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Prof. Stefano Carugo
Health science department

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0 Clinical Cardiology
0 Heart Failure
0 Hypertension
0 Genetic association studies, obesity, CVD, insulin resistance and physiology
0 cardiomiopathies

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Journal article
Published: 12 July 2021 in Healthcare
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Adverse childhood experiences could be important determinants of adult disease. The present study analyzed the association between early traumatic experiences and the onset of cardiovascular disease (CVDs). It was hypothesized that patients with CVD would report a higher number of traumatic experiences during childhood and that this association would be stronger in women. The Traumatic Experiences Checklist (TEC) was fulfilled by 75 patients with a first-time diagnosis of CVD and 84 healthy controls randomly selected from the general population. The two groups were not balanced for age and sex. Multivariate analyses of covariance (MANCOVAs) and analyses of covariance (ANCOVAs), with group (clinical vs. control) and gender (male vs. female) as between-subjects factors, and age of participants as covariate, were performed on the number and the impact of the traumatic experiences (emotional neglect, emotional abuse, physical abuse, sexual harassment, and sexual abuse) for the three age group in which the trauma was experienced (from 0 to 10, from 11 to 18, from 19 years onwards). The main results showed that participants with CVDs have experienced a higher number of early traumatic experiences compared to the control group, such as emotional neglect (p = 0.023), emotional abuse (0.008 ≤ p ≤ 0.033), and physical abuse (0.001 < p ≤ 0.038). The results also revealed that women with CVDs have experienced more traumatic events compared to the women of the control group (0.001 < p ≤ 0.020). These results seem to highlight an association between traumatic experiences in childhood and CVD in adulthood, particularly in women. Such findings could have relevant implications for clinical practice, suggesting the importance of adopting an integrated approach in the care of the patient with cardiovascular diseases paying attention also to the clinical psychological risk factors.

ACS Style

Federica Galli; Carlo Lai; Teresa Gregorini; Chiara Ciacchella; Stefano Carugo. Psychological Traumas and Cardiovascular Disease: A Case-Control Study. Healthcare 2021, 9, 875 .

AMA Style

Federica Galli, Carlo Lai, Teresa Gregorini, Chiara Ciacchella, Stefano Carugo. Psychological Traumas and Cardiovascular Disease: A Case-Control Study. Healthcare. 2021; 9 (7):875.

Chicago/Turabian Style

Federica Galli; Carlo Lai; Teresa Gregorini; Chiara Ciacchella; Stefano Carugo. 2021. "Psychological Traumas and Cardiovascular Disease: A Case-Control Study." Healthcare 9, no. 7: 875.

Review article
Published: 04 July 2021 in Trends in Cardiovascular Medicine
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The preoperative evaluation of candidates to non-cardiac surgery requires a knowledge of factors related both to the type of surgery and to the risk of each patient, in order to predict the potential cardiovascular complications. Over the past several decades, the field of preoperative cardiac evaluation before non-cardiac surgery has evolved substantially on the basis of the current guidelines of international medical societies. The aim of this paper is to summarize available evidence on the risk of non-cardiac surgery, focusing on appropriate cardiovascular assessment prior to surgery.

ACS Style

Gloria Santangelo; Andrea Faggiano; Filippo Toriello; Stefano Carugo; Giuseppe Natalini; Francesca Bursi; Pompilio Faggiano. Risk of cardiovascular complications during non-cardiac surgery and preoperative cardiac evaluation. Trends in Cardiovascular Medicine 2021, 1 .

AMA Style

Gloria Santangelo, Andrea Faggiano, Filippo Toriello, Stefano Carugo, Giuseppe Natalini, Francesca Bursi, Pompilio Faggiano. Risk of cardiovascular complications during non-cardiac surgery and preoperative cardiac evaluation. Trends in Cardiovascular Medicine. 2021; ():1.

Chicago/Turabian Style

Gloria Santangelo; Andrea Faggiano; Filippo Toriello; Stefano Carugo; Giuseppe Natalini; Francesca Bursi; Pompilio Faggiano. 2021. "Risk of cardiovascular complications during non-cardiac surgery and preoperative cardiac evaluation." Trends in Cardiovascular Medicine , no. : 1.

Review
Published: 13 April 2021 in Journal of Clinical Medicine
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The risk prediction of future cardiovascular events is mainly based on conventional risk factor assessment by validated algorithms, such as the Framingham Risk Score, the Pooled Cohort Equations and the European SCORE Risk Charts. The identification of subclinical atherosclerosis has emerged as a promising tool to refine the individual cardiovascular risk identified by these models, to prognostic stratify asymptomatic individuals and to implement preventive strategies. Several imaging modalities have been proposed for the identification of subclinical organ damage, the main ones being coronary artery calcification scanning by cardiac computed tomography and the two-dimensional ultrasound evaluation of carotid arteries. In this context, echocardiography offers an assessment of cardiac calcifications at different sites, such as the mitral apparatus (including annulus, leaflets and papillary muscles), aortic valve and ascending aorta, findings that are associated with the clinical manifestation of atherosclerotic disease and are predictive of future cardiovascular events. The aim of this paper is to summarize the available evidence on clinical implications of cardiac calcification, review studies that propose semiquantitative ultrasound assessments of cardiac calcifications and evaluate the potential of ultrasound calcium scores for risk stratification and prevention of clinical events.

ACS Style

Andrea Faggiano; Gloria Santangelo; Stefano Carugo; Gregg Pressman; Eugenio Picano; Pompilio Faggiano. Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography. Journal of Clinical Medicine 2021, 10, 1668 .

AMA Style

Andrea Faggiano, Gloria Santangelo, Stefano Carugo, Gregg Pressman, Eugenio Picano, Pompilio Faggiano. Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography. Journal of Clinical Medicine. 2021; 10 (8):1668.

Chicago/Turabian Style

Andrea Faggiano; Gloria Santangelo; Stefano Carugo; Gregg Pressman; Eugenio Picano; Pompilio Faggiano. 2021. "Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography." Journal of Clinical Medicine 10, no. 8: 1668.

Journal article
Published: 24 March 2021 in Journal of Clinical Medicine
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Background: Few studies to date have addressed global cardiovascular (CV) risk profile in a “protected” young population as that of medical school students. Objective: to assess CV traditional risk factors and global CV risk profile of Italian medical students throughout the six years of university. Methods: A cross-sectional survey accessible online via quick response (QR) code was conducted among 2700 medical students at the University of Milan, Italy. Data on baseline characteristics, traditional CV risk factors, diet, lifestyle habits, and perceived lifestyle variations were evaluated across different years of school. Results: Overall, 1183 students (mean age, 22.05 years; 729 women (61.6%)) out of 2700 completed the questionnaire (43.8% rate response). More than 16% of the students had at least 3 out of 12 CV risk factors and only 4.6% had ideal cardiovascular health as defined by the American Heart Association. Overweight, underweight, physical inactivity, sub-optimal diet, smoke history, and elevated stress were commonly reported. Awareness of own blood pressure and lipid profile increased over the academic years as well as the number of high-blood-pressure subjects, alcohol abusers, and students constantly stressed for university reasons. Moreover, a reduction in physical-activity levels over the years was reported by half of the students. Conclusion and Relevance: This study demonstrates that a “protected” population as that of young medical students can show an unsatisfactory cardiovascular risk profile and suggests that medical school itself, being demanding and stressful, may have a role in worsening of the lifestyle.

ACS Style

Andrea Faggiano; Francesca Bursi; Gloria Santangelo; Cesare Tomasi; Chiarella Sforza; Pompilio Faggiano; Stefano Carugo. Global Cardiovascular Risk Profile of Italian Medical Students Assessed by a QR Code Survey. Data from UNIMI HEART SURVEY: Does Studying Medicine Hurt? Journal of Clinical Medicine 2021, 10, 1343 .

AMA Style

Andrea Faggiano, Francesca Bursi, Gloria Santangelo, Cesare Tomasi, Chiarella Sforza, Pompilio Faggiano, Stefano Carugo. Global Cardiovascular Risk Profile of Italian Medical Students Assessed by a QR Code Survey. Data from UNIMI HEART SURVEY: Does Studying Medicine Hurt? Journal of Clinical Medicine. 2021; 10 (7):1343.

Chicago/Turabian Style

Andrea Faggiano; Francesca Bursi; Gloria Santangelo; Cesare Tomasi; Chiarella Sforza; Pompilio Faggiano; Stefano Carugo. 2021. "Global Cardiovascular Risk Profile of Italian Medical Students Assessed by a QR Code Survey. Data from UNIMI HEART SURVEY: Does Studying Medicine Hurt?" Journal of Clinical Medicine 10, no. 7: 1343.

Journal article
Published: 18 December 2020 in Biomedicines
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Aims: A considerable proportion of patients affected by coronavirus respiratory disease (COVID-19) develop cardiac injury. The viral impact in cardiomyocytes deserves, however, further investigations, especially in asymptomatic patients. Methods: We investigated for SARS-CoV-2 presence and activity in heart tissues of six consecutive COVID-19 patients deceased from respiratory failure showing no signs of cardiac involvement and with no history of heart disease. Cardiac autopsy samples were collected within 2 h after death, and then analysed by digital PCR, Western blot, immunohistochemistry, immunofluorescence, RNAScope, and transmission electron microscopy assays. Results: The presence of SARS-CoV-2 into cardiomyocytes was invariably detected in all assays. A variable pattern of cardiomyocyte injury was observed, spanning from absence of cell death and subcellular alterations hallmarks, to intracellular oedema and sarcomere ruptures. In addition, we found active viral transcription in cardiomyocytes, by detecting both sense and antisense SARS-CoV-2 spike RNA. Conclusions: In this autopsy analysis of patients with no clinical signs of cardiac involvement, the presence of SARS-CoV-2 in cardiomyocytes has been detected, determining variable patterns of intracellular damage. These findings suggest the need for cardiologic surveillance in surviving COVID-19 patients not displaying a cardiac phenotype.

ACS Style

Gaetano Pietro Bulfamante; Gianluca Lorenzo Perrucci; Monica Falleni; Elena Sommariva; Delfina Tosi; Carla Martinelli; Paola Songia; Paolo Poggio; Stefano Carugo; Giulio Pompilio. Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac Involvement. Biomedicines 2020, 8, 626 .

AMA Style

Gaetano Pietro Bulfamante, Gianluca Lorenzo Perrucci, Monica Falleni, Elena Sommariva, Delfina Tosi, Carla Martinelli, Paola Songia, Paolo Poggio, Stefano Carugo, Giulio Pompilio. Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac Involvement. Biomedicines. 2020; 8 (12):626.

Chicago/Turabian Style

Gaetano Pietro Bulfamante; Gianluca Lorenzo Perrucci; Monica Falleni; Elena Sommariva; Delfina Tosi; Carla Martinelli; Paola Songia; Paolo Poggio; Stefano Carugo; Giulio Pompilio. 2020. "Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac Involvement." Biomedicines 8, no. 12: 626.

Case report
Published: 04 December 2020 in Clinical Case Reports
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Without rescue drugs approved, holistic approach by daily hemodialysis, noninvasive ventilation, anti‐inflammatory medications, fluid assessment by bedside ultrasound, and anxiolytics improved outcomes of a maintenance hemodialysis patient affected by severe COVID‐19.

ACS Style

Andrea Galassi; Francesca Casanova; Lidia Gazzola; Rocco Rinaldo; Marco Ceresa; Elena Restelli; Alessia Giorgini; Simone Birocchi; Marco Giovenzana; Ulisse Zoni; Federica Valli; Laura Massironi; Sebastiano Belletti; Lorenza Magagnoli; Andrea Stucchi; Michela Ippolito; Stefano Carugo; Elena Parazzini; Mario Cozzolino. SARS‐CoV‐2–related ARDS in a maintenance hemodialysis patient: case report on tailored approach by daily hemodialysis, noninvasive ventilation, tocilizumab, anxiolytics, and point‐of‐care ultrasound. Clinical Case Reports 2020, 9, 694 -703.

AMA Style

Andrea Galassi, Francesca Casanova, Lidia Gazzola, Rocco Rinaldo, Marco Ceresa, Elena Restelli, Alessia Giorgini, Simone Birocchi, Marco Giovenzana, Ulisse Zoni, Federica Valli, Laura Massironi, Sebastiano Belletti, Lorenza Magagnoli, Andrea Stucchi, Michela Ippolito, Stefano Carugo, Elena Parazzini, Mario Cozzolino. SARS‐CoV‐2–related ARDS in a maintenance hemodialysis patient: case report on tailored approach by daily hemodialysis, noninvasive ventilation, tocilizumab, anxiolytics, and point‐of‐care ultrasound. Clinical Case Reports. 2020; 9 (2):694-703.

Chicago/Turabian Style

Andrea Galassi; Francesca Casanova; Lidia Gazzola; Rocco Rinaldo; Marco Ceresa; Elena Restelli; Alessia Giorgini; Simone Birocchi; Marco Giovenzana; Ulisse Zoni; Federica Valli; Laura Massironi; Sebastiano Belletti; Lorenza Magagnoli; Andrea Stucchi; Michela Ippolito; Stefano Carugo; Elena Parazzini; Mario Cozzolino. 2020. "SARS‐CoV‐2–related ARDS in a maintenance hemodialysis patient: case report on tailored approach by daily hemodialysis, noninvasive ventilation, tocilizumab, anxiolytics, and point‐of‐care ultrasound." Clinical Case Reports 9, no. 2: 694-703.

Journal article
Published: 01 December 2020 in European Journal of Internal Medicine
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ACS Style

Marco Centola; Alessandro Maloberti; Diego Castini; Simone Persampieri; Ludovico Sabatelli; Giulia Ferrante; Stefano Lucreziotti; Nuccia Morici; Alice Sacco; Fabrizio Oliva; Paola Rebora; Cristina Giannattasio; Antonio Mafrici; Stefano Carugo. Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. European Journal of Internal Medicine 2020, 82, 62 -67.

AMA Style

Marco Centola, Alessandro Maloberti, Diego Castini, Simone Persampieri, Ludovico Sabatelli, Giulia Ferrante, Stefano Lucreziotti, Nuccia Morici, Alice Sacco, Fabrizio Oliva, Paola Rebora, Cristina Giannattasio, Antonio Mafrici, Stefano Carugo. Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome. European Journal of Internal Medicine. 2020; 82 ():62-67.

Chicago/Turabian Style

Marco Centola; Alessandro Maloberti; Diego Castini; Simone Persampieri; Ludovico Sabatelli; Giulia Ferrante; Stefano Lucreziotti; Nuccia Morici; Alice Sacco; Fabrizio Oliva; Paola Rebora; Cristina Giannattasio; Antonio Mafrici; Stefano Carugo. 2020. "Impact of admission serum acid uric levels on in-hospital outcomes in patients with acute coronary syndrome." European Journal of Internal Medicine 82, no. : 62-67.

Journal article
Published: 03 November 2020 in IJC Heart & Vasculature
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During the COVID-19 outbreak, healthcare Authorities of Lombardy modified the regional network concerning time-dependent emergencies. Specifically, 13 Macro-Hubs were identified to deliver timely optimal care to patients with acute coronary syndromes (ACS). Aim of this paper is to present the results of this experience. This is a multicenter, observational study. A total of 953 patients were included, presenting with STEMI in 57.7% of the cases. About 98% of patients received coronary angiography with a median since first medical contact to angiography of 79 (IQR 45–124) minutes for STEMI and 1262 (IQR 643–2481) minutes for NSTEMI. A total of 107 patients (11.2%) had SARS-CoV2 infection, mostly with STEMI (74.8%). The time interval from first medical contact to cath-lab was significant shorter in patients with COVID-19, both in the overall population and in STEMI patients (87 (IQR 41–310) versus 160 (IQR 67–1220) minutes, P = 0.001, and 61 (IQR 23–98) versus 80 (IQR 47–126) minutes, P = 0.01, respectively). In-hospital mortality and cardiogenic shock rates were higher among patients with COVID-19 compared to patients without (32% vs 6%, P < 0.0001, and 16.8% vs 6.7%, P < 0.0003, respectively). During the COVID-19 outbreak in Lombardy, the redefinition of ACS network according to enlarged Macro-Hubs allowed to continue with timely ACS management, while reserving a high number of intensive care beds for the pandemic. Patients with ACS and COVID-19 presented a worst outcome, particularly in case of STEMI.

ACS Style

Stefano Carugo; Marco Ferlini; Diego Castini; Aida Andreassi; Giulio Guagliumi; Marco Metra; Carlo Lombardi; Claudio Cuccia; Stefano Savonitto; Luigi Piatti; Maurizio D'Urbano; Corrado Lettieri; Pietro Vandoni; Maddalena Lettino; Giancarlo Marenzi; Matteo Montorfano; Alberto Zangrillo; Battistina Castiglioni; Roberto De Ponti; Luigi Oltrona Visconti. Management of acute coronary syndromes during the COVID-19 outbreak in Lombardy: The “macro-hub” experience. IJC Heart & Vasculature 2020, 31, 100662 -100662.

AMA Style

Stefano Carugo, Marco Ferlini, Diego Castini, Aida Andreassi, Giulio Guagliumi, Marco Metra, Carlo Lombardi, Claudio Cuccia, Stefano Savonitto, Luigi Piatti, Maurizio D'Urbano, Corrado Lettieri, Pietro Vandoni, Maddalena Lettino, Giancarlo Marenzi, Matteo Montorfano, Alberto Zangrillo, Battistina Castiglioni, Roberto De Ponti, Luigi Oltrona Visconti. Management of acute coronary syndromes during the COVID-19 outbreak in Lombardy: The “macro-hub” experience. IJC Heart & Vasculature. 2020; 31 ():100662-100662.

Chicago/Turabian Style

Stefano Carugo; Marco Ferlini; Diego Castini; Aida Andreassi; Giulio Guagliumi; Marco Metra; Carlo Lombardi; Claudio Cuccia; Stefano Savonitto; Luigi Piatti; Maurizio D'Urbano; Corrado Lettieri; Pietro Vandoni; Maddalena Lettino; Giancarlo Marenzi; Matteo Montorfano; Alberto Zangrillo; Battistina Castiglioni; Roberto De Ponti; Luigi Oltrona Visconti. 2020. "Management of acute coronary syndromes during the COVID-19 outbreak in Lombardy: The “macro-hub” experience." IJC Heart & Vasculature 31, no. : 100662-100662.

Journal article
Published: 12 October 2020 in Journal of Clinical Medicine
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Background: Although studies assessing cardiovascular comorbidities and myocardial injury in Coronavirus disease 2019 (COVID-19) patients have been published, no reports focused on clinical outcomes of myocardial injury in patients with and without chronic coronary syndromes (CCS) are currently available. Methods: In this study, consecutive COVID-19 patients admitted to four different institutions were screened for enrolment. Patients were divided into two groups (CCS vs. no-CCS). Association with in-hospital mortality and related predictors represented the main study outcome; myocardial injury and its predictors were deemed secondary outcomes. Results: A total of 674 COVID-19 patients were enrolled, 112 (16.6%) with an established history of CCS. Myocardial injury occurred in 43.8% patients with CCS vs. 14.4% patients without CCS, as confirmed by high-sensitivity cardiac troponin (hs-cTn) elevation on admission or during hospitalization. The mortality rate in the CCS cohort was nearly three-fold higher. After adjusting for disease severity, myocardial injury resulted significantly associated with in-hospital mortality in the no-CCS group but not in CCS patients. Conclusions: Patients with CCS and COVID-19 showed high mortality rate. Myocardial injury may be a bystander in CCS patients and COVID-19, while in patients without known history of CCS, myocardial injury has a significant role in predicting poor outcomes.

ACS Style

Marco Schiavone; Alessio Gasperetti; Massimo Mancone; Aaron V. Kaplan; Cecilia Gobbi; Giosuè Mascioli; Mattia Busana; Ardan M. Saguner; Gianfranco Mitacchione; Andrea Giacomelli; Gennaro Sardella; Maurizio Viecca; Firat Duru; Spinello Antinori; Stefano Carugo; Antonio L. Bartorelli; Claudio Tondo; Massimo Galli; Francesco Fedele; Giovanni B. Forleo. Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease. Journal of Clinical Medicine 2020, 9, 3263 .

AMA Style

Marco Schiavone, Alessio Gasperetti, Massimo Mancone, Aaron V. Kaplan, Cecilia Gobbi, Giosuè Mascioli, Mattia Busana, Ardan M. Saguner, Gianfranco Mitacchione, Andrea Giacomelli, Gennaro Sardella, Maurizio Viecca, Firat Duru, Spinello Antinori, Stefano Carugo, Antonio L. Bartorelli, Claudio Tondo, Massimo Galli, Francesco Fedele, Giovanni B. Forleo. Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease. Journal of Clinical Medicine. 2020; 9 (10):3263.

Chicago/Turabian Style

Marco Schiavone; Alessio Gasperetti; Massimo Mancone; Aaron V. Kaplan; Cecilia Gobbi; Giosuè Mascioli; Mattia Busana; Ardan M. Saguner; Gianfranco Mitacchione; Andrea Giacomelli; Gennaro Sardella; Maurizio Viecca; Firat Duru; Spinello Antinori; Stefano Carugo; Antonio L. Bartorelli; Claudio Tondo; Massimo Galli; Francesco Fedele; Giovanni B. Forleo. 2020. "Redefining the Prognostic Value of High-Sensitivity Troponin in COVID-19 Patients: The Importance of Concomitant Coronary Artery Disease." Journal of Clinical Medicine 9, no. 10: 3263.

Journal article
Published: 07 October 2020 in European Heart Journal
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ACS Style

Domitilla Gentile; Francesca Bursi; Andrea Mangini; Stefano Carugo. Aortic pseudoaneurysm with fistula to pulmonary trunk causing recurrent pulmonary oedema: a rare late complication of ascending aorta replacement. European Heart Journal 2020, 42, 2509 -2509.

AMA Style

Domitilla Gentile, Francesca Bursi, Andrea Mangini, Stefano Carugo. Aortic pseudoaneurysm with fistula to pulmonary trunk causing recurrent pulmonary oedema: a rare late complication of ascending aorta replacement. European Heart Journal. 2020; 42 (25):2509-2509.

Chicago/Turabian Style

Domitilla Gentile; Francesca Bursi; Andrea Mangini; Stefano Carugo. 2020. "Aortic pseudoaneurysm with fistula to pulmonary trunk causing recurrent pulmonary oedema: a rare late complication of ascending aorta replacement." European Heart Journal 42, no. 25: 2509-2509.

Original investigation
Published: 22 September 2020 in Echocardiography
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Purpose To assess the prognostic utility of quantitative 2D‐echocardiography, including strain, in patients with COVID‐19 disease. Methods COVID‐19‐infected patients admitted to the San Paolo University Hospital of Milan that underwent a clinically indicated echocardiographic examination were included in the study. To limit contamination, all measurements were performed offline. Quantitative measurements were obtained by an operator blinded to the clinical data. Results Among the 49 patients, nonsurvivors (33%) had worse respiratory parameters, index of multiorgan failure, and worse markers of lung involvement. Right ventricular (RV) dysfunction (as assessed by conventional and 2‐dimensional speckle tracking) was a common finding and a powerful independent predictor of mortality. At the ROC curve analyses, RV free wall longitudinal strain (LS) showed an AUC 0.77 ± 0.08 in predicting death, P = .008, and global RV LS (RV‐GLS) showed an AUC 0.79 ± 0.04, P = .004. This association remained significant after correction for age (OR = 1.16, 95%CI 1.01–1.34, P = .029 for RV free wall LS and OR = 1.20, 95%CI 1.01–1.42, P = .033 for RV‐GLS), for oxygen partial pressure at arterial gas analysis/fraction of inspired oxygen (OR = 1.28, 95%CI 1.04–1.57, P = .021 for RV free wall‐LS and OR = 1.30, 95%CI 1.04–1.62, P = .020 for RV‐GLS) and for the severity of pulmonary involvement measured by a computed tomography lung score (OR = 1.27, 95%CI 1.02–1.19, P = .034 for RV free wall LS and OR = 1.30, 95%CI 1.04–1.63, P = .022 for RV‐GLS). Conclusions In patients hospitalized with COVID‐19, offline quantitative 2D‐echocardiographic assessment of cardiac function is feasible. Parameters of RV function are frequently abnormal and have an independent prognostic value over markers of lung involvement.

ACS Style

Francesca Bursi; Gloria Santangelo; Dario Sansalone; Federica Valli; Anna Maria Vella; Filippo Toriello; Andrea Barbieri; Stefano Carugo. Prognostic utility of quantitative offline 2D‐echocardiography in hospitalized patients with COVID‐19 disease. Echocardiography 2020, 37, 2029 -2039.

AMA Style

Francesca Bursi, Gloria Santangelo, Dario Sansalone, Federica Valli, Anna Maria Vella, Filippo Toriello, Andrea Barbieri, Stefano Carugo. Prognostic utility of quantitative offline 2D‐echocardiography in hospitalized patients with COVID‐19 disease. Echocardiography. 2020; 37 (12):2029-2039.

Chicago/Turabian Style

Francesca Bursi; Gloria Santangelo; Dario Sansalone; Federica Valli; Anna Maria Vella; Filippo Toriello; Andrea Barbieri; Stefano Carugo. 2020. "Prognostic utility of quantitative offline 2D‐echocardiography in hospitalized patients with COVID‐19 disease." Echocardiography 37, no. 12: 2029-2039.

Letter to the editors
Published: 19 September 2020 in Clinical Research in Cardiology
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ACS Style

Victoria L. Cammann; Konrad A. Szawan; Fabrizio D’Ascenzo; Sebastiano Gili; Sara Dreiding; Michael Würdinger; Robert Manka; Barbara E. Stähli; Erik W. Holy; Patrick Siegrist; Philipp Jakob; Philippe Meyer; Mario Iannaccone; Emanuela Di Simone; Gioel Gabrio Secco; Matteo Saccocci; Luca Bettari; Alfonso Ielasi; Maurizio Tespili; Giorgio Quadri; Ferdinando Varbella; Sergio Raposeiras-Roubin; Emad Abu-Assi; Massimo Mancone; Gennaro Sardella; Fabio Infusino; Francesco Fedele; Giuseppe Patti; Marco Mennuni; Andrea Rognoni; Mario Bollati; Luca Olivotti; Stefano Cordone; Stefano Carugo; Lucia Barbieri; Luca Gaido; Massimo Giammaria; Alfonso Gambino; Maurizio D’Amico; Alessandro Galluzzo; Fabrizio Ugo; Daniela Trabattoni; Ovidio De Filippo; Gaetano Maria De Ferrari; Carmine Vecchione; Rodolfo Citro; Jelena R. Ghadri; Christian Templin. Outcomes of acute coronary syndromes in coronavirus disease 2019. Clinical Research in Cardiology 2020, 109, 1601 -1604.

AMA Style

Victoria L. Cammann, Konrad A. Szawan, Fabrizio D’Ascenzo, Sebastiano Gili, Sara Dreiding, Michael Würdinger, Robert Manka, Barbara E. Stähli, Erik W. Holy, Patrick Siegrist, Philipp Jakob, Philippe Meyer, Mario Iannaccone, Emanuela Di Simone, Gioel Gabrio Secco, Matteo Saccocci, Luca Bettari, Alfonso Ielasi, Maurizio Tespili, Giorgio Quadri, Ferdinando Varbella, Sergio Raposeiras-Roubin, Emad Abu-Assi, Massimo Mancone, Gennaro Sardella, Fabio Infusino, Francesco Fedele, Giuseppe Patti, Marco Mennuni, Andrea Rognoni, Mario Bollati, Luca Olivotti, Stefano Cordone, Stefano Carugo, Lucia Barbieri, Luca Gaido, Massimo Giammaria, Alfonso Gambino, Maurizio D’Amico, Alessandro Galluzzo, Fabrizio Ugo, Daniela Trabattoni, Ovidio De Filippo, Gaetano Maria De Ferrari, Carmine Vecchione, Rodolfo Citro, Jelena R. Ghadri, Christian Templin. Outcomes of acute coronary syndromes in coronavirus disease 2019. Clinical Research in Cardiology. 2020; 109 (12):1601-1604.

Chicago/Turabian Style

Victoria L. Cammann; Konrad A. Szawan; Fabrizio D’Ascenzo; Sebastiano Gili; Sara Dreiding; Michael Würdinger; Robert Manka; Barbara E. Stähli; Erik W. Holy; Patrick Siegrist; Philipp Jakob; Philippe Meyer; Mario Iannaccone; Emanuela Di Simone; Gioel Gabrio Secco; Matteo Saccocci; Luca Bettari; Alfonso Ielasi; Maurizio Tespili; Giorgio Quadri; Ferdinando Varbella; Sergio Raposeiras-Roubin; Emad Abu-Assi; Massimo Mancone; Gennaro Sardella; Fabio Infusino; Francesco Fedele; Giuseppe Patti; Marco Mennuni; Andrea Rognoni; Mario Bollati; Luca Olivotti; Stefano Cordone; Stefano Carugo; Lucia Barbieri; Luca Gaido; Massimo Giammaria; Alfonso Gambino; Maurizio D’Amico; Alessandro Galluzzo; Fabrizio Ugo; Daniela Trabattoni; Ovidio De Filippo; Gaetano Maria De Ferrari; Carmine Vecchione; Rodolfo Citro; Jelena R. Ghadri; Christian Templin. 2020. "Outcomes of acute coronary syndromes in coronavirus disease 2019." Clinical Research in Cardiology 109, no. 12: 1601-1604.

Other
Published: 26 August 2020
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Background Cardiovascular complication in patients affected by novel Coronavirus respiratory disease (COVID-19) are increasingly recognized. However, although a cardiac tropism of SARS-CoV-2 for inflammatory cells in autopsy heart samples of COVID-19 patients has been reported, the presence of the virus in cardiomyocytes has not been documented yet. Methods We investigated for SARS-CoV-2 presence in heart tissue autopsies of 6 consecutive COVID-19 patients deceased for respiratory failure showing no signs of cardiac involvement and with no history of heart disease. Cardiac autopsy samples were analysed by digital PCR, Western blot, immunohistochemistry, immunofluorescence, RNAScope, and transmission electron microscopy assays. Results The presence of SARS-CoV-2 into cardiomyocytes was invariably detected. A variable pattern of cardiomyocytes injury was observed, spanning from the absence of cell death and subcellular alterations hallmarks to the intracellular oedema and sarcomere ruptures. In addition, we found active viral transcription in cardiomyocytes, by detecting both sense and antisense SARS-CoV-2 spike RNA. Conclusions In this analysis of autopsy cases, the presence of SARS-CoV-2 into cardiomyocytes, determining variable patterns of intracellular involvement, has been documented. All these findings suggest the need of a cardiologic surveillance even in survived COVID-19 patients not displaying a cardiac phenotype, in order to monitor potential long-term cardiac sequelae.

ACS Style

Gaetano Pietro Bulfamante; Gianluca Lorenzo Perrucci; Monica Falleni; Elena Sommariva; Delfina Tosi; Carla Martinelli; Paola Songia; Paolo Poggio; Stefano Carugo; Giulio Pompilio. Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement. 2020, 1 .

AMA Style

Gaetano Pietro Bulfamante, Gianluca Lorenzo Perrucci, Monica Falleni, Elena Sommariva, Delfina Tosi, Carla Martinelli, Paola Songia, Paolo Poggio, Stefano Carugo, Giulio Pompilio. Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement. . 2020; ():1.

Chicago/Turabian Style

Gaetano Pietro Bulfamante; Gianluca Lorenzo Perrucci; Monica Falleni; Elena Sommariva; Delfina Tosi; Carla Martinelli; Paola Songia; Paolo Poggio; Stefano Carugo; Giulio Pompilio. 2020. "Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement." , no. : 1.

Journal article
Published: 12 August 2020 in JACC: Heart Failure
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This study examined the effects of sacubitril/valsartan on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics associated with favorable NT-proBNP reduction response. NT-proBNP levels reflect cardiac wall stress and predict event risk in patients with acute decompensated heart failure (ADHF). Post-hoc analysis of the TRANSITION (Comparison of Pre- and Post-discharge Initiation of Sacubitril/Valsartan Therapy in HFrEF Patients After an Acute Decompensation Event) study, including stabilized ADHF patients with reduced ejection fraction, randomized to open-label sacubitril/valsartan initiation in-hospital (pre-discharge) versus post-discharge. NT-proBNP was measured at randomization (baseline), discharge, and 4 and 10 weeks post-randomization. A favorable NT-proBNP response was defined as reduction to ≤1,000 pg/ml or >30% from baseline. In patients receiving sacubitril/valsartan in-hospital, NT-proBNP was reduced by 28% at discharge, with 46% of patients obtaining favorable NT-proBNP reduction response compared with a 4% reduction and 18% favorable response rate in patients initiated post-discharge (p < 0.001). NT-proBNP was reduced similarly in patients initiating sacubitril/valsartan pre- and post-discharge (reduction at 4 weeks: 25%/22%; 10 weeks: 38%/34%) with comparable favorable response rates (46%/42% and 51%/48% at 4 and 10 weeks, respectively). NT-proBNP favorable response at 4 weeks was associated with lower risk of first heart failure (HF) rehospitalization or cardiovascular death through 26 weeks (hazard ratio: 0.57; 95% confidence interval [CI]: 0.38 to 0.86; p = 0.007). Predictors of a favorable response at 4 weeks were starting dose ≥49/51 mg twice daily, higher baseline NT-proBNP, lower baseline serum creatinine, de novo HF, no atrial fibrillation, angiotensin-converting enzyme inhibitor–naive or angiotensin receptor blocker–naive, and no prior myocardial infarction. In-hospital initiation of sacubitril/valsartan produced rapid reductions in NT-proBNP, statistically significant at discharge. A favorable NT-proBNP response over time was associated with a better prognosis and predicted by higher starting dose and predisposing clinical profile. (Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event [TRANSITION]; NCT02661217)

ACS Style

Domingo Pascual-Figal; Rolf Wachter; Michele Senni; Weibin Bao; Adele Noè; Heike Schwende; Dmytro Butylin; Margaret F. Prescott; Jacek Gniot; Maria Mozheiko; Malgorzata Lelonek; Antonio Reyes Dominguez; Thomas Horacek; Enrique Garcia del Rio; Zhanna Kobalava; Christian Eugen Mueller; Yuksel Cavusoglu; Ewa Straburzynska-Migaj; Miroslav Slanina; Juergen Vom Dahl; Alisdair Ryding; Andrew Moriarty; Manuel Beltran Robles; Julio Nunez Villota; Antonio Garcia Quintana; Thorsten Nitschke; Jose Manuel Garcia Pinilla; Luis Almenar Bonet; Said Chaaban; Samia Filali Zaatari; Jindrich Spinar; Wlodzimierz Musial; Khaled Abdelbaki; Jan Belohlavek; Wolfgang Fehske; Michael Carlos Bott; Geir Hoegalmen; Marisa Crespo Leiro; Ismail Turkay Ozcan; Wilfried Mullens; Radim Kryza; Riadh Al-Ani; Krystyna Loboz-Grudzien; Lyudmila Ermoshkina; Silvia Hojerova; Alberto Alfredo Fernandez; Lenka Spinarova; Harald Lapp; Efraim Bulut; Filipa Almeida; Alexander Vishnevsky; Margita Belicova; Domingo Pascual; Klaus Witte; Kenneth Wong; Walter Droogne; Marc Delforge; Martin Peterka; Hans-Georg Olbrich; Stefano Carugo; Jadwiga Nessler; Thao Huynh McGill; Burkhard Huegl; Ibrahim Akin; Ilidio Moreira; Andrey Baglikov; Jeetendra Thambyrajah; Chris Hayes; Marcelo Raul Barrionuevo; Zerrin Yigit; Hakki Kaya; Zdenek Klimsa; Martin Radvan; Christoph Kadel; Ulf Landmesser; Giuseppe Di Tano; Malgorzata Buksinska Lisik; Candida Fonseca; Luis Oliveira; Irene Marques; Luis Miguel Santos; Egon Lenner; Peter Letavay; Manuel Gomez Bueno; Paula Mota; Aaron Wong; Kristian Bailey; Paul Foley; Eduardo Hasbani; Sean Virani; Tony Abdel Massih; Shukri Al-Saif; Milos Taborsky; Marta Kaislerova; Zuzana Motovska; Aron Ariel Cohen; Damien Logeart; Dierk Endemann; Daniel Ferreira; Dulce Brito; Peter Kycina; Entela Bollano; Enrique Galve Basilio; Lorenzo Facila Rubio; Marcos Garcia Aguado; Lilia Beatriz Schiavi; Daniel Francisco Zivano; Eva Lonn; Ali El Sayed; Anne-Catherine Pouleur; Alex Heyse; Alexandr Schee; Rostislav Polasek; Marek Houra; Christophe Tribouilloy; Marie France Seronde; Michel Galinier; Michel Noutsias; Peter Schwimmbeck; Ingo Voigt; Dirk Westermann; Giovanni Pulignano; Johnny Vegsundvaag; Jose Alexandre Da Silva Antunes; Pedro Monteiro; Jan Stevlik; Eva Goncalvesova; Beata Hulkoova; Antonio Juan Castro Fernandez; Ceri Davies; Iain Squire; Philippe Meyer; Richard Sheppard; Tayfun Sahin; Karel Sochor; Guillaume De Geeter; Alexander Schmeisser; Joachim Weil; Ana Oliveira Soares; Olga Bulashova Vasilevna; Andrey Oshurkov; Shahid Junejo Sunderland; Jason Glover; Tomas Exequiel; Eric Decoulx; Sven Meyer; Thomas Muenzel; Fernando Frioes; Georgy Arbolishvili; Anna Tokarcikova; Patric Karlstrom; Joan Carles Trullas Vila; Gonzalo Pena Perez; Rajiv Sankaranarayanan; Thuraia Nageh; Diego Cristian Alasia; Marwan Refaat; Burcu Demirkan; Jehad Al-Buraiki; Shadi Karabsheh. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction. JACC: Heart Failure 2020, 8, 822 -833.

AMA Style

Domingo Pascual-Figal, Rolf Wachter, Michele Senni, Weibin Bao, Adele Noè, Heike Schwende, Dmytro Butylin, Margaret F. Prescott, Jacek Gniot, Maria Mozheiko, Malgorzata Lelonek, Antonio Reyes Dominguez, Thomas Horacek, Enrique Garcia del Rio, Zhanna Kobalava, Christian Eugen Mueller, Yuksel Cavusoglu, Ewa Straburzynska-Migaj, Miroslav Slanina, Juergen Vom Dahl, Alisdair Ryding, Andrew Moriarty, Manuel Beltran Robles, Julio Nunez Villota, Antonio Garcia Quintana, Thorsten Nitschke, Jose Manuel Garcia Pinilla, Luis Almenar Bonet, Said Chaaban, Samia Filali Zaatari, Jindrich Spinar, Wlodzimierz Musial, Khaled Abdelbaki, Jan Belohlavek, Wolfgang Fehske, Michael Carlos Bott, Geir Hoegalmen, Marisa Crespo Leiro, Ismail Turkay Ozcan, Wilfried Mullens, Radim Kryza, Riadh Al-Ani, Krystyna Loboz-Grudzien, Lyudmila Ermoshkina, Silvia Hojerova, Alberto Alfredo Fernandez, Lenka Spinarova, Harald Lapp, Efraim Bulut, Filipa Almeida, Alexander Vishnevsky, Margita Belicova, Domingo Pascual, Klaus Witte, Kenneth Wong, Walter Droogne, Marc Delforge, Martin Peterka, Hans-Georg Olbrich, Stefano Carugo, Jadwiga Nessler, Thao Huynh McGill, Burkhard Huegl, Ibrahim Akin, Ilidio Moreira, Andrey Baglikov, Jeetendra Thambyrajah, Chris Hayes, Marcelo Raul Barrionuevo, Zerrin Yigit, Hakki Kaya, Zdenek Klimsa, Martin Radvan, Christoph Kadel, Ulf Landmesser, Giuseppe Di Tano, Malgorzata Buksinska Lisik, Candida Fonseca, Luis Oliveira, Irene Marques, Luis Miguel Santos, Egon Lenner, Peter Letavay, Manuel Gomez Bueno, Paula Mota, Aaron Wong, Kristian Bailey, Paul Foley, Eduardo Hasbani, Sean Virani, Tony Abdel Massih, Shukri Al-Saif, Milos Taborsky, Marta Kaislerova, Zuzana Motovska, Aron Ariel Cohen, Damien Logeart, Dierk Endemann, Daniel Ferreira, Dulce Brito, Peter Kycina, Entela Bollano, Enrique Galve Basilio, Lorenzo Facila Rubio, Marcos Garcia Aguado, Lilia Beatriz Schiavi, Daniel Francisco Zivano, Eva Lonn, Ali El Sayed, Anne-Catherine Pouleur, Alex Heyse, Alexandr Schee, Rostislav Polasek, Marek Houra, Christophe Tribouilloy, Marie France Seronde, Michel Galinier, Michel Noutsias, Peter Schwimmbeck, Ingo Voigt, Dirk Westermann, Giovanni Pulignano, Johnny Vegsundvaag, Jose Alexandre Da Silva Antunes, Pedro Monteiro, Jan Stevlik, Eva Goncalvesova, Beata Hulkoova, Antonio Juan Castro Fernandez, Ceri Davies, Iain Squire, Philippe Meyer, Richard Sheppard, Tayfun Sahin, Karel Sochor, Guillaume De Geeter, Alexander Schmeisser, Joachim Weil, Ana Oliveira Soares, Olga Bulashova Vasilevna, Andrey Oshurkov, Shahid Junejo Sunderland, Jason Glover, Tomas Exequiel, Eric Decoulx, Sven Meyer, Thomas Muenzel, Fernando Frioes, Georgy Arbolishvili, Anna Tokarcikova, Patric Karlstrom, Joan Carles Trullas Vila, Gonzalo Pena Perez, Rajiv Sankaranarayanan, Thuraia Nageh, Diego Cristian Alasia, Marwan Refaat, Burcu Demirkan, Jehad Al-Buraiki, Shadi Karabsheh. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction. JACC: Heart Failure. 2020; 8 (10):822-833.

Chicago/Turabian Style

Domingo Pascual-Figal; Rolf Wachter; Michele Senni; Weibin Bao; Adele Noè; Heike Schwende; Dmytro Butylin; Margaret F. Prescott; Jacek Gniot; Maria Mozheiko; Malgorzata Lelonek; Antonio Reyes Dominguez; Thomas Horacek; Enrique Garcia del Rio; Zhanna Kobalava; Christian Eugen Mueller; Yuksel Cavusoglu; Ewa Straburzynska-Migaj; Miroslav Slanina; Juergen Vom Dahl; Alisdair Ryding; Andrew Moriarty; Manuel Beltran Robles; Julio Nunez Villota; Antonio Garcia Quintana; Thorsten Nitschke; Jose Manuel Garcia Pinilla; Luis Almenar Bonet; Said Chaaban; Samia Filali Zaatari; Jindrich Spinar; Wlodzimierz Musial; Khaled Abdelbaki; Jan Belohlavek; Wolfgang Fehske; Michael Carlos Bott; Geir Hoegalmen; Marisa Crespo Leiro; Ismail Turkay Ozcan; Wilfried Mullens; Radim Kryza; Riadh Al-Ani; Krystyna Loboz-Grudzien; Lyudmila Ermoshkina; Silvia Hojerova; Alberto Alfredo Fernandez; Lenka Spinarova; Harald Lapp; Efraim Bulut; Filipa Almeida; Alexander Vishnevsky; Margita Belicova; Domingo Pascual; Klaus Witte; Kenneth Wong; Walter Droogne; Marc Delforge; Martin Peterka; Hans-Georg Olbrich; Stefano Carugo; Jadwiga Nessler; Thao Huynh McGill; Burkhard Huegl; Ibrahim Akin; Ilidio Moreira; Andrey Baglikov; Jeetendra Thambyrajah; Chris Hayes; Marcelo Raul Barrionuevo; Zerrin Yigit; Hakki Kaya; Zdenek Klimsa; Martin Radvan; Christoph Kadel; Ulf Landmesser; Giuseppe Di Tano; Malgorzata Buksinska Lisik; Candida Fonseca; Luis Oliveira; Irene Marques; Luis Miguel Santos; Egon Lenner; Peter Letavay; Manuel Gomez Bueno; Paula Mota; Aaron Wong; Kristian Bailey; Paul Foley; Eduardo Hasbani; Sean Virani; Tony Abdel Massih; Shukri Al-Saif; Milos Taborsky; Marta Kaislerova; Zuzana Motovska; Aron Ariel Cohen; Damien Logeart; Dierk Endemann; Daniel Ferreira; Dulce Brito; Peter Kycina; Entela Bollano; Enrique Galve Basilio; Lorenzo Facila Rubio; Marcos Garcia Aguado; Lilia Beatriz Schiavi; Daniel Francisco Zivano; Eva Lonn; Ali El Sayed; Anne-Catherine Pouleur; Alex Heyse; Alexandr Schee; Rostislav Polasek; Marek Houra; Christophe Tribouilloy; Marie France Seronde; Michel Galinier; Michel Noutsias; Peter Schwimmbeck; Ingo Voigt; Dirk Westermann; Giovanni Pulignano; Johnny Vegsundvaag; Jose Alexandre Da Silva Antunes; Pedro Monteiro; Jan Stevlik; Eva Goncalvesova; Beata Hulkoova; Antonio Juan Castro Fernandez; Ceri Davies; Iain Squire; Philippe Meyer; Richard Sheppard; Tayfun Sahin; Karel Sochor; Guillaume De Geeter; Alexander Schmeisser; Joachim Weil; Ana Oliveira Soares; Olga Bulashova Vasilevna; Andrey Oshurkov; Shahid Junejo Sunderland; Jason Glover; Tomas Exequiel; Eric Decoulx; Sven Meyer; Thomas Muenzel; Fernando Frioes; Georgy Arbolishvili; Anna Tokarcikova; Patric Karlstrom; Joan Carles Trullas Vila; Gonzalo Pena Perez; Rajiv Sankaranarayanan; Thuraia Nageh; Diego Cristian Alasia; Marwan Refaat; Burcu Demirkan; Jehad Al-Buraiki; Shadi Karabsheh. 2020. "NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction." JACC: Heart Failure 8, no. 10: 822-833.

Journal article
Published: 23 July 2020 in IJC Heart & Vasculature
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On March 11th 2020 the World Health Organization declared the pandemic infection of SARS-CoV-2 (COVID-19) and Italy was one of the most affected country. The regional Emergency Medical System (EMS) founded itself facing an exponential increase in hospitalizations with a consequent organizational system crisis. Experts from Cina, UK and US suggested to reconsider thrombolysis as the best treatment in term of balance between time consumption and operators safety for ST-segment elevation myocardial infarction (STEMI) patients respect to primary PCI (pPCI). The system reorganization consisted in a centralization of all the emergency nets: from 55 hospitals with cardiac catheterization laboratories distributed within our region offering a 24/7 service we passed to 13 Hub and 42 Spoke centres. Dedicated in-hospital paths for patients COVID positive or suspected (pCOV+) and COVID negative (pCOV-) were instituted. We analysed all consecutive patients undergoing emergency coronary angiogram from March 14 to April 14 2020 at San Carlo Hospital in Milan comparing the two different in-hospital paths. We collected 30 STEMI patients. Eighteen patients (60%) were treated in pCOV-, while twelve patients (40%) in pCOV+. No significant differences were found among the two groups regarding key time points of STEMI care and interestingly we didn't find any treatment delay in pCOV+. In conclusion, a focused overhaul of the EMS may allow to maintain pPCI as the treatment of choice for patients and operators.

ACS Style

Gabriele Tumminello; Lucia Barbieri; Stefano Lucreziotti; Domitilla Gentile; Barbara Conconi; Marco Centola; Antonio Mafrici; Stefano Carugo. Impact of COVID-19 on STEMI: second youth for fibrinolysis or time to centralized approach? IJC Heart & Vasculature 2020, 30, 100600 .

AMA Style

Gabriele Tumminello, Lucia Barbieri, Stefano Lucreziotti, Domitilla Gentile, Barbara Conconi, Marco Centola, Antonio Mafrici, Stefano Carugo. Impact of COVID-19 on STEMI: second youth for fibrinolysis or time to centralized approach? IJC Heart & Vasculature. 2020; 30 ():100600.

Chicago/Turabian Style

Gabriele Tumminello; Lucia Barbieri; Stefano Lucreziotti; Domitilla Gentile; Barbara Conconi; Marco Centola; Antonio Mafrici; Stefano Carugo. 2020. "Impact of COVID-19 on STEMI: second youth for fibrinolysis or time to centralized approach?" IJC Heart & Vasculature 30, no. : 100600.

Research letter
Published: 23 June 2020 in Circulation
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ACS Style

Giulio G. Stefanini; Matteo Montorfano; Daniela Trabattoni; Daniele Andreini; Giuseppe Ferrante; Marco Bruno Maria Ancona; Marco Metra; Salvatore Curello; Diego Maffeo; Gaetano Pero; Michele Cacucci; Emilio Assanelli; Barbara Bellini; Filippo Russo; Alfonso Ielasi; Maurizio Tespili; Gian Battista Danzi; Pietro Vandoni; Mario Bollati; Lucia Barbieri; Jacopo Oreglia; Corrado Lettieri; Alberto Cremonesi; Stefano Carugo; Bernhard Reimers; Gianluigi Condorelli; Alaide Chieffo. ST-Elevation Myocardial Infarction in Patients With COVID-19. Circulation 2020, 141, 2113 -2116.

AMA Style

Giulio G. Stefanini, Matteo Montorfano, Daniela Trabattoni, Daniele Andreini, Giuseppe Ferrante, Marco Bruno Maria Ancona, Marco Metra, Salvatore Curello, Diego Maffeo, Gaetano Pero, Michele Cacucci, Emilio Assanelli, Barbara Bellini, Filippo Russo, Alfonso Ielasi, Maurizio Tespili, Gian Battista Danzi, Pietro Vandoni, Mario Bollati, Lucia Barbieri, Jacopo Oreglia, Corrado Lettieri, Alberto Cremonesi, Stefano Carugo, Bernhard Reimers, Gianluigi Condorelli, Alaide Chieffo. ST-Elevation Myocardial Infarction in Patients With COVID-19. Circulation. 2020; 141 (25):2113-2116.

Chicago/Turabian Style

Giulio G. Stefanini; Matteo Montorfano; Daniela Trabattoni; Daniele Andreini; Giuseppe Ferrante; Marco Bruno Maria Ancona; Marco Metra; Salvatore Curello; Diego Maffeo; Gaetano Pero; Michele Cacucci; Emilio Assanelli; Barbara Bellini; Filippo Russo; Alfonso Ielasi; Maurizio Tespili; Gian Battista Danzi; Pietro Vandoni; Mario Bollati; Lucia Barbieri; Jacopo Oreglia; Corrado Lettieri; Alberto Cremonesi; Stefano Carugo; Bernhard Reimers; Gianluigi Condorelli; Alaide Chieffo. 2020. "ST-Elevation Myocardial Infarction in Patients With COVID-19." Circulation 141, no. 25: 2113-2116.

Journal article
Published: 01 May 2020 in Minerva Cardioangiologica
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Heavy calcified lesions can decrease effectiveness of drug eluted stents in preventing restenosis. Rotational atherectomy (RA) demonstrated to improve outcomes in patients with severely calcified lesions pretreated with debulking. However, its feasibility and its safety are continuously on stage. Our aim has been to identify predictors of clinical and procedural outcome in RA. We retrospectively analyzed a population of patients referred to our cath lab for urgent or elective coronary catheterization treated with RA. The associations between clinical variables and clinical or procedural events were evaluated using logistic regression. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE) from procedure date to last day of follow-up. MACE have been defined as follows: cardiovascular death, heart failure hospitalization and target lesion revascularization. The registry included 68 of the 1908 (3.6%) patients that underwent percutaneous coronary intervention. Procedural success was as high as 94% and more than 90% of cases were treated without any complication. The most common complication during PCI with RA was vessel dissection (8.8%) and no procedural death occurred. None of the clinical nor procedural characteristics were associated with burr entrapment or vascular access hematoma. We identified as independent predictor of treated vessel dissection the female sex (OR 16.9, 95% CI 1.55-183.77, P<0.05). Logistic regression revealed age (OR 1.17, 95% CI: 1.02-1.33, P<0.02) as the only independent predictor of MACE. We therefore calculated the ROC curve on age in predicting MACE, that showed a C-statistics of 0.75 (95% CI 0.628 to 0.852, P=0.02), with 80 years old as the best threshold in defining high risk population. RA is a feasible and safe procedure. Females and elderly patients must be carefully selected in order to balance the risk/benefit ratio in these high-risk populations.

ACS Style

Simone Persampieri; Stefano Lucreziotti; Diego Salerno-Uriarte; Lucia Barbieri; Carlo Sponzilli; Federica Valli; Marco Centola; Diego Castini; Stefano Carugo. Predictors of procedural and clinical outcome in rotational atherectomy: analysis of a single center registry. Minerva Cardioangiologica 2020, 68, 126 -133.

AMA Style

Simone Persampieri, Stefano Lucreziotti, Diego Salerno-Uriarte, Lucia Barbieri, Carlo Sponzilli, Federica Valli, Marco Centola, Diego Castini, Stefano Carugo. Predictors of procedural and clinical outcome in rotational atherectomy: analysis of a single center registry. Minerva Cardioangiologica. 2020; 68 (2):126-133.

Chicago/Turabian Style

Simone Persampieri; Stefano Lucreziotti; Diego Salerno-Uriarte; Lucia Barbieri; Carlo Sponzilli; Federica Valli; Marco Centola; Diego Castini; Stefano Carugo. 2020. "Predictors of procedural and clinical outcome in rotational atherectomy: analysis of a single center registry." Minerva Cardioangiologica 68, no. 2: 126-133.

Other
Published: 01 May 2020
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Background The emergence of the COVID-19 pandemic has resulted in over two million affected and over 150 thousand deaths to date. There is no known effective therapy for the disease. Initial reports suggesting the potential benefit of Hydroxychloroquine/Azithromycin (HY/AZ) have resulted in massive adoption of this combination worldwide. However, while the true efficacy of this regimen is unknown, initial reports have raised concerns regarding the potential risk of QT prolongation and induction of torsade de pointes (TdP). Methods This is a multicenter retrospective study of 251 patients with COVID-19 treated with HY/AZ. We reviewed ECG tracings from baseline and until 3 days after completion of therapy to determine the progression of QTc and incidence of arrhythmia and mortality. Results QTc prolonged in parallel with increasing drug exposure and incompletely shortened after its completion. Extreme new QTc prolongation to > 500 ms, a known marker of high risk for TdP had developed in 15.9% of patients. One patient developed TdP requiring emergent cardioversion. Seven patients required premature termination of therapy. The baseline QTc of patients exhibiting QTc prolongation of > 60 ms was normal. Conclusion The combination of HY/AZ significantly prolongs the QTc in patients with COVID-19. This prolongation may be responsible for life threating arrhythmia in the form of TdP. This risk mandates careful consideration of HY/AZ therapy in lights of its unproven efficacy. Strict QTc monitoring should be performed if the regimen is given.

ACS Style

Ehud Chorin; Lalit Wadhwani; Silvia Magnani; Matthew Dai; Eric Shulman; Charles Nadeau-Routhier; Robert Knotts; Roi Bar-Cohen; Edward Kogan; Chirag Barbhaiya; Anthony Aizer; Douglas Holmes; Scott Bernstein; Michael Spinelli; David S Park; Carugo Stefano; Larry A Chinitz; Lior Jankelson. QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin. 2020, 1 .

AMA Style

Ehud Chorin, Lalit Wadhwani, Silvia Magnani, Matthew Dai, Eric Shulman, Charles Nadeau-Routhier, Robert Knotts, Roi Bar-Cohen, Edward Kogan, Chirag Barbhaiya, Anthony Aizer, Douglas Holmes, Scott Bernstein, Michael Spinelli, David S Park, Carugo Stefano, Larry A Chinitz, Lior Jankelson. QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin. . 2020; ():1.

Chicago/Turabian Style

Ehud Chorin; Lalit Wadhwani; Silvia Magnani; Matthew Dai; Eric Shulman; Charles Nadeau-Routhier; Robert Knotts; Roi Bar-Cohen; Edward Kogan; Chirag Barbhaiya; Anthony Aizer; Douglas Holmes; Scott Bernstein; Michael Spinelli; David S Park; Carugo Stefano; Larry A Chinitz; Lior Jankelson. 2020. "QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin." , no. : 1.

Commentary
Published: 24 April 2020 in International Journal of Cardiology
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The ongoing coronavirus disease 2019 (COVID-19) outbreak may be associated with direct and indirect adverse consequences on the heart. Besides severe pneumonia, myocarditis and myocardial injury have been suspected as additional causes of death in patients affected by COVID-19 [1Du R.H. Liang L.R. Yang C.Q. et al.Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.Eur. Respir. J. 2020; https://doi.org/10.1183/13993003.00524-2020Crossref Scopus (170) Google Scholar]. However, as recently reported by Q. Deng et al. troponin levels were increased particularly in patients who died during hospitalization although they did not present with typical signs of myocarditis [2Deng Q. Hu B. Zhang Y. et al.Suspected myocardial injury in patients with COVID-19: evidence from front-line clinical observation in Wuhan, China.Int. J. Cardiol. 2020; https://doi.org/10.1016/j.ijcard.2020.03.087Abstract Full Text Full Text PDF Scopus (53) Google Scholar].

ACS Style

Marco Ferlini; Aida Andreassi; Stefano Carugo; Claudio Cuccia; Beatrice Bianchini; Battistina Castiglioni; Maurizio D' Urbano; Giulio Guagliumi; Corrado Lettieri; Maddalena Lettino; Giancarlo Marenzi; Marco Metra; Maurizio Migliori; Matteo Montorfano; Fabrizio Oliva; Stefano Savonitto; Romano Seregni; Luigi Oltrona Visconti. Centralization of the ST elevation myocardial infarction care network in the Lombardy region during the COVID-19 outbreak. International Journal of Cardiology 2020, 312, 24 -26.

AMA Style

Marco Ferlini, Aida Andreassi, Stefano Carugo, Claudio Cuccia, Beatrice Bianchini, Battistina Castiglioni, Maurizio D' Urbano, Giulio Guagliumi, Corrado Lettieri, Maddalena Lettino, Giancarlo Marenzi, Marco Metra, Maurizio Migliori, Matteo Montorfano, Fabrizio Oliva, Stefano Savonitto, Romano Seregni, Luigi Oltrona Visconti. Centralization of the ST elevation myocardial infarction care network in the Lombardy region during the COVID-19 outbreak. International Journal of Cardiology. 2020; 312 ():24-26.

Chicago/Turabian Style

Marco Ferlini; Aida Andreassi; Stefano Carugo; Claudio Cuccia; Beatrice Bianchini; Battistina Castiglioni; Maurizio D' Urbano; Giulio Guagliumi; Corrado Lettieri; Maddalena Lettino; Giancarlo Marenzi; Marco Metra; Maurizio Migliori; Matteo Montorfano; Fabrizio Oliva; Stefano Savonitto; Romano Seregni; Luigi Oltrona Visconti. 2020. "Centralization of the ST elevation myocardial infarction care network in the Lombardy region during the COVID-19 outbreak." International Journal of Cardiology 312, no. : 24-26.

Journal article
Published: 04 March 2020 in Open Heart
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Background The aim of this study was to assess by a census supported by the Italian Society of Cardiology (Società Italiana di Cardiologia, SIC) the present implementation of telemedicine in the field of cardiovascular disease in Italy. Methods A dedicated questionnaire was sent by email to all the members of the SIC: data on telemedicine providers, service provided, reimbursement, funding and organisational solutions were collected and analysed. Results Reported telemedicine activities were mostly stable and public hospital based, focused on acute cardiovascular disease and prehospital triage of suspected acute myocardial infarction (prehospital ECG, always interpreted by a cardiologist and not automatically reported by computerised algorithms). Private companies delivering telemedicine services in cardiology (ECGs, ambulatory ECG monitoring) were also present. In 16% of cases, ECGs were also delivered through pharmacies or general practitioners. ICD/CRT-D remote control was performed in 42% of cases, heart failure patient remote monitoring in 37% (21% vital parameters monitoring, 32% nurse telephone monitoring). Telemedicine service was public in 74% of cases, paid by the patient in 26%. About half of telemedicine service received no funding, 17% received State and/or European Union funding. Conclusions Several telemedicine activities have been reported for the management of acute and chronic cardiovascular disease in Italy. The whole continuum of cardiovascular disease is covered by telemedicine solutions. A periodic census may be useful to assess the implementation of guidelines recommendations on telemedicine.

ACS Style

Natale Daniele Brunetti; Giuseppe Molinari; Flavio Acquistapace; Tecla Zimotti; Gianfranco Parati; Ciro Indolfi; Francesco Fedele; Stefano Carugo. 2019 Italian Society of Cardiology Census on telemedicine in cardiovascular disease: a report from the working group on telecardiology and informatics. Open Heart 2020, 7, e001157 .

AMA Style

Natale Daniele Brunetti, Giuseppe Molinari, Flavio Acquistapace, Tecla Zimotti, Gianfranco Parati, Ciro Indolfi, Francesco Fedele, Stefano Carugo. 2019 Italian Society of Cardiology Census on telemedicine in cardiovascular disease: a report from the working group on telecardiology and informatics. Open Heart. 2020; 7 (1):e001157.

Chicago/Turabian Style

Natale Daniele Brunetti; Giuseppe Molinari; Flavio Acquistapace; Tecla Zimotti; Gianfranco Parati; Ciro Indolfi; Francesco Fedele; Stefano Carugo. 2020. "2019 Italian Society of Cardiology Census on telemedicine in cardiovascular disease: a report from the working group on telecardiology and informatics." Open Heart 7, no. 1: e001157.