Khadija Gambouz

Mrs. Khadija Gambouz


Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 June 2020 in Molecules
Verified
Journal Article
Open access
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KGKhadija Gambouz
Khadija Gambouz
AAABDELMOULA EL ABBOUCHI
ABDELMOULA EL ABBOUCHI
SNSarah Nassiri
Sarah Nassiri
FSFranck Suzenet
Franck Suzenet
MBMostapha Bousmina
Mostapha Bousmina
SKSaïd El Kazzouli
Saïd El Kazzouli
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3-aryled 1H-7-azaindazoles via a C3 direct arylation using water as solvent. On water, PPh3 was effective as a ligand along with a lower charge of the catalyst Pd(OAc)2 (5 mol%) at 100 °C, leading to C3-aryled 1H-indazoles or C3-aryled 1H-7-azaindazoles in moderate to good yields.