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The main causes of death in patients with chronic kidney disease (CKD) are of cardiovascular nature. The interaction between traditional cardiovascular risk factors (CVRF) and non-traditional risk factors (RF) triggers various complex pathophysiological mechanisms that will lead to accelerated atherosclerosis in the context of decreased renal function. In terms of mortality, CKD should be considered equivalent to ischemic coronary artery disease (CAD) and properly monitored. Vascular calcification, endothelial dysfunction, oxidative stress, anemia, and inflammatory syndrome represents the main uremic RF triggered by accumulation of the uremic toxins in CKD subjects. Proteinuria that appears due to kidney function decline may initiate an inflammatory status and alteration of the coagulation—fibrinolysis systems, favorizing acute coronary syndromes (ACS) occurrence. All these factors represent potential targets for future therapy that may improve CKD patient’s survival and prevention of CV events. Once installed, the CAD in CKD population is associated with negative outcome and increased mortality rate, that is the reason why discovering the complex pathophysiological connections between the two conditions and a proper control of the uremic RF are crucial and may represent the solutions for influencing the prognostic. Exclusion of CKD subjects from the important trials dealing with ACS and improper use of the therapeutical options because of the declined kidney functioned are issues that need to be surpassed. New ongoing trials with CKD subjects and platelets reactivity studies offers new perspectives for a better clinical approach and the expected results will clarify many aspects.
Mădălina Ioana Moisi; Simona Gabriela Bungau; Cosmin Mihai Vesa; Camelia Cristina Diaconu; Tapan Behl; Manuela Stoicescu; Mirela Mărioara Toma; Cristiana Bustea; Cristian Sava; Mircea Ioachim Popescu. Framing Cause-Effect Relationship of Acute Coronary Syndrome in Patients with Chronic Kidney Disease. Diagnostics 2021, 11, 1518 .
AMA StyleMădălina Ioana Moisi, Simona Gabriela Bungau, Cosmin Mihai Vesa, Camelia Cristina Diaconu, Tapan Behl, Manuela Stoicescu, Mirela Mărioara Toma, Cristiana Bustea, Cristian Sava, Mircea Ioachim Popescu. Framing Cause-Effect Relationship of Acute Coronary Syndrome in Patients with Chronic Kidney Disease. Diagnostics. 2021; 11 (8):1518.
Chicago/Turabian StyleMădălina Ioana Moisi; Simona Gabriela Bungau; Cosmin Mihai Vesa; Camelia Cristina Diaconu; Tapan Behl; Manuela Stoicescu; Mirela Mărioara Toma; Cristiana Bustea; Cristian Sava; Mircea Ioachim Popescu. 2021. "Framing Cause-Effect Relationship of Acute Coronary Syndrome in Patients with Chronic Kidney Disease." Diagnostics 11, no. 8: 1518.
Membranes are associated with the efficient processes of separation, concentration and purification, but a very important aspect of them is the realization of a reaction process simultaneously with the separation process. From a practical point of view, chemical reactions have been introduced in most membrane systems: with on-liquid membranes, with inorganic membranes or with polymeric and/or composite membranes. This paper presents the obtaining of polymeric membranes containing metallic osmium obtained in situ. Cellulose acetate (CA), polysulfone (PSf) and polypropylene hollow fiber membranes (PPM) were used as support polymer membranes. The metallic osmium is obtained directly onto the considered membranes using a solution of osmium tetroxide (OsO4), dissolved in tert–butyl alcohol (t–Bu–OH) by reduction with molecular hydrogen. The composite osmium–polymer (Os–P)-obtained membranes were characterized in terms of the morphological and structural points of view: scanning electron microscopy (SEM), high-resolution SEM (HR–SEM), energy-dispersive spectroscopy analysis (EDAX), Fourier Transform Infra-Red (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The process performance was tested for reduction of 5–nitrobenzimidazole to 5–aminobenzimidazole with molecular hydrogen. The paper presents the main aspects of the possible mechanism of transformation of 5–nitrobenzimidazole to 5–aminobenzimidazole with hydrogen gas in the reaction system with osmium–polymer membrane (Os–P).
Aurelia Cristina Nechifor; Alexandru Goran; Vlad-Alexandru Grosu; Andreia Pîrțac; Paul Constantin Albu; Ovidiu Oprea; Alexandra Raluca Grosu; Dumitru Pașcu; Florentina Mihaela Păncescu; Gheorghe Nechifor; Szidonia-Katalin Tanczos; Simona Gabriela Bungău. Reactional Processes on Osmium–Polymeric Membranes for 5–Nitrobenzimidazole Reduction. Membranes 2021, 11, 633 .
AMA StyleAurelia Cristina Nechifor, Alexandru Goran, Vlad-Alexandru Grosu, Andreia Pîrțac, Paul Constantin Albu, Ovidiu Oprea, Alexandra Raluca Grosu, Dumitru Pașcu, Florentina Mihaela Păncescu, Gheorghe Nechifor, Szidonia-Katalin Tanczos, Simona Gabriela Bungău. Reactional Processes on Osmium–Polymeric Membranes for 5–Nitrobenzimidazole Reduction. Membranes. 2021; 11 (8):633.
Chicago/Turabian StyleAurelia Cristina Nechifor; Alexandru Goran; Vlad-Alexandru Grosu; Andreia Pîrțac; Paul Constantin Albu; Ovidiu Oprea; Alexandra Raluca Grosu; Dumitru Pașcu; Florentina Mihaela Păncescu; Gheorghe Nechifor; Szidonia-Katalin Tanczos; Simona Gabriela Bungău. 2021. "Reactional Processes on Osmium–Polymeric Membranes for 5–Nitrobenzimidazole Reduction." Membranes 11, no. 8: 633.
Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.
Tanima Bhattacharya; Soumam Dutta; Rokeya Akter; Habibur Rahman; Chenmala Karthika; Hechanur Puttappa Nagaswarupa; Hanabe Chowdappa Ananda Murthy; Ovidiu Fratila; Roxana Brata; Simona Bungau. Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer. Biomolecules 2021, 11, 1176 .
AMA StyleTanima Bhattacharya, Soumam Dutta, Rokeya Akter, Habibur Rahman, Chenmala Karthika, Hechanur Puttappa Nagaswarupa, Hanabe Chowdappa Ananda Murthy, Ovidiu Fratila, Roxana Brata, Simona Bungau. Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer. Biomolecules. 2021; 11 (8):1176.
Chicago/Turabian StyleTanima Bhattacharya; Soumam Dutta; Rokeya Akter; Habibur Rahman; Chenmala Karthika; Hechanur Puttappa Nagaswarupa; Hanabe Chowdappa Ananda Murthy; Ovidiu Fratila; Roxana Brata; Simona Bungau. 2021. "Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer." Biomolecules 11, no. 8: 1176.
The management of the side effects caused by the antiretroviral therapy is one of the main problems facing clinicians. The patient’s tolerability and safety influence the success of the therapy. This retrospective study assesses the tolerability and impact on metabolic profiles of antiretroviral regimens containing darunavir/ritonavir (DRV/r) versus those containing darunavir/cobicistat (DRV/c), in routine clinical practice. The database of Prof. Dr Matei Bals of the National Institute of Infectious Diseases (INBI MB) was studied for the period 2017–2020, allowing the inclusion in the study of 462 HIV-infected patients who received the current regimen at least three months before evaluation. The following parameters were collected and analyzed: significant medical history, associated diseases, serum levels for profile evaluation: carbohydrate, lipidic, serum level of liver and pancreatic enzymes, serum markers of cardiac function, coagulation, and renal function. DRV/c (800 mg/150 mg, once daily) administrated in combination with other antiretroviral (ARV) in HIV-1 infected subjects proved to be better tolerated and with a lower impact on metabolic profile than DRV/r (600 mg/100 mg, twice daily). Patients in DRV/r group are significantly more at risk of developing, over time, side effects and metabolic impairments than those in DRV/c group, in all body functions studied, with statistically significant differences (p< 0.05) between the two groups. Laboratory data were correlated with patient’s demographic and clinical characteristics and statistically significant outcomes have been found, proving that a personalized regimen is needed to minimize the ART side effects and to maximize the success of therapy. The results of the study showed that DRV/c, associated with other antiretroviral drugs in the regimens of Romanian HIV infected subjects, have a more favorable metabolic profile than those containing DRV/r.
Ruxandra-Cristina Marin; Delia Mirela Tiț; Oana Săndulescu; Adrian Streinu-Cercel; Simona Gabriela Bungău. Comparison of Tolerability and Impact on Metabolic Profiles of Antiretroviral Regimens Containing Darunavir/Ritonavir or Darunavir/Cobicistat in Romanian HIV Infected Patients. Biomedicines 2021, 9, 987 .
AMA StyleRuxandra-Cristina Marin, Delia Mirela Tiț, Oana Săndulescu, Adrian Streinu-Cercel, Simona Gabriela Bungău. Comparison of Tolerability and Impact on Metabolic Profiles of Antiretroviral Regimens Containing Darunavir/Ritonavir or Darunavir/Cobicistat in Romanian HIV Infected Patients. Biomedicines. 2021; 9 (8):987.
Chicago/Turabian StyleRuxandra-Cristina Marin; Delia Mirela Tiț; Oana Săndulescu; Adrian Streinu-Cercel; Simona Gabriela Bungău. 2021. "Comparison of Tolerability and Impact on Metabolic Profiles of Antiretroviral Regimens Containing Darunavir/Ritonavir or Darunavir/Cobicistat in Romanian HIV Infected Patients." Biomedicines 9, no. 8: 987.
The natural polymer chitosan is the second most abundant biopolymer on earth after chitin and has been extensively explored for preparation of versatile drug delivery systems. The presence of two distinct reactive functional groups (an amino group at C2, and a primary and secondary hydroxyl group at C3 and C6) of chitosan are involved in the transformation of expedient derivatives such as acylated, alkylated, carboxylated, quaternized and esterified chitosan. Amongst these, quaternized chitosan is preferred in pharmaceutical industries owing to its prominent features including superior water solubility, augmented antimicrobial actions, modified wound healing, pH-sensitive targeting, biocompatibility, and biodegradability. It has been explored in a large realm of pharmaceuticals, cosmeceuticals, and the biomedical arena. Immense classy drug delivery systems containing quaternized chitosan have been intended for tissue engineering, wound healing, gene, and vaccine delivery. This review article outlines synthetic techniques, basic characteristics, inherent properties, biomedical applications, and ubiquitous challenges associated to quaternized chitosan.
Kamla Pathak; Shashi Misra; Aayush Sehgal; Sukhbir Singh; Simona Bungau; Agnieszka Najda; Robert Gruszecki; Tapan Behl. Biomedical Applications of Quaternized Chitosan. Polymers 2021, 13, 2514 .
AMA StyleKamla Pathak, Shashi Misra, Aayush Sehgal, Sukhbir Singh, Simona Bungau, Agnieszka Najda, Robert Gruszecki, Tapan Behl. Biomedical Applications of Quaternized Chitosan. Polymers. 2021; 13 (15):2514.
Chicago/Turabian StyleKamla Pathak; Shashi Misra; Aayush Sehgal; Sukhbir Singh; Simona Bungau; Agnieszka Najda; Robert Gruszecki; Tapan Behl. 2021. "Biomedical Applications of Quaternized Chitosan." Polymers 13, no. 15: 2514.
In the early differential diagnosis of endometrial cancer (EC), decisive and mandatory histological aspects are considered, in addition to obvious clinical manifestations. In addition, sonographic aspects are characteristic in relation to the stage, degree, and histological types of identified cancer. This bi-center retrospective observational study included 594 women with abnormal uterine bleeding outside pregnancy, for which a biopsy was performed in the Obstetrics and Gynecology Departments of the Emergency County Hospitals of Arad and Timis Counties, Romania, between 2015 and 2019. Most of the cases were represented by EC or endometrial hyperplasia (EH). Of the 594 cases, 25.5% (n = 153) were EC at women aged between 41 and 85 years. High International Endometrial Tumor Analysis (IETA) scores (3, 4) were associated with a relative risk of 2.9335 compared with other endometrial lesions (95% CI 2.3046 to 3.734, p< 0.0001, NNT 1.805). Histological aspects and pelvic ultrasound using IETA scores represent valuable noninvasive assets in diagnosing and differentiating endometrial cancer from benign uterine pathology.
Alexandru Furau; Mirela Toma; Cringu Ionescu; Cristian Furau; Simona Bungau; Mihai Dimitriu; Delia Tit; Gheorghe Furau; Izabella Petre; Marius Craina. The Correlation of the IETA Ultrasound Score with the Histopathology Results for Women with Abnormal Bleeding in Western Romania. Diagnostics 2021, 11, 1342 .
AMA StyleAlexandru Furau, Mirela Toma, Cringu Ionescu, Cristian Furau, Simona Bungau, Mihai Dimitriu, Delia Tit, Gheorghe Furau, Izabella Petre, Marius Craina. The Correlation of the IETA Ultrasound Score with the Histopathology Results for Women with Abnormal Bleeding in Western Romania. Diagnostics. 2021; 11 (8):1342.
Chicago/Turabian StyleAlexandru Furau; Mirela Toma; Cringu Ionescu; Cristian Furau; Simona Bungau; Mihai Dimitriu; Delia Tit; Gheorghe Furau; Izabella Petre; Marius Craina. 2021. "The Correlation of the IETA Ultrasound Score with the Histopathology Results for Women with Abnormal Bleeding in Western Romania." Diagnostics 11, no. 8: 1342.
Botulism is a rare, acute, life-threatening neuro-paralysis. The digestive onset may raise diagnostic issues. The objective of our study was to analyze the clinical and epidemiological data of patients diagnosed with botulism and hospitalized in “Gavril Curteanu” Municipal Clinical Hospital (Oradea, Romania). Detection of the Clostridium botulinum neurotoxin (type B) in the laboratories of the National Institute of Medical-Military Research Development “Cantacuzino”, Bucharest, Romania (using the mouse bioassays method) confirmed the diagnostics. The statistical analysis was performed using the IBM SPSS software. Forty-eight patients with the diagnosis of foodborne botulism were hospitalized between 2012 and 2018 (36.92% of the total number of cases of botulism reported in Romania). The winter-spring period was the period when most cases were registered (36 patients, p=0.020). Women from rural areas were predominant (but not statistically significant), and the patients’ mean age was 39.93±12.59 years. The most common source/cause of botulism was the consumption of homemade ham. The incubation period was 26.68±22.94 h, and 2.25±1.68 days passed from the clinical onset to diagnosis. The results prove that botulism is still a public health issue, especially in areas where homemade products are prepared using inappropriate/unsafe recipes/procedures.
Nicoleta Negrut; Lotfi Aleya; Tapan Behl; Camelia C. Diaconu; Mihai A. Munteanu; Emilia E. Babes; Mirela M. Toma; Simona Bungau. Epidemiology of botulism in the north-western Romania—a 7-year survey. Environmental Science and Pollution Research 2021, 1 -7.
AMA StyleNicoleta Negrut, Lotfi Aleya, Tapan Behl, Camelia C. Diaconu, Mihai A. Munteanu, Emilia E. Babes, Mirela M. Toma, Simona Bungau. Epidemiology of botulism in the north-western Romania—a 7-year survey. Environmental Science and Pollution Research. 2021; ():1-7.
Chicago/Turabian StyleNicoleta Negrut; Lotfi Aleya; Tapan Behl; Camelia C. Diaconu; Mihai A. Munteanu; Emilia E. Babes; Mirela M. Toma; Simona Bungau. 2021. "Epidemiology of botulism in the north-western Romania—a 7-year survey." Environmental Science and Pollution Research , no. : 1-7.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. They are potentially malignant, and have an unpredictable evolution. The origin of these tumors is in the interstitial cells of Cajal, which are cells that are interposed between the intramural neurons and the smooth muscle cells of the digestive tract. GISTs are characterized by mutations in the gene c-Kit, but also other mutations, such as those of the platelet-derived growth factor receptor alpha. The most common locations of these tumors are the stomach and small intestine, although they can occur at any level of the digestive tract and occasionally in the omentum, mesentery and peritoneum. Most cases of GISTs are sporadic, and about 5% of cases are part of family genetic syndromes. The correct diagnosis of GIST is determined by histopathological examination and immunohistochemistry. According to histopathology, there are three main types of GISTs: spindle cell type, epithelioid type and mixed type. The therapeutic management of GIST includes surgery, endoscopic treatment and chemotherapy. The prognosis of patients with GIST varies depending on a number of factors, such as risk category, GIST stage, treatment applied and recurrence after treatment.
Gina Gheorghe; Nicolae Bacalbasa; Gabriela Ceobanu; Madalina Ilie; Valentin Enache; Gabriel Constantinescu; Simona Bungau; Camelia Diaconu. Gastrointestinal Stromal Tumors—A Mini Review. Journal of Personalized Medicine 2021, 11, 694 .
AMA StyleGina Gheorghe, Nicolae Bacalbasa, Gabriela Ceobanu, Madalina Ilie, Valentin Enache, Gabriel Constantinescu, Simona Bungau, Camelia Diaconu. Gastrointestinal Stromal Tumors—A Mini Review. Journal of Personalized Medicine. 2021; 11 (8):694.
Chicago/Turabian StyleGina Gheorghe; Nicolae Bacalbasa; Gabriela Ceobanu; Madalina Ilie; Valentin Enache; Gabriel Constantinescu; Simona Bungau; Camelia Diaconu. 2021. "Gastrointestinal Stromal Tumors—A Mini Review." Journal of Personalized Medicine 11, no. 8: 694.
Chemical composition, antioxidant capacity, and antimicrobial activity of lavender essential oils (LEOs) extracted from three different varieties of Lavandula angustifolia Mill. (1-Moldoveanca 4, 2-Vis magic 10, and 3-Alba 7) have been determined. These plants previously patented in the Republic of Moldova were cultivated in an organic agriculture system in the northeastern part of Romania and then harvested in 3 consecutive years (2017–2019) to obtain the essential oils. From the inflorescences in the complete flowering stage, the LEOs were extracted by hydrodistillation. Then, their composition was analyzed by gas chromatography coupled with mass spectrometry (GC-MS) and by Fourier Transformed Infrared spectroscopy (FT-IR). The major identified constituents are as follows: linalool (1: 32.19–46.83%; 2: 29.93–30.97%; 3: 31.97–33.77%), linalyl acetate (1: 17.70–35.18%; 2: 27.55–37.13%; 3: 28.03–35.32%), and terpinen-4-ol (1: 3.63–7.70%; 2: 3.06–7.16%; 3: 3.10–6.53%). The antioxidant capacity as determined by ABTS and DPPH assays indicates inhibition, with the highest activity obtained for LEO var. Alba 7 from 2019. The in vitro antimicrobial activities of the LEOs and combinations were investigated as well, by using the disk diffusion method and minimum inhibitory concentration (MIC) against the Gram-positive bacterial strain Staphylococcus aureus (ATCC 6538), Gram-negative Pseudomonas aeruginosa (ATCC 27858), Escherichia coli (ATCC 25922), the yeast Candida albicans (ATCC 10231), and clinical isolates. Our results have shown that LEOs obtained from the three studied varieties of L. angustifolia manifest significant bactericidal effects against tested microorganisms (Staphylococcus aureus and Escherichia coli), and antifungal effects against Candida albicans. The mixture of LEOs (Var. Alba 7) and geranium, respectively, in tea tree EOs, in different ratios, showed a significant enhancement of the antibacterial effect against all the studied strains, except Pseudomonas aeruginosa.
Mihaela Bogdan; Simona Bungau; Delia Tit; Dana Zaha; Aurelia Nechifor; Tapan Behl; Dorina Chambre; Andreea Lupitu; Lucian Copolovici; Dana Copolovici. Chemical Profile, Antioxidant Capacity, and Antimicrobial Activity of Essential Oils Extracted from Three Different Varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of Lavandula angustifolia. Molecules 2021, 26, 4381 .
AMA StyleMihaela Bogdan, Simona Bungau, Delia Tit, Dana Zaha, Aurelia Nechifor, Tapan Behl, Dorina Chambre, Andreea Lupitu, Lucian Copolovici, Dana Copolovici. Chemical Profile, Antioxidant Capacity, and Antimicrobial Activity of Essential Oils Extracted from Three Different Varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of Lavandula angustifolia. Molecules. 2021; 26 (14):4381.
Chicago/Turabian StyleMihaela Bogdan; Simona Bungau; Delia Tit; Dana Zaha; Aurelia Nechifor; Tapan Behl; Dorina Chambre; Andreea Lupitu; Lucian Copolovici; Dana Copolovici. 2021. "Chemical Profile, Antioxidant Capacity, and Antimicrobial Activity of Essential Oils Extracted from Three Different Varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of Lavandula angustifolia." Molecules 26, no. 14: 4381.
Persian walnut (Juglans regia L., Juglandaceae), one of the essential nut crops, is affected by different diseases, including mite attacks which result in gall and erineum formation. As the proportion of leaf area covered by mite galls or erineum is typically relatively low, the impact on tree photosynthetic productivity is often considered minor, and no pest control management is usually suggested. However, the effect of erineum-forming mites on walnut photosynthesis might be disproportionately larger than can be predicted from the leaf area impacted. In the present study, we studied how the foliage photosynthetic characteristics, pigment contents, and stress-induced volatile organic compounds scaled with the severity of infection varied from 0% (control trees) to 9.9%, by erineum-forming mite Aceria erinea in J. regia. Both leaf net assimilation rate (up to 75% reduction) and stomatal conductance (up to 82%) decreased disproportionately, increasing infection severity. Leaf total chlorophyll and β-carotene contents also decreased with infection severity, although the reduction was less than for photosynthetic characteristics (28% for chlorophyll and 25% for β-carotene). The infection induced significant emissions of green leaves volatiles ((Z)-3-hexenol, (E)-2-hexenal, (Z)-3-hexenyl acetate and 1-hexanol), monoterpenes and the homoterpene 3-(E)-4,8-dimethyl-1,3,7-nonatriene, and these emissions scaled positively with the percentage of leaf area infected. These results collectively indicate that erineum-forming mite infection of walnut leaves results in profound modifications in foliage physiological characteristics that can significantly impact tree photosynthetic productivity.
Corina Popitanu; Andreea Lupitu; Lucian Copolovici; Simona Bungău; Ülo Niinemets; Dana Copolovici. Induced Volatile Emissions, Photosynthetic Characteristics, and Pigment Content in Juglans regia Leaves Infected with the Erineum-Forming Mite Aceria erinea. Forests 2021, 12, 920 .
AMA StyleCorina Popitanu, Andreea Lupitu, Lucian Copolovici, Simona Bungău, Ülo Niinemets, Dana Copolovici. Induced Volatile Emissions, Photosynthetic Characteristics, and Pigment Content in Juglans regia Leaves Infected with the Erineum-Forming Mite Aceria erinea. Forests. 2021; 12 (7):920.
Chicago/Turabian StyleCorina Popitanu; Andreea Lupitu; Lucian Copolovici; Simona Bungău; Ülo Niinemets; Dana Copolovici. 2021. "Induced Volatile Emissions, Photosynthetic Characteristics, and Pigment Content in Juglans regia Leaves Infected with the Erineum-Forming Mite Aceria erinea." Forests 12, no. 7: 920.
The human body is highly complex and comprises a variety of living cells and extracellular material, which forms tissues, organs, and organ systems. Human cells tend to turn over readily to maintain homeostasis in tissues. However, postmitotic nerve cells exceptionally have an ability to regenerate and be sustained for the entire life of an individual, to safeguard the physiological functioning of the central nervous system. For efficient functioning of the CNS, neuronal death is essential, but extreme loss of neurons diminishes the functioning of the nervous system and leads to the onset of neurodegenerative diseases. Neurodegenerative diseases range from acute to chronic severe life-altering conditions like Parkinson’s disease and Alzheimer’s disease. Millions of individuals worldwide are suffering from neurodegenerative disorders with little or negligible treatment available, thereby leading to a decline in their quality of life. Neuropathological studies have identified a series of factors that explain the etiology of neuronal degradation and its progression in neurodegenerative disease. The onset of neurological diseases depends on a combination of factors that causes a disruption of neurons, such as environmental, biological, physiological, and genetic factors. The current review highlights some of the major pathological factors responsible for neuronal degradation, such as oxidative stress, cell death, and neuroinflammation. All these factors have been described in detail to enhance the understanding of their mechanisms and target them for disease management.
Tapan Behl; Rashita Makkar; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Gokhan Zengin; Simona Bungau; Felicia Andronie-Cioara; Mihai Munteanu; Mihaela Brisc; Diana Uivarosan; Ciprian Brisc. Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation. International Journal of Molecular Sciences 2021, 22, 7432 .
AMA StyleTapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Andronie-Cioara, Mihai Munteanu, Mihaela Brisc, Diana Uivarosan, Ciprian Brisc. Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation. International Journal of Molecular Sciences. 2021; 22 (14):7432.
Chicago/Turabian StyleTapan Behl; Rashita Makkar; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Gokhan Zengin; Simona Bungau; Felicia Andronie-Cioara; Mihai Munteanu; Mihaela Brisc; Diana Uivarosan; Ciprian Brisc. 2021. "Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation." International Journal of Molecular Sciences 22, no. 14: 7432.
Tarapati Rana; Tapan Behl; Aayush Sehgal; Vineet Mehta; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Simona Bungau. Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders. Molecular Neurobiology 2021, 1 -20.
AMA StyleTarapati Rana, Tapan Behl, Aayush Sehgal, Vineet Mehta, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Simona Bungau. Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders. Molecular Neurobiology. 2021; ():1-20.
Chicago/Turabian StyleTarapati Rana; Tapan Behl; Aayush Sehgal; Vineet Mehta; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Simona Bungau. 2021. "Exploring the Role of Autophagy Dysfunction in Neurodegenerative Disorders." Molecular Neurobiology , no. : 1-20.
Progressive degeneration of neurons and aggravation of dopaminergic neurons in the substantia nigra pars compacta results in the loss of dopamine in the brain of Parkinson’s disease (PD) patients. Numerous therapies, exhibiting transient efficacy have been developed; however, they are mostly accompanied by side effects and limited reliability, therefore instigating the need to develop novel optimistic treatment targets. Significant therapeutic targets have been identified, namely: chaperones, protein Abelson, glucocerebrosidase-1, calcium, neuromelanin, ubiquitin-proteasome system, neuroinflammation, mitochondrial dysfunction, and the kynurenine pathway (KP). The role of KP and its metabolites and enzymes in PD, namely quinolinic acid (QUIN), kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranillic acid (3-HAA), kunurenine-3-monooxygenase (KMO), etc. has been reported. The neurotoxic QUIN, N-methyl-D-aspartate (NMDA) receptor agonist, and neuroprotective KYNA—which antagonizes QUIN actions—primarily justify the Janus-faced role of KP in PD. Moreover, KP has been reported to play a biomarker role in PD detection. Therefore, the authors detail the neurotoxic, neuroprotective, and immunomodulatory neuroactive components, alongside the upstream and downstream metabolic pathways of KP, forming a basis for a therapeutic paradigm of the disease while recognizing KP as a potential biomarker in PD, thus facilitating the development of a suitable target in PD management.
Tapan Behl; Ishnoor Kaur; Aayush Sehgal; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Gokhan Zengin; Adrian Bumbu; Felicia Andronie-Cioara; Aurelia Nechifor; Daniela Gitea; Alexa Bungau; Mirela Toma; Simona Bungau. The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications. International Journal of Molecular Sciences 2021, 22, 6737 .
AMA StyleTapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Gokhan Zengin, Adrian Bumbu, Felicia Andronie-Cioara, Aurelia Nechifor, Daniela Gitea, Alexa Bungau, Mirela Toma, Simona Bungau. The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications. International Journal of Molecular Sciences. 2021; 22 (13):6737.
Chicago/Turabian StyleTapan Behl; Ishnoor Kaur; Aayush Sehgal; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Gokhan Zengin; Adrian Bumbu; Felicia Andronie-Cioara; Aurelia Nechifor; Daniela Gitea; Alexa Bungau; Mirela Toma; Simona Bungau. 2021. "The Footprint of Kynurenine Pathway in Neurodegeneration: Janus-Faced Role in Parkinson’s Disorder and Therapeutic Implications." International Journal of Molecular Sciences 22, no. 13: 6737.
Raluca A. Corb Aron; Delia M. Tit; Anamaria L. Purza; Areha Abid; Cosmin M. Vesa; Gabriela Angelescu; Simona Bungau. Effects of probiotic supplementation on metabolic syndrome components in type 2 diabetes mellitus patients – a case-control study. Archives of the Balkan Medical Union 2021, 56, 201 -212.
AMA StyleRaluca A. Corb Aron, Delia M. Tit, Anamaria L. Purza, Areha Abid, Cosmin M. Vesa, Gabriela Angelescu, Simona Bungau. Effects of probiotic supplementation on metabolic syndrome components in type 2 diabetes mellitus patients – a case-control study. Archives of the Balkan Medical Union. 2021; 56 (2):201-212.
Chicago/Turabian StyleRaluca A. Corb Aron; Delia M. Tit; Anamaria L. Purza; Areha Abid; Cosmin M. Vesa; Gabriela Angelescu; Simona Bungau. 2021. "Effects of probiotic supplementation on metabolic syndrome components in type 2 diabetes mellitus patients – a case-control study." Archives of the Balkan Medical Union 56, no. 2: 201-212.
Despite not being utilized as considerably as other antidepressants in the therapy of depression, the monoamine oxidase inhibitors (MAOIs) proceed to hold a place in neurodegeneration and to have a somewhat broad spectrum in respect of the treatment of neurological and psychiatric conditions. Preclinical and clinical studies on MAOIs have been developing in recent times, especially on account of rousing discoveries manifesting that these drugs possess neuroprotective activities. The altered brain levels of monoamine neurotransmitters due to monoamine oxidase (MAO) are directly associated with various neuropsychiatric conditions like Alzheimer’s disease (AD). Activated MAO induces the amyloid-beta (Aβ) deposition via abnormal cleavage of the amyloid precursor protein (APP). Additionally, activated MAO contributes to the generation of neurofibrillary tangles and cognitive impairment due to neuronal loss. No matter the attention of researchers on the participation of MAOIs in neuroprotection has been on monoamine oxidase-B (MAO-B) inhibitors, there is a developing frame of proof indicating that monoamine oxidase-A (MAO-A) inhibitors may also play a role in neuroprotection. The therapeutic potential of MAOIs alongside the complete understanding of the enzyme’s physiology may lead to the future advancement of these drugs.
Tapan Behl; Dapinder Kaur; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Gokhan Zengin; Felicia Andronie-Cioara; Mirela Toma; Simona Bungau; Adrian Bumbu. Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors. Molecules 2021, 26, 3724 .
AMA StyleTapan Behl, Dapinder Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Felicia Andronie-Cioara, Mirela Toma, Simona Bungau, Adrian Bumbu. Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors. Molecules. 2021; 26 (12):3724.
Chicago/Turabian StyleTapan Behl; Dapinder Kaur; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Gokhan Zengin; Felicia Andronie-Cioara; Mirela Toma; Simona Bungau; Adrian Bumbu. 2021. "Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors." Molecules 26, no. 12: 3724.
Two different conditions are included in inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), being distinguished by chronic recurrence of gut inflammation in persons that are genetically predisposed and subjected to environmental causative factors. The normal structure of the gut microbiome and its alterations in IBD were defined in several microbial studies. An important factor in the prolonged inflammatory process in IBD is the impaired microbiome or “dysbiosis”. Thus, gut microbiome management is likely to be an objective in IBD treatment. In this review, we analyzed the existing data regarding the pathophysiological/therapeutic implications of intestinal microflora in the development and evolution of IBD. Furthermore, the main effects generated by the administration of probiotics, prebiotics, fecal transplantation, and phytochemicals supplementation were analyzed regarding their potential roles in improving the clinical and biochemical status of patients suffering from Crohn’s disease (CD) and ulcerative colitis (UC), and are depicted in the sections/subsections of the present paper. Data from the literature give evidence in support of probiotic and prebiotic therapy, showing effects such as improving remission rate, improving macroscopic and microscopic aspects of IBD, reducing the pro-inflammatory cytokines and interleukins, and improving the disease activity index. Therefore, the additional benefits of these therapies should not be ignored as adjuvants to medical therapy.
Flavia Pavel; Cosmin Vesa; Gina Gheorghe; Camelia Diaconu; Manuela Stoicescu; Mihai Munteanu; Elena Babes; Delia Tit; Mirela Toma; Simona Bungau. Highlighting the Relevance of Gut Microbiota Manipulation in Inflammatory Bowel Disease. Diagnostics 2021, 11, 1090 .
AMA StyleFlavia Pavel, Cosmin Vesa, Gina Gheorghe, Camelia Diaconu, Manuela Stoicescu, Mihai Munteanu, Elena Babes, Delia Tit, Mirela Toma, Simona Bungau. Highlighting the Relevance of Gut Microbiota Manipulation in Inflammatory Bowel Disease. Diagnostics. 2021; 11 (6):1090.
Chicago/Turabian StyleFlavia Pavel; Cosmin Vesa; Gina Gheorghe; Camelia Diaconu; Manuela Stoicescu; Mihai Munteanu; Elena Babes; Delia Tit; Mirela Toma; Simona Bungau. 2021. "Highlighting the Relevance of Gut Microbiota Manipulation in Inflammatory Bowel Disease." Diagnostics 11, no. 6: 1090.
With advanced technology and its development, bioinformatics is one of the avant-garde fields that has managed to make amazing progress in the pharmaceutical–medical field by modeling the infrastructural dimensions of healthcare and integrating computing tools in drug innovation, facilitating prevention, detection/more accurate diagnosis, and treatment of disorders, while saving time and money. By association, bioinformatics and pharmacovigilance promoted both sample analyzes and interpretation of drug side effects, also focusing on drug discovery and development (DDD), in which systems biology, a personalized approach, and drug repositioning were considered together with translational medicine. The role of bioinformatics has been highlighted in DDD, proteomics, genetics, modeling, miRNA discovery and assessment, and clinical genome sequencing. The authors have collated significant data from the most known online databases and publishers, also narrowing the diversified applications, in order to target four major areas (tetrad): DDD, anti-microbial research, genomic sequencing, and miRNA research and its significance in the management of current pandemic context. Our analysis aims to provide optimal data in the field by stratification of the information related to the published data in key sectors and to capture the attention of researchers interested in bioinformatics, a field that has succeeded in advancing the healthcare paradigm by introducing developing techniques and multiple database platforms, addressed in the manuscript.
Tapan Behl; Ishnoor Kaur; Aayush Sehgal; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Gokhan Zengin; Elena Babes; Ciprian Brisc; Manuela Stoicescu; Mirela Toma; Cristian Sava; Simona Bungau. Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry. International Journal of Molecular Sciences 2021, 22, 6184 .
AMA StyleTapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Gokhan Zengin, Elena Babes, Ciprian Brisc, Manuela Stoicescu, Mirela Toma, Cristian Sava, Simona Bungau. Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry. International Journal of Molecular Sciences. 2021; 22 (12):6184.
Chicago/Turabian StyleTapan Behl; Ishnoor Kaur; Aayush Sehgal; Sukhbir Singh; Saurabh Bhatia; Ahmed Al-Harrasi; Gokhan Zengin; Elena Babes; Ciprian Brisc; Manuela Stoicescu; Mirela Toma; Cristian Sava; Simona Bungau. 2021. "Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry." International Journal of Molecular Sciences 22, no. 12: 6184.
The separation, concentration and transport of the amino acids through membranes have been continuously developed due to the multitude of interest amino acids of interest and the sources from which they must be recovered. At the same time, the types of membranes used in the sepa-ration of the amino acids are the most diverse: liquids, ion exchangers, inorganic, polymeric or composites. This paper addresses the recuperative separation of three amino acids (alanine, phe-nylalanine, and methionine) using membranes from cellulosic derivatives in polypropylene ma-trix. The microfiltration membranes (polypropylene hollow fibers) were impregnated with solu-tions of some cellulosic derivatives: cellulose acetate, 2-hydroxyethyl-cellulose, methyl 2-hydroxyethyl-celluloseand sodium carboxymethyl-cellulose. The obtained membranes were characterized in terms of the separation performance of the amino acids considered (retention, flux, and selectivity) and from a morphological and structural point of view: scanning electron microscopy (SEM), high resolution SEM (HR-SEM), Fourier transform infrared spectroscopy (FT-IR), energy dispersive spectroscopy (EDS) and thermal gravimetric analyzer (TGA). The re-sults obtained show that phenylalanine has the highest fluxes through all four types of mem-branes, followed by methionine and alanine. Of the four kinds of membrane, the most suitable for recuperative separation of the considered amino acids are those based on cellulose acetate and methyl 2-hydroxyethyl-cellulose.
Aurelia Nechifor; Andreia Pîrțac; Paul Albu; Alexandra Grosu; Florina Dumitru; Ioana Dimulescu (Nica); Ovidiu Oprea; Dumitru Pașcu; Gheorghe Nechifor; Simona Bungău. Recuperative Amino Acids Separation through Cellulose Derivative Membranes with Microporous Polypropylene Fiber Matrix. Membranes 2021, 11, 429 .
AMA StyleAurelia Nechifor, Andreia Pîrțac, Paul Albu, Alexandra Grosu, Florina Dumitru, Ioana Dimulescu (Nica), Ovidiu Oprea, Dumitru Pașcu, Gheorghe Nechifor, Simona Bungău. Recuperative Amino Acids Separation through Cellulose Derivative Membranes with Microporous Polypropylene Fiber Matrix. Membranes. 2021; 11 (6):429.
Chicago/Turabian StyleAurelia Nechifor; Andreia Pîrțac; Paul Albu; Alexandra Grosu; Florina Dumitru; Ioana Dimulescu (Nica); Ovidiu Oprea; Dumitru Pașcu; Gheorghe Nechifor; Simona Bungău. 2021. "Recuperative Amino Acids Separation through Cellulose Derivative Membranes with Microporous Polypropylene Fiber Matrix." Membranes 11, no. 6: 429.
The metabolic disorders are the edge points for the initiation of various diseases. These disorders comprised of several diseases including diabetes, obesity, and cardiovascular complications. Worldwide, the prevalence of these disorders is increasing day by day. The world’s population is at higher threat of developing metabolic disease, especially diabetes. Therefore, there is an impregnable necessity of searching for a newer therapeutic target to reduce the burden of these disorders. Diabetes mellitus (DM) is marked with the dysregulated insulin secretion and resistance. The lipid and glucose transporters portray a pivotal role in the metabolism and transport of both of these. The excess production of lipid and glucose and decreased clearance of these leads to the emergence of DM. The ATP-binding cassette transporters (ABCT) are important for the metabolism of glucose and lipid. Various studies suggest the key involvement of ABCT in the pathologic process of different diseases. In addition, the involvement of other pathways, including IGF signaling, P13-Akt/PKC/MAPK signaling, and GLP-1 via regulation of ABCT, may help develop new treatment strategies to cope with insulin resistance dysregulated glucose metabolism, key features in DM.
Tapan Behl; Aayush Sehgal; Madhuri Grover; Sukhbir Singh; Neelam Sharma; Saurabh Bhatia; Ahmed Al-Harrasi; Lotfi Aleya; Simona Bungau. Uncurtaining the pivotal role of ABC transporters in diabetes mellitus. Environmental Science and Pollution Research 2021, 28, 41533 -41551.
AMA StyleTapan Behl, Aayush Sehgal, Madhuri Grover, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Lotfi Aleya, Simona Bungau. Uncurtaining the pivotal role of ABC transporters in diabetes mellitus. Environmental Science and Pollution Research. 2021; 28 (31):41533-41551.
Chicago/Turabian StyleTapan Behl; Aayush Sehgal; Madhuri Grover; Sukhbir Singh; Neelam Sharma; Saurabh Bhatia; Ahmed Al-Harrasi; Lotfi Aleya; Simona Bungau. 2021. "Uncurtaining the pivotal role of ABC transporters in diabetes mellitus." Environmental Science and Pollution Research 28, no. 31: 41533-41551.
The mitochondria, apart from being known as the cell’s “powerhouse,” are crucial in the viability of nerve cells. Any damage to these cellular organelles can result in their cellular level dysfunction which includes rapidly multiplying reactive oxygen species (ROS) from the mitochondrial membrane, impaired calcium ion homeostasis, and disturbed mitochondrial dynamics by the formation of permeability transition pore in mitochondria. All these impaired biochemical changes lead to various neurological disorders such as progressive supranuclear palsy (PSP), Parkinson’s disease (PD), and Alzheimer’s disease (AD). Moreover, impaired mitochondrial functions are particularly prone to damage owing to prolonged lifespan and stretched length of the neurons. At the same time, neurons are highly dependent on ATP, and thus, the mitochondria play a central role in the pathogenesis pertaining to neuronal disorders. Dysfunction in the mitochondria is an early pathological hallmark of neurological disorders, and its early detection with the help of suitable biomarkers can lead to promising treatment in this area. Thus, the drugs which are targeting mitochondrial dysfunctions are the emerging area of research in connection with neurological disorders. This can be evidenced by the great opportunities for mitigation, diagnosis, and treatment of numerous human disorders that entail mitochondrial dysfunction at the nexus of their pathogenesis. Here, we throw light at the mitochondrial pathologies and indications of dysfunctional mitochondria in PD, AD, and PSP. There is also an insight into the possible therapeutic strategies highlighting the need for mitochondria-based medicine and made an attempt for claiming the prerequisite for the therapy of neurological diseases.
Arpita Arora; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Bijo Mathew; Simona Bungau. Targeting cellular batteries for the therapy of neurological diseases. Environmental Science and Pollution Research 2021, 28, 41517 -41532.
AMA StyleArpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Bijo Mathew, Simona Bungau. Targeting cellular batteries for the therapy of neurological diseases. Environmental Science and Pollution Research. 2021; 28 (31):41517-41532.
Chicago/Turabian StyleArpita Arora; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Bijo Mathew; Simona Bungau. 2021. "Targeting cellular batteries for the therapy of neurological diseases." Environmental Science and Pollution Research 28, no. 31: 41517-41532.