Cleofe Palocci

Dr. Cleofe Palocci

Department of Chemistry, Università degli Studi di Roma La Sapienza, Roma, Italy

Research Focus & Metrics

Academic Career Length

33Years (1994-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 August 2022 in Materials
Verified
Journal Article
Open access
PDF file
Roya BinaymotlaghRoya Binaymotlagh
Roya Binaymotlagh
Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
FHFarid Hajareh Haghighi
Farid Hajareh Haghighi
Ilaria FratoddiIlaria Fratoddi
Ilaria Fratoddi
Cleofe PalocciCleofe Palocci
Cleofe Palocci
Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

6 December 2020 in Biology
Verified
Journal Article
Open access
PDF file
FSFabio Sciubba
Fabio Sciubba
Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
DPDaniele Pizzichini
Daniele Pizzichini
VLVincenzo Lionetti
Vincenzo Lionetti
CFClaudia Fontana
Claudia Fontana
DBDaniela Bellincampi
Daniela Bellincampi
Olive oil production generates high amounts of liquid and solid wastes. For a long time, such complex matrices were considered only as an environmental issue, due to their polluting properties. On the other hand, olive mill wastes (OMWs) exert a positive effect on plant growth when applied to soil due to the high content of organic matter and mineral nutrients. Moreover, OMWs also exhibit antimicrobial activity and protective properties against plant pathogens possibly due to the presence of bioactive molecules including phenols and polysaccharides. This review covers the recent advances made in the identification, isolation, and characterization of OMW-derived bioactive molecules able to influence important plant processes such as plant growth and defend against pathogens. Such studies are relevant from different points of view. First, basic research in plant biology may benefit from the isolation and characterization of new biomolecules to be potentially applied in crop growth and protection against diseases. Moreover, the valorization of waste materials is necessary for the development of a circular economy, which is foreseen to drive the future development of a more sustainable agriculture.

22 April 2024 in Gels
Verified
Journal Article
Open access
PDF file
Roya BinaymotlaghRoya Binaymotlagh
Roya Binaymotlagh
FHFarid Hajareh Haghighi
Farid Hajareh Haghighi
Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
Cleofe PalocciCleofe Palocci
Cleofe Palocci
Various controlled delivery systems (CDSs) have been developed to overcome the shortcomings of traditional drug formulations (tablets, capsules, syrups, ointments, etc.). Among innovative CDSs, hydrogels and liposomes have shown great promise for clinical applications thanks to their cost-effectiveness, well-known chemistry and synthetic feasibility, biodegradability, biocompatibility and responsiveness to external stimuli. To date, several liposomal- and hydrogel-based products have been approved to treat cancer, as well as fungal and viral infections, hence the integration of liposomes into hydrogels has attracted increasing attention because of the benefit from both of them into a single platform, resulting in a multifunctional drug formulation, which is essential to develop efficient CDSs. This short review aims to present an updated report on the advancements of liposome–hydrogel systems for drug delivery purposes.

28 April 2010 in Soft Matter
Verified
Journal Article
Closed access
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Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
SLSilvia Lorenzoni
Silvia Lorenzoni
GMgiancarlo masci
giancarlo masci
MDMariella Dentini
Mariella Dentini
ATAnna Rita Togna
Anna Rita Togna
Cleofe PalocciCleofe Palocci
Cleofe Palocci
Self-assembling gelling peptides are increasingly being investigated as defined biomatrices for biomedical applications. Using an enzymatic reaction to convert a precursor into a hydrogelator one can control or modulate functions and responses of a hydrogel, depending on its preparation conditions. This work details the self-assembly, under physiological conditions, of amphiphilic building blocks consisting of tripeptides (Phe3) linked to fluorenylmethoxycarbonyl (Fmoc) obtained by using a lipase to link an Fmoc–Phe amino acid to the dipeptide diphenylalanine (Phe2 ). The viscoelastic properties of the tripeptides obtained were investigated. SEM and AFM images of Fmoc–peptides confirmed that they self-assemble to generate supramolecular aggregates driven by π–π stacking interactions of the Fmoc groups.

22 November 2014 in Journal of Nanoparticle Research
Verified
Journal Article
Closed access
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Alessio VallettaAlessio Valletta
Alessio Valletta
Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
Cleofe PalocciCleofe Palocci
Cleofe Palocci
BBBarbara Baldan
Barbara Baldan
LDLivia Donati
Livia Donati
GPGabriella Pasqua
Gabriella Pasqua

10 February 2011 in Soft Matter
Verified
Journal Article
Closed access
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Laura ChronopoulouLaura Chronopoulou
Laura Chronopoulou
GKGihan Kamel
Gihan Kamel
CSCarolina Sparago
Carolina Sparago
FBFederico Bordi
Federico Bordi
SLStefano Lupi
Stefano Lupi
Cleofe PalocciCleofe Palocci
Cleofe Palocci
Interfacing proteins with nanostructured materials offers the possibility to obtain novel bioconjugates for many applications. We report herein the ability of nanostructured poly-DL-lactic acid (PDLLA) based carriers to enhance enzymatic activity and stability. PDLLA was processed using an innovative patented methodology that permitted to obtain spherical nanoparticles with an average diameter of 220 nm that were used as carrier for the physical adsorption of Candida rugosalipase (CRL). Enzymatic activity and stability of CRL before and after conjugation to the nanopolymeric support were evaluated in different conditions (pH, T, organic solvents) and the conformational changes of CRL produced by its interaction with the nanopolymeric carrier were investigated by using Fourier Transform Infrared (FTIR) spectroscopy. A comparative study between X-ray diffraction data in the literature and experimental FTIR results gave deeper insight into the conformational features of the immobilized protein.