Michael Thompson

Dr. Michael Thompson

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, ON M5S 3H6, Canada
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Research Focus & Metrics

Academic Career Length

27Years (2000-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2016 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
VCVictor Crivianu-Gaita
Victor Crivianu-Gaita
Michael ThompsonMichael Thompson
Michael Thompson

6 July 2012 in Chemical Society Reviews
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Journal Article
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CBChristophe Blaszykowski
Christophe Blaszykowski
SSSonia Sheikh
Sonia Sheikh
Michael ThompsonMichael Thompson
Michael Thompson
Upon contact with bodily fluids/tissues, exogenous materials spontaneously develop a layer of proteins on their surface. In the case of biomedical implants and equipment, biological processes with deleterious effects may ensue. For biosensing platforms, it is synonymous with an overwhelming background signal that prevents the detection/quantification of target analytes present in considerably lower concentrations. To address this ubiquitous problem, tremendous efforts have been dedicated over the years to engineer protein-resistant coatings. There is now extensive literature available on stealth organic adlayers able to minimize fouling down to a few ng cm−2, however from technologically irrelevant single-protein buffered solutions. Unfortunately, few coatings have been reported to present such level of performance when exposed to highly complex proteinaceous, real-world media such as blood serum and plasma, even diluted. Herein, we concisely review the surface chemistry developed to date to minimize fouling from these considerably more challenging blood-based fluids. Adsorption dynamics is also discussed.

4 April 2002 in The Analyst
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Journal Article
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ADAnil K. Deisingh
Anil K. Deisingh
Michael ThompsonMichael Thompson
Michael Thompson


26 February 2016 in Biomacromolecules
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Journal Article
Closed access
APAndres de los Santos Pereira
Andres de los Santos Pereira
SSSonia Sheikh
Sonia Sheikh
CBChristophe Blaszykowski
Christophe Blaszykowski
OPOgnen Pop-Georgievski
Ognen Pop-Georgievski
KFKiril Fedorov
Kiril Fedorov
CRCésar Rodríguez-Emmenegger
César Rodríguez-Emmenegger

30 July 2012 in Journal of Biomedical Materials Research Part B: Applied Biomaterials
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Journal Article
Closed access
PDF file
FNFeroze Nazneen
Feroze Nazneen
GHGrégoire Herzog
Grégoire Herzog
DADamien W.M. Arrigan
Damien W.M. Arrigan
NCNoel Caplice
Noel Caplice
PBPasquale Benvenuto
Pasquale Benvenuto
Michael ThompsonMichael Thompson
Michael Thompson