Background: Strain gauge analysis and finite element (FE) simulations were used to estimate the bone strain and micromovement at the bone–implant interface (BII) for platform switching and different diameters of a single, immediately loaded mandibular implant.Methods: Four models were created, including 5‐mm‐diameter implants assembled with abutments that were 5 or 4 mm in diameter on bonded (delay‐loading treatment) and contact (immediate‐loading treatment) BIIs; a model with an implant diameter of 3.75 mm was also analyzed. Vertical and lateral loads of 130 N were applied to all models.Results: During lateral loading, the strains were highly concentrated on one side of the mandible in the experimental and validation FE models. Bone strains were reduced by <10% when platform switching was used compared to no platform switching. However, increasing implant diameter decreased the surrounding bone strain significantly. The sliding and gap distances at the BII did not differ significantly among all models considered.Conclusions: Bone strain was reduced more by increasing the diameter of the implant than by using platform switching in the immediately loaded implant. However, neither a wide implant nor platform switching reduced micromotion at the BII for enhancing implant stability.

Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus and reduce halitosis. The aim of this study was to evaluate the antimicrobial activity of 3 different dental root canal sealers with hinokitiol (sealers+H) and their physical and biological effects. AH Plus (epoxy amine resin-based, AH), Apexit Plus (calcium-hydroxide-based, AP), and Canals (zinc-oxide-eugenol-based, CA), were used in this study. The original AH and CA exhibited strong anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity, but AP did not. The setting time, working time, flowability, film thickness, and solubility of each sealer+0.2%H complied with ISO 6876:2001. CA+0.2%H exhibited high cytotoxicity, but the others sealers+0.2%H did not. Because hinokitiol combined with Zn²⁺ in CA creates a synergistic effect. The physical tests of AP+0.5%–1%H complied with ISO 6876:2001, improved antimicrobial activity, inhibited inflammation genes cyclooxygenase-2 (COX-2) and hypoxia-inducible factor-1α (HIF-1α) mRNA in MG-63 cells and human gingival fibroblasts (HGF), and down-regulated lysyl oxidase (LOX) mRNA of HGF. In summary, AH and CA demonstrated strong antimicrobial activity, but AP did not. Application of hinokitiol increases AH anti-MRSA activity should less than 0.2% for keep well flowability. AP+0.5%–1% hinokitiol exhibited strong physical, antibacterial, and anti-inflammation potentials, and inhibited S. aureus abscess formation. Applying an appreciable proportion of hinokitiol to epoxy-amine-resin-based and calcium-hydroxide-based root canal sealers is warranted, but the enhanced cytotoxicity and synergistic effect must be considered.