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Dr. Katarzyna Wróblewska-Seniuk
Poznan University of Medical Sciences, Department of Newborns' Infectious Diseases

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0 Hypoglycemia
0 Newborn
0 Diabetes In Pregnancy
0 hearing screening
0 hearing deficit

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Review
Published: 04 March 2021 in Journal of Clinical Medicine
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Pediatric-adolescent or developmental gynecology has been separated from general gynecology because of the unique issues that affect the development and anatomy of growing girls and young women. It deals with patients from the neonatal period until maturity. There are not many gynecological problems that can be diagnosed in newborns; however, some are typical of the neonatal period. This paper aims to discuss the most frequent gynecological issues in the neonatal period.

ACS Style

Katarzyna Wróblewska-Seniuk; Grażyna Jarząbek-Bielecka; Witold Kędzia. Gynecological Problems in Newborns and Infants. Journal of Clinical Medicine 2021, 10, 1071 .

AMA Style

Katarzyna Wróblewska-Seniuk, Grażyna Jarząbek-Bielecka, Witold Kędzia. Gynecological Problems in Newborns and Infants. Journal of Clinical Medicine. 2021; 10 (5):1071.

Chicago/Turabian Style

Katarzyna Wróblewska-Seniuk; Grażyna Jarząbek-Bielecka; Witold Kędzia. 2021. "Gynecological Problems in Newborns and Infants." Journal of Clinical Medicine 10, no. 5: 1071.

Journal article
Published: 04 November 2020 in Journal of Clinical Medicine
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Background: Our aim was to investigate whether the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) glycemic thresholds used for detecting hyperglycemia in pregnancy can be predictive for malformations in women with hyperglycemia detected in early pregnancy. Methods: a single-center, retrospective observational trial of 125 mother-infant pairs from singleton pregnancies with hyperglycemia according to the IADPSG criteria diagnosed at the gestational age below 16 weeks. Glucose values obtained from 75-g OGTT (oral glucose tolerance test) were investigated as predictors for congenital malformations in newborns. Results: Characteristics of the cohort: maternal age: 31.5 ± 5.2, pre-pregnancy body mass index (BMI) ≥ 30 kg/m2: 42.0%, gestational age at diagnosis (weeks): 12.0 ± 4.0, and newborns with congenital malformations: 8.8%. Fasting blood glycemia (FBG) and HbA1c (Haemoglobin A1c) at baseline significantly predicted the outcome (expB: 1.06 (1.02–1.1), p = 0.007 and expB: 2.05 (1.24–3.38), p = 0.005, respectively). Both the fasting blood glucose (FBG) value of 5.1 mmol/dL (diagnostic for gestational diabetes mellitus (GDM)) and 5.5 mmol/dL (upper limit for normoglycemia in the general population) significantly increased the likelihood ratio (LR) for fetal malformations: 1.3 (1.1; 1.4) and 1.5 (1.0; 2.4), respectively. Conclusions: (1) Fasting glycemia diagnostic for GDM measured in early pregnancy is associated with a significantly elevated risk for congenital malformations. (2) Our data suggest that women at elevated risks of GDM/diabetes in pregnancy (DiP) should have their fasting blood glucose assessed before becoming pregnant, and the optimization of glycemic control should be considered if the FBG exceeds 5.1 mmol/dL.

ACS Style

Agnieszka Zawiejska; Katarzyna Wróblewska-Seniuk; Paweł Gutaj; Urszula Mantaj; Anna Gomulska; Joanna Kippen; Ewa Wender-Ozegowska. Early Screening for Gestational Diabetes Using IADPSG Criteria May Be a Useful Predictor for Congenital Anomalies: Preliminary Data from a High-Risk Population. Journal of Clinical Medicine 2020, 9, 3553 .

AMA Style

Agnieszka Zawiejska, Katarzyna Wróblewska-Seniuk, Paweł Gutaj, Urszula Mantaj, Anna Gomulska, Joanna Kippen, Ewa Wender-Ozegowska. Early Screening for Gestational Diabetes Using IADPSG Criteria May Be a Useful Predictor for Congenital Anomalies: Preliminary Data from a High-Risk Population. Journal of Clinical Medicine. 2020; 9 (11):3553.

Chicago/Turabian Style

Agnieszka Zawiejska; Katarzyna Wróblewska-Seniuk; Paweł Gutaj; Urszula Mantaj; Anna Gomulska; Joanna Kippen; Ewa Wender-Ozegowska. 2020. "Early Screening for Gestational Diabetes Using IADPSG Criteria May Be a Useful Predictor for Congenital Anomalies: Preliminary Data from a High-Risk Population." Journal of Clinical Medicine 9, no. 11: 3553.

Journal article
Published: 25 September 2020 in Children
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The goal of this analysis is to identify risk factors for infantile hemangiomas (IH) to better delineate hemangioma predisposition. We analyzed live birth children with isolated cutaneous hemangioma that were reported to the Polish Registry of Congenital Malformations from across Poland between the years 1998 and 2016. Lower birthweight and gestational age were the most significant risk factors associated with IH. We also observed a trend for a higher risk of IH with a lower level of maternal and paternal education. Moreover, mothers with IH have a higher probability of having a child with IH compared to fathers. However, this association is only present when the child is female. Similarly, a higher risk of hemangioma in a female child is found among mothers having relatives of the first degree with IH, compared to fathers with a similar pedigree. Our results suggest the role of exogenous factors in the etiology of IH. The analysis of familial cases suggests a multifactorial model of inheritance. The study indicates that female gender is an important risk factor for the expression of familial IH. Potential interaction of genetic risk factors with exposure to female sex hormones may play a role in the development of IH.

ACS Style

Anna Materna-Kiryluk; Katarzyna Wiśniewska; Barbara Więckowska; Katarzyna Wróblewska-Seniuk; Beata Jaroszewska-Świątek; Ewa Helwich; Anna Latos-Bieleńska. Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants. Children 2020, 7, 150 .

AMA Style

Anna Materna-Kiryluk, Katarzyna Wiśniewska, Barbara Więckowska, Katarzyna Wróblewska-Seniuk, Beata Jaroszewska-Świątek, Ewa Helwich, Anna Latos-Bieleńska. Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants. Children. 2020; 7 (10):150.

Chicago/Turabian Style

Anna Materna-Kiryluk; Katarzyna Wiśniewska; Barbara Więckowska; Katarzyna Wróblewska-Seniuk; Beata Jaroszewska-Świątek; Ewa Helwich; Anna Latos-Bieleńska. 2020. "Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants." Children 7, no. 10: 150.

Novel insights from clinical practice
Published: 13 July 2020 in Biomedicine Hub
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Congenital laryngeal stenosis is a rare and unusual anomaly that usually presents in the first minutes after delivery as severe life-threatening respiratory distress. It may exist as an isolated entity or in association with other congenital malformations, in particular cardiac anomalies. In this paper, we present the case of an infant with prenatal suspicion of tetralogy of Fallot. Immediately after delivery, the patient required intubation, which proved difficult. He was eventually diagnosed with laryngeal stenosis requiring laryngological treatment.

ACS Style

Patrycja Tesmer; Katarzyna Wróblewska-Seniuk; Jan Mazela; Jarosław Szydłowski. Congenital Laryngeal Stenosis and Concomitant Birth Defects in a Term Newborn: A Case Report. Biomedicine Hub 2020, 5, 1 -7.

AMA Style

Patrycja Tesmer, Katarzyna Wróblewska-Seniuk, Jan Mazela, Jarosław Szydłowski. Congenital Laryngeal Stenosis and Concomitant Birth Defects in a Term Newborn: A Case Report. Biomedicine Hub. 2020; 5 (2):1-7.

Chicago/Turabian Style

Patrycja Tesmer; Katarzyna Wróblewska-Seniuk; Jan Mazela; Jarosław Szydłowski. 2020. "Congenital Laryngeal Stenosis and Concomitant Birth Defects in a Term Newborn: A Case Report." Biomedicine Hub 5, no. 2: 1-7.

Journal article
Published: 01 January 2020 in Clinical and Experimental Obstetrics & Gynecology
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ACS Style

K. Wróblewska-Seniuk; G. Jarząbek-Bielecka; W. Kędzia. Freeman-Sheldon syndrome - a course of the disease from birth to adulthood. Clinical and Experimental Obstetrics & Gynecology 2020, 47, 978 -982.

AMA Style

K. Wróblewska-Seniuk, G. Jarząbek-Bielecka, W. Kędzia. Freeman-Sheldon syndrome - a course of the disease from birth to adulthood. Clinical and Experimental Obstetrics & Gynecology. 2020; 47 (6):978-982.

Chicago/Turabian Style

K. Wróblewska-Seniuk; G. Jarząbek-Bielecka; W. Kędzia. 2020. "Freeman-Sheldon syndrome - a course of the disease from birth to adulthood." Clinical and Experimental Obstetrics & Gynecology 47, no. 6: 978-982.

Journal article
Published: 29 March 2019 in Ginekologia Polska
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An attempt was made to demonstrate the superiority of the treatment model using continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) of insulin in achieving a successful pregnancy outcome and good newborn's condition in patients with type 1 diabetes. The study included 297 infants born to type 1 diabetic patients; 175 patients were treated with MDI and 122 with CSII. Maternal metabolic control during pregnancy, gestational weight gain, insulin requirements, pregnancy outcome and neonatal status were compared between MDI and CSII arm. The composite adverse neonatal outcome was diagnosed if at least one of the following was found: abnormal birth weight (LGA or SGA), congenital malformation, miscarriage, intrauterine fetal death, emergency CS due to fetal risk, iatrogenic prematurity, RDS, hypoglycemia, hyperbilirubinemia, and the postpartum pH in the umbilical artery ≤ 7.1. The studied groups did not differ regarding gestational week at delivery, a proportion of births at full term, preterm births, miscarriages, or late pregnancy losses (intrauterine fetal death > 22 weeks). Newborns of mothers treated with CSII showed lower incidence of neonatal complications (composite adverse neonatal outcome) compared to those of mothers treated with MDI (60% vs 74%, respectively; p = 0.01). We did not find any association between the mode of treatment and composite adverse maternal outcome. The use of CSII in the treatment of pregnant women with type 1 diabetes was associated with reduced number of neonatal complications presented as neonatal composite outcome but had no influence on maternal outcome.

ACS Style

Urszula Mantaj; Pawel Gutaj; Katarzyna Ozegowska; Agnieszka Zawiejska; Katarzyna Wróblewska-Seniuk; Danuta Olejniczak; Ewa Wender-Ozegowska. Continuous subcutaneous insulin infusion reduces neonatal risk in pregnant women with type 1 diabetes mellitus. Ginekologia Polska 2019, 90, 154 -160.

AMA Style

Urszula Mantaj, Pawel Gutaj, Katarzyna Ozegowska, Agnieszka Zawiejska, Katarzyna Wróblewska-Seniuk, Danuta Olejniczak, Ewa Wender-Ozegowska. Continuous subcutaneous insulin infusion reduces neonatal risk in pregnant women with type 1 diabetes mellitus. Ginekologia Polska. 2019; 90 (3):154-160.

Chicago/Turabian Style

Urszula Mantaj; Pawel Gutaj; Katarzyna Ozegowska; Agnieszka Zawiejska; Katarzyna Wróblewska-Seniuk; Danuta Olejniczak; Ewa Wender-Ozegowska. 2019. "Continuous subcutaneous insulin infusion reduces neonatal risk in pregnant women with type 1 diabetes mellitus." Ginekologia Polska 90, no. 3: 154-160.

Journal article
Published: 01 February 2018 in International Journal of Pediatric Otorhinolaryngology
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The prevalence of most risk factors of hearing deficit was similar in children with sensorineural, conductive and mixed type of hearing loss, only hyperbilirubinemia seemed to predispose to sensorineural hearing deficit and isolated craniofacial malformations seemed to be associated with conductive hearing loss. Sensorineural hearing deficit usually occurred bilaterally and was severe or profound, while conductive and mixed type of hearing deficit were most often of mild degree. Most children with the final diagnosis of sensorineural hearing deficit had positive result of hearing screening by means of otoacoustic emissions.

ACS Style

Katarzyna Wroblewska-Seniuk; Piotr Dabrowski; Grazyna Greczka; Katarzyna Szabatowska; Agata Glowacka; Witold Szyfter; Jan Mazela. Sensorineural and conductive hearing loss in infants diagnosed in the program of universal newborn hearing screening. International Journal of Pediatric Otorhinolaryngology 2018, 105, 181 -186.

AMA Style

Katarzyna Wroblewska-Seniuk, Piotr Dabrowski, Grazyna Greczka, Katarzyna Szabatowska, Agata Glowacka, Witold Szyfter, Jan Mazela. Sensorineural and conductive hearing loss in infants diagnosed in the program of universal newborn hearing screening. International Journal of Pediatric Otorhinolaryngology. 2018; 105 ():181-186.

Chicago/Turabian Style

Katarzyna Wroblewska-Seniuk; Piotr Dabrowski; Grazyna Greczka; Katarzyna Szabatowska; Agata Glowacka; Witold Szyfter; Jan Mazela. 2018. "Sensorineural and conductive hearing loss in infants diagnosed in the program of universal newborn hearing screening." International Journal of Pediatric Otorhinolaryngology 105, no. : 181-186.

Research article
Published: 14 September 2017 in PLoS ONE
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The incidence of sensorineural hearing loss is between 1 and 3 per 1000 in healthy neonates and 2–4 per 100 in high-risk infants. The national universal neonatal hearing screening carried out in Poland since 2002 enables selection of infants with suspicion and/or risk factors of hearing loss. In this study, we assessed the incidence and risk factors of hearing impairment in infants ≤33 weeks’ gestational age (wga). We analyzed the database of the Polish Universal Newborns Hearing Screening Program from 2010 to 2013. The study group involved 11438 infants born before 33 wga, the control group—1487730 infants. Screening was performed by means of transient evoked otoacoustic emissions. The risk factors of hearing loss were recorded. Infants who failed the screening test and/or had risk factors were referred for further audiological evaluation. Hearing deficit was diagnosed in 11% of infants ≤25 wga, 5% at 26–27 wga, 3.46% at 28 wga and 2–3% at 29–32 wga. In the control group the incidence of hearing deficit was 0.2% (2.87% with risk factors). The most important risk factors were craniofacial malformations, very low birth weight, low Apgar score and mechanical ventilation. Hearing screening was positive in 22.42% newborns ≤28 wga and 10% at 29–32 wga and in the control group. Hearing impairment is a severe consequence of prematurity. Its prevalence is inversely related to the maturity of the baby. Premature infants have many concomitant risk factors which influence the occurrence of hearing deficit.

ACS Style

Katarzyna Wroblewska-Seniuk; Grazyna Greczka; Piotr Dabrowski; Joanna Szyfter-Harris; Jan Mazela. Hearing impairment in premature newborns—Analysis based on the national hearing screening database in Poland. PLoS ONE 2017, 12, e0184359 .

AMA Style

Katarzyna Wroblewska-Seniuk, Grazyna Greczka, Piotr Dabrowski, Joanna Szyfter-Harris, Jan Mazela. Hearing impairment in premature newborns—Analysis based on the national hearing screening database in Poland. PLoS ONE. 2017; 12 (9):e0184359.

Chicago/Turabian Style

Katarzyna Wroblewska-Seniuk; Grazyna Greczka; Piotr Dabrowski; Joanna Szyfter-Harris; Jan Mazela. 2017. "Hearing impairment in premature newborns—Analysis based on the national hearing screening database in Poland." PLoS ONE 12, no. 9: e0184359.

Journal article
Published: 20 February 2017 in International Journal of Pediatric Otorhinolaryngology
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Long term monitoring and the appropriate management of hearing deficit in children is essential. UNHS seems to be the most efficient way of finding children who require treatment of hearing impairment. The prevalence of most risk factors of hearing deficit has significantly changed over the years. The number of false positive results has significantly decreased over the years thanks to better staff training.

ACS Style

Katarzyna Wroblewska-Seniuk; Grazyna Greczka; Piotr Dabrowski; Witold Szyfter; Jan Mazela. The results of newborn hearing screening by means of transient otoacoustic emissions – has anything changed over 10 years? International Journal of Pediatric Otorhinolaryngology 2017, 96, 4 -10.

AMA Style

Katarzyna Wroblewska-Seniuk, Grazyna Greczka, Piotr Dabrowski, Witold Szyfter, Jan Mazela. The results of newborn hearing screening by means of transient otoacoustic emissions – has anything changed over 10 years? International Journal of Pediatric Otorhinolaryngology. 2017; 96 ():4-10.

Chicago/Turabian Style

Katarzyna Wroblewska-Seniuk; Grazyna Greczka; Piotr Dabrowski; Witold Szyfter; Jan Mazela. 2017. "The results of newborn hearing screening by means of transient otoacoustic emissions – has anything changed over 10 years?" International Journal of Pediatric Otorhinolaryngology 96, no. : 4-10.

Obstetrics
Published: 01 October 2013 in Obstetrical & Gynecological Survey
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Perinatal outcomes similar to those in nondiabetic parturients are the aim for pregnancies complicated by type 1 diabetes mellitus (T1DM). The inability to achieve stable daily maternal glycemic control is a main cause for poor pregnancy outcomes in diabetic women. Currently, the methods to enhance glycemic control in T1DM are continuous subcutaneous insulin infusion through a pump and multiple daily injections. This retrospective observational study was designed to assess and compare insulin injections and the insulin pump for their ability to improve maternal glycemic control. This study involved 128 patients with T1DM treated between 2004 and 2009. Data from 64 T1DM women treated with insulin pumps and 64 treated with insulin injections during pregnancy were obtained and retrospectively matched for age, beginning and duration of diabetes, body mass index before gestation, and HbA1c in the first trimester. A basalbolus protocol in patients utilizing insulin injections involved 4 or 5 daily injections of short- and long-lasting human insulin (or short-acting insulin analogues). Women received 20% to 30%, 15%, and 20% of total daily requirement of short-acting insulin before breakfast, lunch, and supper, respectively. Neutral protamine Hagedorn (NPH) insulin was administered once daily at bedtime (∼40% of the total daily dosage) or twice a day for a 5-injection protocol (morning and bedtime injections). Women on insulin pumps received short-acting insulin analogs (50% in the basal flow and remaining 50% of the daily requirements divided as boluses before meals). All parturients self-controlled their blood glucose levels 4 times daily and completed a diurnal glucose profile once a week. The target fasting glucose level was less than 5.0 mmol/L, and the 2-hour postprandial glucose target was less than 6.7 mmol/L. Episodes of hypoglycemia (glucose level G3.3mmol/L) and hyperglycemia (glucose level Q7.8mmol/L) and insulin requirements in each trimester were recorded. Neonatal data included gestational age at delivery, birth weight, 5-minute Apgar score, arterial umbilical pH value, numbers of preterm deliveries, and large- and small-for-gestational age infants. Infant hypoglycemia was diagnosed if the glucose level was less than 2.2 mmol/L, hypocalcemia if the calcium level was less than 1.8 mmol/L, and hypomagnesemia if the magnesium level was less than 0.6mmol/L. Hyperbilirubinemia and perinatal acidosis were also determined. The study groups were similar in demographic characteristics. The reduction in HbA1c level during pregnancy was significant only in the insulin pump group (P < 0.0004). In addition, there was a statistically significant decline in hypoglycemic episodes only in the insulin pump group. In both groups, perinatal outcomes and neonatal characteristics were similar, except for the incidences of neonatal hypocalcemia (injections, n = 25 [44.6%]; pump, n = 13 [22%]; P < 0.01). This study showed that the insulin pump can be safe as intensive insulin therapy with similar glycemic effects as subcutaneous injections, with a reduced rate of hypoglycemia and decreased insulin requirements.

ACS Style

Ewa Wender-Ozegowska; Agnieszka Zawiejska; Katarzyna Ozegowska; Katarzyna Wroblewska-Seniuk; Rafal Iciek; Urszula Mantaj; Danuta Olejniczak; Jacek Brazert. Multiple Daily Injections of Insulin Versus Continuous Subcutaneous Insulin Infusion for Pregnant Women With Type 1 Diabetes. Obstetrical & Gynecological Survey 2013, 68, 675 -677.

AMA Style

Ewa Wender-Ozegowska, Agnieszka Zawiejska, Katarzyna Ozegowska, Katarzyna Wroblewska-Seniuk, Rafal Iciek, Urszula Mantaj, Danuta Olejniczak, Jacek Brazert. Multiple Daily Injections of Insulin Versus Continuous Subcutaneous Insulin Infusion for Pregnant Women With Type 1 Diabetes. Obstetrical & Gynecological Survey. 2013; 68 (10):675-677.

Chicago/Turabian Style

Ewa Wender-Ozegowska; Agnieszka Zawiejska; Katarzyna Ozegowska; Katarzyna Wroblewska-Seniuk; Rafal Iciek; Urszula Mantaj; Danuta Olejniczak; Jacek Brazert. 2013. "Multiple Daily Injections of Insulin Versus Continuous Subcutaneous Insulin Infusion for Pregnant Women With Type 1 Diabetes." Obstetrical & Gynecological Survey 68, no. 10: 675-677.

Comparative study
Published: 01 August 2013 in Journal of Biomedical Optics
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The aim of this study is to compare a two-wavelength light emitting diode–based tissue oximeter (INVOS), which is designed to show trends in tissue oxygenation, with a four-wavelength laser–based oximeter (FORE-SIGHT), designed to deliver absolute values of tissue oxygenation. Simultaneous values of cerebral tissue oxygenation (StO2) are measured using both devices in 15 term and 15 preterm clinically stable newborns on the first and third day of life. Values are recorded simultaneously in two periods between which oximeter sensor positions are switched to the contralateral side. Agreement between StO2 values before and after the change of sensor position is analyzed. We find that mean cerebral StO2 values are similar between devices for term and preterm babies, but INVOS shows StO2 values spread over a wider range, with wider standard deviations than shown by the FORE-SIGHT. There is relatively good agreement with a bias up to 3.5% and limits of agreement up to 11.8%. Measurements from each side of the forehead show better repeatability for the FORE-SIGHT monitor. We conclude that performance of the two devices is probably acceptable for clinical purposes. Both performed sufficiently well, but the use of FORE-SIGHT may be associated with tighter range and better repeatability of data.

ACS Style

Tomasz Szczapa; Łukasz Karpiński; Jerzy Moczko; Michael Weindling; Alicja Kornacka; Katarzyna Wróblewska-Seniuk; Aleksandra Adamczak; Aleksandra Jopek; Karolina Chojnacka; Janusz Gadzinowski. Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy devices: an absolute and a relative trending oximeter. Journal of Biomedical Optics 2013, 18, 087006 -087006.

AMA Style

Tomasz Szczapa, Łukasz Karpiński, Jerzy Moczko, Michael Weindling, Alicja Kornacka, Katarzyna Wróblewska-Seniuk, Aleksandra Adamczak, Aleksandra Jopek, Karolina Chojnacka, Janusz Gadzinowski. Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy devices: an absolute and a relative trending oximeter. Journal of Biomedical Optics. 2013; 18 (8):087006-087006.

Chicago/Turabian Style

Tomasz Szczapa; Łukasz Karpiński; Jerzy Moczko; Michael Weindling; Alicja Kornacka; Katarzyna Wróblewska-Seniuk; Aleksandra Adamczak; Aleksandra Jopek; Karolina Chojnacka; Janusz Gadzinowski. 2013. "Comparison of cerebral tissue oxygenation values in full term and preterm newborns by the simultaneous use of two near-infrared spectroscopy devices: an absolute and a relative trending oximeter." Journal of Biomedical Optics 18, no. 8: 087006-087006.

Comparative study
Published: 15 January 2013 in Australian and New Zealand Journal of Obstetrics and Gynaecology
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The aim was to evaluate the outcome of pregnancies with type 1 diabetes (T1DM) treated from the first trimester with continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). In a retrospective, observational study, we matched 64 CSII patients for age, age at onset and duration of diabetes and HbA1c in the first trimester with 64 MDI pregnancies. We analysed carbohydrate metabolism, insulin requirements, development of PIH, progression of retinopathy and fetal outcome. In CSII group, we found a significantly smaller insulin requirement both at the beginning of pregnancy and before delivery, significant decrease in HbA1c levels and significantly smaller number of hypoglycaemic episodes in the second trimester and significantly more hyperglycaemic episodes in the first trimester. In both groups, maternal, fetal and perinatal outcomes were similar and the number of hypo‐ and hyperglycaemic episodes decreased throughout pregnancy. Continuous subcutaneous insulin infusion (CSII) treatment in pregnant women with type 1 diabetes is associated with a reduced number of hypoglycaemia and decreased insulin requirement. We noted no difference in perinatal outcome comparing women on multiple insulin injections with those on continuous insulin infusion.

ACS Style

Ewa Wender-Ozegowska; Agnieszka Zawiejska; Katarzyna Ozegowska; Katarzyna Wroblewska-Seniuk; Rafal Iciek; Urszula Mantaj; Danuta Olejniczak; Jacek Brazert. Multiple daily injections of insulin versus continuous subcutaneous insulin infusion for pregnant women with type 1 diabetes. Australian and New Zealand Journal of Obstetrics and Gynaecology 2013, 53, 130 -135.

AMA Style

Ewa Wender-Ozegowska, Agnieszka Zawiejska, Katarzyna Ozegowska, Katarzyna Wroblewska-Seniuk, Rafal Iciek, Urszula Mantaj, Danuta Olejniczak, Jacek Brazert. Multiple daily injections of insulin versus continuous subcutaneous insulin infusion for pregnant women with type 1 diabetes. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2013; 53 (2):130-135.

Chicago/Turabian Style

Ewa Wender-Ozegowska; Agnieszka Zawiejska; Katarzyna Ozegowska; Katarzyna Wroblewska-Seniuk; Rafal Iciek; Urszula Mantaj; Danuta Olejniczak; Jacek Brazert. 2013. "Multiple daily injections of insulin versus continuous subcutaneous insulin infusion for pregnant women with type 1 diabetes." Australian and New Zealand Journal of Obstetrics and Gynaecology 53, no. 2: 130-135.

Journal article
Published: 01 November 2009 in Pediatric Diabetes
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Many epidemiological and experimental studies have proven that some adult diseases might have their origin in fetal life. It has been also hypothesized that intra-uterine environment in pregnancy complicated with diabetes might influence the development of obesity, type 2 diabetes, and cardiovascular diseases in the offspring. To assess glucose metabolism, insulin secretion, and prevalence of obesity in the offspring of mothers with pregestational diabetes mellitus (PGDM) and gestational diabetes mellitus (GDM) and to evaluate the relationship between maternal metabolic control during pregnancy and metabolic disturbances in children. Children of mothers with PGDM (n = 43) and GDM (n = 34) were examined at 4-9 yr of age and compared with the control group (n = 108; metabolic parameters available for n = 29). The incidence of overweight and obesity, impaired glucose tolerance, and insulin resistance were analyzed based on anthropometric and biochemical measurements. Statistical analysis was performed with statistica package. In children of GDM mothers, body mass index z-score (0.81 +/- 1.01 vs. -0.04 +/- 1.42 PGDM vs. 0.07 +/- 1.28 control group) and insulin resistance indices (homeostasis model assessment index - insulin resistance 1.112 vs. 0.943 PGDM vs. 0.749 control group) were significantly higher than in other groups. Obesity and insulin resistance were also most frequent in GDM group [not significant (NS)]. In addition, we observed the relationship between maternal hemoglobin A1c and mean glycemia in perinatal period and insulin resistance in children. There was not such correlation for the class of maternal diabetes. Children born to mothers with gestational diabetes seem to be at risk for obesity and metabolic disturbances.

ACS Style

Katarzyna Wróblewska-Seniuk; Ewa Wender-Ozegowska; Jerzy Szczapa. Long-term effects of diabetes during pregnancy on the offspring. Pediatric Diabetes 2009, 10, 432 -440.

AMA Style

Katarzyna Wróblewska-Seniuk, Ewa Wender-Ozegowska, Jerzy Szczapa. Long-term effects of diabetes during pregnancy on the offspring. Pediatric Diabetes. 2009; 10 (7):432-440.

Chicago/Turabian Style

Katarzyna Wróblewska-Seniuk; Ewa Wender-Ozegowska; Jerzy Szczapa. 2009. "Long-term effects of diabetes during pregnancy on the offspring." Pediatric Diabetes 10, no. 7: 432-440.

Conference abstract
Published: 30 November 2008 in Early Human Development
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ACS Style

Katarzyna Wroblewska-Seniuk⁎; Jerzy Szczapa. Long-term effects of neonatal macrosomia. Early Human Development 2008, 84, S118 -118.

AMA Style

Katarzyna Wroblewska-Seniuk⁎, Jerzy Szczapa. Long-term effects of neonatal macrosomia. Early Human Development. 2008; 84 ():S118-118.

Chicago/Turabian Style

Katarzyna Wroblewska-Seniuk⁎; Jerzy Szczapa. 2008. "Long-term effects of neonatal macrosomia." Early Human Development 84, no. : S118-118.

Journal article
Published: 01 November 2005 in Infection and Immunity
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Escherichia coli bearing adhesins of the Dr/Afa family frequently causes urogenital infections during pregnancy in humans and has been associated with mortality in pregnant rats. Two components of the adhesin, Dra/AfaE and Dra/AfaD, considered virulence factors, are responsible for bacterial binding and internalization. We hypothesize that gestational mortality caused by Dr/Afa + E. coli is mediated by one of these two proteins, Dra/AfaE or Dra/AfaD. In this study, using afaE and/or afaD mutants, we investigated the role of the afaE and afaD genes in the mortality of pregnant rats from intrauterine infection. Sprague-Dawley rats, on the 17th day of pregnancy, were infected with the E. coli afaE + afaD and afaE afaD + mutants. The clinical E. coli strain ( afaE + afaD + ) and the afaE afaD double mutant were used as positive and negative controls, respectively. The mortality rate was evaluated 24 h after infection. The highest maternal mortality was observed in the group infected with the afaE + afaD + strain, followed by the group infected with the afaE + afaD strain. The mortality was dose dependent. The afaE afaD double mutant did not cause maternal mortality, even with the highest infection dose. The in vivo studies corresponded with the invasion assay, where the afaE + strains were the most invasive ( afaE + afaD strain > afaE + afaD + strain), while the afaE mutant strains ( afaE afaD + and afaE afaD strains) seemed to be noninvasive. This study shows for the first time that the afaE gene coding for the AfaE subunit of Dr/Afa adhesin is involved in the lethal outcome of gestational infection in rats. This lethal effect associated with AfaE correlates with the invasiveness of afaE + E. coli strains in vitro.

ACS Style

K. Wroblewska-Seniuk; R. Selvarangan; A. Hart; R. Pladzyk; P. Goluszko; A. Jafari; L. du Merle; S. Nowicki; C. Yallampalli; C. Le Bouguénec. Dra/AfaE Adhesin of Uropathogenic Dr/Afa + Escherichia coli Mediates Mortality in Pregnant Rats. Infection and Immunity 2005, 73, 7597 -7601.

AMA Style

K. Wroblewska-Seniuk, R. Selvarangan, A. Hart, R. Pladzyk, P. Goluszko, A. Jafari, L. du Merle, S. Nowicki, C. Yallampalli, C. Le Bouguénec. Dra/AfaE Adhesin of Uropathogenic Dr/Afa + Escherichia coli Mediates Mortality in Pregnant Rats. Infection and Immunity. 2005; 73 (11):7597-7601.

Chicago/Turabian Style

K. Wroblewska-Seniuk; R. Selvarangan; A. Hart; R. Pladzyk; P. Goluszko; A. Jafari; L. du Merle; S. Nowicki; C. Yallampalli; C. Le Bouguénec. 2005. "Dra/AfaE Adhesin of Uropathogenic Dr/Afa + Escherichia coli Mediates Mortality in Pregnant Rats." Infection and Immunity 73, no. 11: 7597-7601.

Journal article
Published: 01 October 2005 in International Journal of Pediatric Otorhinolaryngology
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The incidence of sensorineural hearing loss is between 1 and 3 per 1000 in healthy neonates and 2-4 per 100 in high-risk children. Transient evoked otoacoustic emissions (TEOAEs) represent a method which can be applied to all newborns prior to hospital discharge, enabling early identification of hearing loss. The aim of the study was to evaluate the results of newborn hearing screening by means of TEOAEs.

ACS Style

Katarzyna Wroblewska-Seniuk; Karolina Chojnacka; Beata Pucher; Jerzy Szczapa; Janusz Gadzinowski; Michal Grzegorowski. The results of newborn hearing screening by means of transient evoked otoacoustic emissions. International Journal of Pediatric Otorhinolaryngology 2005, 69, 1351 -1357.

AMA Style

Katarzyna Wroblewska-Seniuk, Karolina Chojnacka, Beata Pucher, Jerzy Szczapa, Janusz Gadzinowski, Michal Grzegorowski. The results of newborn hearing screening by means of transient evoked otoacoustic emissions. International Journal of Pediatric Otorhinolaryngology. 2005; 69 (10):1351-1357.

Chicago/Turabian Style

Katarzyna Wroblewska-Seniuk; Karolina Chojnacka; Beata Pucher; Jerzy Szczapa; Janusz Gadzinowski; Michal Grzegorowski. 2005. "The results of newborn hearing screening by means of transient evoked otoacoustic emissions." International Journal of Pediatric Otorhinolaryngology 69, no. 10: 1351-1357.

Comparative study
Published: 29 April 2005 in Medycyna wieku rozwojowego
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ACS Style

Katarzyna Wróblewska-Seniuk; Ewa Wender-Ozegowska; Jerzy Szczapa; Karolina Chojnacka; Ewa Biegańska; Marek Pietryga; Romuald Biczysko; Janusz Gadzinowski. [Perinatal complications in newborns of mothers with gestational diabetes]. Medycyna wieku rozwojowego 2005, 8, 1 .

AMA Style

Katarzyna Wróblewska-Seniuk, Ewa Wender-Ozegowska, Jerzy Szczapa, Karolina Chojnacka, Ewa Biegańska, Marek Pietryga, Romuald Biczysko, Janusz Gadzinowski. [Perinatal complications in newborns of mothers with gestational diabetes]. Medycyna wieku rozwojowego. 2005; 8 (3):1.

Chicago/Turabian Style

Katarzyna Wróblewska-Seniuk; Ewa Wender-Ozegowska; Jerzy Szczapa; Karolina Chojnacka; Ewa Biegańska; Marek Pietryga; Romuald Biczysko; Janusz Gadzinowski. 2005. "[Perinatal complications in newborns of mothers with gestational diabetes]." Medycyna wieku rozwojowego 8, no. 3: 1.