An important component of micropollutants are PPCPs (pharmaceuticals and personal care products). This paper contains the results of the monitoring of surface water, groundwater and wastewater in the surrounding area of the Svihov drinking water reservoir. Over the period 2017–2019, over 21,000 water samples were taken and analyzed for 112 pharmaceuticals, their metabolites, and other chemicals. The results are discussed in detail for two streams with the highest observed concentration of PPCPs (Hnevkovice, Dolni Kralovice) and two streams with the highest water inflow into the reservoir, representing also the highest mass flow of PPCPs into the reservoir (Miletin, Kacerov). The overall analysis of the results shows that acesulfame, azithromycin, caffeine, gabapentin, hydrochlorothiazide, ibuprofen and its metabolites, oxypurinol, paraxanthine, and saccharin (on some profiles up to tens of thousands ng/dm³) attain the highest concentration and occur most frequently. The evaluation of raw water and treated drinking water quality showed the significant positive effect of water retention in the reservoir (retention time of 413 days) and also of the treatment process, so that the treated drinking water is of high quality and contains only negligible residues of few PPCPs near the detection limit of the analytical method used.

The Káraný waterworks supplies drinking water to about one-third of Prague, the capital city of the Czech Republic with a population of more than 1 million. The combination of two technologies—bank infiltration and artificial recharge—are used for production of drinking water. The two-year monitoring of PPCPs (pharmaceuticals and personal care products) at monthly intervals observed temporal changes in 81 substances in the source river and groundwater, and the efficacy of contamination removal depended on the treatment technology used. The results showed a very wide range of PPCPs discharged from the waste water treatment plant at Mladá Boleslav into the Jizera River at concentrations ranging from ng/L to μg/L. Acesulfame and oxypurinol in concentrations exceeding 100 ng/L systematically occurred, and then a few tens of ng/L of carbamazepine, sulfamethoxazole, primidone, and lamotrigine were regularly detected at the water outlet using the artificial recharge for production of drinking water. Bank infiltration was found more efficient in removing PPCP substances at the Káraný locality where none of the monitored substances was systematically detected in the mixed sample.