Sungrim Seirin-Lee

Prof. Sungrim Seirin-Lee

Hiroshima University
orcid

Research Focus & Metrics

Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 March 2010 in Bulletin of Mathematical Biology
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SSSungrim Seirin-Lee
Sungrim Seirin-Lee
EGEamonn Gaffney
Eamonn Gaffney
NMN. A. M. Monk
N. A. M. Monk

24 February 2011 in Bulletin of Mathematical Biology
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SSSungrim Seirin-Lee
Sungrim Seirin-Lee
EGEamonn Gaffney
Eamonn Gaffney
RBR. E. Baker
R. E. Baker

1 August 2013 in Journal of Theoretical Biology
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Journal Article
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SSSungrim Seirin-Lee
Sungrim Seirin-Lee
RBR.E. Baker
R.E. Baker
EGEamonn Gaffney
Eamonn Gaffney
SWS.M. White
S.M. White

22 May 2012 in Physical Review E
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Thomas WoolleyThomas Woolley
Thomas Woolley
RBRuth E. Baker
Ruth E. Baker
EGEamonn Gaffney
Eamonn Gaffney
Philip K. MainiPhilip K. Maini
Philip K. Maini
SSSungrim Seirin-Lee
Sungrim Seirin-Lee
Cellular gene expression is a complex process involving many steps, including the transcription of DNA and translation of mRNA; hence the synthesis of proteins requires a considerable amount of time, from ten minutes to several hours. Since diffusion-driven instability has been observed to be sensitive to perturbations in kinetic delays, the application of Turing patterning mechanisms to the problem of producing spatially heterogeneous differential gene expression has been questioned. In deterministic systems a small delay in the reactions can cause a large increase in the time it takes a system to pattern. Recently, it has been observed that in undelayed systems intrinsic stochasticity can cause pattern initiation to occur earlier than in the analogous deterministic simulations. Here we are interested in adding both stochasticity and delays to Turing systems in order to assess whether stochasticity can reduce the patterning time scale in delayed Turing systems. As analytical insights to this problem are difficult to attain and often limited in their use, we focus on stochastically simulating delayed systems. We consider four different Turing systems and two different forms of delay. Our results are mixed and lead to the conclusion that, although the sensitivity to delays in the Turing mechanism is not completely removed by the addition of intrinsic noise, the effects of the delays are clearly ameliorated in certain specific cases. DOI: http://dx.doi.org/10.1103/PhysRevE.85.051914 ©2012 American Physical Society

1 October 2015 in Journal of Theoretical Biology
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SSSungrim Seirin-Lee
Sungrim Seirin-Lee
TSTatsuo Shibata
Tatsuo Shibata