Aims To compare intraobserver repeatability and interobserver and intersession reproducibility of lower tear meniscus height measurements (LTMH) obtained with the new Keratograph 5M and a Fourier-domain optical-coherence tomography (OCT; Spectralis OCT) and to assess the agreement between the two devices. Methods This is a observational cross-sectional study. Thirty eyes of 30 normal subjects were randomly imaged twice with both devices in our setting. Two examiners randomly made LTMH measurements using the devices. To assess intraobserver repeatability and interobserver and intersession reproducibility within-subject SD (S_w), test–retest repeatability, coefficient of variation (CoV) and intraclass correlation coefficients (ICCs) were calculated. Agreement between both devices was also determined. Results Average LMTH for Keratograph was 235.46±57.61 μm, whereas the mean LTMH measured by OCT was 245.84±67.18 μm. Intraobserver repeatability and interobserver and intersession reproducibility were moderate with Keratograph (CoV ≥0.16%, ≥0.19%, ≥0.17% and ICC ≤0.83, ≤0.76, ≤0.83, respectively) and high for the Spectralis OCT (CoV ≤0.13%, ≤0.12%, ≤0.11% and ICC ≥0.9, ≥0.92, ≥0.92, respectively). No statistically significant difference was detected in mean LMTH measurements made with both devices, although correlation was low (CoV 0.25%, ICC 0.55). Conclusions Spectralis OCT LTMH measurements were more reliable than the new Keratograph data. Agreement between the devices was poor.

Objective: To evaluate the potential utility of perfusion density measurements to discriminate patients with arterial hypertension by cardiovascular risk category. Methods: In this cross-sectional study, one eye per subject was evaluated (N = 73). The study cohort was divided into three groups according to the clinical criteria established by the European Guidelines for Arterial Hypertension: 26 controls, 24 patients with low cardiovascular risk, and 23 patients with very high cardiovascular risk. All patients were examined using RS-3000 Advance optical coherence tomography angiography to analyze macular and peripapillary perfusion density. Results: There were no differences among the three risk groups by sex or age. Decreased macular perfusion density was found at the level of the superficial and deep plexuses (p ⩽ 0.047). No differences were observed in peripapillary perfusion density (p = 0.18). Conclusion: Optical coherence tomography angiography can detect changes in macular perfusion density in patients with hypertension and high cardiovascular risk and might represent a supportive imaging method in the evaluation of the cardiovascular risk in hypertensive patients.

Purpose: To measure the length, thickness and area of the trabecular meshwork (TM) in vivo using Fourier domain optical coherence tomography (FD-OCT) in a Caucasian population of healthy subjects. Methods: Cross-sectional study of 1,006 healthy subjects. Left eyes were randomly selected. Age, gender, intraocular pressure and spherical refractive error were noted down. The depth and volume of the anterior chamber and the central corneal thickness were measured with Pentacam®, while IOL Master® was used to measure the axial length. The length, thickness and area of the TM were measured through FD-OCT RTVue®. A study was carried out to determine the correlation between TM size and other demographic and ocular parameters. Finally, the reproducibility of the measurements was assessed for a subgroup of 50 eyes from 50 patients. Results: We were able to measure the TM in 91.1% of the total eyes studied. The mean TM length was 496.99 ±92.77 µm (range 275 to 800), TM thickness: 174.16 ±28.14 µm (range 100 to 276) and TM area: 0.069 ±0.031 mm2 (range 0.023 to 0.133). No differences were found in terms of length and area between gender, although the TM was slightly thicker in men (p<0.039). No correlation was observed between the TM measurements and any of the studied demographic or ocular parameters (R<0.09; p0.750; p<0.001). Conclusions: FD-OCT is an effective and reproducible examination technique to measure the length, thickness and area of the trabecular meshwork in vivo.