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Dr. Wenmin Xing
Zhejiang Hospital

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0 Aging
0 Toxicology
0 Pharmaceutical And Medicinal Chemistry
0 stem cell
0 senescence

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Review
Published: 12 October 2020 in Journal of Telemedicine and Telecare
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Introduction Elevated blood pressure (BP) is a leading risk factor for many chronic diseases. Many investigations conducted using telemedicine (TM)-based interventions have the potential to control BP. The purpose of this study was to assess the efficacy of TM-based interventions in reducing BP. Methods Studies were selected from PubMed, PMC, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM) according to the inclusion and exclusion criteria. The mean and standard deviation changes in systolic BP (SBP) and diastolic BP (DBP) were analysed using standard mean difference (SMD) and 95% confidence intervals (CI) with a random-effects model or fixed-effects model to assess the efficiency of controlling BP. Subgroup analysis, influence analysis and publication bias analysis were also conducted. Results Sixteen randomised clinical trials were included in this meta-analysis. A TM-based lifestyle intervention significantly reduced daytime SBP (SMD = −0.18, 95% CI −0.27 to −0.10; p < 0.001) and DBP (SMD = −0.18, 95% CI −0.27 to −0.09; p < 0.001). The results of subgroup analysis indicated that this reduction in BP was reliable when BP interventions lasted for 6 months or longer in populations with cardiovascular disease and hypertension. Moreover, the detection data should be delivered by a device system to ensure accuracy. Discussion A TM-based intervention could reduce daytime SBP and DBP in populations with hypertension and cardiovascular disease. This review provides intuitive evidence of a reduction in BP using TM-based interventions.

ACS Style

Wenyan Gao; Xiaoling Lv; Xiaogang Xu; Zhongshan Zhang; Jing Yan; Genxiang Mao; Wenmin Xing. Telemedicine intervention–reduced blood pressure in a chronic disease population: A meta-analysis. Journal of Telemedicine and Telecare 2020, 1 .

AMA Style

Wenyan Gao, Xiaoling Lv, Xiaogang Xu, Zhongshan Zhang, Jing Yan, Genxiang Mao, Wenmin Xing. Telemedicine intervention–reduced blood pressure in a chronic disease population: A meta-analysis. Journal of Telemedicine and Telecare. 2020; ():1.

Chicago/Turabian Style

Wenyan Gao; Xiaoling Lv; Xiaogang Xu; Zhongshan Zhang; Jing Yan; Genxiang Mao; Wenmin Xing. 2020. "Telemedicine intervention–reduced blood pressure in a chronic disease population: A meta-analysis." Journal of Telemedicine and Telecare , no. : 1.

Research article
Published: 18 September 2020 in Medicine
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Background: Neurofilament light (NfL) level was obviously increased in traumatic brain injury (TBI) individuals. But, no comprehensive meta-analysis has ever been conducted to assess the diagnostic performance of NfL. This study aims to evaluate the relationship between NfL level and TBI through a meta-analysis. Methods: Studies were selected from Pubmed, Web of science, Embase, Google Scholar, PMC and Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. The standard mean difference (SMD) and 95% confidence interval (CI) were calculated using the random-effect model or fixed-effect model to assess the association between NfL level and TBI. Subgroup analysis according to sample collection time, sample type and detection method was performed. The influence analysis and publication bias was also conducted. All analyses were performed using the RevMan 5.3 and Stata 12 software. Results: A total of 9 studies were included. Results indicated that TBI individuals had a higher NfL expression level compared with the non-TBI individuals (SMD = 2.48, 95% CI = 1.52–3.43, I2 = 96%, P < .01). Similar NfL increasing was also observed in Caucasian population, 0–48 hour and 6–10 days sample collection time, as well as cerebrospinal fluid (CSF), serum, plasma sample subgroup analysis. Moreover, the NfL increasing still existed no matter the NfL expression level was detected by ELISA or Simoa assay. Conclusion: NfL expression level was increased in TBI individuals, which indicated that NfL could be a potential biomarker in the diagnosis of TBI and other neurodegenerative diseases.

ACS Style

Wenyan Gao; Zhongshan Zhang; Xiaoling Lv; Qing Wu; Jing Yan; Genxiang Mao; Wenmin Xing. Neurofilament light chain level in traumatic brain injury. Medicine 2020, 99, e22363 .

AMA Style

Wenyan Gao, Zhongshan Zhang, Xiaoling Lv, Qing Wu, Jing Yan, Genxiang Mao, Wenmin Xing. Neurofilament light chain level in traumatic brain injury. Medicine. 2020; 99 (38):e22363.

Chicago/Turabian Style

Wenyan Gao; Zhongshan Zhang; Xiaoling Lv; Qing Wu; Jing Yan; Genxiang Mao; Wenmin Xing. 2020. "Neurofilament light chain level in traumatic brain injury." Medicine 99, no. 38: e22363.

Review
Published: 28 March 2020 in Disease Markers
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Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR=0.79, 95%CI=0.72‐0.86; del/del vs. ins/ins+del/ins: OR=0.74, 95%CI=0.59‐0.91; del/ins vs. ins/ins: OR=0.84, 95%CI=0.67‐1.05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR=0.79, 95%CI=0.70‐0.90; CC vs. CT+TT: OR=0.49, 95%CI=0.37‐0.65; CC vs. TT: OR=0.49, 95%CI=0.37‐0.66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

ACS Style

Xiaoyan Dong; Wenyan Gao; Xiaoling Lv; Yazhen Wang; Qing Wu; Zhouxin Yang; Genxiang Mao; Wenmin Xing. Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis. Disease Markers 2020, 2020, 1 -13.

AMA Style

Xiaoyan Dong, Wenyan Gao, Xiaoling Lv, Yazhen Wang, Qing Wu, Zhouxin Yang, Genxiang Mao, Wenmin Xing. Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis. Disease Markers. 2020; 2020 ():1-13.

Chicago/Turabian Style

Xiaoyan Dong; Wenyan Gao; Xiaoling Lv; Yazhen Wang; Qing Wu; Zhouxin Yang; Genxiang Mao; Wenmin Xing. 2020. "Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis." Disease Markers 2020, no. : 1-13.

Journal article
Published: 19 November 2019 in European Journal of Internal Medicine
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ACS Style

Wenyan Gao; Xiaoyan Dong; Zhouxin Yang; Genxiang Mao; Wenmin Xing. Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis. European Journal of Internal Medicine 2019, 71, 101 -103.

AMA Style

Wenyan Gao, Xiaoyan Dong, Zhouxin Yang, Genxiang Mao, Wenmin Xing. Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis. European Journal of Internal Medicine. 2019; 71 ():101-103.

Chicago/Turabian Style

Wenyan Gao; Xiaoyan Dong; Zhouxin Yang; Genxiang Mao; Wenmin Xing. 2019. "Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis." European Journal of Internal Medicine 71, no. : 101-103.

Special article
Published: 11 June 2017 in Clinical and Experimental Pharmacology and Physiology
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The aging process directly impacts bodily functions on multiple levels, including a reduced ability to resist stress, damage and disease. Besides changes in metabolic control, the aging process coincides with the altered long non‐coding RNAs (lncRNAs) expression, which are ≥200nt long class of non‐protein coding RNAs. The majority of non‐coding transcripts of mammalian organs and tissues are expressed in developmentally regulated and cell‐type specific manners. Specific altered lncRNA level has been involved in induction and maintenance of the whole human body aging with highly specific spatial andtemporal expression patterns. Furthermore, many lncRNAs are transcribed in sense, antisense and bidirectional manners in the mammalian genome. They play a vital role in regulating organ or tissue differentiation during aging by binding with miRNA or proteins to act as a decoy. Recently, the correlation between lncRNAs and aging has been studied intensely. Here, we have summarized some examples of known and novel lncRNAs that have been implicated in the aging process in the whole mammalian body and we discuss these patterns, conservation and characters during aging. This may further promote the development of research on lncRNAs and the aging process.

ACS Style

Wenmin Xing; Wenyan Gao; Genxiang Mao; Jing Zhang; Xiaoling Lv; Guofu Wang; Jing Yan. Long non-coding RNAs in aging organs and tissues. Clinical and Experimental Pharmacology and Physiology 2017, 44, 30 -37.

AMA Style

Wenmin Xing, Wenyan Gao, Genxiang Mao, Jing Zhang, Xiaoling Lv, Guofu Wang, Jing Yan. Long non-coding RNAs in aging organs and tissues. Clinical and Experimental Pharmacology and Physiology. 2017; 44 ():30-37.

Chicago/Turabian Style

Wenmin Xing; Wenyan Gao; Genxiang Mao; Jing Zhang; Xiaoling Lv; Guofu Wang; Jing Yan. 2017. "Long non-coding RNAs in aging organs and tissues." Clinical and Experimental Pharmacology and Physiology 44, no. : 30-37.

Randomized controlled trial
Published: 31 March 2017 in International Journal of Environmental Research and Public Health
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The aim of the current study was to test the hypothesis that forest bathing would be beneficial for elderly patients with chronic heart failure (CHF) as an adjunctive therapy. Two groups of participants with CHF were simultaneously sent to the forest or an urban control area for a four-day trip, respectively. Subjects exposed to the forest site showed a significant reduction of brain natriuretic peptide (BNP) in comparison to that of the city group and their own baseline levels. The values for the cardiovascular disease related pathological factors, including endothelin-1 (ET-1), and constituents of the renin-angiotensin system (RAS), including renin, angiotensinogen (AGT), angiotensin II (ANGII), and ANGII receptor type 1 or 2 (AT1 or AT2) in subjects exposed to the forest environment were lower than those in the urban control group. Obviously, a decreased level of inflammatory cytokines and improved antioxidant function was observed in the forest group rather than in the city group. The assessment of the profile of mood states (POMS) indicated that the negative emotional mood state was alleviated after forest bathing. As anticipated, a better air quality in the forest site was observed according to the detection of PM2.5 (particulate matter <2.5 μm) and negative ions. These results provided direct evidence that forest bathing has a beneficial effect on CHF patients, and thus may pave the way for potential development of forest bathing as an effective adjunctive therapy on cardiovascular disorders.

ACS Style

Genxiang Mao; Yongbao Cao; Bozhong Wang; Sanying Wang; Zhuomei Chen; Jirong Wang; Wenmin Xing; Xiaoxu Ren; Xiaoling Lv; Jianhua Dong; Shasha Chen; Xiuyuan Chen; Guofu Wang; Jing Yan. The Salutary Influence of Forest Bathing on Elderly Patients with Chronic Heart Failure. International Journal of Environmental Research and Public Health 2017, 14, 368 .

AMA Style

Genxiang Mao, Yongbao Cao, Bozhong Wang, Sanying Wang, Zhuomei Chen, Jirong Wang, Wenmin Xing, Xiaoxu Ren, Xiaoling Lv, Jianhua Dong, Shasha Chen, Xiuyuan Chen, Guofu Wang, Jing Yan. The Salutary Influence of Forest Bathing on Elderly Patients with Chronic Heart Failure. International Journal of Environmental Research and Public Health. 2017; 14 (4):368.

Chicago/Turabian Style

Genxiang Mao; Yongbao Cao; Bozhong Wang; Sanying Wang; Zhuomei Chen; Jirong Wang; Wenmin Xing; Xiaoxu Ren; Xiaoling Lv; Jianhua Dong; Shasha Chen; Xiuyuan Chen; Guofu Wang; Jing Yan. 2017. "The Salutary Influence of Forest Bathing on Elderly Patients with Chronic Heart Failure." International Journal of Environmental Research and Public Health 14, no. 4: 368.