The application of multi-floor manufacturing (MFM) in huge cities is related to the rational use of urban areas and the solution to traffic problems. The operation of the city MFM clusters depends on the efficiency of production and transport management considering technical, economic, environmental, and other factors. The primary goal of this paper was to identify and analyze the drivers of sustainable supply chains (SSCs) that influence or encourage the design of sustainable processes in city MFM clusters under uncertainty in supply chains. This paper presents an SSC performance model for city MFM clusters under uncertainty. The proposed model is universal and is based on material flow analysis (MFA) methodology. The presented analysis helps to determine the conditions for rhythmic deliveries with the use of the multi-IRTs. The coefficients of rhythmic deliveries for multiple intelligent reconfigurable trolleys (IRTs) and the capacity loss of freight elevators allow us to periodically assess the sustainability processes in city MFM clusters related to the flow materials. These assessments are the basis for the decision-making and planning of SSCs.

The application of multi-floor cellular manufacturing in huge cities is related to the rational use of urban areas and the solution of traffic problems. The select of freight elevators is a vital part of decision process in the multi-floor manufacturing which allows the enterprise to select equipment considering technical, economic, environmental, social and other factors. This paper presents the specific approach to the selection of freight elevators for the multi-floor cellular manufacturing. A model for freight elevators selection is proposed considering the manufacturing performance, the carrying capacity of vertical transport system, and the number of floors of cellular manufacturing.

We investigated the effect of daunorubicin on glutathione content and activity of GSH-related enzymes in cultured normal and diabetic human fibroblasts. Cells were incubated with 4 microM daunorubicin (DNR) for 2 h followed by culture in drug-free medium for up to 72 h. Treatment of diabetic cells with the drug caused a time-dependent depletion of intracellular GSH and a decrease of the GSH to total glutathione ratio. GSH depletion was accompanied by apoptotic changes in morphology of the nucleus. Analysis of GSH-related enzymes showed a significant increase of the activities of Se-dependent and Se-independent peroxidases and glutathione S-transferase. In contrast, glutathione reductase activity was reduced by 50%. Significant differences between normal and diabetic cells exposed to DNR were observed in the level of GST and Se-dependent glutathione peroxidase activities. These findings indicated that daunorubicin efficiently affects the GSH antioxidant defense system both in normal and diabetic fibroblasts leading to disturbances in glutathione content as well as in the activity of GSH-related enzymes.

The article discusses the statistics of bus accidents in Poland in 2013-2017 in the context of all accidents that took place on Polish roads in the analyzed period, and attempted to assess the causes and how to reduce accidents in this group of vehicles.