Lumpy skin disease (LSD), a current global concern, causes economic devastation in livestock industries, with cattle and water buffalo reported to have higher morbidity and lower mortality rates. LSD is caused by lumpy skin disease virus (LSDV), a member of the Poxviridae family. It is an enzootic, rapidly explorative and sometimes fatal infection, characterized by multiple raised nodules on the skin of infected animals. It was first reported in Zambia in 1929 and is considered endemic in Africa south of the Sahara desert. It has gradually spread beyond Africa into the Middle East, with periodic occurrences in Asian and East European countries. Recently, it has been spreading in most Asian countries including far East Asia and threatens incursion to LSD-free countries. Rapid and accurate diagnostic capabilities, virus identification, vaccine development, vector control, regional and international collaborations and effective biosecurity policies are important for the control, prevention, and eradication of LSD infections. This review critically evaluates the global burden of LSD, the chronological historical outbreaks of LSD, and future directions for collaborative global actions.

Aims: The study investigated critical biosecurity control points and dairy farmers’ motivations towards biosecurity practices among selected dairy farmers across Australia. Methods: A questionnaire template was administered via an online survey. A three-stage process was used to develop the questionnaire by pooling of potential questions, selection and reduction of the questions to fit an 8–10 min survey. Key results: A total of 55 responses were obtained. Mixed species rearing was practiced on 69% of the farms, with a majority keeping either sheep or beef cattle within the same property as dairy cattle. Approximately half of the farms (49%) did not provide formal training to new staff on aspects of animal health, as well as not conducting bull breeding soundness. Most of the farms (98%) required staff to use personal protective equipment, such as overalls and gumboots, but only a few of the farms (34%) had designated areas to clean footwear and a system for recording visitors (17%). Record keeping pertaining to animal health, maintenance of good fences and use of vendor declaration forms was practiced in a majority of the farms. The practice of quarantining new stock before mixing with other stock was practiced in only 45% of the farms. Monthly herd health visits by a veterinarian were utilised by 55% of the farms. Multivariable analysis showed positive significant associations between mixed species rearing with the practice of regular pest control (P = 0.004) and use of footbaths (P = 0.024) and no biosecurity plan (P = 0.025). Furthermore, a positive significant association was also recorded on the presence of a biosecurity plan and the presence of a designated area to clean footwear (P = 0.002) and no regular deworming (P = 0.024). Animal and human health reasons were the main motivators for implementing and maintaining ‘best practice’ biosecurity practices, whereas government regulation was the lowest motivator. Conclusions: It is concluded that the biosecurity practices were variable, and animal and human health reasons were the primary motivators for instituting biosecurity practices. Implications: There is a need to continue educating farmers on the importance of biosecurity practices.

The objectives of this study were to assess antibody and cellular immune responses in first-lactation dairy heifers reared under a pasture-based production system and to investigate associations between immune competence and stress responsiveness, health, and productivity. A commercial vaccine was used to induce antibody and cellular immune responses and, based on measured responses, animals were classified as above average, average, and below average for each trait independently and in combination (overall immune competence). Overall immune competence phenotypic rankings were generated by combining standardized residual values for antibody and cellular responses measured in individual heifers. Cortisol responses to handling and yarding were used to assess stress responsiveness, worm egg counts were used to assess internal parasite burden, somatic cell counts to assess udder health and estimates of total daily milk volume, and milk fat and milk protein contents to assess productivity. A total of 393 Holstein-Friesian and Holstein-Friesian × Jersey crossbred heifers from 2 herds practicing seasonal calving in a pasture-fed production system were enrolled in the study. The immune competence phenotypes of individual heifers were assessed before their first mating and their subsequent performance during their first lactation was monitored. Animals with below-average antibody and cellular immune competence had higher serum cortisol concentrations compared with their counterparts following handling, suggesting they had a reduced ability to cope with management-induced stress. Furthermore, a significant negative (favorable) correlation was observed between antibody responses and stress responsiveness. Similarly, correlations between antibody responses and internal parasite burden were significant and negative (favorable). No correlations were observed between overall immune competence and milk yield, milk fat, and milk protein content.

The objective of this study was to determine the repeatability of ranking Holstein-Friesian heifers reared in an Australian pasture-based production system for immune responses (IR) when ranking was based on secondary versus tertiary IR. Further objectives were to investigate associations between IR and stress responsiveness, ADG and resistance to internal parasites. A total of 100 heifers were IR phenotyped at 5 to 6 mo of age and again at 12 to 13 mo of age using commercial vaccine antigens to induce measurable IR. Antibody production to tetanus toxoid (TT) was used to assess antibody-mediated IR (AMIR), and delayed-type hypersensitivity reactions to vaccine antigens were used to assess cell-mediated IR (CMIR). Changes in serum cortisol and haptoglobin were used to assess stress responsiveness and fecal egg counts used as a measure of resistance to internal parasites. Based on testing, animals were categorized as either average to above-average (High) or low responders for IR. Secondary and tertiary AMIR were well correlated (r = 0.651, adjusted R² = 0.418, P < 0.0001), whereas correlations between secondary and tertiary CMIR were poor (r = 0.078, R² = –0.004, P = 0.450). A Cohen kappa (κ) test of agreement was used to test the consistency of ranking of individual animal for IR and, therefore, the ability to consistently identify low immune responder animals within the herd across test periods. The consistency of ranking (High versus low) was moderately high for AMIR (κ = 0.445), poor for CMIR (κ = –0.055), and fair to moderate for combined IR (κ = 0.395). High AMIR phenotype animals had significantly higher serum cortisol concentrations than their low immune responder counterparts (P = 0.045). A similar relationship was observed in heifers categorized for CMIR, with High CMIR responders having higher serum cortisol concentrations than their low responder counterparts (P = 0.008). High AMIR calves had a higher ADG compared with low AMIR calves (0.72 ± 0.02 versus 0.66 ± 0.06 kg/d; P = 0.009). Serum haptoglobin concentrations and worm egg counts were very low and could not be used to investigate associations with immune responsiveness. It is concluded that secondary and tertiary antibody responses to TT were well correlated in the Holstein-Friesian heifers in this study and that by using the testing procedure described here, low antibody responders were able to be consistently identified in the herd.