Landsat 8, the most recently launched satellite of the series, promises to maintain the continuity of Landsat 7. However, in addition to subtle differences in sensor characteristics and vegetation index (VI) generation algorithms, VIs respond differently to the seasonality of the various types of vegetation cover. The purpose of this study was to elucidate the effects of these variations on VIs between Operational Land Imager (OLI) and Enhanced Thematic Mapper Plus (ETM+). Ground spectral data for vegetation were used to simulate the Landsat at-senor broadband reflectance, with consideration of sensor band-pass differences. Three band-geometric VIs (Normalized Difference Vegetation Index (NDVI), Soil-Adjusted Vegetation Index (SAVI), Enhanced Vegetation Index (EVI)) and two band-transformation VIs (Vegetation Index based on the Universal Pattern Decomposition method (VIUPD), Tasseled Cap Transformation Greenness (TCG)) were tested to evaluate the performance of various VI generation algorithms in relation to multi-sensor continuity. Six vegetation types were included to evaluate the continuity in different vegetation types. Four pairs of data during four seasons were selected to evaluate continuity with respect to seasonal variation. The simulated data showed that OLI largely inherits the band-pass characteristics of ETM+. Overall, the continuity of band-transformation derived VIs was higher than band-geometry derived VIs. VI continuity was higher in the three forest types and the shrubs in the relatively rapid growth periods of summer and autumn, but lower for the other two non-forest types (grassland and crops) during the same periods.