Systems for determining the position of objects inside buildings have a wide range of applications, such as the surveillance of people’s movements in hospitals, and of goods or mobile robots in warehouse spaces or production halls. Hence, there is a need for the development of methods that could be applied for those purposes. This paper presents the results of research on an experimental system for localizing people being evacuated from a building. The proposed solution was designed as a part of the building evacuation management system. The method used for finding location belongs to the class of proximity-type methods and is based on Received Signal Strength Indicator (RSSI) information of Bluetooth Low-Energy (BLE) devices. The devices used to build the system (BLE receivers) and the evacuee’s wristband (BLE transmitters) are low-budget electronic modules. The paper presents preliminary research and the process of selecting data processing methods, as well as the results of tests of the experimental network created for the evacuation system. The results of measurements and statistical analyses of the properties of the RSSI parameter of the BLE signal transmission between the modules used in the designed system are presented. In addition, the results of RSSI measurements and the analyses of RSSI recorded under varying environmental conditions in the building are presented. The choice of the data processing method and its parameters was made with the use of the determined probabilities of the nearest locator node detection. Finally, the performance of the experimental installation of the evacuee tracking system was tested and the effectiveness of the proximity method was evaluated. The experimental tests aimed to analyze the detection range and the impact of shading. They also allowed for determining the mean error and for estimating the maximum position determination error. It should be emphasized that the proposed position estimation method has a very low computational load, allowing the implementation of an extensive real-time system on a typical personal computer. Although the proposed system should be classified as a coarse positioning system, its features such as low cost, simplicity, flexibility, the use of commonly available components and low requirements for computational load make it attractive. Such a system is directly transferable to other applications in, for example, Industry 4.0.

The novel approach to the Low Energy Bluetooth RSSI (Received Signal Strength Indicator) examination for a personal location during the evacuation process is presented in this paper. The presented system is based on stationary locating localization nodes installed inside the facility and portable wristbands worn by people. A method based on the propagation model and preliminary determination of its characteristics is used to calculate the wristband-locator distance. The accuracy of the distance estimations is increased by assuming Gaussian model of RSSI measurements and using the estimator of RSSI mean value. A modified multilateration approach is used to estimate the person’s position in the 2D Cartesian coordinate system. The paper also includes the outcomes of experiments conducted on the proposed approach as it was applied to the prototype evacuation supervision system. The paper presents a comparison of the position estimation error for the proposed method based on the mean RSSI value estimator with the results obtained when raw RSSI values were used. Analysis and discussion of wristband position estimation error are also included.

This pilot study is aimed at implementing an approach for comprehensive clinical pharmacogenomics (PGx) profiling. Fifty patients with cardiovascular diseases and 50 healthy individuals underwent whole-exome sequencing. Data on 1800 PGx genes were extracted and analyzed through deep filtration separately. Theoretical drug induced phenoconversion was assessed for the patients, using sequence2script. In total, 4539 rare variants (including 115 damaging non-synonymous) were identified. Four publicly available PGx bioinformatics algorithms to assign PGx haplotypes were applied to nine selected very important pharmacogenes (VIP) and revealed a 45–70% concordance rate. To ensure availability of the results at point-of-care, actionable variants were stored in a web-hosted database and PGx-cards were developed for quick access and handed to the study subjects. While a comprehensive clinical PGx profile could be successfully extracted from WES data, available tools to interpret these data demonstrated inconsistencies that complicate clinical application.

W artykule zostały omówione wyniki praktycznych eksperymentów mających na celu określenie możliwości wykonania skutecznej transmisji danych z czujnika pomiarowego do aplikacji poprzez sieć LoRaWAN w warunkach zabudowy miejskiej w sytuacjach zróżnicowanych położeń węzła końcowego względem bramy sieci LoRaWAN zarówno pod względem odległości jak i charakteru zabudowy na linii węzeł-brama.

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