In this study, successful synthesis of ZnO nanoparticles (NPs), CuO NPs, and ZnO/CuO nanocomposite through an eco-friendly method using Corriandrum sativum leaf extract as a capping agent is reported. Using XRD, FTIR, UV-Vis, and SEM techniques, the synthesized materials were characterized for structural analysis, functional groups identification, spectroscopic measurements, and morphological analysis. The percentage composition and purity of the samples were determined by using Energy Dispersive X-ray (EDX), which showed the synthesis of materials. Morphological analysis was done by Scanning Electron Microscopy (SEM) which reflected that the CuO NPs, ZnO NPs and ZnO/CuO nanocomposite were spherical, and the average size calculated by using Image J software was around 25 nm, 55 nm, and 11 nm, respectively. FTIR and UV-Vis analyses were used for synthetic confirmation through characteristic peaks of materials. The synthesized (ZnO, CuO, and CuO/ZnO) nanomaterials were evaluated for photocatalytic activity using methylene blue (MB) dye. Among all three photocatalysts, the composite showed maximum photodegradation compared to the other two materials. The present work could lead to a pathway for the decontamination of harmful dyes of wastewater released from different industries.

While the consumption of seaweed and seaweed-based products is very common amongst East Asian nations, forming a notable component of the daily diet, relatively very few studies have concerned the concentrations of heavy metals in these together with potential effects on human health. The present study analyses the concentrations of 17 elements in locally resourced seaweed, also assessing potential noncarcinogenic and carcinogenic risks. The samples were ground, homogenized, and quantified using the ICP-OES technique. It has been found that the essential elements K, Ca, Mg, Zn, and Na typically show concentrations somewhat greater than a number of potentially toxic metals, in particular, Cd, Pb, Ag, and As, with exceptions being Ni, Cr-VI, and Si. Statistical analysis indicates all of the latter to have similar origin, with increased concentration of these metals within the marine ecosystem. While the daily estimated intake of most metals is seen to be within the daily dietary allowance level recommended by various international organizations, the noncarcinogenic risk shows a value greater than unity, estimated via the hazard quotient. This indicates a potential for adverse effects to health arising from consumption of the sampled seaweed. The carcinogenic risk resulting from nonessential elements shows values greater than the United States Environmental Protection Agency (US-EPA) reference limit of 10⁻⁴. Considering the nonbiodegradability of heavy metals and metalloids and their potential accumulation in seaweed, there is need for critical examination of metal levels in the seaweeds obtained from the present study locations, together with the introduction of practices of removal of heavy metals via bio-adsorbent techniques.

This paper describes the establishment of free-standing rolled graphene oxide (roll-GO) and polypyrrole (Ppy) using a modified Hummer method and oxidative polymerization. Then, a photodetector was created by removing a thin film of the free-standing rolled graphene oxide from a filter paper and attaching it to a tape. The chemical structure of the roll-GO was confirmed using XRD and FTIR analysis, while SEM and TEM showed that it was rolled in nature. The material had a small bandgap of 2.4 eV and a high current density in light conditions. The photodetector responded well to monochromatic light, with J_ph values changing from 0.027 to 0.019 mA/cm² as the light wavelengths decreased from 340 to 730 nm. The photoresponsivity (R) and detectivity (D) values were high, at 340 nm (0.27 mA/W and 6.0 × 10⁷ Jones, respectively) and at 730 nm (0.19 and 4.25 × 10⁷ Jones, respectively). The addition of Ppy improved these parameters, with the Ppy/roll-GO/tape photoelectrode showing excellent R and D values of 0.33 mA/W and 7.34 × 10⁷ Jones, respectively. Furthermore, the production of a photocurrent at V = 0 indicated that the Ppy/roll-GO layer could be used for solar cell applications. Overall, the results suggest that the prepared free-standing Ppy/roll-GO/tape photodetector has high potential for use in the optical region between 340 and 730 nm and may be suitable for industrial applications.

P-glycoprotein (P-gp) is known as the "multidrug resistance protein" because it contributes to tumor resistance to several different classes of anticancer drugs. The effectiveness of such polymers in treating cancer and delivering drugs has been shown in a wide range of in vitro and in vivo experiments. The primary objective of the present study was to investigate the inhibitory effects of several naturally occurring polymers on P-gp efflux, as it is known that P-gp inhibition can impede the elimination of medications. The objective of our study is to identify polymers that possess the potential to inhibit P-gp, a protein involved in drug resistance, with the aim of enhancing the effectiveness of anticancer drug formulations. The ADMET profile of all the selected polymers (Agarose, Alginate, Carrageenan, Cyclodextrin, Dextran, Hyaluronic acid, and Polysialic acid) has been studied, and binding affinities were investigated through a computational approach using the recently released crystal structure of P-gp with PDB ID: 7O9W. The advanced computational study was also done with the help of molecular dynamics simulation. The aim of the present study is to overcome MDR resulting from the activity of P-gp by using such polymers that can inhibit P-gp when used in formulations. The docking scores of native ligand, Agarose, Alginate, Carrageenan, Chitosan, Cyclodextrin, Dextran, Hyaluronic acid, and Polysialic acid were found to be −10.7, −8.5, −6.6, −8.7, −8.6, −24.5, −6.7, −8.3, and −7.9, respectively. It was observed that, Cyclodextrin possess multiple properties in drug delivery science and here also demonstrated excellent binding affinity. We propose that drug efflux-related MDR may be prevented by the use of Agarose, Carregeenan, Chitosan, Cyclodextrin, Hyaluronic acid, and/or Polysialic acid in the administration of anticancer drugs.