Background. Parkinson’s disease (PD) is believed to develop from epigenetic modulation of gene expression through environmental factors that accounts for up to 85% of all PD cases. The main objective of this study was to examine the association between PD onset and a cumulative exposure to potentially modifiable ambient exposures. Methods. The study population comprised 3343 incident PD cases and 31,324 non-PD controls in Southern Israel. The exposures were determined based on the monitoring stations and averaged per year. Their association with PD was modeled using a distributed lag non-linear model and presented as an effect of exposure to the 75th percentile as compared to the 50th percentile of each pollutant, accumulated over the span of 5 years prior to the PD. Results. We recorded an adverse effect of particulate matter of size ≤10 μm in diameter (PM₁₀) and solar radiation (SR) with odds ratio (OR) = 1.06 (95%CI: 1.02; 1.10) and 1.23 (95%CI: 1.08; 1.39), respectively. Ozone (O₃) was also adversely linked to PD, although with a borderline significance, OR: 1.12 (95%CI: 0.99; 1.25). Immigrants arriving in Israel after 1989 appeared to be more vulnerable to exposure to O₃ and SR. The dose response effect of SR, non-existent for Israeli-born (OR = 0.67, 95%CI: 0.40; 1.13), moderate for immigrants before 1989 (OR = 1.17, 95%CI: 0.98; 1.40) and relatively high for new immigrants (OR = 1.25, 95%CI: 1.25; 2.38) indicates an adaptation ability to SR. Conclusions. Our findings supported previous reports on adverse association of PD with exposure to PM₁₀ and O₃. Additionally, we revealed a link of Parkinson’s Disease with SR that warrants an extensive analysis by research groups worldwide.

We aimed to estimate the association of urinary metal content with the exposure to hazardous household factors and ambient air pollution in pregnant women. We analyzed urine samples of 143 women enrolled at delivery and assessed household exposure by questionnaire. Air pollution estimates were based on monitoring stations and satellite-based models. Complaints about noise, rubbish, and sewage in the neighborhood were associated with higher uranium concentrations (prevalence ratio (PR) = 1.42, 1.46, and 1.18, respectively). Complaints about noise were more frequent in women with higher cobalt, nickel, molybdenum, cadmium, and vanadium urine concentrations (PRs = 2.42–9.43), and complaints about smell in women with higher cobalt and strontium (PRs = 2.55–6.27). Exposure to nitrogen oxides was associated with higher concentrations of nickel, aluminum, lead, and chromium in urine (PRs = 1.80–5.85). Women exposed to elevated levels of particulate matter were more likely to have higher concentrations of cobalt, nickel, thallium, lead, iron, strontium, barium, silver, and chromium (PRs = 1.97–13.64). Exposure to high levels of sulfur dioxide was positively associated with cobalt and nickel (PR = 1.98 and 1.88, respectively). The current analysis suggests the possibility of a related simultaneous exposure to multiple pollutants. Further studies are warranted to corroborate the findings and reveal the multiple exposure effect on human health.

The global decline in sperm quality remains poorly understood, with limited research on environmental exposures like rising temperatures from climate change. This study explored the association between extreme temperatures and sperm quality, focusing on normal and abnormal sperm parameters. Sperm data from Soroka fertility clinics (2009–2023) were analyzed alongside ambient temperatures from nearby monitoring stations up to 90 days before sample collection. Summer temperatures ranged from 25.3°C to 46.4°C, and winter minimums ranged from 0.1°C to 24.5°C. Directed Acyclic Graphs guided confounder selection for Generalized Additive Mixed Models and Distributed Lag Models, while Mixed-Effect Negative Binomial Regressions compared sperm quality across temperature extremes. Low winter temperatures were significantly associated with reduced motility, with a 5.8% decrease (p < 0.001). Men with abnormal motility, Jewish men, and older men were most affected, showing motility reductions of 3.59%–6.53%. Minimal effects of extreme summer heat were observed, except for a borderline significant 5.92% decrease in motility among men from lower socioeconomic backgrounds. These findings highlight the negative impact of extreme cold on sperm motility, with potential adaptation to summer heat in desert climates. Further research is needed, particularly among vulnerable groups, as climate change increases temperature extremes.