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Access to a registered dietitian experienced in celiac disease (CD) is still limited, and consultation when available focuses primarily on the elimination of gluten from the diet. Thus, the aim of this study was to evaluate the nutritional value of a gluten-free diet (GFD) in adult CD patients before, and one year after, the standard dietary education. The study included 72 CD patients on a GFD and 30 healthy controls. The dietary intake of both groups was assessed through a 3-day food diary, while adherence to a GFD in celiac subjects was assessed using Standardized Dietician Evaluation (SDE). Subsequently, all CD patients received detailed education on gluten sources, and 48 of them participated in a one-year follow-up. Results: Comparison with the control group showed that consumption of plant protein in CD patients was significantly lower, whereas fat and calories were higher. At baseline, only 62% of CD patients adhered to a GFD, but the standard dietary education successfully improved it. However, the nutritional value of a GFD after one year did not change, except for a reduced sodium intake. The CD subjects still did not consume enough calcium, iron, vitamin D, folic acid or fiber. In conclusion, while the standard dietary education improved GFD adherence, it did not significantly alter its nutritional value. Therefore, it is necessary to increase the role of a dietitian in the treatment of CD.
Katarzyna Gładyś; Jolanta Dardzińska; Marek Guzek; Krystian Adrych; Zdzisław Kochan; Sylwia Małgorzewicz. Expanded Role of a Dietitian in Monitoring a Gluten-Free Diet in Patients with Celiac Disease: Implications for Clinical Practice. Nutrients 2021, 13, 1859 .
AMA StyleKatarzyna Gładyś, Jolanta Dardzińska, Marek Guzek, Krystian Adrych, Zdzisław Kochan, Sylwia Małgorzewicz. Expanded Role of a Dietitian in Monitoring a Gluten-Free Diet in Patients with Celiac Disease: Implications for Clinical Practice. Nutrients. 2021; 13 (6):1859.
Chicago/Turabian StyleKatarzyna Gładyś; Jolanta Dardzińska; Marek Guzek; Krystian Adrych; Zdzisław Kochan; Sylwia Małgorzewicz. 2021. "Expanded Role of a Dietitian in Monitoring a Gluten-Free Diet in Patients with Celiac Disease: Implications for Clinical Practice." Nutrients 13, no. 6: 1859.
Adherence to a gluten-free diet (GFD) is currently the mainstay of treatment strategy for celiac disease (CD). The aim of our study was measuring a GFD adherence in CD patients using two newly validated methods of dietary assessment—Standardized Dietician Evaluation (SDE) and the Celiac Dietary Adherence Test (CDAT). Ninety-two adults with CD were evaluated by a registered dietitian with extensive experience with the use of SDE and CDAT. Duodenal biopsy was performed and blood was drawn for serum anti-endomysial, anti-deamidated gliadin peptide and anti-tissue transglutaminase antibodies in forty four of those patients. The results of CDAT and SDE were very convergent, but SDE scores better correlated with serologic and histologic findings. As many as 24–52% of study participants did not adhere well enough to a GFD. Insufficient adherence to a GFD in CD patients is still a significant problem. The knowledge about gluten content in food ingredients and additives is very low among adults with CD. SDE is the most accurate method in assessing compliance with a GFD and is especially helpful in determining hidden sources of gluten. The CDAT may be a fast tool for screening for a GFD adherence in CD patients.
Katarzyna Gładyś; Jolanta Dardzińska; Marek Guzek; Krystian Adrych; Sylwia Małgorzewicz. Celiac Dietary Adherence Test and Standardized Dietician Evaluation in Assessment of Adherence to a Gluten-Free Diet in Patients with Celiac Disease. Nutrients 2020, 12, 2300 .
AMA StyleKatarzyna Gładyś, Jolanta Dardzińska, Marek Guzek, Krystian Adrych, Sylwia Małgorzewicz. Celiac Dietary Adherence Test and Standardized Dietician Evaluation in Assessment of Adherence to a Gluten-Free Diet in Patients with Celiac Disease. Nutrients. 2020; 12 (8):2300.
Chicago/Turabian StyleKatarzyna Gładyś; Jolanta Dardzińska; Marek Guzek; Krystian Adrych; Sylwia Małgorzewicz. 2020. "Celiac Dietary Adherence Test and Standardized Dietician Evaluation in Assessment of Adherence to a Gluten-Free Diet in Patients with Celiac Disease." Nutrients 12, no. 8: 2300.
Gastrointestinal complaints of scleroderma (SS) patients are risk factors for impaired nutritional status, so insightful assessment is necessary. The aim was comparison of malnutrition rates in SS patients using different tools. Nutritional status was assessed using 7-SGA and SNAQ in 56 patients (47F, 9M) with SS. Anthropometric measurements and analysis of body composition were done. Serum levels of CRP, albumin, and hemoglobin were determined. Retrospectively, in 2018, diagnosis of malnutrition was verified using ESPEN 2015 and GLIM 2018 criteria. Gastrointestinal complaints were present in 76.8% of respondents. BMI < 18.5 was found in only 5.4% subjects. However, the percentage of patients with impaired nutritional status was higher and varied, depending on the tools used: 16.1% in SNAQ, 17.9% according to ESPEN 2015, 23.2% in 7-SGA, and as high as 62.5% when GLIM criteria were used. A significant part of patients with SS is malnourished. Screening for malnutrition should be focused on the percentage of unintentional weight loss, presence of gastrointestinal symptoms, and analysis of body composition. The choice of diagnostic tool appropriate for patients with SS will enable starting on-time nutritional intervention.Key Points:• Gastrointestinal involvement causes a significant proportion of patients to be malnourished.• It is important to look for early signs of malnutrition in patients with SS.• Assessment of nutritional status by adequate tools enables starting on-time nutritional intervention and improving prognosis in SS patients.
Anna Wojteczek; Jolanta A. Dardzińska; Sylwia Małgorzewicz; Agnieszka Gruszecka; Zbigniew Zdrojewski. Prevalence of malnutrition in systemic sclerosis patients assessed by different diagnostic tools. Clinical Rheumatology 2019, 39, 227 -232.
AMA StyleAnna Wojteczek, Jolanta A. Dardzińska, Sylwia Małgorzewicz, Agnieszka Gruszecka, Zbigniew Zdrojewski. Prevalence of malnutrition in systemic sclerosis patients assessed by different diagnostic tools. Clinical Rheumatology. 2019; 39 (1):227-232.
Chicago/Turabian StyleAnna Wojteczek; Jolanta A. Dardzińska; Sylwia Małgorzewicz; Agnieszka Gruszecka; Zbigniew Zdrojewski. 2019. "Prevalence of malnutrition in systemic sclerosis patients assessed by different diagnostic tools." Clinical Rheumatology 39, no. 1: 227-232.
Background: There is still a lack of data on the nutritional status of older people with aortic stenosis (AS) and the effect of poor nutrition on the occurrence of complications and mortality after an aortic valve replacement (AVR) procedure. The aim of this study was to assess the impact of selected nutritional status parameters in elderly patients with severe AS on the occurrence of postoperative complications and one-year mortality after the AVR procedure. Methods: 101 elderly patients with AS aged 74.6 ± 5.2 years who qualified for surgical treatment (aortic valve area [AVA] 0.73 ± 0.2 cm2) were enrolled in the study. A nutritional status assessment was performed before AVR surgery, and the frequency of postoperative complications occurring within 30 days of surgery was assessed. The one-year mortality rate was also captured. Results: Adverse events (both major and minor) up to 30 days occurred in 49.5% (n = 50) of the study population. Low Mini Nutritional Assessment (f-MNA) and Subjective Global Assessment (7-SGA) scores and low concentrations of total cholesterol, LDL-cholesterol, and prealbumin were associated with a higher risk of postoperative complications. The risk of complications increased 1.22 times (95% CI; 1.030–1.453; p = 0.019) with an impaired nutritional status. The annual mortality rate in the study group was 7.9%. Unintentional weight loss of >2.8% in the six months preceding surgery proved useful for predicting death within the first year after AVR surgery. Conclusions: The results indicate that poor nutritional status is an important factor affecting the adverse outcomes in elderly patients with severe aortic valve stenosis undergoing an AVR procedure.
Edyta Wernio; Sylwia Małgorzewicz; Jolanta Anna Dardzińska; Dariusz Jagielak; Jan Rogowski; Agnieszka Gruszecka; Andrzej Klapkowski; Peter Bramlage. Association between Nutritional Status and Mortality after Aortic Valve Replacement Procedure in Elderly with Severe Aortic Stenosis. Nutrients 2019, 11, 446 .
AMA StyleEdyta Wernio, Sylwia Małgorzewicz, Jolanta Anna Dardzińska, Dariusz Jagielak, Jan Rogowski, Agnieszka Gruszecka, Andrzej Klapkowski, Peter Bramlage. Association between Nutritional Status and Mortality after Aortic Valve Replacement Procedure in Elderly with Severe Aortic Stenosis. Nutrients. 2019; 11 (2):446.
Chicago/Turabian StyleEdyta Wernio; Sylwia Małgorzewicz; Jolanta Anna Dardzińska; Dariusz Jagielak; Jan Rogowski; Agnieszka Gruszecka; Andrzej Klapkowski; Peter Bramlage. 2019. "Association between Nutritional Status and Mortality after Aortic Valve Replacement Procedure in Elderly with Severe Aortic Stenosis." Nutrients 11, no. 2: 446.
Severe aortic stenosis (AS) is associated with the reduction of muscle mass and may be associated with deterioration of nutritional status. Furthermore, malnourished cardiac patients are characterized by a higher risk of postoperative complications and mortality. The aim of this study was the evaluation and comparison of nutritional status, appetite and body composition in older people with severe aortic stenosis before aortic valve replacement and healthy elderly volunteers. One hundred and one patients, aged >65 years old with severe AS were included in the study. Nutritional status was assessed. Body composition was estimated using bioelectrical impedance analysis. Concentrations of albumin, prealbumin, triglycerides, total cholesterol and C-reactive protein were measured, and a complete blood count was done. About 40% of AS patients were at risk of malnutrition. They had decreased hand grip strength and they lost more body mass than the control group. Malnourished AS patients were older, had lower body mass indexes (BMIs) and lower aortic valve areas in comparison to well-nourished patients. Older AS patients, like their peers, show excessive body mass and, at the same time, the features of malnutrition. They have additional factors such as unintentional weight lost and decreased muscle strength which may be associated with worse outcomes.
Edyta Wernio; Dariusz Jagielak; Jolanta Anna Dardzińska; Ewa Aleksandrowicz-Wrona; Jan Rogowski; Agnieszka Gruszecka; Sylwia Małgorzewicz. Analysis of Outcomes of the Nutritional Status in Patients Qualified for Aortic Valve Replacement in Comparison to Healthy Elderly. Nutrients 2018, 10, 304 .
AMA StyleEdyta Wernio, Dariusz Jagielak, Jolanta Anna Dardzińska, Ewa Aleksandrowicz-Wrona, Jan Rogowski, Agnieszka Gruszecka, Sylwia Małgorzewicz. Analysis of Outcomes of the Nutritional Status in Patients Qualified for Aortic Valve Replacement in Comparison to Healthy Elderly. Nutrients. 2018; 10 (3):304.
Chicago/Turabian StyleEdyta Wernio; Dariusz Jagielak; Jolanta Anna Dardzińska; Ewa Aleksandrowicz-Wrona; Jan Rogowski; Agnieszka Gruszecka; Sylwia Małgorzewicz. 2018. "Analysis of Outcomes of the Nutritional Status in Patients Qualified for Aortic Valve Replacement in Comparison to Healthy Elderly." Nutrients 10, no. 3: 304.
Introduction The mechanism underlying beneficial outcomes of bariatric surgery still remains unclear. Especially little is known about hormonal and metabolic changes induced by the novel bariatric procedure mini gastric bypass (MGB). Aim To evaluate pre- and post-prandial changes in both...
Jolanta Dardzinska; Łukasz Kaska; Monika Proczko-Stepaniak; Maria Szymańska-Gnacińska; Ewa Aleksandrowicz-Wrona; Sylwia Małgorzewicz. Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery. Videosurgery and Other Miniinvasive Techniques 2018, 13, 366 -375.
AMA StyleJolanta Dardzinska, Łukasz Kaska, Monika Proczko-Stepaniak, Maria Szymańska-Gnacińska, Ewa Aleksandrowicz-Wrona, Sylwia Małgorzewicz. Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery. Videosurgery and Other Miniinvasive Techniques. 2018; 13 (3):366-375.
Chicago/Turabian StyleJolanta Dardzinska; Łukasz Kaska; Monika Proczko-Stepaniak; Maria Szymańska-Gnacińska; Ewa Aleksandrowicz-Wrona; Sylwia Małgorzewicz. 2018. "Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery." Videosurgery and Other Miniinvasive Techniques 13, no. 3: 366-375.
BACKGROUNDː The mechanisms underlying the metabolic effect of surgical treatment for morbid obesity are still unclear. Furthermore, the hormonal and metabolic response to the promising and less-invasive version of Roux-en-Y gastric bypass (RYGB), i.e. mini gastric bypass (MGB), is poorly known. The aim of this study was to evaluate pre- and postprandial changes in peptide YY (PYY) and metabolic parameters in obese patients without diabetes and cardiovascular complications treated by both versions of gastric bypass. METHODSː Venous blood for PYY and other assays was collected three months before and six months after bariatric operation (MGB and RYGB), in the fasting state and two hours after the consumption of a standard 300-kcal mixed meal (Nutridrink Standard, Nutricia Advanced Medical Nutrition, part of the Danone company, Schiphol, The Netherlands). RESULTSː In the MGB group, elevated concentrations of the PYY has been detected both fasting and postprandially. The effect of the MGB on the PYY levels did not differ from the RYGB group outcomes. CONCLUSIONSː The results of our study suggest similar endocrine and metabolic effects of MGB and RYGB procedures. Long-term efficacy and metabolic benefits of MGB require further research.
Jolanta A Dardzińska; Łukasz Kaska; Piotr Wiśniewski; Ewa Aleksandrowicz-Wrona; Sylwia Małgorzewicz. Fasting and post-prandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass. Minerva Chirurgica 2017, 72, 24 -30.
AMA StyleJolanta A Dardzińska, Łukasz Kaska, Piotr Wiśniewski, Ewa Aleksandrowicz-Wrona, Sylwia Małgorzewicz. Fasting and post-prandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass. Minerva Chirurgica. 2017; 72 (1):24-30.
Chicago/Turabian StyleJolanta A Dardzińska; Łukasz Kaska; Piotr Wiśniewski; Ewa Aleksandrowicz-Wrona; Sylwia Małgorzewicz. 2017. "Fasting and post-prandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass." Minerva Chirurgica 72, no. 1: 24-30.
The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin's (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.
Jolanta Dardzinska; Sylwia Małgorzewicz; Łukasz Kaska; Monika Proczko; Tomasz Stefaniak; Marta Stankiewicz; Zbigniew Śledziński. Przedposiłkowe i poposiłkowe zmiany stężeń obu form greliny u osób otyłych i nieotyłych. Endokrynologia Polska 2014, 65, 377 -381.
AMA StyleJolanta Dardzinska, Sylwia Małgorzewicz, Łukasz Kaska, Monika Proczko, Tomasz Stefaniak, Marta Stankiewicz, Zbigniew Śledziński. Przedposiłkowe i poposiłkowe zmiany stężeń obu form greliny u osób otyłych i nieotyłych. Endokrynologia Polska. 2014; 65 (5):377-381.
Chicago/Turabian StyleJolanta Dardzinska; Sylwia Małgorzewicz; Łukasz Kaska; Monika Proczko; Tomasz Stefaniak; Marta Stankiewicz; Zbigniew Śledziński. 2014. "Przedposiłkowe i poposiłkowe zmiany stężeń obu form greliny u osób otyłych i nieotyłych." Endokrynologia Polska 65, no. 5: 377-381.
The aim of the present study was to evaluate the effects of commonly used treatment regimens such as metformin (MET) or an oral contraceptive pill (OC) containing ethynyloestradiol and cyproterone acetate (EE-CPA) on surrogate serum CVD risk factors and markers of endothelial dysfunction (CRP, IL-6, sVCAM) in women with PCOS.This study was conducted in a crossover design in order to compare the effects of 2 different treatment regimens in the same subject and has been registered under the number NCT01798875 in the ClinicalTrials.gov registry.42 women with PCOS (age range 18-36 years, median BMI 24.9) were randomly assigned to treatment with MET (850 mg bid) or EE-CPA containing OC for 4 months. After 2 months washout period, treatments were crossed over.Treatment with and OC increased significantly serum CRP concentrations (from 0.77 mg/l [95% CI: 0.70; 2.18] to 1.70 mg/l [95% CI: 1.65; 3.69], P0.05).Treatment with EE-CPA containing OC for 4 months in women with PCOS significantly raises serum CRP. Since this rise was not accompanied by the increase in serum concentrations of IL-6, which is the most potent and effective stimulant of hepatic CRP production, we can speculate that this effect is caused by the liver first-pass effect of oral oestrogen administration. If this in turn can confer, cardiovascular risk among these women warrants further -studies.
Jolanta Dardzinska; D. Rachoń; M. Kuligowska-Jakubowska; E. Aleksandrowicz-Wrona; A. Płoszyński; B. Wyrzykowski; W. Łysiak-Szydłowska. Effects of Metformin or an Oral Contraceptive Containing Cyproterone Acetate on Serum C-reactive Protein, Interleukin-6 and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Women with Polycystic Ovary Syndrome. Experimental and Clinical Endocrinology & Diabetes 2014, 122, 118 -125.
AMA StyleJolanta Dardzinska, D. Rachoń, M. Kuligowska-Jakubowska, E. Aleksandrowicz-Wrona, A. Płoszyński, B. Wyrzykowski, W. Łysiak-Szydłowska. Effects of Metformin or an Oral Contraceptive Containing Cyproterone Acetate on Serum C-reactive Protein, Interleukin-6 and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Women with Polycystic Ovary Syndrome. Experimental and Clinical Endocrinology & Diabetes. 2014; 122 (2):118-125.
Chicago/Turabian StyleJolanta Dardzinska; D. Rachoń; M. Kuligowska-Jakubowska; E. Aleksandrowicz-Wrona; A. Płoszyński; B. Wyrzykowski; W. Łysiak-Szydłowska. 2014. "Effects of Metformin or an Oral Contraceptive Containing Cyproterone Acetate on Serum C-reactive Protein, Interleukin-6 and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Women with Polycystic Ovary Syndrome." Experimental and Clinical Endocrinology & Diabetes 122, no. 2: 118-125.
We review the studies on the links between obesity, the immune system and lifestyle (limited or excessive calorie intake) that provoke changes in the current therapeutic course. There is no doubt that the positive energy balance of the body affects the immune cells, and consequently, the changes intracellular pathways, leading to the disruption of their function. Research suggests that metformin, a drug long used to treat diabetes, and an alternative remedy in the treatment of obesity, increases the activity of 5-adenosinemonophosphate (AMP)-activated kinase (AMPK). Thus, this review comes to the conclusion that alongside traditional methods, such as reducing calorie intake and increasing the energy expenditure of the body, the therapeutic outcome may be improved by implementing drugs affecting the activity of AMPK. In future, other new therapeutic options may be available. The targeting receptors or immunocompetent cells residing in adipose tissue may help to reduce the effects of obesity.
Sylwia Małgorzewicz; Jolanta Dardzinska; Maria Gnacińska; Jerzy Jankun; Ewa Bryl; Krzysztof Sworczak. Complex interaction between the immune system and adipose tissue (Review). International Journal of Molecular Medicine 2013, 33, 3 -7.
AMA StyleSylwia Małgorzewicz, Jolanta Dardzinska, Maria Gnacińska, Jerzy Jankun, Ewa Bryl, Krzysztof Sworczak. Complex interaction between the immune system and adipose tissue (Review). International Journal of Molecular Medicine. 2013; 33 (1):3-7.
Chicago/Turabian StyleSylwia Małgorzewicz; Jolanta Dardzinska; Maria Gnacińska; Jerzy Jankun; Ewa Bryl; Krzysztof Sworczak. 2013. "Complex interaction between the immune system and adipose tissue (Review)." International Journal of Molecular Medicine 33, no. 1: 3-7.