Nowadays, we are assisting in the exceptional growth in research relating to the development of wearable devices for sweat analysis. Sweat is a biofluid that contains useful health information and allows a non-invasive, continuous and comfortable collection. For this reason, it is an excellent biofluid for the detection of different analytes. In this work, electrochemical sensors based on polyaniline thin films deposited on the flexible substrate polyethylene terephthalate coated with indium tin oxide were studied. Polyaniline thin films were abstained by the potentiostatic deposition technique, applying a potential of +2 V vs. SCE for 90 s. To improve the sensor performance, the electronic substrate was modified with reduced graphene oxide, obtained at a constant potential of −0.8 V vs. SCE for 200 s, and then polyaniline thin films were electrodeposited on top of the as-deposited substrate. All samples were characterized by XRD, SEM, EDS, static contact angle and FT-IR/ATR analysis to correlate the physical-chemical features with the performance of the sensors. The obtained electrodes were tested as pH sensors in the range from 2 to 8, showing good behavior, with a sensitivity of 62.3 mV/pH, very close to a Nernstian response, and a reproducibility of 3.8%. Interference tests, in the presence of competing ions, aimed to verify the selectivity, were also performed. Finally, a real sweat sample was collected, and the sweat pH was quantified with both the proposed sensor and a commercial pH meter, showing an excellent concordance.

Effective safety procedures play a fundamental role in high-risk industrial contexts, because the occurrence of an accident can cause environmental catastrophes, severe damages to the structures, and fatal injuries to the workers. In particular, maintaining detailed and up-to-date information about potential accident areas is a crucial issue to prevent the occurrence of disasters and to safely plan the rescue process. In such contexts, periodic safety inspections are therefore performed on a regular basis, although they may expose the inspection personnel to harsh or hazardous environments. The employment of unmanned aerial vehicles (UAVs) in such situations can provide unprecedented opportunities for predisaster analyses and site management operations. According to the current regulations, however, industrial contexts are classified as “critical,” which substantially limits the possibilities of performing UAV operations in such places. The recent introduction of a simplified regulatory system for inoffensive UAVs has opened a wide landscape of new business opportunities. The article discusses the application of such technology for site analysis in industrial contexts, and illustrates the mandatory risk assessment procedure prescribed by the regulation. The results obtained show that although the technical advantages and economic convenience of employing this technology is generally recognized, at the dawn of the fourth industrial revolution, the market spread is still poor due to fragmented regulations, cultural barriers, and technical issues. In particular, the compliance with the ATEX directives still constitutes a significant technological problem substantially limiting the spread of innovative industrial services. Such issues are discussed in the article referring to a case study, in order to provide a reference guideline and to highlight the boundaries of application of innovative approaches to the prevention and management of industrial disasters based on UAV technology. In addition, the article identifies some important directives for further research and development of UAV systems capable to operate in high-risk industrial contexts, which constitutes an emerging business area with a vast potential market.

Exposure of the airways epithelium to environmental insults, including cigarette smoke, results in increased oxidative stress due to unbalance between oxidants and antioxidants in favor of oxidants. Oxidative stress is a feature of inflammation and promotes the progression of chronic lung diseases, including Chronic Obstructive Pulmonary Disease (COPD). Increased oxidative stress leads to exhaustion of antioxidant defenses, alterations in autophagy/mitophagy and cell survival regulatory mechanisms, thus promoting cell senescence. All these events are amplified by the increase of inflammation driven by oxidative stress. Several models of bronchial epithelial cells are used to study the molecular mechanisms and the cellular functions altered by cigarette smoke extract (CSE) exposure, and to test the efficacy of molecules with antioxidant properties. This review offers a comprehensive synthesis of human in-vitro and ex-vivo studies published from 2011 to 2021 describing the molecular and cellular mechanisms evoked by CSE exposure in bronchial epithelial cells, the most used experimental models and the mechanisms of action of cellular antioxidants systems as well as natural and synthetic antioxidant compounds.