Treatment of brain diseases is always limited by the physiological nature of the highly selective blood-brain barrier (BBB) and the electrostatic charge of the nanoporous extracellular matrix. Nanomedical application provides a promising drug delivery revolution for the treatment of neurodegenerative diseases (NDDs). It depends on improving the pharmacokinetic distribution of drugs through the central nervous system. Nanotechnology offers various forms of nanoparticles, and these nanoparticles have brain-targeted and long-acting properties with minimal systemic adverse effects and motor complications. Gene delivery vehicles and nanocarriers including neurotrophic factors are promising therapeutics for many NDDs, and they can modulate neuronal survival and synaptic connectivity. Neurotrophic factors when integrated with the nanotechnological approaches can pass the BBB merely, representing a significant challenging track. Clinical trials proved that levodopa nanoparticles cause little motor complications which is a considerable drawback in treating Parkinson’s disease with levodopa. Recently, nanotechnology had patented new formulations and achieved various advanced procedures for management, and even prevention, of NDDs. Nanotechnology can be integrated into neuroscience to fight against neurodegenerative diseases. Primary research studies in using nanoparticles to cure Alzheimer disease (AD) are promising but are still in need for more investigations. The present paper aims to review, outline, and summarize various efforts done in the field of using nanoparticles in the management of Alzheimer.

Background: A pragmatic shift in the healthcare sector characterized by moving from curative to preventive approaches highlights the role of pharmacovigilance in patient safety. There have been few published studies on patient reporting of adverse drug reactions (ADRs) in Saudi Arabia. This qualitative study aims to explore the community opinions and the need for patient-friendly smartphone applications (SPAs) to enhance their participation in ADR reporting. Methods: Purposeful sampling was followed to recruit study participants, a semi-structured interview guide was used to conduct interviews, and the saturation was reached after the 13th interviewer; no new information was obtained after two subsequent interviews. All the interviews were audio-recorded, transcribed verbatim, and analyzed by means of a standard content analysis framework. Results: As per the WHO guidelines, eleven participants were aware of the term “ADR”. All the participants denied receiving any prior education and attending events about ADRs and were unaware of the Saudi FDA-ADR reporting systems. The use of technologies such as SPAs has been widely accepted with a high level of concern for data confidentiality and privacy. Conclusions: These findings point out the need to build patient-oriented educational programs to increase their awareness of ADR reporting and to prioritize the use of artificial intelligence (AI) to be integrated in the Saudi healthcare system to develop future SPAs for improving both patient safety and signal detection of ADRs.

Solid waste management is highly considered in the Kingdom of Saudi Arabia (KSA) for the protection of the environment, preserving resources, and producing energy. Solid waste is collected in bins from Qassim University (QU) as a mixture without any segregation processes. The key to obtaining university stakeholders’ involvement in the waste separation program is awareness coupled with participation. This study evaluates the stakeholders’ knowledge and practices related to solid waste separation at QU, KSA, as well as explores the current collection system of solid waste on the university’s campus. A self-administered questionnaire was designed to measure the knowledge and practices of QU stakeholders, as well as the existing management of solid waste in the University. The questionnaire consists of three sections; knowledge, practices, and actual waste management in QU. A total of corrected 437 responses were collected from QU demographic variables based on gender, language, age, and job. Frequency analysis, Chi-square test, t-test, and correlation test were utilized to estimate the average values and the association between the survey statements and demographic variables. The results revealed that the awareness level of respondents is high, and their application is good. Although fewer than 50% of the QU stakeholders have practiced waste separation at the generation site in specific bins, the majority are willing to do that with an agreement level of 98%. Additionally, the analysis proved that the solid waste is collected efficiently in QU but the waste separation at the generation point is poor. The responses of the participants implied that the most disposed of waste in QU is paper, followed by plastic. Teaching courses, workshops, and advertisements related to waste are recommended to increase awareness of the benefits of waste separation at the source, both economically and environmentally. The results of this study help the decision-makers in the programs’ implementation of sustainable development and resource reservation that is also consistent with KSA vision 2030.

This study aims to investigate CAM use among CD patients from Qassim, Saudi Arabia and to compare CAM practice with different demographic and disease characteristics of the participants. A cross-sectional study was conducted among CD patients. During the three-months of data collection period, a total of 377 patients were approached and 208 patients participated in the study, giving a response rate of 55.17%. A p value of <0.05 was considered as significant. Among the study population, 94 (45.2%) patients were CAM users. Diabetes mellitus patients were the majority (48 (51.06%)) followed by hypertensive patients (34 (36.17%)). Spiritual therapies were the most common CAM followed by herbal products. Among CAM users, 41 (19.7%) patients reported disclosing CAM use to their health care providers. Among all the sociodemographic variables, gender (p = 0.029), marital status (p = 0.034) and education level (p = 0.047) were significantly associated with CAM use. In conclusion, the use of CAM among CD patients was relatively high in Qassim. Patients reported using CAM without disclosing to their health care providers which is a major health risk. It is critical to counsel CD patients regarding rational and informed CAM use in order to prevent harmful and unwanted effects.

The spread of many infectious diseases by vectors is a globally severe issue. Climate change and the increase of vector resistance are the primary sources of rising mosquito populations. Therefore, advanced approaches are needed to prevent the dispersal of life-threatening diseases. Herein, Mn₂O₃ NPs and MnCoO nanocomposites were presented as mosquitocidal agents. The synthesized samples were prepared by a co-precipitation route and characterized using different techniques indicating the change of host Mn₂O₃ structure to 2D MnCoO nanoflakes with Co³⁺ integration. The thermal decomposition of the nanoparticles was examined by TGA analysis, showing high stability. The energy gap (${\mathrm{E}}_{\mathrm{g}}$) of Mn₂O₃ was estimated within the visible spectrum of the value 2.95 eV, which reduced to 2.80 eV with doping support. The impact of Mn₂O₃ and MnCoO on immature stages was investigated by semithin photomicrographs exhibiting significant changes in the midgut, fat tissue and muscles of the third larval instar. Moreover, the external deformations in pupae were examined using scanning electron microscopy (SEM).

Herein, we report the synthesis of spinel cobalt oxide nanorods (Co₃O₄ NRs) by a modified co-precipitation approach and examine their larvicidal activity against Culex pipiens. The structure and morphology of the as-prepared Co₃O₄ NRs were emphasized using X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDAX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). It was found that Co₃O₄ nanostructures have a face-centered spinel cubic crystal structure with a mean crystallite size of 38 nm. These nanostructures have a rod like shape with a mean diameter of 30 nm and an average length of 60 nm. The TGA measurements revealed the high stability of the formed spinel cubic structure at 400 °C. The optical behavior indicates the direct transition of electrons through an optical band gap in the range of 2.92–3.08 eV. These unique chemical and physical properties of Co₃O₄ NRs enabled them to be employed as a strong agent for killing the C. pipiens. A comparison study was employed between the as-prepared Co₃O₄ and the entomopathogenic fungus Metarhizium brunneum as a control agent of C. pipiens larvae. The results revealed that the as-prepared nanorods have higher mortality against C. pipiens larvae compared with the well-known M. brunneum.