In the field of disease diagnosis where only a small dataset of medical images may be accessible, the light-weight convolutional neural network (CNN) has become popular because it can help to avoid the over-fitting problem and improve computational efficiency. However, the feature extraction capability of the light-weight CNN is inferior to that of the heavy-weight counterpart. Although the attention mechanism provides a feasible solution to this problem, the existing attention modules, such as the squeeze and excitation module and the convolutional block attention module, have insufficient non-linearity, thereby influencing the ability of the light-weight CNN to discover the key features. To address this issue, we have proposed a spiking cortical model based global and local (SCM-GL) attention module. The SCM-GL module analyzes the input feature maps in parallel and decomposes each map into several components according to the relation between pixels and their neighbors. The components are weighted summed to obtain a local mask. Besides, a global mask is produced by discovering the correlation between the distant pixels in the feature map. The final attention mask is generated by combining the local and global masks, and it is multiplied by the original map so that the important components can be highlighted to facilitate accurate disease diagnosis. To appreciate the performance of the SCM-GL module, this module and some mainstream attention modules have been embedded into the popular light-weight CNN models for comparison. Experiments on the classification of brain MR, chest X-ray, and osteosarcoma image datasets demonstrate that the SCM-GL module can significantly improve the classification performance of the evaluated light-weight CNN models by enhancing the ability of discovering the suspected lesions and it is generally superior to state-of-the-art attention modules in terms of accuracy, recall, specificity and F1 score.

This Letter presents a guided filtering (GF)-based nonlocal means (NLM) method for despeckling of optical coherence tomography (OCT) images. Unlike existing NLM methods that determine weights using image intensities or features, the proposed method first uses the GF to capture both grayscale information and features of the input image and then introduces them into the NLM for accurate weight computation. The boosting and iterative strategies are further incorporated to ensure despeckling performance. Experiments on the real OCT images demonstrate that our method outperforms the compared methods by delivering sufficient noise reduction and preserving image details well.

In many medical image classification tasks, there is insufficient image data for deep convolutional neural networks (CNNs) to overcome the over-fitting problem. The light-weighted CNNs are easy to train but they usually have relatively poor classification performance. To improve the classification ability of light-weighted CNN models, we have proposed a novel batch similarity-based triplet loss to guide the CNNs to learn the weights. The proposed loss utilizes the similarity among multiple samples in the input batches to evaluate the distribution of training data. Reducing the proposed loss can increase the similarity among images of the same category and reduce the similarity among images of different categories. Besides this, it can be easily assembled into regular CNNs. To appreciate the performance of the proposed loss, some experiments have been done on chest X-ray images and skin rash images to compare it with several losses based on such popular light-weighted CNN models as EfficientNet, MobileNet, ShuffleNet and PeleeNet. The results demonstrate the applicability and effectiveness of our method in terms of classification accuracy, sensitivity and specificity.

Optical coherence tomography (OCT) has found wide application to the diagnosis of ophthalmic diseases, but the quality of OCT images is degraded by speckle noise. The convolutional neural network (CNN) based methods have attracted much attention in OCT image despeckling. However, these methods generally need noisy-clean image pairs for training and they are difficult to capture the global context information effectively. To address these issues, we have proposed a novel unsupervised despeckling method. This method uses the cross-scale CNN to extract the local features and uses the intra-patch and inter-patch based transformer to extract and merge the local and global feature information. Based on these extracted features, a reconstruction network is used to produce the final denoised result. The proposed network is trained using a hybrid unsupervised loss function, which is defined by the loss produced from Nerighbor2Neighbor, the structural similarity between the despeckled results of the probabilistic non-local means method and our method as well as the mean squared error between their features extracted by the VGG network. Experiments on two clinical OCT image datasets show that our method performs better than several popular despeckling algorithms in terms of visual evaluation and quantitative indexes.

In the proposed network, the features were first extracted from the gonioscopically obtained anterior segment photographs using the densely-connected high-resolution network. Then the useful information is further strengthened using the hybrid attention module to improve the classification accuracy. Between October 30, 2020, and January 30, 2021, a total of 146 participants underwent glaucoma screening. One thousand seven hundred eighty original images of the ACA were obtained with the gonioscope and slit lamp microscope. After data augmentation, 4457 images are used for the training and validation of the HahrNet, and 497 images are used to evaluate our algorithm. Experimental results demonstrate that the proposed HahrNet exhibits a good performance of 96.2% accuracy, 99.0% specificity, 96.4% sensitivity, and 0.996 area under the curve (AUC) in classifying the ACA test dataset. Compared with several deep learning-based classification methods and nine human readers of different levels, the HahrNet achieves better or more competitive performance in terms of accuracy, specificity, and sensitivity. Indeed, the proposed ACA classification method will provide an automatic and accurate technology for the grading of glaucoma.