Barbara Bojko

Dr. Barbara Bojko

Department of Pharmacodynamics and Molecular Pharmacology Faculty of Pharmacy Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń Dr. A. Jurasza 2, 85-089 Bydgoszcz Poland
orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 November 2017 in Analytical Chemistry
Verified
Journal Article
Open access
NRNathaly Reyes-Garcés
Nathaly Reyes-Garcés
Emanuela GionfriddoEmanuela Gionfriddo
Emanuela Gionfriddo
GGGerman Augusto Gómez-Ríos
German Augusto Gómez-Ríos
NANazmul Alam
Nazmul Alam
EBEzel Boyacı
Ezel Boyacı
JPJanusz Pawliszyn
Janusz Pawliszyn
Solid phase microextraction (SPME) is a versatile, non-exhaustive sample preparation tool that has been demonstrated to be well-suited for facile and effective analysis of a broad range of compounds in a plethora of studies. A growing number of reports describing diverse SPME workflows for novel investigations in a variety of fields, such as flavor and fragrance investigations, environmental studies, and diverse bioanalytical applications, among others, corroborate the applicability of this microextraction tool in the analytical sciences

1 September 2015 in TrAC Trends in Analytical Chemistry
Verified
Journal Article
Closed access
ÉSÉrica A. Souza-Silva
Érica A. Souza-Silva
NRNathaly Reyes-Garcés
Nathaly Reyes-Garcés
GGGerman Gomez
German Gomez
EBEzel Boyacı
Ezel Boyacı
Barbara BojkoBarbara Bojko
Barbara Bojko
JPJanusz Pawliszyn
Janusz Pawliszyn

1 October 2012 in Analytica Chimica Acta
Verified
Journal Article
Closed access
Barbara BojkoBarbara Bojko
Barbara Bojko
ECErasmus Cudjoe
Erasmus Cudjoe
GGGerman Gomez
German Gomez
Krzysztof GorynskiKrzysztof Gorynski
Krzysztof Gorynski
RJRuifen Jiang
Ruifen Jiang
JPJanusz Pawliszyn
Janusz Pawliszyn

14 June 2015 in Cancer Research
Verified
Journal Article
Open access
PDF file
ELEric A. Lee
Eric A. Lee
LALeonard Angka
Leonard Angka
SRSarah-Grace Rota
Sarah-Grace Rota
THThomas Hanlon
Thomas Hanlon
AMAndrew Mitchell
Andrew Mitchell
PSPaul Spagnuolo
Paul Spagnuolo
Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AML. Avocatin B reduced human primary AML cell viability without effect on normal peripheral blood stem cells. Functional stem cell assays demonstrated selectivity toward AML progenitor and stem cells without effects on normal hematopoietic stem cells. Mechanistic investigations indicated that cytotoxicity relied on mitochondrial localization, as cells lacking functional mitochondria or CPT1, the enzyme that facilitates mitochondria lipid transport, were insensitive to avocatin B. Furthermore, avocatin B inhibited fatty acid oxidation and decreased NADPH levels, resulting in ROS-dependent leukemia cell death characterized by the release of mitochondrial proteins, apoptosis-inducing factor, and cytochrome c. This study reveals a novel strategy for selective leukemia cell eradication based on a specific difference in mitochondrial function. Cancer Res; 75(12); 2478–88. ©2015 AACR.

1 October 2014 in TrAC Trends in Analytical Chemistry
Verified
Journal Article
Closed access
Barbara BojkoBarbara Bojko
Barbara Bojko
NRNathaly Reyes-Garcés
Nathaly Reyes-Garcés
VBVincent Bessonneau
Vincent Bessonneau
Krzysztof GorynskiKrzysztof Gorynski
Krzysztof Gorynski
FMFatemeh Mousavi
Fatemeh Mousavi
JPJanusz Pawliszyn
Janusz Pawliszyn

29 December 2015 in Analytical Chemistry
Verified
Journal Article
Open access
GGGerman Gomez
German Gomez
NRNathaly Reyes-Garcés
Nathaly Reyes-Garcés
Barbara BojkoBarbara Bojko
Barbara Bojko
JPJanusz Pawliszyn
Janusz Pawliszyn
In recent years, different geometrical configurations of SPME have been directly coupled to mass spectrometry, resulting in benefits such as diminishing matrix effects, improvement of detection limits, and considerable enhancement of analysis throughput. Although SPME fibers have been used for years, their potential for quantitative analysis when directly combined with mass spectrometry has not been explored to its full extent. In this study, we present the direct coupling of biocompatible-SPME (Bio-SPME) fibers to mass spectrometry via nano-ESI emitters as a powerful tool for fast quantitative analysis of target analytes in biofluids. Total sample preparation time does not exceed 2 min and, by selecting an appropriate fiber length and sample vessel, sample volumes ranging between 10 and 1500 μL can be used. Despite the short extraction time of the technique, limits of detection in the sub-nanogram per millilitre with good accuracy (≥ 90 %) and linearity (R2>0.999) were attained for all the studied probes...