Ines Chaves

Dr. Ines Chaves

Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands
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Academic Career Length

16Years (2011-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 June 2011 in Annual Review of Plant Biology
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Journal Article
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ICInes Chaves
Ines Chaves
RPRichard Pokorny
Richard Pokorny
MBMartin Byrdin
Martin Byrdin
NHNathalie Hoang
Nathalie Hoang
TRThorsten Ritz
Thorsten Ritz
MAMargaret Ahmad
Margaret Ahmad
Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles in growth and development. Subsequently identified in prokaryotes, archaea, and many eukaryotes, cryptochromes function in the animal circadian clock and are proposed as magnetoreceptors in migratory birds. Cryptochromes are closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review the structural, photochemical, and molecular properties of cry-DASH, plant, and animal cryptochromes in relation to biological signaling mechanisms and uncover common features that may contribute to better understanding the function of cryptochromes in diverse systems including in man.
18 December 2021 in Nutrients
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Journal Article
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RCRocco Caliandro
Rocco Caliandro
ASAstrid A. Streng
Astrid A. Streng
LKLinda W. M. van Kerkhof
Linda W. M. van Kerkhof
GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
ICInes Chaves
Ines Chaves
The term social jetlag is used to describe the discrepancy between biological time, determined by our internal body clock, and social times, mainly dictated by social obligations such as school or work. In industrialized countries, two-thirds of the studying/working population experiences social jetlag, often for several years. Described for the first time in 2006, a considerable effort has been put into understanding the effects of social jetlag on human physiopathology, yet our understanding of this phenomenon is still very limited. Due to its high prevalence, social jetlag is becoming a primary concern for public health. This review summarizes current knowledge regarding social jetlag, social jetlag associated behavior (e.g., unhealthy eating patterns) and related risks for human health.
4 August 2020 in Nutrients
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Journal Article
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MIMerel Italianer
Merel Italianer
ENEva F G Naninck
Eva F G Naninck
JRJorine A. Roelants
Jorine A. Roelants
GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
IRIrwin Reiss
Irwin Reiss
MVMarijn J. Vermeulen
Marijn J. Vermeulen
Background: Breastfeeding is considered the most optimal mode of feeding for neonates and mothers. Human milk changes over the course of lactation in order to perfectly suit the infant’s nutritional and immunological needs. Its composition also varies throughout the day. Circadian fluctuations in some bioactive components are suggested to transfer chronobiological information from mother to child to assist the development of the biological clock. This review aims to give a complete overview of studies examining human milk components found to exhibit circadian variation in their concentration. Methods: We included studies assessing the concentration of a specific human milk component more than once in 24 h. Study characteristics, including gestational age, lactational stage, sampling strategy, analytical method, and outcome were extracted. Methodological quality was graded using a modified Newcastle-Ottawa Scale (NOS). Results: A total of 83 reports assessing the circadian variation in the concentration of 71 human milk components were included. Heterogeneity among studies was high. The methodological quality varied widely. Significant circadian variation is found in tryptophan, fats, triacylglycerol, cholesterol, iron, melatonin, cortisol, and cortisone. This may play a role in the child’s growth and development in terms of the biological clock.
1 May 2020 in Journal of Molecular Biology
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Journal Article
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EFElham Farshadi
Elham Farshadi
GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
ICInes Chaves
Ines Chaves
Circadian control of cell division is well established in diverse organisms. Recent single-cell studies on mouse fibroblasts have shown that the circadian clock and cell cycle systems are robustly phase-coupled in a bidirectional manner. In healthy cells, coupling of clock and cell cycle results in timed mitosis and rhythmic DNA replication. However, little is known about the interplay between these two oscillators in cancer cells, which often display de-regulated cell proliferation and circadian gene expression. Here we review the molecular organization of the circadian clock and the cell cycle, as well as the reciprocal interaction between the circadian clock and the cell cycle in normal and in cancer cells. Understanding how the circadian clock and cell cycle are coupled in cancer cells will be instrumental to optimally take advantage of chronotherapy in cancer treatment, as efficiency of therapy benefits from asynchrony in timed mitosis between the host and the malignant cells in order to predict the optimal time of treatment.
28 December 2018 in Cell Cycle
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Journal Article
Open access
EFElham Farshadi
Elham Farshadi
JYJie Yan
Jie Yan
PLPierre Leclere
Pierre Leclere
AGAlbert Goldbeter
Albert Goldbeter
ICInes Chaves
Ines Chaves
GHGijsbertus T. J. Van Der Horst
Gijsbertus T. J. Van Der Horst
We previously identified a tight bidirectional phase coupling between the circadian clock and the cell cycle. To understand the role of the CLOCK/BMAL1 complex, representing the main positive regulator of the circadian oscillator, we knocked down Bmal1 or Clock in NIH3T33C mouse fibroblasts (carrying fluorescent reporters for clock and cell cycle phase) and analyzed timing of cell division in individual cells and cell populations. Inactivation of Bmal1 resulted in a loss of circadian rhythmicity and a lengthening of the cell cycle, originating from delayed G2/M transition. Subsequent molecular analysis revealed reduced levels of Cyclin B1, an important G2/M regulator, upon suppression of Bmal1 gene expression. In complete agreement with these experimental observations, simulation of Bmal1 knockdown in a computational model for coupled mammalian circadian clock and cell cycle oscillators (now incorporating Cyclin B1 induction by BMAL1) revealed a lengthening of the cell cycle. Similar data were obtained upon knockdown of Clock gene expression. In conclusion, the CLOCK/BMAL1 complex controls cell cycle progression at the level of G2/M transition through regulation of Cyclin B1 expression.
31 October 2023 in Nutrients
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HOHenrik Oster
Henrik Oster
ICInes Chaves
Ines Chaves
Among the many factors affecting general health and resilience to disease, lifestyle is at the same time the most controllable and the most influential factor