Microarray data analysis is a major challenging field of research in recent days. Machine learning–based automated gene data classification is an essential aspect for diagnosis of gene related any malfunctions and diseases. As the size of the data is very large, it is essential to design a suitable classifier that can process huge amount of data. Deep learning is one of the advanced machine learning techniques to mitigate these types of problems. Due the presence of more number of hidden layers, it can easily handle the big amount of data. We have presented a method of classification to understand the convergence of training deep neural network (DNN). The assumptions are taken as the inputs do not degenerate and the network is over-parameterized. Also the number of hidden neurons is sufficiently large. Authors in this piece of work have used DNN for classifying the gene expressions data. The dataset used in the work contains the bone marrow expressions of 72 leukemia patients. A five-layer DNN classifier is designed for classifying acute lymphocyte (ALL) and acute myelocytic (AML) samples. The network is trained with 80% data and rest 20% data is considered for validation purpose. Proposed DNN classifier is providing a satisfactory result as compared to other classifiers. Two types of leukemia are classified with 98.2% accuracy, 96.59% sensitivity, and 97.9% specificity. The different types of computer-aided analyses of genes can be helpful to genetic and virology researchers as well in future generation.

Background: The modern era of human society has seen the rise of a different variety of diseases. The mortality rate, therefore, increases without adequate care which consequently causes wealth loss. It has become a priority of humans to take care of health and wealth in a genuine way. Methods: In this article, the authors endeavored to design a hospital management system with secured data processing. The proposed approach consists of three different phases. In the first phase, a smart healthcare system is proposed for providing an effective health service, especially to patients with a brain tumor. An application is developed that is compatible with Android and Microsoft-based operating systems. Through this application, a patient can enter the system either in person or from a remote place. As a result, the patient data are secured with the hospital and the patient only. It consists of patient registration, diagnosis, pathology, admission, and an insurance service module. Secondly, deep-learning-based tumor detection from brain MRI and EEG signals is proposed. Lastly, a modified SHA-256 encryption algorithm is proposed for secured medical insurance data processing which will help detect the fraud happening in healthcare insurance services. Standard SHA-256 is an algorithm which is secured for short data. In this case, the security issue is enhanced with a long data encryption scheme. The algorithm is modified for the generation of a long key and its combination. This can be applicable for insurance data, and medical data for secured financial and disease-related data. Results: The deep-learning models provide highly accurate results that help in deciding whether the patient will be admitted or not. The details of the patient entered at the designed portal are encrypted in the form of a 256-bit hash value for secured data management.