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Luiz Caldas
Faculty of Medicine, Universidade Federal Fluminense—UFF, Niterói 24001-970, Brazil

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Journal article
Published: 25 May 2021 in World
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If the current policy explores the utilization of active ingredients in use quickly and to the maximum, the same does not occur with the ban on the registration of products highly dangerous to both health and the environment. The current policy does not aim at reducing pesticide toxicity and ecotoxicity, required to reduce environmental contamination and human exposure. To this end, it is essential to adjust scientific evaluation parameters concerning lower concentration tolerance limits to modernity standards, in addition to banning products for which there is scientific evidence of carcinogenic, teratogenic, and mutagenic actions. In ecotoxicology, reducing the applicable concentration limits is paramount for preserving bees, birds, and other forms of domestic and wildlife. When evaluating active ingredients, it is imperative to prioritize more biodegradable molecules with low potential for environmental mobilization through volatilization and leaching, preserving both air and water quality. Another goal, among others, is a program for the generalized reduction of successfully implemented in several countries. Brazil, a tropical agriculture leader, should stand out by incorporating sustainability while preserving both health and the environment.

ACS Style

Tomaz Langenbach; Luiz Caldas; Tácio De Campos; Fábio Correia; Nelson Lorenz; Daniele Marinho; Denise Mano; Luiz Meirelles; Manildo Oliveira; Claudio Parente; João Torres; Leonardo Vicente; Eliana Vieira. Perspectives on Sustainable Pesticide Control in Brazil. World 2021, 2, 295 -301.

AMA Style

Tomaz Langenbach, Luiz Caldas, Tácio De Campos, Fábio Correia, Nelson Lorenz, Daniele Marinho, Denise Mano, Luiz Meirelles, Manildo Oliveira, Claudio Parente, João Torres, Leonardo Vicente, Eliana Vieira. Perspectives on Sustainable Pesticide Control in Brazil. World. 2021; 2 (2):295-301.

Chicago/Turabian Style

Tomaz Langenbach; Luiz Caldas; Tácio De Campos; Fábio Correia; Nelson Lorenz; Daniele Marinho; Denise Mano; Luiz Meirelles; Manildo Oliveira; Claudio Parente; João Torres; Leonardo Vicente; Eliana Vieira. 2021. "Perspectives on Sustainable Pesticide Control in Brazil." World 2, no. 2: 295-301.

Journal article
Published: 15 April 2016 in African Journal of Pharmacy and Pharmacology
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The present work aimed to compare the relative bioavailability of Zolapin with 100 mg tablet Leponex as a reference formulation, through a simple, robust and low-cost bioequivalence assays method. The study design was multiple-dose, randomized, crossover with patients in steady-state, and was performed with 24 schizophrenic male patients. Subjects received 100 mg twice a day of either Leponex or Zolapin for 10 days. At day 10 days of each study phase, blood samples were collected at different times during 12 h after drug administration and the clozapine concentration was determined by high performance liquid chromatography (HPLC). The individual peak plasma concentrations (Cmax) and the area under the concentration-time curve (AUC0-12h) ratios were calculated. The evaluated pharmacokinetic parameters were quite similar for both formulations. The 90% confidence interval for mean ratio of lnCmax (0.9677 to 0.9937) and lnAUC0-12h (0.9811 to 1.0029) were within accepted international guidelines. The results demonstrate that this methodological approach was able to identify Zolapin as bioequivalent to Leponex when orally administered, both in terms of the rate and extent of absorption, and therefore, suitable as a potential low-cost alternative to branded antipsychotic drugs. Key words: Clozapine, bioavailability, pharmacokinetics, schizophrenia.

ACS Style

De Oliveira Tim Oacute Teo Margareth; Gomes Alves Gutemberg; Perez Cardoso Gilberto; OleJ Beni; Vitor Mendlowicz Mauro; Guillermo Coca Velarde Luis; Querino De Ara Uacute Jo Caldas Luiz; Margareth De Oliveira Timóteo; Gutemberg Gomes Alves; Gilberto Perez Cardoso; Beni Olej; Mauro Vitor Mendlowicz; Luis Guillermo Coca Velarde; Luiz Querino De Araújo Caldas. Steady-state bioequivalence study of clozapine psychotic patients in Brazil. African Journal of Pharmacy and Pharmacology 2016, 10, 289 -297.

AMA Style

De Oliveira Tim Oacute Teo Margareth, Gomes Alves Gutemberg, Perez Cardoso Gilberto, OleJ Beni, Vitor Mendlowicz Mauro, Guillermo Coca Velarde Luis, Querino De Ara Uacute Jo Caldas Luiz, Margareth De Oliveira Timóteo, Gutemberg Gomes Alves, Gilberto Perez Cardoso, Beni Olej, Mauro Vitor Mendlowicz, Luis Guillermo Coca Velarde, Luiz Querino De Araújo Caldas. Steady-state bioequivalence study of clozapine psychotic patients in Brazil. African Journal of Pharmacy and Pharmacology. 2016; 10 (14):289-297.

Chicago/Turabian Style

De Oliveira Tim Oacute Teo Margareth; Gomes Alves Gutemberg; Perez Cardoso Gilberto; OleJ Beni; Vitor Mendlowicz Mauro; Guillermo Coca Velarde Luis; Querino De Ara Uacute Jo Caldas Luiz; Margareth De Oliveira Timóteo; Gutemberg Gomes Alves; Gilberto Perez Cardoso; Beni Olej; Mauro Vitor Mendlowicz; Luis Guillermo Coca Velarde; Luiz Querino De Araújo Caldas. 2016. "Steady-state bioequivalence study of clozapine psychotic patients in Brazil." African Journal of Pharmacy and Pharmacology 10, no. 14: 289-297.