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Dr. Massimiliano Tucci
University of Milan

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Research Keywords & Expertise

0 Health
0 Nutrition
0 Sustainable Dietary Pattern
0 Food Dietary patterns
0 , Food bioactives

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Short Biography

The aim of my project is to provide evidence on the protective role of bioactive-rich foods and dietary patterns in the context of sustainable diets. Specific aims will be the evaluation of the actual bioavailability of food bioactives, their potential biological effects and their role in the promotion of health-related markers (e.g. oxidative stress, inflammation, endothelial and vascular functions, metabolic activity) in specific target groups of population (e.g. older subjects and those with cardiovascular/metabolic risks). In addition, the obtained results will be considered for the development of dietary patterns able to respond to health and sustainability needs in the context of climate change. This will be performed though the exploitation of comprehensive nutritional evaluations (e.g. in terms of nutrients and food bioactives) and possible in vivo validation of the most promising patterns.

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Review
Published: 27 May 2021 in Nutrients
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Food choices and eating behaviours have a large impact on both human and planetary health. Recently, the Food and Agricultural Organisation (FAO) of the United Nations and the World Health Organisation have developed a list of 16 guiding principles to achieve sustainable healthy diets (SHDs). They proposed that development of food-based dietary guidelines (FBDGs) should be a core element in the implementation of these SHDs in each country. The objective of this review is to explore the degree of alignment of current FBDGs to these guiding principles. A total of 43 FBDGs, written or translated into English, were collected from the online repository developed by the FAO and were analysed for their adherence to each of the guiding principles. Results were stratified for period of publication and geographical macro-area. Overall, there were high levels of inclusion of the factors related to health outcomes, especially in the most recent FBDGs. Conversely, environmental impact and socio-cultural aspects of diet were considered less frequently, especially in the older FBDGs. These results highlight the importance of revising FBDGs, especially to include emerging topics which represent the areas with the highest scope for improvement in the future versions of FBDGs. Replication of the present study in the coming years will be worthwhile to monitor improvements in the adherence of global FBDGs to the guiding principles of SHDs. The attainment of such a goal could promote a more rapid transition towards SHDs, as well as highlighting pivotal research trajectories to increase adoption and evaluate the impact on the food system.

ACS Style

Daniela Martini; Massimiliano Tucci; James Bradfield; Antonio Di Giorgio; Mirko Marino; Cristian Del Bo'; Marisa Porrini; Patrizia Riso. Principles of Sustainable Healthy Diets in Worldwide Dietary Guidelines: Efforts So Far and Future Perspectives. Nutrients 2021, 13, 1827 .

AMA Style

Daniela Martini, Massimiliano Tucci, James Bradfield, Antonio Di Giorgio, Mirko Marino, Cristian Del Bo', Marisa Porrini, Patrizia Riso. Principles of Sustainable Healthy Diets in Worldwide Dietary Guidelines: Efforts So Far and Future Perspectives. Nutrients. 2021; 13 (6):1827.

Chicago/Turabian Style

Daniela Martini; Massimiliano Tucci; James Bradfield; Antonio Di Giorgio; Mirko Marino; Cristian Del Bo'; Marisa Porrini; Patrizia Riso. 2021. "Principles of Sustainable Healthy Diets in Worldwide Dietary Guidelines: Efforts So Far and Future Perspectives." Nutrients 13, no. 6: 1827.

Journal article
Published: 08 March 2021 in Foods
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There is an urgent need to promote healthy and sustainable diets that are tailored to the preferences and cultures of different populations. The present study aimed to (i) define a Mediterranean dietary pattern in line with the EAT-Lancet Commission reference diet (ELCRD), based on 2500 kcal/day and adapted to the Italian food habits (EAT-IT); (ii) develop a mid/long-term dietary plan based on EAT-IT and a dietary plan based on the Italian Dietary Guidelines (IDG); (iii) compare the two dietary plans in terms of portions, frequencies of consumption, and nutritional adequacy based on the nutrient and energy recommendations for the Italian adult population. The main differences between the two plans were related to the higher amount of fruit and vegetables in the IDG compared to the EAT-IT, while the EAT-IT plan was higher in nuts and legumes, which represent the main protein sources in the ELCRD. Differences in the protein sources, especially milk and derivatives, and for cereal-based foods, were also found. Dietary plans were comparable for most nutrients, except for higher energy from lipids and vegetal protein, a higher amount of fiber, and lower levels of calcium that were evidenced for the EAT-IT dietary plan compared to the IDG-based one. In conclusion, the analysis of the EAT-IT demonstrated certain nutritional issues. It remains to be determined whether this may represent a health concern in further studies aimed at investigating the feasibility of sustainable dietary patterns.

ACS Style

Massimiliano Tucci; Daniela Martini; Cristian Del Bo’; Mirko Marino; Alberto Battezzati; Simona Bertoli; Marisa Porrini; Patrizia Riso. An Italian-Mediterranean Dietary Pattern Developed Based on the EAT-Lancet Reference Diet (EAT-IT): A Nutritional Evaluation. Foods 2021, 10, 558 .

AMA Style

Massimiliano Tucci, Daniela Martini, Cristian Del Bo’, Mirko Marino, Alberto Battezzati, Simona Bertoli, Marisa Porrini, Patrizia Riso. An Italian-Mediterranean Dietary Pattern Developed Based on the EAT-Lancet Reference Diet (EAT-IT): A Nutritional Evaluation. Foods. 2021; 10 (3):558.

Chicago/Turabian Style

Massimiliano Tucci; Daniela Martini; Cristian Del Bo’; Mirko Marino; Alberto Battezzati; Simona Bertoli; Marisa Porrini; Patrizia Riso. 2021. "An Italian-Mediterranean Dietary Pattern Developed Based on the EAT-Lancet Reference Diet (EAT-IT): A Nutritional Evaluation." Foods 10, no. 3: 558.

Journal article
Published: 15 August 2020 in Nutrients
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The evaluation of food intake in older subjects is crucial in order to be able to verify adherence to nutritional recommendations. In this context, estimation of the intake of specific dietary bioactives, such as polyphenols, although particularly challenging, is necessary to plan possible intervention strategies to increase their intake. The aims of the present study were to: (i) evaluate the nutritional composition of dietary menus provided in a residential care setting; (ii) estimate the actual intake of nutrients and polyphenols in a group of older subjects participating in the MaPLE study; and (iii) investigate the impact of an eight-week polyphenol-rich dietary pattern, compared to an eight-week control diet, on overall nutrient and polyphenol intake in older participants. The menus served to the participants provided ~770 mg per day of total polyphenols on average with small variations between seasons. The analysis of real consumption, measured using weighed food diaries, demonstrated a lower nutrient (~20%) and polyphenol intake (~15%) compared to that provided by the menus. The feasibility of dietary patterns that enable an increase in polyphenol intake with putative health benefits for age-related conditions is discussed, with a perspective to developing dietary guidelines for this target population.

ACS Style

Daniela Martini; Stefano Bernardi; Cristian Del Bo’; Nicole Hidalgo Liberona; Raul Zamora-Ros; Massimiliano Tucci; Antonio Cherubini; Marisa Porrini; Giorgio Gargari; Raúl González-Domínguez; Gregorio Peron; Benjamin Kirkup; Paul A. Kroon; Cristina Andres-Lacueva; Simone Guglielmetti; Patrizia Riso. Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects. Nutrients 2020, 12, 2458 .

AMA Style

Daniela Martini, Stefano Bernardi, Cristian Del Bo’, Nicole Hidalgo Liberona, Raul Zamora-Ros, Massimiliano Tucci, Antonio Cherubini, Marisa Porrini, Giorgio Gargari, Raúl González-Domínguez, Gregorio Peron, Benjamin Kirkup, Paul A. Kroon, Cristina Andres-Lacueva, Simone Guglielmetti, Patrizia Riso. Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects. Nutrients. 2020; 12 (8):2458.

Chicago/Turabian Style

Daniela Martini; Stefano Bernardi; Cristian Del Bo’; Nicole Hidalgo Liberona; Raul Zamora-Ros; Massimiliano Tucci; Antonio Cherubini; Marisa Porrini; Giorgio Gargari; Raúl González-Domínguez; Gregorio Peron; Benjamin Kirkup; Paul A. Kroon; Cristina Andres-Lacueva; Simone Guglielmetti; Patrizia Riso. 2020. "Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects." Nutrients 12, no. 8: 2458.

Article
Published: 28 February 2020 in Nutrients
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The present study aims to evaluate the ability of peonidin and petunidin-3-glucoside (Peo-3-glc and Pet-3-glc) and their metabolites (vanillic acid; VA and methyl-gallic acid; MetGA), to prevent monocyte (THP-1) adhesion to endothelial cells (HUVECs), and to reduce the production of vascular cell adhesion molecule (VCAM)-1, E-selectin and vascular endothelial growth factor (VEGF) in a stimulated pro-inflammatory environment, a pivotal step of atherogenesis. Tumor necrosis factor-α (TNF-α; 100 ng mL−1) was used to stimulate the adhesion of labelled monocytes (THP-1) to endothelial cells (HUVECs). Successively, different concentrations of Peo-3-glc and Pet-3-glc (0.02 µM, 0.2 µM, 2 µM and 20 µM), VA and MetGA (0.05 µM, 0.5 µM, 5 µM and 50 µM) were tested. After 24 h, VCAM-1, E-selectin and VEGF were quantified by ELISA, while the adhesion process was measured spectrophotometrically. Peo-3-glc and Pet-3-glc (from 0.02 µM to 20 µM) significantly (p < 0.0001) decreased THP-1 adhesion to HUVECs at all concentrations (−37%, −24%, −30% and −47% for Peo-3-glc; −37%, −33%, −33% and −45% for Pet-3-glc). VA, but not MetGA, reduced the adhesion process at 50 µM (−21%; p < 0.001). At the same concentrations, a significant (p < 0.0001) reduction of E-selectin, but not VCAM-1, was documented. In addition, anthocyanins and their metabolites significantly decreased (p < 0.001) VEGF production. The present findings suggest that while Peo-3-glc and Pet-3-glc (but not their metabolites) reduced monocyte adhesion to endothelial cells through suppression of E-selectin production, VEGF production was reduced by both anthocyanins and their metabolites, suggesting a role in the regulation of angiogenesis.

ACS Style

Mirko Marino; Cristian Del Bo’; Massimiliano Tucci; Dorothy Klimis-Zacas; Patrizia Riso; Marisa Porrini. Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In Vitro Model of Atherosclerosis. Nutrients 2020, 12, 655 .

AMA Style

Mirko Marino, Cristian Del Bo’, Massimiliano Tucci, Dorothy Klimis-Zacas, Patrizia Riso, Marisa Porrini. Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In Vitro Model of Atherosclerosis. Nutrients. 2020; 12 (3):655.

Chicago/Turabian Style

Mirko Marino; Cristian Del Bo’; Massimiliano Tucci; Dorothy Klimis-Zacas; Patrizia Riso; Marisa Porrini. 2020. "Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In Vitro Model of Atherosclerosis." Nutrients 12, no. 3: 655.

Preprint
Published: 11 January 2020
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The present study aims to evaluate the ability of peonidin and petunidin-3-glucoside (Peo and Pet-3-glc) and their metabolites (vanillic acid; VA and methyl-gallic acid; MetGA), to prevent monocyte (THP-1) adhesion to endothelial cells (HUVECs), and to reduce the production of VCAM-1, E-selectin and VEGF in a stimulated pro-inflammatory environment, a pivotal step of atherogenesis. Tumor necrosis factor-α (TNF-α; 100 ng mL-1) was used to stimulate the adhesion of labelled monocytes (THP-1) to endothelial cells (HUVECs). Successively, different concentrations of Peo-3-glc and Pet-3-glc (0.02, 0.2, 2 and 20 µM) and VA and MetGA (0.05, 0.5, 5 and 50 µM) were tested. After 24 h, the production of VCAM-1, E-selectin and VEGF was quantified by ELISA kits, while the adhesion process was measured spectrophotometrically. Peo-3-glc and Pet-3-glc (from 0.02 to 20 µM) significantly (p<0.0001) decreased THP-1 adhesion to HUVECs at all concentrations (-37%, -24%, -30% and -47% for Peo-3-glc; -37%, -33%, -33% and -45% for Pet-3-glc). VA, but not MetGA, reduced the adhesion process at 50 µM (-21%; p<0.001). At the same concentrations, a significant (p<0.0001) reduction of E-selectin, but not VCAM-1, was documented. In addition, anthocyanins and their metabolites significantly decreased (p<0.001) VEGF production. The present findings suggest, that while Peo-3-glc and Pet-3-glc, but not their metabolites, reduced monocyte adhesion to endothelial cells through suppression of E-selectin production, VEGF production was reduced by both anthocyanins and their metabolites suggesting a role in regulation of angiogenesis.

ACS Style

Mirko Marino; Cristian Del Bo’; Massimiliano Tucci; Dorothy Klimis-Zacas; Patrizia Riso; Marisa Porrini. Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In-Vitro Model of Atherosclerosis. 2020, 1 .

AMA Style

Mirko Marino, Cristian Del Bo’, Massimiliano Tucci, Dorothy Klimis-Zacas, Patrizia Riso, Marisa Porrini. Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In-Vitro Model of Atherosclerosis. . 2020; ():1.

Chicago/Turabian Style

Mirko Marino; Cristian Del Bo’; Massimiliano Tucci; Dorothy Klimis-Zacas; Patrizia Riso; Marisa Porrini. 2020. "Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In-Vitro Model of Atherosclerosis." , no. : 1.