones for personal purpose or to include them in tourism circuits. One of the conclusions of this paper is that buried houses, derived from the traditional models and equipped with the contemporary technologies, could be a solution built in all respects with less impact on the environment and capable of revitalizing rural areas through eco-tourism.

It is well known that at a European level, a large building fund must be retrofitted by 2050 to meet the climate and energy targets defined by a reduction of greenhouse gas emissions up to 80 - 95% compared to 1990 levels. In this regard, the proposed recast of the energy performance directive defines a new path: going from nearly Zero Energy Buildings to Zero Emission Buildings for residential and non-residential buildings. Thus, practitioners need more adequate instruments to perform reliable field measurements that can later be used for providing retrofit solutions. In recent years it was observed that infrared thermography could be an excellent substitution for already used techniques that require a significant number of sensors or various equipment. The paper presents an overview of the aerial and terrestrial thermography applications and a description of the THERMOG research project, which focuses on using the thermal imaging approach as both a qualitative and a quantitative approach. The project aims to develop a methodology accompanied by software that evaluates the thermal performance of the building envelope under actual operating conditions using aerial and terrestrial thermography methods. The calculation methodology and the associated software will also be used in the structural and energy expertise activity of buildings, as well as in assessing the energy performance of a new building before the reception phase.