Gijsbertus T. J. Van Der Horst

Dr. Gijsbertus T. J. Van Der Horst

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Academic Career Length

45Years (1982-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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15 April 1999 in Nature
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GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
MMManja Muijtjens
Manja Muijtjens
KKKumiko Kobayashi
Kumiko Kobayashi
RTRiya Takano
Riya Takano
SKShin-Ichiro Kanno
Shin-Ichiro Kanno
AYAkira Yasui
Akira Yasui
12 May 2000 in Science
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Journal Article
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LSLauren P. Shearman
Lauren P. Shearman
SSSathyanarayanan Sriram
Sathyanarayanan Sriram
DWDavid R. Weaver
David R. Weaver
EMElizabeth S. Maywood
Elizabeth S. Maywood
ICInẽs Chaves
Inẽs Chaves
SRSteven M. Reppert
Steven M. Reppert
We show that, in the mouse, the core mechanism for the master circadian clock consists of interacting positive and negative transcription and translation feedback loops. Analysis of Clock/Clock mutant mice, homozygous Period2 Brdm1 mutants, and Cryptochrome -deficient mice reveals substantially altered Bmal1 rhythms, consistent with a dominant role of PERIOD2 in the positive regulation of the Bmal1 loop. In vitro analysis of CRYPTOCHROME inhibition of CLOCK: BMAL1-mediated transcription shows that the inhibition is through direct protein:protein interactions, independent of the PERIOD and TIMELESS proteins. PERIOD2 is a positive regulator of the Bmal1 loop, and CRYPTOCHROMES are the negative regulators of the Period and Cryptochrome cycles.
2 June 2011 in Annual Review of Plant Biology
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Journal Article
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ICInes Chaves
Ines Chaves
RPRichard Pokorny
Richard Pokorny
MBMartin Byrdin
Martin Byrdin
NHNathalie Hoang
Nathalie Hoang
TRThorsten Ritz
Thorsten Ritz
MAMargaret Ahmad
Margaret Ahmad
Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles in growth and development. Subsequently identified in prokaryotes, archaea, and many eukaryotes, cryptochromes function in the animal circadian clock and are proposed as magnetoreceptors in migratory birds. Cryptochromes are closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review the structural, photochemical, and molecular properties of cry-DASH, plant, and animal cryptochromes in relation to biological signaling mechanisms and uncover common features that may contribute to better understanding the function of cryptochromes in diverse systems including in man.
21 December 2006 in Nature
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LNLaura J. Niedernhofer
Laura J. Niedernhofer
George GarinisGeorge Garinis
George Garinis
ARAnja Raams
Anja Raams
ALAstrid S. Lalai
Astrid S. Lalai
ARAndria Rasile Robinson
Andria Rasile Robinson
JHJan H. J. Hoeijmakers
Jan H. J. Hoeijmakers
17 May 2002 in Science
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JBJan de Boer
Jan de Boer
Jaan-Olle AndressooJaan-Olle Andressoo
Jaan-Olle Andressoo
JWJan de Wit
Jan de Wit
JHJan Huijmans
Jan Huijmans
RBRudolph B. Beems
Rudolph B. Beems
JHJan H. J. Hoeijmakers
Jan H. J. Hoeijmakers
One of the factors postulated to drive the aging process is the accumulation of DNA damage. Here, we provide strong support for this hypothesis by describing studies of mice with a mutation in XPD , a gene encoding a DNA helicase that functions in both repair and transcription and that is mutated in the human disorder trichothiodystrophy (TTD). TTD mice were found to exhibit many symptoms of premature aging, including osteoporosis and kyphosis, osteosclerosis, early greying, cachexia, infertility, and reduced life-span. TTD mice carrying an additional mutation in XPA , which enhances the DNA repair defect, showed a greatly accelerated aging phenotype, which correlated with an increased cellular sensitivity to oxidative DNA damage. We hypothesize that aging in TTD mice is caused by unrepaired DNA damage that compromises transcription, leading to functional inactivation of critical genes and enhanced apoptosis.
13 April 2001 in Science
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KYKazuhiro Yagita
Kazuhiro Yagita
FTFilippo Tamanini
Filippo Tamanini
GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
HOHitoshi Okamura
Hitoshi Okamura
In mammals, the central circadian pacemaker resides in the hypothalamic suprachiasmatic nucleus (SCN), but circadian oscillators also exist in peripheral tissues. Here, using wild-type and cryptochrome ( mCry )–deficient cell lines derived from mCry mutant mice, we show that the peripheral oscillator in cultured fibroblasts is identical to the oscillator in the SCN in (i) temporal expression profiles of all known clock genes, (ii) the phase of the various mRNA rhythms (i.e., antiphase oscillation of Bmal1 and mPer genes), (iii) the delay between maximum mRNA levels and appearance of nuclear mPER1 and mPER2 protein, (iv) the inability to produce oscillations in the absence of functional mCry genes, and (v) the control of period length by mCRY proteins.