This page has only limited features, please log in for full access.

Unclaimed
Asma A. Alothman
Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 08 April 2021 in Nanomaterials
Reads 0
Downloads 0

Controlling the kinetics of CuTCNQ (TCNQ = 7,7,8,8-tetracyanoquinodimethane) crystallization has been a major challenge, as CuTCNQ crystallizing on Cu foil during synthesis in conventional solvents such as acetonitrile simultaneously dissolves into the reaction medium. In this work, we address this challenge by using water as a universal co-solvent to control the kinetics of crystallization and growth of phase I CuTCNQ. Water increases the dielectric constant of the reaction medium, shifting the equilibrium toward CuTCNQ crystallization while concomitantly decreasing the dissolution of CuTCNQ. This allows more CuTCNQ to be controllably crystallized on the surface of the Cu foil. Different sizes of CuTCNQ crystals formed on Cu foil under different water/DMSO admixtures influence the solvophilicity of these materials. This has important implications in their catalytic performance, as water-induced changes in the surface properties of these materials can make them highly hydrophilic, which allows the CuTCNQ to act as an efficient catalyst as it brings the aqueous reactants in close vicinity of the catalyst. Evidently, the CuTCNQ synthesized in 30% (v/v) water/DMSO showed superior catalytic activity for ferricyanide reduction with 95% completion achieved within a few minutes in contrast to CuTCNQ synthesized in DMSO that took over 92 min.

ACS Style

Zakir Hussain; Ayman Nafady; Samuel Anderson; Abdullah Al-Enizi; Asma Alothman; Rajesh Ramanathan; Vipul Bansal. Increased Crystallization of CuTCNQ in Water/DMSO Bisolvent for Enhanced Redox Catalysis. Nanomaterials 2021, 11, 954 .

AMA Style

Zakir Hussain, Ayman Nafady, Samuel Anderson, Abdullah Al-Enizi, Asma Alothman, Rajesh Ramanathan, Vipul Bansal. Increased Crystallization of CuTCNQ in Water/DMSO Bisolvent for Enhanced Redox Catalysis. Nanomaterials. 2021; 11 (4):954.

Chicago/Turabian Style

Zakir Hussain; Ayman Nafady; Samuel Anderson; Abdullah Al-Enizi; Asma Alothman; Rajesh Ramanathan; Vipul Bansal. 2021. "Increased Crystallization of CuTCNQ in Water/DMSO Bisolvent for Enhanced Redox Catalysis." Nanomaterials 11, no. 4: 954.

Journal article
Published: 16 March 2021 in Journal of Industrial and Engineering Chemistry
Reads 0
Downloads 0

In this study, to impart silk fibers with excellent coloration, UV-protection, antimicrobial activity, as well as creatinine adsorption from artificial blood, silk fibers were designed via facile fabrication approach. These diverse properties were introduced by in-situ incorporation of nanoparticles based on either silver (AgNPs) or gold (AuNPs) as well as bimetallic (Ag-AuNPs) onto silk fibers using an eco-friendly, effective one-pot process. The proteins present in the silk fibers acted as a redox-active bio-template to reduce the Ag(I) and Au(III) ions to their zero-valent state with simultaneous deposition of the generated nanoparticles onto the silk fiber surfaces. The obtained results clearly indicated that both AgNPs and AuNPs colored the silk fibers with brown and red color, respectively, thereby affirming the deposition of these metallic NPs onto and inside the surface of silk fibers as S/Ag-AuNPs. Significantly, the prepared colored silk fibers exhibited excellent antimicrobial and cytotoxicity activities against different pathogenic microbes as well as very good UV protection properties. Moreover, the results attested that the as prepared S/AgNPs and S/AuNPs fibers have good adsorption potential with maximal adsorption capacity of creatinine in artificial blood was found to be 94.2 mg/g for S/AuNPs sample, which is 1.55 times greater than that of silk fibers.

ACS Style

Mohamed Rehan; Mehrez E. El-Naggar; Abdullah M. Al-Enizi; Asma A. Alothman; Ayman Nafady; Reda M. Abdelhameed. Development of silk fibers decorated with the in situ synthesized silver and gold nanoparticles: antimicrobial activity and creatinine adsorption capacity. Journal of Industrial and Engineering Chemistry 2021, 97, 584 -596.

AMA Style

Mohamed Rehan, Mehrez E. El-Naggar, Abdullah M. Al-Enizi, Asma A. Alothman, Ayman Nafady, Reda M. Abdelhameed. Development of silk fibers decorated with the in situ synthesized silver and gold nanoparticles: antimicrobial activity and creatinine adsorption capacity. Journal of Industrial and Engineering Chemistry. 2021; 97 ():584-596.

Chicago/Turabian Style

Mohamed Rehan; Mehrez E. El-Naggar; Abdullah M. Al-Enizi; Asma A. Alothman; Ayman Nafady; Reda M. Abdelhameed. 2021. "Development of silk fibers decorated with the in situ synthesized silver and gold nanoparticles: antimicrobial activity and creatinine adsorption capacity." Journal of Industrial and Engineering Chemistry 97, no. : 584-596.

Review article
Published: 14 February 2021 in Journal of Industrial and Engineering Chemistry
Reads 0
Downloads 0

This review delivers a summary of the recent advances in polyaniline based electrocatalyst for direct methanol fuel cell applications. Today’s world is urging for global energy due to the fossil fuel diminution and ecological contamination which is overthrown by the direct methanol fuel cell. Amongst the conducting polymers, polyaniline has a significant role in the direct methanol fuel cell. Due to the high conductivity, unique redox properties, high flexibility, better solubility, reasonable stability, ease synthesis, and low cost. The nanocomposite of polyaniline with other electrochemically active materials such as metallic compounds and carbonaceous materials as well as nitrogen-doped carbon materials derived from PANI based nanocomposite were in detailly discussed in this review.

ACS Style

Suba Lakshmi Madaswamy; Asma A. Alothman; Murefah Mana Al-Anazy; Ahmad A. Ifseisi; Khadraa N. Alqahtani; Sendhil Kumar Natarajan; Subramania Angaiah; Dhanusuraman Ragupathy. Polyaniline-based nanocomposites for direct methanol fuel cells (DMFCs) - A Recent Review. Journal of Industrial and Engineering Chemistry 2021, 97, 79 -94.

AMA Style

Suba Lakshmi Madaswamy, Asma A. Alothman, Murefah Mana Al-Anazy, Ahmad A. Ifseisi, Khadraa N. Alqahtani, Sendhil Kumar Natarajan, Subramania Angaiah, Dhanusuraman Ragupathy. Polyaniline-based nanocomposites for direct methanol fuel cells (DMFCs) - A Recent Review. Journal of Industrial and Engineering Chemistry. 2021; 97 ():79-94.

Chicago/Turabian Style

Suba Lakshmi Madaswamy; Asma A. Alothman; Murefah Mana Al-Anazy; Ahmad A. Ifseisi; Khadraa N. Alqahtani; Sendhil Kumar Natarajan; Subramania Angaiah; Dhanusuraman Ragupathy. 2021. "Polyaniline-based nanocomposites for direct methanol fuel cells (DMFCs) - A Recent Review." Journal of Industrial and Engineering Chemistry 97, no. : 79-94.

Journal article
Published: 19 January 2021 in Colloids and Surfaces B: Biointerfaces
Reads 0
Downloads 0

In this work, we report a novel preparation of selenium nanorods (Se) doped cobalt oxide (Co3O4) nanoflowers encapsulated with graphene oxide (GO) nanocomposite (NC). Se nanorods were successfully decorated on Co3O4 nanoflowers and an increase in electrical conductivity was observed in [email protected] The as-prepared [email protected] was utilized as an effective nanocomposite for the electrochemical detection of dimetridazole (DMZ) for the first time in the field of electrochemical sensors. [email protected] modified glassy carbon electrode (GCE) which showed an excellent cathodic current response (17.6 μA) at the lower potential at -0.7314 V upon DMZ sensing. With the various optimized conditions, [email protected] based electrochemical sensor displayed a lengthy linear range of 0.02–83.72 μM, limit of detection 3.4 nM and sensitivity of 1.898 μA.μM−1. cm−2 for DMZ detection. In addition, [email protected] revealed fabulous catalytic reduction activity for DMZ, when compared to GO and Se-Co3O4 modified GCE. Additionally, [email protected] is applied in real sample analysis of pigeon egg, milk and pigeon meat. The results illustrated that [email protected] can be a promising nanocomposite for the electrocatalytic reduction of DMZ in clinical samples in biomedical field.

ACS Style

N.M. Umesh; J. Antolin Jesila; Sea-Fue Wang; K.S. Shalini Devi; M. Govindasamy; Asma A. Alothman; Razan A. Alshgari. An enhanced electrochemical performance of in milk, pigeon meat and eggs samples using se nanorods capped with Co3O4 nanoflowers decorated on graphene oxide. Colloids and Surfaces B: Biointerfaces 2021, 200, 111577 .

AMA Style

N.M. Umesh, J. Antolin Jesila, Sea-Fue Wang, K.S. Shalini Devi, M. Govindasamy, Asma A. Alothman, Razan A. Alshgari. An enhanced electrochemical performance of in milk, pigeon meat and eggs samples using se nanorods capped with Co3O4 nanoflowers decorated on graphene oxide. Colloids and Surfaces B: Biointerfaces. 2021; 200 ():111577.

Chicago/Turabian Style

N.M. Umesh; J. Antolin Jesila; Sea-Fue Wang; K.S. Shalini Devi; M. Govindasamy; Asma A. Alothman; Razan A. Alshgari. 2021. "An enhanced electrochemical performance of in milk, pigeon meat and eggs samples using se nanorods capped with Co3O4 nanoflowers decorated on graphene oxide." Colloids and Surfaces B: Biointerfaces 200, no. : 111577.

Journal article
Published: 29 October 2020 in Materials
Reads 0
Downloads 0

A series of oligomeric (salen)Mn(III) complexes featuring tartrate linkers were prepared and immobilized over layered double hydroxide, and then used as catalysts for asymmetric epoxidation of unfunctionalized olefins. Comprehensive characterizations including 1H NMR, FT-IR, UV-Vis, elemental analysis, GPC, and ICP-AES were used to illustrate structures of oligomeric (salen)Mn(III) complexes, while powdered XRD, nitrogen physisorption, together with XPS studies provided further details to detect structures of heterogeneous catalysts. Interestingly, scanning electron microscopy found an interesting morphology change during modification of layered supporting material. Catalytic experiments indicated that configuration of major epoxide products was determined by salen chirality more than that of tartrate linker, but enantioselectivity (e.e. values) could be enhanced when tartrate and salen showed identical chiral configurations. Furthermore, the (R,R)-salen moieties linked with (R,R)-tartrate spacers usually offered higher enantioselectivity compared to other combinations. Lastly, Zn(II)/Al(III) layered double hydroxide played as a rigid supporting material in catalysis, showing positive chiral induction and high recycling potential in catalytic reactions.

ACS Style

Yihong Jia; Asma A. Alothman; Rui Liang; Xiaoyong Li; Weiyi Ouyang; Xiangdong Wang; Yong Wu; Sameh M. Osman; Zhaorui Li; Min Gao; Yang Sun. Oligomeric (Salen)Mn(III) Complexes Featuring Tartrate Linkers Immobilized over Layered Double Hydroxide for Catalytically Asymmetric Epoxidation of Unfunctionalized Olefins. Materials 2020, 13, 4860 .

AMA Style

Yihong Jia, Asma A. Alothman, Rui Liang, Xiaoyong Li, Weiyi Ouyang, Xiangdong Wang, Yong Wu, Sameh M. Osman, Zhaorui Li, Min Gao, Yang Sun. Oligomeric (Salen)Mn(III) Complexes Featuring Tartrate Linkers Immobilized over Layered Double Hydroxide for Catalytically Asymmetric Epoxidation of Unfunctionalized Olefins. Materials. 2020; 13 (21):4860.

Chicago/Turabian Style

Yihong Jia; Asma A. Alothman; Rui Liang; Xiaoyong Li; Weiyi Ouyang; Xiangdong Wang; Yong Wu; Sameh M. Osman; Zhaorui Li; Min Gao; Yang Sun. 2020. "Oligomeric (Salen)Mn(III) Complexes Featuring Tartrate Linkers Immobilized over Layered Double Hydroxide for Catalytically Asymmetric Epoxidation of Unfunctionalized Olefins." Materials 13, no. 21: 4860.

Journal article
Published: 12 October 2020 in Coatings
Reads 0
Downloads 0

Ethylenediamine modified ammonium polyphosphate (EDA-MAPP) and charring-foaming agents (CFA) were prepared using a simple chemical method and further used to make intumescent flame retardant coatings based on epoxy resin. The content of MAPP and CFA was fixed at a ratio of 2:1. Nanoparticles of magnesium aluminate (MgAl2O4 NPs) have been introduced into the flame retardant coating formulation in various quantities to evaluate the promotional action of MgAl2O4 NPs with a flame retardant coating system. The promotional action of MgAl2O4 NPs on the flame retardant coating formulation was studied using a vertical burning test (UL-94V), limiting oxygen index (LOI), thermogravimetric analysis (TGA) and Fourier transform infra-red spectroscopy (FTIR). The UL-94V results indicated that the addition of MgAl2O4 effectively increased flame retardancy and met the V-0 rating at each concentration. The TGA results revealed that the incorporation of MgAl2O4 NPs at each concentration effectively increased the thermal stability of the flame retardant coating system. Cone-calorimeter experiments show that MgAl2O4 NPs effectively decreased peak heat release rate (PHRR) and total heat release (THR). The FTIR results indicated that MgAl2O4 NPs can react with MAPP and generate a dense char layer that prevents the transfer of oxygen and heat.

ACS Style

Hatem Abuhimd; Tentu Nageswara Rao; Jung-Il Song; Prashanthi Yarasani; Faheem Ahmed; Botsa Parvatamma; Asma A. Alothman; Murefah Mana Al-Anazy; Ahmad A. Ifseisi. Influence of Magnesium Aluminate Nanoparticles on Epoxy-Based Intumescent Flame Retardation Coating System. Coatings 2020, 10, 968 .

AMA Style

Hatem Abuhimd, Tentu Nageswara Rao, Jung-Il Song, Prashanthi Yarasani, Faheem Ahmed, Botsa Parvatamma, Asma A. Alothman, Murefah Mana Al-Anazy, Ahmad A. Ifseisi. Influence of Magnesium Aluminate Nanoparticles on Epoxy-Based Intumescent Flame Retardation Coating System. Coatings. 2020; 10 (10):968.

Chicago/Turabian Style

Hatem Abuhimd; Tentu Nageswara Rao; Jung-Il Song; Prashanthi Yarasani; Faheem Ahmed; Botsa Parvatamma; Asma A. Alothman; Murefah Mana Al-Anazy; Ahmad A. Ifseisi. 2020. "Influence of Magnesium Aluminate Nanoparticles on Epoxy-Based Intumescent Flame Retardation Coating System." Coatings 10, no. 10: 968.

Research article
Published: 22 September 2020 in Journal of Sensors
Reads 0
Downloads 0

The harsh testing environments of underwater scenarios make it extremely hard to plan a reasonable routing protocol for Underwater Sensor Networks (UWSNs). The main challenge in UWSNs is energy confinement. It is needed to plan an energy effective scheme which increases the life span of the network and also reduces the energy usage in data transfer from supplier to sink. In this research, we present the design of a routing protocol known as Energy Harvesting in UWSN (EH-UWSN). EH-UWSN is a compact, energy efficient, and high throughput routing protocol, in which we present utilization of energy gaining with coordinating transfer of data packets through relay nodes. Through Energy Harvesting, the nodes are capable to recharge their batteries from the outside surrounding with the ultimate objective to improve the time span of network and proceed data through cooperation, along with restricting energy usage. At the sink node, the mixing plan applied is centered on Signal-to-Noise Ratio Combination (SNRC). Outcomes of EH-UWSN procedure reveal good results in terms of usage of energy, throughput, and network life span in comparing with our previous Cooperative Routing Scheme for UWSNs (Co-UWSN). Simulation results show that EH-UWSN has consumed considerably lesser energy when compared with Co-UWSN along with extending network lifetime and higher throughput at the destination.

ACS Style

Sheeraz Ahmed; Ahmed Ali; Asma A. Alothman; Asif Nawaz; M. Shahzad; Ahmed Ali Shah; Awais Ahmad; M. Yousaf Ali Khan; Zeeshan Najam; Asma Shaheen. EH-UWSN: Improved Cooperative Routing Scheme for UWSNs Using Energy Harvesting. Journal of Sensors 2020, 2020, 1 -18.

AMA Style

Sheeraz Ahmed, Ahmed Ali, Asma A. Alothman, Asif Nawaz, M. Shahzad, Ahmed Ali Shah, Awais Ahmad, M. Yousaf Ali Khan, Zeeshan Najam, Asma Shaheen. EH-UWSN: Improved Cooperative Routing Scheme for UWSNs Using Energy Harvesting. Journal of Sensors. 2020; 2020 ():1-18.

Chicago/Turabian Style

Sheeraz Ahmed; Ahmed Ali; Asma A. Alothman; Asif Nawaz; M. Shahzad; Ahmed Ali Shah; Awais Ahmad; M. Yousaf Ali Khan; Zeeshan Najam; Asma Shaheen. 2020. "EH-UWSN: Improved Cooperative Routing Scheme for UWSNs Using Energy Harvesting." Journal of Sensors 2020, no. : 1-18.

Journal article
Published: 21 September 2020 in Coatings
Reads 0
Downloads 0

The wettability of the metal/SiC system is not always excellent, resulting in the limitation of the widespread use of SiC ceramic. In this paper, three implantation doses of Si ions (5 × 1015, 1 × 1016, 5 × 1016 ions/cm2) were implanted into the 6H-SiC substrate. The wetting of Cu-(2.5, 5, 7.5, 10) Sn alloys on the pristine and Si-SiC were studied by the sessile drop technique, and the interfacial chemical reaction of Cu-Sn/SiC wetting couples was investigated and discussed. The Si ion can markedly enhance the wetting of Cu-Sn on 6H-SiC substrate, and those of the corresponding contact angles (θ) are raised partly, with the Si ion dose increasing due to the weakening interfacial chemical reactions among four Cu-Sn alloys and 6H-SiC ceramics. Moreover, the θ of Cu-Sn on (Si-)SiC substrate is first decreased and then increased from ~62° to ~39°, and ~70° and ~140°, with the Sn concentration increasing from 2.5%, 5% and 7.5% to 10%, which is linked to the reactivity of Cu-Sn alloys and SiC ceramic and the variation of liquid-vapor surface energy. Particularly, only a continuous graphite layer is formed at the interface of the Cu-10Sn/Si-SiC system, resulting in a higher contact angle (>40°).

ACS Style

Xiang Zhao Zhang; Pu Hao Xu; Gui Wu Liu; Awais Ahmad; Xiao Hui Chen; Ya Long Zhu; Asma Alothman; Shahid Hussain; Guan Jun Qiao. Synthesis, Characterization and Wettability of Cu-Sn Alloy on the Si-Implanted 6H-SiC. Coatings 2020, 10, 906 .

AMA Style

Xiang Zhao Zhang, Pu Hao Xu, Gui Wu Liu, Awais Ahmad, Xiao Hui Chen, Ya Long Zhu, Asma Alothman, Shahid Hussain, Guan Jun Qiao. Synthesis, Characterization and Wettability of Cu-Sn Alloy on the Si-Implanted 6H-SiC. Coatings. 2020; 10 (9):906.

Chicago/Turabian Style

Xiang Zhao Zhang; Pu Hao Xu; Gui Wu Liu; Awais Ahmad; Xiao Hui Chen; Ya Long Zhu; Asma Alothman; Shahid Hussain; Guan Jun Qiao. 2020. "Synthesis, Characterization and Wettability of Cu-Sn Alloy on the Si-Implanted 6H-SiC." Coatings 10, no. 9: 906.

Journal article
Published: 20 August 2020 in Asian Journal of Chemistry
Reads 0
Downloads 0

A series of Cu(II), Ni(II) and Co(II) azo chelates (AZC1-AZC3) of 7-((3-phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol have been designed and obtained. Thermal measurements, molar conductance, magnetic moment, elemental analyses, spectral (IR, UV-Vis, 1H and 13C NMR, ESR, mass) were used to characterize insulated solid complexes. The metal complexes were assumed to be non-electrolytic by molar conductance values. Thermal properties and decomposition kinetics of the metal chelates are investigated using Coats-Redfern method. The kinetic parameters like activation energy (E*), pre-exponential factor (A) and entropy of activation (ΔS*) were quantified. Results of spectral studies of mass and TGA data confirmed the octahedral geometry for all chelates. Finally, the synthesized metalcomplexes were tested for their in vitro antimicrobial efficacy.

ACS Style

Asma A. Alothman; Munirah D. Albaqami; Razan A. Alshgari. Spectral Characterization, Thermal and Antimicrobial Studies of Some Divalent Metal Chelates of 7-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol. Asian Journal of Chemistry 2020, 32, 2356 -2364.

AMA Style

Asma A. Alothman, Munirah D. Albaqami, Razan A. Alshgari. Spectral Characterization, Thermal and Antimicrobial Studies of Some Divalent Metal Chelates of 7-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol. Asian Journal of Chemistry. 2020; 32 (9):2356-2364.

Chicago/Turabian Style

Asma A. Alothman; Munirah D. Albaqami; Razan A. Alshgari. 2020. "Spectral Characterization, Thermal and Antimicrobial Studies of Some Divalent Metal Chelates of 7-((3-Phenyl-4,5-dihydroisoxazol-5-yl)methyl)quinolin-8-ol." Asian Journal of Chemistry 32, no. 9: 2356-2364.

Full paper
Published: 13 July 2020 in Applied Organometallic Chemistry
Reads 0
Downloads 0

Two new divalent copper (C1) and zinc (C2) chelates having the formulae [M(PIMC)2] (where M = Cu(II), Zn(II) and PIMC = Ligand [(E)‐3‐(((3‐hydroxypyridin‐2‐yl)imino)methyl)‐4H‐chromen‐4‐one] were obtained and characterized by several techniques. Structures and geometries of the synthesized complexes were judged based on the results of alternative analytical and spectral tools supporting the proposed formulae. IR spectral data confirmed the coordination of the ligands to the copper and zinc centers as monobasic tridentate in the enol form. Thermal analysis, UV‐Vis spectra and magnetic moment confirmed the geometry around the copper center to be tetrahedral, square pyramidal and octahedral. Study of the binding ability of the synthesized compounds with Circulating tumor DNA (CT‐DNA) bas been evaluated applying UV‐Vis spectral titration and viscosity measurements. The copper and zinc oxides were achieved from the copper and zinc nano‐particles structures Schiff base complexes as the raw material after calcination for 5 hr at 600°C. On the other hand, synthesized of C1 and C2 NPs were used as suitable precursors to the preparation of CuO and ZnO NPs. Finally, the synthesized of the two complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli ) and fungal strains (Candida albicans and Aspergillus fumigatus ) as compared to HPIMC. Among all these synthesized compounds, C1 exhibits good cleaving ability compared to other newly synthesized C2.

ACS Style

Asma A. Alothman; Munirah D. Albaqami. Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities. Applied Organometallic Chemistry 2020, 34, 1 .

AMA Style

Asma A. Alothman, Munirah D. Albaqami. Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities. Applied Organometallic Chemistry. 2020; 34 (10):1.

Chicago/Turabian Style

Asma A. Alothman; Munirah D. Albaqami. 2020. "Nano‐sized Cu(II) and Zn(II) complexes and their use as a precursor for synthesis of CuO and ZnO nanoparticles: A study on their sonochemical synthesis, characterization, and DNA‐binding/cleavage, anticancer, and antimicrobial activities." Applied Organometallic Chemistry 34, no. 10: 1.

Article
Published: 10 July 2020 in Journal of the Chinese Chemical Society
Reads 0
Downloads 0

In this study, Seven new complexes incorporating (E)‐2‐(((5‐([2‐hydroxyphenoxy]methyl)furan‐2‐yl)methylene)amino)phenol derived from 2‐hydroxyphenoxymethylfuran‐5‐carbaldehyde and 2‐aminophenol have been synthesized using Cu(II), Cr(III), Fe(III), Ni(II), Co(II), Zn(II), and Pt(IV) metal salts. Thermal measurements, molar conductance, magnetic moment, elemental analyses, spectral (IR, UV–Vis, 1H nuclear magnetic resonance (NMR), ESR, Mass), were used to characterize insulated solid complexes. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the complexes were carried out in the range of 30–900°C. Magnetic susceptibility and electronic spectral data, as well as quantum chemical calculations, reveal the square planar geometry for Ni (II) complex, square planar/octahedral geometry for Cu (II) complex, while Co(II), Zn(II), Cr(III), Fe(III), and Pt (IV) complexes are octahedral geometry. Density functional theory (DFT) studies revealed that geometries of metal complexes and Schiff base were entirely optimized in relation to use energy by 6–31 + g (d,p) basis set. The complexes show a well‐defined crystal system indicated by a powder‐X‐ray diffraction pattern. The scanning electron microscope showed complexes were nanocrystalline in nature, in addition to the interaction of the complexes with calf thymus CT‐DNA, which was investigated via the UV–visible absorption method. Therefore, the DNA cleavage activity by the H2L ligand and its metal complexes was performed. Finally, the synthesized complexes were tested for their in‐vitro antimicrobial efficacy.

ACS Style

Amal M. Al‐Mohaimeed; Eida S. Al‐Farraj; Wedad A. Al‐Onazi; Asma Alothman; Zainab M. Almarhoon. Synthesis, characterization, density functional theory, thermal, antimicrobial efficacy, and DNA binding/cleavage studies of Cu( II ), Cr( III ), Fe( III ), Ni( II ), Co( II ), Zn( II ), and Pt( IV ) complexes with a derivative of 2‐hydroxyphenoxymethylfuran‐5‐carbaldehyde. Journal of the Chinese Chemical Society 2020, 67, 2100 -2117.

AMA Style

Amal M. Al‐Mohaimeed, Eida S. Al‐Farraj, Wedad A. Al‐Onazi, Asma Alothman, Zainab M. Almarhoon. Synthesis, characterization, density functional theory, thermal, antimicrobial efficacy, and DNA binding/cleavage studies of Cu( II ), Cr( III ), Fe( III ), Ni( II ), Co( II ), Zn( II ), and Pt( IV ) complexes with a derivative of 2‐hydroxyphenoxymethylfuran‐5‐carbaldehyde. Journal of the Chinese Chemical Society. 2020; 67 (11):2100-2117.

Chicago/Turabian Style

Amal M. Al‐Mohaimeed; Eida S. Al‐Farraj; Wedad A. Al‐Onazi; Asma Alothman; Zainab M. Almarhoon. 2020. "Synthesis, characterization, density functional theory, thermal, antimicrobial efficacy, and DNA binding/cleavage studies of Cu( II ), Cr( III ), Fe( III ), Ni( II ), Co( II ), Zn( II ), and Pt( IV ) complexes with a derivative of 2‐hydroxyphenoxymethylfuran‐5‐carbaldehyde." Journal of the Chinese Chemical Society 67, no. 11: 2100-2117.

Full paper
Published: 06 July 2020 in Applied Organometallic Chemistry
Reads 0
Downloads 0

Although salens and imidazoles are well‐studied motifs among bioactive and therapeutic agents, their properties when combined in transition metal complexes are not well developed. To explore the structure/reactivity of this class of compounds, a salen‐based ligand, namely (2,2′‐{1,2‐ethanediylbis[nitrilo(E)methylylidene]}diphenol, S), and its binary (MS) and ternary (MSI) complexes (I = imidazole; M = Co (II), Ni (II), Cu (II), Cd (II), Al (III), and La (III)) have been synthesized and fully characterized by standard physicochemical and theoretical methods. Evidence from structural analysis tools along with DFT modeling revealed an unusual monobasic tridentate salen binding mode, involving the phenolic oxygen, the nitrogen of the azomethine group, and NH group formed via phenol‐to‐cyclohexadienone tautomerization, giving rise to a general molecular formula of MSI complexes as [M(S)(I)2(Cl)] for M (II) = Co, Ni, Cu and Cd or [M(S)(I)(Cl)2] for M (III) = Al and La, respectively. The antimicrobial activities of S, MS, and MSI were screened against several bacterial and fungal strains. Of all tested complexes, CdS and CuSI were the most effective antimicrobials, giving larger inhibition zones than the reference antibiotics. The antimicrobial efficacy for the MS complexes follows the order: CdS > gentamicin > CuS > NiS > CoS > LaS > AlS > S, whereas MSI complex, potencies are ordered as CuSI > gentamicin > CdSI >NiSI > CoSI > LaSI > AlSI > S. In vitro cytotoxicity screening of MSI complexes disclosed that both CuSI and CdSI exhibited higher activity against human liver (Hep‐G2) and breast (MDA‐MB231) carcinoma cell lines than the reference (cisplatin) drug. The satisfactory bioactivities observed for several of these compounds supports the underlying design idea for combining important bioactive motifs for possible therapeutic benefit.

ACS Style

Ehab Abdalla; Laila H. Abdel Rahman; Antar A. Abdelhamid; Mohamed Shehata; Asma A. Alothman; Ayman Nafady. Synthesis, Characterization, Theoretical Studies, and Antimicrobial/Antitumor Potencies of Salen and Salen/Imidazole Complexes of Co (II), Ni (II), Cu (II), Cd (II), Al (III) and La (III). Applied Organometallic Chemistry 2020, 34, 1 .

AMA Style

Ehab Abdalla, Laila H. Abdel Rahman, Antar A. Abdelhamid, Mohamed Shehata, Asma A. Alothman, Ayman Nafady. Synthesis, Characterization, Theoretical Studies, and Antimicrobial/Antitumor Potencies of Salen and Salen/Imidazole Complexes of Co (II), Ni (II), Cu (II), Cd (II), Al (III) and La (III). Applied Organometallic Chemistry. 2020; 34 (11):1.

Chicago/Turabian Style

Ehab Abdalla; Laila H. Abdel Rahman; Antar A. Abdelhamid; Mohamed Shehata; Asma A. Alothman; Ayman Nafady. 2020. "Synthesis, Characterization, Theoretical Studies, and Antimicrobial/Antitumor Potencies of Salen and Salen/Imidazole Complexes of Co (II), Ni (II), Cu (II), Cd (II), Al (III) and La (III)." Applied Organometallic Chemistry 34, no. 11: 1.

Full paper
Published: 08 June 2020 in Applied Organometallic Chemistry
Reads 0
Downloads 0

In the search of effective bioactive compounds, Co(II) (C1 ) and Cd(II) (C2 ) complexes of the type [M(FMAPIMP)(H2O)Cl].n H2O (where M = Co(II); n = 2, Cd(II); n = 3, and FMAPIMP = ligand[2‐((E)‐((2‐(((E)‐furan‐2‐ylmethylene)amino)phenyl)imino)methyl)phenol]) were synthesized and characterized using elemental analysis, UV–Vis., cyclic voltammetry, Fourier‐transform infrared (FT‐IR), nuclear magnetic resonance, and mass spectral studies. The thermal stability of nano‐sized Co(II) and Cd(II) complexes was studied using thermogravimetric analysis (TGA). Cobalt and cadmium oxides were synthesized using cobalt and cadmium nanoparticle (NP) structure Schiff base complexes as the raw material after calcination for 5 h at 600 °C. According to the results, Co(II) and Cd(II) complexes with mole ratio 1:1 of metal: H‐FMAPIMP which octahedral are the most probable geometry for it. On the contrary, synthesized C1 and C2 NPs were used as suitable precursors for the preparation of CoO and CdO NPs. The obtained NPs were characterized using FT‐IR, UV–Vis., TGA, powder X‐ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy techniques. PXRD analysis revealed that the obtained oxides were crystalline and corresponded to CoO and CdO phases. Crystal size, shape, and morphology were determined using SEM and TEM. H‐FMAPIMP and its two complexes (C1 and C2 ) were tested against human ovarian cancer cell line (PA‐1). The synthesized Co(II) and Cd(II) complexes exhibited enhanced activity against the tested bacterial (Staphylococcus aureus and Escherichia Coli ) and fungal strains (Candida albicans and Aspergillus fumigatus ) as compared to H‐FMAPIMP. The results of the DNA‐cleavage activity indicated that the ligand and its two complexes can cleave calf thymus‐DNA at different degrees. Further, antituberculosis activity was performed using microplate alamarBlue assay. Among all these synthesized compounds, C1 exhibited good cleaving ability compared to the newly synthesized C2 . Finally, the geometry of H‐FMAPIMP and its Co(II) and Cd(II) complexes was optimized using molecular modeling.

ACS Style

Asma A. Alothman; Reda A.A. Ammar. Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles. Applied Organometallic Chemistry 2020, 34, 1 .

AMA Style

Asma A. Alothman, Reda A.A. Ammar. Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles. Applied Organometallic Chemistry. 2020; 34 (10):1.

Chicago/Turabian Style

Asma A. Alothman; Reda A.A. Ammar. 2020. "Synthesis, characterization, DNA binding/cleavage, and anticancer and antimicrobial activities: Nano‐sized Co(II) and Cd(II) complexes and their use as a precursor for CoO and CdO nanoparticles." Applied Organometallic Chemistry 34, no. 10: 1.

Journal article
Published: 30 May 2020 in Crystals
Reads 0
Downloads 0

Various ZnO nanomaterials such as nanorods, nanoparticles, and nanosheets were synthesized using Salvadora persica leaf extract via the sol–gel method. The prepared nanomaterials possess a large number of nanocavities. The synthesized nanomaterials were characterized using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), UV-visible diffuse reflectance studies (UV-DRS), scanning electron microscopy (SEM), and high resolution transmission electron microscopy (HT-TEM), and these nanomaterials were used to test photocatalytic applications for the degradation of highly hazardous methylene blue dye. The degradation efficiency was higher for materials with nanorods and nanosheets with nanocavities; this was due to the presence of the nanocavities, which made the catalyst more sensitive to light absorption. This method offers a green synthesis of different nanomaterials in bulk quantity at low cost.

ACS Style

Fahad A. Alharthi; Abdulaziz Ali Alghamdi; Asma A. Alothman; Zainab M. Almarhoon; Munairah F. Alsulaiman; Nabil Al-Zaqri. Green Synthesis of ZnO Nanostructures Using Salvadora Persica Leaf Extract: Applications for Photocatalytic Degradation of Methylene Blue Dye. Crystals 2020, 10, 441 .

AMA Style

Fahad A. Alharthi, Abdulaziz Ali Alghamdi, Asma A. Alothman, Zainab M. Almarhoon, Munairah F. Alsulaiman, Nabil Al-Zaqri. Green Synthesis of ZnO Nanostructures Using Salvadora Persica Leaf Extract: Applications for Photocatalytic Degradation of Methylene Blue Dye. Crystals. 2020; 10 (6):441.

Chicago/Turabian Style

Fahad A. Alharthi; Abdulaziz Ali Alghamdi; Asma A. Alothman; Zainab M. Almarhoon; Munairah F. Alsulaiman; Nabil Al-Zaqri. 2020. "Green Synthesis of ZnO Nanostructures Using Salvadora Persica Leaf Extract: Applications for Photocatalytic Degradation of Methylene Blue Dye." Crystals 10, no. 6: 441.

Journal article
Published: 10 January 2020 in Journal of Molecular Structure
Reads 0
Downloads 0

The novel Schiff base ligand that is based on the condensation of 1-aminoquinolin-2(1H)-one and 2-hydroxybenzaldehyde and its metal complexes with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Hg(II) ions have been synthesized. Furthermore, the structure, electronic properties, and chemical reactivity of Schiff base and its metal complexes have been examined via Elemental analysis, Mass, (1H, 13C and 15N) NMR, FT-IR, CV, ESR spectra, Thermal analysis, and theoretically using the density functional theory. Initially, the ligand behaved as a neutral tridentate (NOO) ligand and all complexes displayed octahedral geometry, except Hg(II), which showed tetrahedral geometry. The values of molar conductance in DMSO suggested the non-electrolytic nature for all complexes. The coordinated and crystalline water molecules have been investigated by (TG/DTG) studies. The kinetic and thermodynamic parameters were computed using Horowitz–Metzger and Coats–Redfern methods. Moreover, the data obtained from XRD, SEM, TEM, EDX and AFM images unequivocally asserted the nano-sized metal chelates. In molecular modelling the geometries of Schiff base and its nano-sized Cu(II), Co(II) and Zn(II) hybrids were fully optimized with respect to the energy generated due to using the DFT method from DMOL3 calculations. The anticancer activity of the parent Schiff base and its nano-sized metal hybrids were screened, in addition to the interaction of the complexes with calf thymus CT–DNA, which was investigated via the UV–visible absorption method. Additionally, the mode of CT‒DNA binding to the HL ligand and its nano-sized hybrids has been explored. Therefore the DNA cleavage activity by the HL ligand and its nano-sized hybrids was performed allowing the measurement of the solid-state dc electrical conductivity of the HL ligand and its nano-sized Co(II), Cu(II) and Zn(II) hybrids over 303–423 K, which were then found to be of semiconducting nature.

ACS Style

Asma A. Alothman; Zainab M. Almarhoon. Nano-sized some transition metal complexes of Schiff base ligand based on 1-aminoquinolin-2(1H)-one. Journal of Molecular Structure 2020, 1206, 127704 .

AMA Style

Asma A. Alothman, Zainab M. Almarhoon. Nano-sized some transition metal complexes of Schiff base ligand based on 1-aminoquinolin-2(1H)-one. Journal of Molecular Structure. 2020; 1206 ():127704.

Chicago/Turabian Style

Asma A. Alothman; Zainab M. Almarhoon. 2020. "Nano-sized some transition metal complexes of Schiff base ligand based on 1-aminoquinolin-2(1H)-one." Journal of Molecular Structure 1206, no. : 127704.

Research article
Published: 01 July 2019 in Journal of Chemistry
Reads 0
Downloads 0

A new series of p-dimethylaminobenzaldehyde derivatives were tested for therapeutic potential by exploring their properties through characterization. The derivatives were synthesized by 1 : 1 condensation reaction of p-dimethylaminobenzaldehyde and substituted amines. The synthesized compounds 1–8 were characterized by different characterization techniques including IR, mass, 1H NMR, and 13C NMR spectroscopy, elemental analysis, and mass spectrometry. Furthermore, binding of these Schiff bases to Ct-DNA was examined by absorption spectroscopy, fluorescence quenching, circular dichroic, viscosity measurement, molecular docking, and molecular dynamics simulation methods. Schiff bases were tested for antimicrobial activity against bacterial species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus by the disc diffusion method. The pharmacological treatment of Schiff bases showed that 1–8 have promising potential against tested bacterial strains. The molecular docking study of the target compounds was also carried out against B-DNA dodecamer d(CGCGAATTCGCG)2, and it has been found that 1–8 can bind to Ct-DNA via an intercalative mode. DPPH free radical and hydrogen peroxide scavenging assays were employed to assess the antioxidant potential of synthesized Schiff bases.

ACS Style

Zainab M. Almarhoon; Wedad A. Al-Onazi; Asma A. Alothman; Amal M. Al-Mohaimeed; Eida S. Al-Farraj. Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases. Journal of Chemistry 2019, 2019, 1 -14.

AMA Style

Zainab M. Almarhoon, Wedad A. Al-Onazi, Asma A. Alothman, Amal M. Al-Mohaimeed, Eida S. Al-Farraj. Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases. Journal of Chemistry. 2019; 2019 ():1-14.

Chicago/Turabian Style

Zainab M. Almarhoon; Wedad A. Al-Onazi; Asma A. Alothman; Amal M. Al-Mohaimeed; Eida S. Al-Farraj. 2019. "Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases." Journal of Chemistry 2019, no. : 1-14.

Article
Published: 17 June 2019 in Journal of the Chinese Chemical Society
Reads 0
Downloads 0

A potentiometric method was used to determine the stability constants for the various complexes of copper(II) with carbamoylcholine chloride (C) drug as a ligand in the presence of some biorelevant amino acid constituents like glycine (Gly), alanine (Ala), valine (Val), proline (Pro), β‐phenylalanine (Phe), S‐methylcysteine (Met), threonine (Thr), ornithine (Orn), lysine (Lys), histidine (Hisd), histamine (Hist), and imidazole (Imz) as ligands (L). Stability constants of complexes were determined at 25°C and I = 0.10 mol/L NaNO3. The relative stability of each ternary complex was compared with that of the corresponding binary complexes in terms of Δlog K and % R.S. values. Cu(II) complexes of drug C were synthesized in 1:1 and 1:1:1 M ratios of copper to drug [Cu(C)(NO3)2] (1) and copper to drug to glycine[Cu(C)(Gly)(NO3)].NO3 (2), respectively. Glycine ternary complex with drug and copper [Cu(C)(Gly)(NO3)].NO3 was considered as representative amino acid. The complexes 1 and 2 were isolated and characterized using various physicochemical and spectral techniques. Both complexes 1 and 2 were found to have magnetic moments corresponding to one unpaired electron. The possible square planar and square‐pyramidal geometries of the copper (II) complexes were assigned on the basis of electron paramagnetic resonance (EPR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), X‐ray powder diffraction (XRPD), ultraviolet–visible (UV–Vis) and infrared (IR) spectral studies, and the discrete Fourier transform method from DMOL3 calculations. Antioxidant activities of all the synthesized compounds were also investigated.

ACS Style

Wedad A. Al-Onazi; Amal M. Al-Mohaimeed; Zainab M. Almarhoon; Eida S. Al-Farraj; Asma Alothman. Potentiometric, spectral characterization, and antioxidant activity studies of ternary complexes involving Cu(II) and carbamoylcholine chloride drug with amino acids. Journal of the Chinese Chemical Society 2019, 67, 125 -134.

AMA Style

Wedad A. Al-Onazi, Amal M. Al-Mohaimeed, Zainab M. Almarhoon, Eida S. Al-Farraj, Asma Alothman. Potentiometric, spectral characterization, and antioxidant activity studies of ternary complexes involving Cu(II) and carbamoylcholine chloride drug with amino acids. Journal of the Chinese Chemical Society. 2019; 67 (1):125-134.

Chicago/Turabian Style

Wedad A. Al-Onazi; Amal M. Al-Mohaimeed; Zainab M. Almarhoon; Eida S. Al-Farraj; Asma Alothman. 2019. "Potentiometric, spectral characterization, and antioxidant activity studies of ternary complexes involving Cu(II) and carbamoylcholine chloride drug with amino acids." Journal of the Chinese Chemical Society 67, no. 1: 125-134.

Journal article
Published: 11 June 2019 in Bioorganic Chemistry
Reads 0
Downloads 0

A potent Nonsterodial Anti-inflammatory Drug (NSAID) candidates has been conceived and built by an assembly of a hydrophilic, fluorescent and COX-2 inhibiting units in the same molecule. The isatinimino-acridinedione core (TM-7) was achieved in a simple three step synthetic procedure viz (i) a multicomponent reaction between dimedone, aldehyde and amine to furnish the nitroacridinedione (4), (ii) reduction step and (iii) schiff’s-base condensation with isatin. The excellent anti-inflammatory pharmacological efficiency of the drug was established by in vivo biological experiments. Accordingly, it was found that the treatment with the synthesized isatinimino analogues (dosage: 30 mg/kg) inhibited protein expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and nuclear factor kappa B (NF-κB) as well as production of prostaglandin E2 (PGE2), nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin-6 (IL-6) levels induced by carrageenan. Further, a comparative molecular modeling analysis of TM-7 carried out with the crystal structure of aspirin acetylated human COX-2 suggested effectively binding and efficient accommodation inside the active site’s gorge.

ACS Style

Govindasami Periyasami; Paulrayer Antonisamy; Karthikeyan Perumal; Antony Stalin; Mostafizur Rahaman; Asma Alothman. A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling. Bioorganic Chemistry 2019, 90, 103047 .

AMA Style

Govindasami Periyasami, Paulrayer Antonisamy, Karthikeyan Perumal, Antony Stalin, Mostafizur Rahaman, Asma Alothman. A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling. Bioorganic Chemistry. 2019; 90 ():103047.

Chicago/Turabian Style

Govindasami Periyasami; Paulrayer Antonisamy; Karthikeyan Perumal; Antony Stalin; Mostafizur Rahaman; Asma Alothman. 2019. "A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling." Bioorganic Chemistry 90, no. : 103047.

Journal article
Published: 16 May 2019 in Journal of Molecular Structure
Reads 0
Downloads 0

A novel series of nano-sized Co(II), Ni(II), Cu(II) and Zn(II) hybrids has been synthesized using the template method, i.e. by the in situ reaction of oxazin–Schiff's base [(E)-3-(2-(4-(diethylamino)-2-mercaptobenzylidene)hydrazineyl)-2H-benzo[b][1,4]oxazin-2-one] (HL) derived from 4-(diethylamino)-2-mercaptobenzaldehyde with 3-hydrazineyl-2H-benzo[b][1,4]oxazin-2-one in the presence of Co(II), Ni(II), Cu(II), Zn(II) chloride in ethanol. The structures and geometry of the optained compounds have been described by using the different analytical and spectroscopic tools such as elemental analysis, UV-VIS, IR, MS, 1H NMR, ESR, CV, TGA, XRD, SEM, AFM, magnetic and molar conductivity measurements. IR spectral studies confirmed the coordination of the ligand to the metal ions through the thiol sulfur, azomethine nitrogen and carbonyl oxygen. The Schiff's base ligand acts as monobasic tridentate OSN donor. The geometrical structures have been found to be octahedral and tetrahedral. The molar conductance measurements of the nano-sized hybrids in DMF and DMSO correspond to be nonelectrolytic nature for all nano-sized metal (II) hybrids. The elemental analyses confirm 1 M: 2 L stoichiometry of the type [ML2] (M= Co(II), Ni(II), Cu(II) and Zn(II)). Electrochemical behaviour of nano-sized metal (II) hybrids were determined by cyclic voltammetry. Degradation pattern of the ligand HL and its nano-sized hybrids is shown by thermal studies. The activation of thermodynamic parameters are calculated using Coast-Redfern (CR) and Horowitz-Metzger (HM) methods. The data obtained from XRD, SEM, TEM and AFM images unequivocally asserted the nano-sized metal chelates. The percentage antioxidant activities are also more for complexes than the ligand. The investigated ligand and metal complexes were screened for their in-vitro antimicrobial activities against different types of fungal and bacterial strains. The resulting data assert on the inspected compounds as a highly promising bactericides and fungicides. The antitumor activities of all synthesized compounds were evaluated towards human liver Carcinoma (HepG2) cell line. DNA-binding, DNA cleavage and fluorescence properties of nano-sized hybrids with this ligand are reported.

ACS Style

Eida S. Al-Farraj; Zainab M. Almarhoon; Asma Alothman; Amal M. Al-Mohaimeed; Wedad A. Al-Onazi. Synthesis, spectroscopic characterization and biological studies of nano-sized Co(II), Ni(II), Cu(II) and Zn(II) Schiff's base hybrids. Journal of Molecular Structure 2019, 1195, 17 -31.

AMA Style

Eida S. Al-Farraj, Zainab M. Almarhoon, Asma Alothman, Amal M. Al-Mohaimeed, Wedad A. Al-Onazi. Synthesis, spectroscopic characterization and biological studies of nano-sized Co(II), Ni(II), Cu(II) and Zn(II) Schiff's base hybrids. Journal of Molecular Structure. 2019; 1195 ():17-31.

Chicago/Turabian Style

Eida S. Al-Farraj; Zainab M. Almarhoon; Asma Alothman; Amal M. Al-Mohaimeed; Wedad A. Al-Onazi. 2019. "Synthesis, spectroscopic characterization and biological studies of nano-sized Co(II), Ni(II), Cu(II) and Zn(II) Schiff's base hybrids." Journal of Molecular Structure 1195, no. : 17-31.

Research article
Published: 22 April 2019 in Journal of Chemistry
Reads 0
Downloads 0

Potentiometric titration method has been used to define stoichiometries and stability constants of ternary complexes of Cu(II) with duloxetine (D) and some selected amino acids (L). The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) with the ligands were calculated from the potentiometric data using the HYPERQUAD program. The formation constants of the complexes formed in aqueous solutions and their concentration distributions as a function of pH were evaluated at 25°C and ionic strength 0.10 mol·L−1 NaNO3. Respective stabilities of ternary complexes have been determined compared with the corresponding binary complexes in terms of Δlog K and %R.S. values. A novel binary and ternary duloxetine (D) drug with glycine and its Cu(II) complexes has been synthesized and characterized by several spectroscopic methods. Electronic spectra and magnetic susceptibility measurements reveal square planar geometry for both complexes. The elemental analyses and mass spectral data have justified the [Cu(D)(Gly)] and [Cu(D)Cl(H2O)] composition of complexes, where D = duloxetine and Gly = glycine. The EPR spectra of Cu(II) complexes support the mononuclear structures. Thermal properties and decomposition kinetics of Cu(II) complexes are investigated.

ACS Style

Amal M. Al-Mohaimeed; Asma A. Alothman. Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids. Journal of Chemistry 2019, 2019, 1 -13.

AMA Style

Amal M. Al-Mohaimeed, Asma A. Alothman. Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids. Journal of Chemistry. 2019; 2019 ():1-13.

Chicago/Turabian Style

Amal M. Al-Mohaimeed; Asma A. Alothman. 2019. "Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids." Journal of Chemistry 2019, no. : 1-13.