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Shamim Ahmad Khan
Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania

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Journal article
Published: 21 September 2020 in Healthcare
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Clostridioides difficile (CD) is responsible for nosocomial diarrhea syndrome with possible severe progression. Recurrence of the disease induces higher health system costs, as well as exposes patients to additional health risks. Patients with recurrence of this disease are difficult to identify, so the purpose of this study is to quantify various demographic, clinical, and treatment factors that could prevent further progression to recurrence of the disease. In the period 2018–2019, about 195 patients were diagnosed with more than one episode of CDI in the three months following the first episode. The recurrence rate for CDI was 53.84% (60.95% for one episode and 39.05% for multiple episodes). Most commonly afflicted were 60–69-year-old patients, or those with higher Charlson Comorbidity Index (CCI). Multiple analyses associated cardiovascular (odds ratios (OR) = 3.02, 95% confidence intervals (CI) = 1.23–7.39, p = 0.015), digestive (OR = 3.58, 95% CI = 1.01–12.63, p = 0.047), dementia (OR = 3.26, 95% CI = 1.26–8.41, p = 0.014), immunosuppressive (OR = 3.88, 95% CI = 1.34–11.21, p = 0.012) comorbidities with recurrences. Risk factor identification in the first episode of CDI could lead to the implementation of treatment strategies to improve the patients’ quality of life affected by this disease.

ACS Style

Nicoleta Negrut; Simona Bungau; Tapan Behl; Shamim Khan; Cosmin Vesa; Cristiana Bustea; Delia Nistor-Cseppento; Marius Rus; Flavia-Maria Pavel; Delia Tit. Risk Factors Associated with Recurrent Clostridioides difficile Infection. Healthcare 2020, 8, 352 .

AMA Style

Nicoleta Negrut, Simona Bungau, Tapan Behl, Shamim Khan, Cosmin Vesa, Cristiana Bustea, Delia Nistor-Cseppento, Marius Rus, Flavia-Maria Pavel, Delia Tit. Risk Factors Associated with Recurrent Clostridioides difficile Infection. Healthcare. 2020; 8 (3):352.

Chicago/Turabian Style

Nicoleta Negrut; Simona Bungau; Tapan Behl; Shamim Khan; Cosmin Vesa; Cristiana Bustea; Delia Nistor-Cseppento; Marius Rus; Flavia-Maria Pavel; Delia Tit. 2020. "Risk Factors Associated with Recurrent Clostridioides difficile Infection." Healthcare 8, no. 3: 352.

Journal article
Published: 29 May 2020 in Sustainability
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Clostridium difficile infection (CDI) is the most common infectious disease related to antibiotic-associated diarrhoea and is a current leading cause of morbidity/mortality, with substantial consequences for healthcare services and overall public health. Thus, we performed a retrospective epidemiological study of CDI for a long period (8 years), in an infectious hospital located in north-western Romania, which serves an entire county of the country (617,827 inhabitants). From 2011 to 2018, 877 patients were diagnosed with CDI; the mean incidence of this disease was 2.76 cases/10,000 patient-days, with an increasing trend in the annual incidence until 2016, at which point there was a decrease. The most commonly afflicted were patients in the 75–84 age group, observed in winter and spring. The results show that the antibiotics were administered in 679 (77.42%) subjects, within the last 3 months before CDI, statistically significant more than proton-pump inhibitors (PPIs)—128 (14.60%) and antidepressant medications—60 (6.84%), which were administered during the same period (p < 0.001). No medication was reported in 10 (6.84%) cases of CDI, in the last 3 months of the study. The fatality rate attained 4.1%, tripling in 2018 vs. 2011. CDI became a significant public health conundrum that can, nevertheless, be combatted through a judicious use of antibiotics.

ACS Style

Nicoleta Negrut; Delia Carmen Nistor-Cseppento; Shamim Ahmad Khan; Carmen Pantis; Teodor Andrei Maghiar; Octavian Maghiar; Selim Aleya; Marius Rus; Delia Mirela Tit; Lotfi Aleya; Abbas Rahdar; Simona Bungau. Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study. Sustainability 2020, 12, 4439 .

AMA Style

Nicoleta Negrut, Delia Carmen Nistor-Cseppento, Shamim Ahmad Khan, Carmen Pantis, Teodor Andrei Maghiar, Octavian Maghiar, Selim Aleya, Marius Rus, Delia Mirela Tit, Lotfi Aleya, Abbas Rahdar, Simona Bungau. Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study. Sustainability. 2020; 12 (11):4439.

Chicago/Turabian Style

Nicoleta Negrut; Delia Carmen Nistor-Cseppento; Shamim Ahmad Khan; Carmen Pantis; Teodor Andrei Maghiar; Octavian Maghiar; Selim Aleya; Marius Rus; Delia Mirela Tit; Lotfi Aleya; Abbas Rahdar; Simona Bungau. 2020. "Clostridium difficile Infection Epidemiology over a Period of 8 Years—A Single Centre Study." Sustainability 12, no. 11: 4439.