According to the article, pregnancy in adolescence is associated with a high risk of developing adverse outcomes both during pregnancy and childbirth in the later period. The purpose of our study was to identify the features of pregnancy and childbirth, the postpartum period in young mothers. Materials and methods. A retrospective analysis of the birth history of 299 maternity hospitals was performed. The research material was archived data from the Regional perinatal center No. 3 in Turkestan (Kazakhstan). The main (1) group was formed by 199 maternity women under 19 years of age (2019). The control (2) group was formed by 100 maternity women aged 20 to 30 years, whose sexual life began after the age of 18. Results. The age of the surveyed women in group 1 ranges from 15 to 19 years, averaging ~16.9 years. 17-year-old girls predominated (66.7%). The average age of women in group 2 was ~25.8 years. Adolescent pregnancy is a risk factor for adverse child outcomes, such as premature birth, low birth weight, fetal growth retardation, neonatal and infant mortality. In the adolescent pregnancy and delivery group, preterm birth occurred in 35 cases, which accounted for 6.8% of the total preterm birth population for 2019, but in the adolescent birth group it was 17.5%. Of the 199 births in 2 were multiple births (1%), 197 live births, the percentage of live births among adolescents was 98%, respectively, the stillbirth rate was 2% (4 cases). Conclusion: the frequency of teenage pregnancy in the dynamics of years does not tend to decrease, among young mothers only every 6 received pre-pregnancy training, and every 5 was re-pregnant and among re-pregnant women under 19 years.

The article presents features of epidemiology and clinical picture of a new virus - COVID-2019 in Kazakhstan, features of dynamics among the child population. As of April 15, 2020, there are 1,295 cases of COVID-19. In total, the infection was confirmed in 80 children. Among them, one newborn, two children under one year old and this has allowed to limit the spread of this serious disease with the cooperation of all citizens in terms of containment and individual protection measures. Objective: to evaluate the prevalence, clinical and epidemiological features and risk factors of COVID-19 in children of different ages. The design of the study corresponded to the observational analytical one. The COVID-19 pandemic has spread very quickly, so it is children of all ages who should be the focus of special attention, as they play a huge role in the spread of the disease.

Stroke significantly impacts not only patients but also their relatives, who face the emotional and physical burden of caregiving. The aim of this study was to examine the influence of caregiving for stroke patients on the emotional state of their relatives and to identify their needs for support and education. Methods: The study involved n-1336 relatives of patients, based on n-396 patients who had suffered a stroke, using questionnaires to assess emotional state, stress levels, and access to rehabilitation services. Respondents are patients who have suffered a severe stroke, requiring constant external care, with an NIHSS score of at least 15 at the first stage of rehabilitation and according to the Renkin scale, >3 points which had pronounced impairments in Activities of Daily Living (ADL). Statistical methods, including Kruskal-Wallis tests and chi-square tests, were applied. Results: The emotional state of respondents significantly differs (p < 0.005) for those who do not receive or rarely receive rehabilitation services (χ² = 51.4600, df = 6, p < 0.001). (H (9, n=1136) = 643,7460, p < 0.001). Conclusions: Data analysis showed that many relatives experience significant psychological pressure, negatively affecting their emotional well-being. Participants who received regular rehabilitation and tele-rehabilitation reported a higher quality of life. Deficiencies in the accessibility of rehabilitation centers and a lack of knowledge about proper caregiving were identified.

Background/Objectives: Since the first successful birth following assisted reproductive technologies (ART) several decades ago, the global population of ART-conceived children has surpassed 13 million, with over 40,000 born in Kazakhstan. Despite this growth, questions remain about their long-term neurological outcomes, with existing studies reporting inconsistent findings. This study aimed to assess psychomotor development and the prevalence of nervous system pathologies among ART-conceived children in Kazakhstan and to develop a prognostic model for identifying pathological neurodevelopmental conditions. Methods: We studied 252 children (120 conceived via ART and 132 controls) using clinical examination and medical history data. Brain immaturity predictors were identified by univariate and multivariate logistic regression. Results: ART-conceived children exhibited a higher incidence of neurosonographic signs of brain structure immaturity. However, multivariate analysis indicated that ART itself was not an independent risk factor. Instead, perinatal complications—including prematurity, multiple pregnancy, low birth weight, asphyxia, and intrauterine infections—explained the observed differences. The prognostic model highlighted prematurity and preconceptional progesterone therapy as significant predictors. Overall neurological development did not differ significantly between the groups. Conclusions: These findings underscore the importance of early identification of perinatal risk factors and targeted preventive interventions to mitigate adverse neurodevelopmental outcomes in ART-conceived children.

Currently, there is uncertainty about the ideal treatment for recovery and a personalized approach to the management of patients with terminal renal failure.Therefore, a systematic review was conducted over the past 10 years.Network meta-analysis of randomized control trials (RCTS), which compared the prevalence of chronic renal failure (CRF), according to various literature data. AccordingtoWHOitisfrom 50 to 250 peopleper 1 millionpopulationperyear.Active therapy for terminal CRF (hemodialysis, peritoneal dialysis, kidney transplantation) is received in Western Europe by 500-600 patients, in the USA and Japan - 1000-1200 patients, while in Kazakhstan-about 100 patients per 1 million population per year. The ten-year probability of survival of patients with terminal CRF in active therapy exceeds 50%, excluding patients with diabetes mellitus.Arterial hypertension remains the most frequent symptom, largely determining the prognosis of patients with CRF. Ten-year survival of patients with CRF in combination with hypertension in hemodialysis is lower than in normotensive patients by 30-50%. Successfully performed a kidney transplant can eliminate the symptoms of chronic renal failure. Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 851-863

Introduction. Nowadays, metabolic syndrome continues to be a significant challenge in medicine. Experts from the World Health Organization have called metabolic syndrome (MetS) “the pandemic of the 21st century.” MetS is one of the cardiometabolic risk factors with a high prevalence in the adult population and a high cost to public health systems worldwide. The prevalence of MetS is very high: according to WHO, the incidence of MetS among adults is 20-40% and may increase by 50% in the next 20 years. The most threatening complications closely related to metabolic syndrome are cardiovascular diseases and type 2 diabetes mellitus. Due to the high prevalence of metabolic syndrome, its early detection is of great importance for the timely initiation of the prevention of complications. Aim. To study the association between the main lifestyle and socio-demographic factors and the risk of developing metabolic syndrome. Material’s and method. The present study is part of a large metabolic syndrome research project in Turkestan city (AP19676909) “Investigation of genetic aspects of nutrition, lifestyle and compliance of patients with metabolic syndrome in a 10-year prospective study”. The sample consisted of 552 patients from the attached population of the outpatient clinic of the H.A. Yasavi International Kazakh-Turkish University. Individuals with acute conditions requiring emergency care, chronic severe decompensated conditions were not included in the study. Results: The final patient sample was 549 patients, as study participants without data on any of the sociodemographic factors and any of the lipid and carbohydrate metabolism parameters were excluded from the analysis. The association between the presence of MetS and lifestyle indicators, including time spent sitting during the working day and physical activity, was assessed using multivariate logistic regression analysis. After adjusting for the potential confounding factors, such as gender, smoking, and alcohol consumption, the association between MetS and the sitting time during the working day was maintained statistical significance. In contrast, the adjusted logistic regression analysis revealed a statistically significant inverse relationship between the metabolic syndrome and level of physical activity. Сonclusion: The results of our study suggest a significant role for modifiable risk factors, such as a sedentary lifestyle and the level of physical activity, in the development of metabolic syndrome among our study participants. Personalized management tactics for patients with metabolic syndrome, by correcting modifiable lifestyle factors, can help prevent complications. Актуальность. На сегодняшний день метаболический синдром остается актуальной проблемой медицины. Эксперты Всемирной организации здравоохранения назвали метаболический синдром (МС) «пандемией XXI века». Метаболический синдром (МС) является одним из кардиометаболических факторов риска, имеющим высокую распространенность среди взрослого населения и высокую стоимость для систем общественного здравоохранения во всем мире. По данным ВОЗ частота МС среди взрослого населения составляет 20-40% и может увеличиться на 50% в ближайшие 20 лет. Наиболее грозными осложнениями, тесно связанными с метаболическим синдромом, являются сердечно-сосудистые заболевания и сахарный диабет 2 типа. В связи с высокой распространенностью метаболического синдрома его раннее выявление имеет большое значение для своевременной профилактики осложнений. Цель: Изучить связь между основными факторами образа жизни и социально-демографическими факторами с риском развития метаболического синдрома. Материалы и методы: Настоящее исследование является частью научного проекта по изучению метаболического синдрома в городе Туркестан «Изучение генетических аспектов питания, образа жизни и комплаентности пациентов с метаболическим синдромом в 10-летнем проспективном исследовании» (AP19676909). Выборку составили 552 пациента из прикрепленного населения поликлиники Международного казахско-турецкого университета имени Х.А. Ясави. В исследование не включались пациенты с острыми состояниями, требующими неотложной помощи, хроническими тяжелыми декомпенсированными состояниями. Результаты: Окончательная выборка пациентов составила 549 человек, так как участники, у которых отсутствовали данные по одному из социально-демографических факторов, либо по одному из параметров липидного и углеводного обмена были исключены...