Depression is one of the most common mood disorders in the late-life population and is associated with poor quality of life and increased morbidity, disability and mortality. Nevertheless, in older adults, it often remains undetected and untreated. This narrative review aims at giving an overview on the main definitions, clinical manifestations, risk and protective factors for depression in the elderly, and at discussing the main reasons for its under/misdiagnosis, such as cognitive decline and their overlapping symptomatology. A practical approach for the global and multidisciplinary care of the older adult with depression, derived from cross-checking evidence emerging from the literature with everyday clinical experience, is thus provided, as a short and flexible “pocket” guide to orient clinicians in recognizing, diagnosing and treating depression in the elderly.

Non-invasive brain stimulation (NIBS) techniques, including transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), have provided valuable insights into the role of the cerebellum in cognitive processes. However, replicating findings from studies involving cerebellar stimulation poses challenges. This meta-analysis investigates the impact of NIBS on cognitive processes associated with the cerebellum. We conducted a systematic search and analyzed 66 studies and 91 experiments involving healthy adults who underwent either TMS or transcranial direct current stimulation (tDCS) targeting the cerebellum. The results indicate that anodal tDCS applied to the medial cerebellum enhances cognitive performance. In contrast, high-frequency TMS disrupts cognitive performance when targeting the lateral cerebellar hemispheres or when employed in online protocols. Similarly, low-frequency TMS and continuous theta burst stimulation (cTBS) diminish performance in offline protocols. Moreover, high-frequency TMS impairs accuracy. By identifying consistent effects and moderators of modulation, this meta-analysis contributes to improving the replicability of studies using NIBS on the cerebellum and provides guidance for future research aimed at developing effective NIBS interventions targeting the cerebellum.

Neurophysiological findings in the typical population demonstrate that spatial scrutiny for visual selection determines a center-surround profile of the attentional focus, which is the result of recurrent processing in the visual system. Individuals with autism spectrum disorder (ASD) manifest several anomalies in their visual selection, with strengths in detail-oriented tasks, but also difficulties in distractor inhibition tasks. Here, we asked whether contradictory aspects of perception in ASD might be due to a different center-surround profile of their attentional focus. In two experiments, we tested two independent samples of children with ASD, comparing them with typically developing (TD) peers. In Experiment 1, we used a psychophysical task that mapped the entire spatial profile of the attentional focus. In Experiment 2, we used dense-array electroencephalography (EEG) to explore its neurophysiological underpinnings. Experiment 1 results showed that the suppression, surrounding the attentional focus, was markedly reduced in children with ASD. Experiment 2 showed that the center-surround profile in TD children resulted in a modulation of the posterior N2 ERP component, with cortical sources in the lateral-occipital and medial/inferior temporal areas. In contrast, children with ASD did not show modulation of the N2 and related activations in the ventral visual stream. Furthermore, behavioural and neurophysiological measures of weaker suppression predicted more severe autistic symptomatology. The present findings, showing an altered center-surround profile during attentional selection, give an important insight to understand superior visual processing in autism as well as the experiencing of sensory overload.

Obstructive sleep apnea syndrome is a sleep disorder that may affect many brain functions. We are interested in the cognitive consequences of the condition with regard to the quality of life of individuals with this disorder. A debate is still underway as to whether cognitive difficulties caused by obstructive sleep apnea actually induce a "pseudodementia" pattern. This work provides a brief overview of the main controversies currently surrounding this issue. We report findings and opinions on structural and cognitive brain changes in individuals affected by obstructive sleep apnea by highlighting the involvement of executive functions and the possible reversibility of signs following-treatment with continuous positive airway pressure. Much research has been done on this issue but, to the best of our knowledge, a review of the present state of the literature evaluating different points of view has not yet been carried out.