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Dr. Maria Morini
Dipartimento di scienze mediche veterinarie Università di Bologna

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0 Cytology
0 Histopathology
0 Immunohistochemistry
0 Veterinary Pathology
0 diagnostic pathology

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Journal article
Published: 05 August 2021 in Animals
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The aim of this retrospective single-center study was to evaluate which factors, including expression of P-glycoprotein (P-gp), a membrane-bound protein involved in multiple drug resistance, could predict the response to treatment in canine immunosuppressant-responsive enteropathy (IRE). Dogs with IRE or non-responsive enteropathy (NRE) that were examined from 2005 to 2014 were included and were divided into two groups (IRE vs. NRE). Signalment, history, and clinical and laboratory findings were collected. P-glycoprotein immunohistochemistry was carried out on duodenal biopsies of both groups stored in our biobank, and immunophenotyping and molecular clonality were performed on the NRE samples. Ninety-two dogs were enrolled, 73 IRE (79.3%) and 19 NRE (20.7%), with a prevalence of pure breed (78.3% vs. 21.7%) and male dogs (p< 0.001). Factors associated with a worse prognosis were previous treatment with steroids (p = 0.033) and lower serum total protein concentration (p = 0.005). Clonality testing on the NRE duodenal biopsies showed 5/16 clonal responses, assuming a latent undiagnosed lymphoma as a possible cause of the NRE.

ACS Style

Marco Pietra; Giorgia Galiazzo; Francesca Bresciani; Maria Morini; Sara Licarini; Maria Turba; Gianmaria Amaducci; Giuliano Bettini; Federico Fracassi; Fabio Ostanello. Evaluation of Prognostic Factors, including Duodenal P-Glycoprotein Expression, in Canine Chronic Enteropathy. Animals 2021, 11, 2315 .

AMA Style

Marco Pietra, Giorgia Galiazzo, Francesca Bresciani, Maria Morini, Sara Licarini, Maria Turba, Gianmaria Amaducci, Giuliano Bettini, Federico Fracassi, Fabio Ostanello. Evaluation of Prognostic Factors, including Duodenal P-Glycoprotein Expression, in Canine Chronic Enteropathy. Animals. 2021; 11 (8):2315.

Chicago/Turabian Style

Marco Pietra; Giorgia Galiazzo; Francesca Bresciani; Maria Morini; Sara Licarini; Maria Turba; Gianmaria Amaducci; Giuliano Bettini; Federico Fracassi; Fabio Ostanello. 2021. "Evaluation of Prognostic Factors, including Duodenal P-Glycoprotein Expression, in Canine Chronic Enteropathy." Animals 11, no. 8: 2315.

Journal article
Published: 12 May 2021 in Animals
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Severe equine asthma (EA) syndrome is a chronic obstructive disease characterized by exaggerated contraction, inflammation, and structural alteration of the airways in adult horses, when exposed to airborne molds and particulate material. However, little is known about the relationship between the degree and type of inflammation on one hand, and the severity of the disease and the response to treatment on the other. Furthermore, to date, very few studies evaluate the diagnostic value of histology and immunohistochemical features of endoscopic biopsies on subjects with severe equine asthma. To investigate the expression of two inflammatory markers (NKA and IL-8) before, during, and after the exacerbation of severe EA, a histological and immunohistochemical study was carried out on a series of biopsy samples collected by bronchoscopy from six EA-affected horses subjected to process exacerbation through environmental stimuli and then to pharmacological treatment. The application of a histological biopsy scoring system revealed a significant difference between control cases and the EA-affected horses in all experimental phases (asymptomatic, early exacerbation phase, late exacerbation phase, and remission phase). For immunohistochemistry (IHC), only the intensity of NKA positivity increases significantly between control horses and the EA horses at late exacerbation and remission phases. In EA-affected horses, a difference was detected by comparing histology between asymptomatic and remission phase, meanwhile, NKA and IL-8 showed no differences between the experimental phases. Based on these results we can assert that: (1) The endoscopic biopsies generate reliable and homogeneous samples in the entire bronchial tree; (2) the clinical improvement associated with treatment is characterized by a significant worsening of the histological findings; and (3) the NKA immunopositivity seems to increase significantly rather than decrease, as one would have expected, after pharmacological treatment. Further studies are necessary both to implement the number of samples and to use other markers of inflammation to characterize the potential role of cytokines in the diagnosis and therapeutic approach of severe equine asthma.

ACS Style

Maria Morini; Angelo Peli; Riccardo Rinnovati; Giuseppe Magazzù; Noemi Romagnoli; Alessandro Spadari; Marco Pietra. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase. Animals 2021, 11, 1376 .

AMA Style

Maria Morini, Angelo Peli, Riccardo Rinnovati, Giuseppe Magazzù, Noemi Romagnoli, Alessandro Spadari, Marco Pietra. Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase. Animals. 2021; 11 (5):1376.

Chicago/Turabian Style

Maria Morini; Angelo Peli; Riccardo Rinnovati; Giuseppe Magazzù; Noemi Romagnoli; Alessandro Spadari; Marco Pietra. 2021. "Immunohistochemical Expression of Neurokinin-A and Interleukin-8 in the Bronchial Epithelium of Horses with Severe Equine Asthma Syndrome during Asymptomatic, Exacerbation, and Remission Phase." Animals 11, no. 5: 1376.

Journal article
Published: 05 May 2021 in Research in Veterinary Science
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Feline Vector-Borne Diseases show increased global prevalence and some Anaplasma and Ehrlichia species may pose a risk to human health. The diagnosis of Anaplasma and Ehrlichia species infection in cats is achieved by the combined use of different methods as cytologic examination evidencing intracytoplasmic morulae, serologic tests and molecular assays. The peripheral whole blood is considered the sample of choice for Anaplasma and Ehrlichia species DNA detection in cats, but false negative results are reported leading to underestimation of infection prevalence. In order to have a more accurate assessment of the spread of feline vector-borne pathogens, the presence of Anaplasma spp. and Ehrlichia spp. DNA in 37 owner and shelter cats subjected to necropsy were prospectively investigated by testing in end-point PCR spleen, bone marrow, blood clot and hair samples. The bacteria identified were genetically characterised. Three shelter cats tested positive for A. phagocytophilum DNA in spleen (one cat) or in hair samples (two cats). None of the cats tested positive in bone marrow and blood samples. From the results obtained, it can be assumed that the use of spleen or hair samples could allow a more reliable detection of A. phagocytophilum DNA in cats with blood tested negative. In the phylogeny constructed with a fragment of the heat shock (groEL) gene nucleotide sequences, all the identified A. phagocytophilum clustered with bacteria infecting a wide range of hosts, including humans, showing a potential zoonotic role.

ACS Style

Andrea Balboni; Lorenza Urbani; Maria Morini; Francesco Dondi; Mara Battilani. Molecular detection of Anaplasma phagocytophilum in hair and spleen of cats revealed a possible underestimation of feline vector-borne pathogens. Research in Veterinary Science 2021, 137, 144 -149.

AMA Style

Andrea Balboni, Lorenza Urbani, Maria Morini, Francesco Dondi, Mara Battilani. Molecular detection of Anaplasma phagocytophilum in hair and spleen of cats revealed a possible underestimation of feline vector-borne pathogens. Research in Veterinary Science. 2021; 137 ():144-149.

Chicago/Turabian Style

Andrea Balboni; Lorenza Urbani; Maria Morini; Francesco Dondi; Mara Battilani. 2021. "Molecular detection of Anaplasma phagocytophilum in hair and spleen of cats revealed a possible underestimation of feline vector-borne pathogens." Research in Veterinary Science 137, no. : 144-149.

Case report
Published: 04 March 2021 in Animals
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A 2-year-old Boxer with a history of subaortic stenosis and immunosuppressant therapy developed aortic valve infective endocarditis. On echocardiographic examination with simultaneous electrocardiographic tracing, multiple uncommon periannular complications of the aortic valve endocarditis were found, including aorto-cavitary fistula with diastolic left-to-right shunt, tricuspid valve endocarditis, and third-degree atrioventricular block. Necropsy confirmed the above echocardiographic findings. Although aortic valve endocarditis represents a well-known disease entity in dogs, the dynamic nature of this condition may allow development of complex and uncommon echocardiographic features.

ACS Style

Giovanni Romito; Alessia Diana; Antonella Rigillo; Maria Morini; Mario Cipone. Unusual Presentation of Aortic Valve Infective Endocarditis in a Dog: Aorto-Cavitary Fistula, Tricuspid Valve Endocarditis, and Third-Degree Atrioventricular Block. Animals 2021, 11, 690 .

AMA Style

Giovanni Romito, Alessia Diana, Antonella Rigillo, Maria Morini, Mario Cipone. Unusual Presentation of Aortic Valve Infective Endocarditis in a Dog: Aorto-Cavitary Fistula, Tricuspid Valve Endocarditis, and Third-Degree Atrioventricular Block. Animals. 2021; 11 (3):690.

Chicago/Turabian Style

Giovanni Romito; Alessia Diana; Antonella Rigillo; Maria Morini; Mario Cipone. 2021. "Unusual Presentation of Aortic Valve Infective Endocarditis in a Dog: Aorto-Cavitary Fistula, Tricuspid Valve Endocarditis, and Third-Degree Atrioventricular Block." Animals 11, no. 3: 690.

Original research article
Published: 27 November 2020 in Frontiers in Veterinary Science
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Large colon volvulus in horses is associated with a poor prognosis, especially when ischemic-reperfusion injury of the affected intestinal tract develops. Proteinase-activated receptor 2 (PAR2) plays an important role in the pathogenesis of inflammation in the gastrointestinal tract. The aim of this study was to evaluate the distribution and expression of PAR2 in colonic pelvic flexure of horses spontaneously affected by large colon volvulus (CVH group). Eight horses admitted for severe abdominal colon volvolus and which underwent surgery were included. Colon samples were collected after enterotomy. Data previously obtained from healthy horses were used as a control group. Histologic evaluation was carried out to grade the severity of the colon lesions. Immunofluorescence, western blot and quantitative polymerase chain reaction (RT-qPCR) were carried out on colon samples to evaluate PAR2 expression. In addition, the transcriptional profile of cytokines and chemokines was evaluated using RT2 Profiler™ PCR Array Horse Cytokines & Chemokines. Three out of the eight patients were euthanised due to clinical deterioration. Immunostaining for PAR2 was observed in the enterocytes, intestinal glands and neurons of the submucosal and myenteric plexi. In the CVH horses, the expression of PAR2 mesenger RNA (mRNA) did not differ significantly from that of the healthy animals; western blots of the mucosa of the colon tracts showed a clear band of the expected molecular weight for PAR2 (~44 kDa) and a band smaller than the expected molecular weight for PAR2 (25kDa), suggesting its activation. The gene expressions for C-X-C motif ligand 1 (CXCL1); interleukin 8 (IL8), macrophage inflammatory protein 2 beta (MIP-2BETA) were upregulated in the colic horses as compared with the colons of the healthy horses. Therefore, in the present study, the expression and activation of PAR2 in the colons of horses in the presence of an inflammatory reaction like that occurring in those with spontaneous colon volvulus was confirmed.

ACS Style

Carlotta Lambertini; Augusta Zannoni; Noemi Romagnoli; Cristiano Bombardi; Maria Morini; Francesco Dondi; Chiara Bernardini; Monica Forni; Riccardo Rinnovati; Alessandro Spadari. Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse. Frontiers in Veterinary Science 2020, 7, 1 .

AMA Style

Carlotta Lambertini, Augusta Zannoni, Noemi Romagnoli, Cristiano Bombardi, Maria Morini, Francesco Dondi, Chiara Bernardini, Monica Forni, Riccardo Rinnovati, Alessandro Spadari. Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse. Frontiers in Veterinary Science. 2020; 7 ():1.

Chicago/Turabian Style

Carlotta Lambertini; Augusta Zannoni; Noemi Romagnoli; Cristiano Bombardi; Maria Morini; Francesco Dondi; Chiara Bernardini; Monica Forni; Riccardo Rinnovati; Alessandro Spadari. 2020. "Expression of Proteinase-Activated Receptor 2 During Colon Volvulus in the Horse." Frontiers in Veterinary Science 7, no. : 1.

Case report
Published: 22 October 2020 in Veterinary Sciences
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Oxytetracycline (OTC) administration has become a frequent practice in equine neonatology for the treatment of flexural limb deformity. The cause of this condition remains unclear but clinical studies revealed that following IV administration of OTC a relaxation of the metacarpophalangeal joint occurs in foals affected by flexural deformity. Studies concluded that OTC administration in neonatal foals did not adversely affect the kidneys. Other adverse effects of OTC have never been reported. This report presents two cases with different outcomes of 3-day-old foals which presented acute collapse and progressive depression after OTC administration. The clinical aspects, the increased activity of serum enzymes indicative of muscular damage, the presence of myoglobin in urine were clear diagnostic indicators of severe rhabdomyolysis, and the gross and histological findings confirmed a myopathy associated with renal damage in one case. Adverse effects on the musculoskeletal and urinary systems in healthy foals were first reported and were probably associated with multiple doses administered to foals less than 24–48 h old and/or at dosing intervals less than 24–48 h. The risk of development of rhabdomyolysis and nephrotoxicity in neonatal foals treated with OTC for flexural deformity from now on should be considered.

ACS Style

Nicola Ellero; Francesca Freccero; Aliai Lanci; Maria Morini; Carolina Castagnetti; Jole Mariella. Rhabdomyolysis and Acute Renal Failure Associated with Oxytetracycline Administration in Two Neonatal Foals Affected by Flexural Limb Deformity. Veterinary Sciences 2020, 7, 160 .

AMA Style

Nicola Ellero, Francesca Freccero, Aliai Lanci, Maria Morini, Carolina Castagnetti, Jole Mariella. Rhabdomyolysis and Acute Renal Failure Associated with Oxytetracycline Administration in Two Neonatal Foals Affected by Flexural Limb Deformity. Veterinary Sciences. 2020; 7 (4):160.

Chicago/Turabian Style

Nicola Ellero; Francesca Freccero; Aliai Lanci; Maria Morini; Carolina Castagnetti; Jole Mariella. 2020. "Rhabdomyolysis and Acute Renal Failure Associated with Oxytetracycline Administration in Two Neonatal Foals Affected by Flexural Limb Deformity." Veterinary Sciences 7, no. 4: 160.

Original research article
Published: 31 March 2020 in Frontiers in Veterinary Science
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Proteinase activated receptor 4 (PAR4) in the gastrointestinal tract is involved in the regulation of inflammation and pain pathways. The aim of the present study was to evaluate the distribution and expression of PAR4 in the jejunum of healthy horses and in the pathologic tracts from horses undergoing surgery for herniation of the small intestine through the epiploic foramen. Eight healthy horses (Group H) and eight horses with epiploic hernia (Group EH) were included; the jejunum samples were collected at the slaughter or intraoperatively after enterectomy, respectively. To evaluate PAR4 expression in sections of the jejunum, immunofluorescence, western blot and quantitative polymerase chain reaction (qRT-PCR) were performed. Immunohistochemistry of PAR4 in the jejunum of the healthy horses showed that receptors are predominantly expressed in the immune cell population scattered throughout the lamina propria of the mucosa and in the submucosa. Quantitative PCR data demonstrated that PAR4 mRNA was detectable in all of the samples analyzed without any difference between the H and the EH groups, however the PAR4 protein level was significantly lower in the jejunums of the EH horses. In the Group EH horses, PAR4 immunoreactivity was mainly expressed in the mast cells and was extensively distributed in the sierosa. In the lamina propria of mucosa of Group EH, leukocytes were less abundant than in Group H. In this study, the distribution and expression of PAR4 in the jejunums of the healthy horses and in those with spontaneous occurring epiploic hernia was demonstrated.

ACS Style

Carlotta Lambertini; Cristiano Bombardi; Augusta Zannoni; Chiara Bernardini; Francesco Dondi; Maria Morini; Riccardo Rinnovati; Alessandro Spadari; Noemi Romagnoli. Proteinase Activated Receptor 4 in the Jejunum of Healthy Horses and of Horses With Epiploic Hernia. Frontiers in Veterinary Science 2020, 7, 1 .

AMA Style

Carlotta Lambertini, Cristiano Bombardi, Augusta Zannoni, Chiara Bernardini, Francesco Dondi, Maria Morini, Riccardo Rinnovati, Alessandro Spadari, Noemi Romagnoli. Proteinase Activated Receptor 4 in the Jejunum of Healthy Horses and of Horses With Epiploic Hernia. Frontiers in Veterinary Science. 2020; 7 ():1.

Chicago/Turabian Style

Carlotta Lambertini; Cristiano Bombardi; Augusta Zannoni; Chiara Bernardini; Francesco Dondi; Maria Morini; Riccardo Rinnovati; Alessandro Spadari; Noemi Romagnoli. 2020. "Proteinase Activated Receptor 4 in the Jejunum of Healthy Horses and of Horses With Epiploic Hernia." Frontiers in Veterinary Science 7, no. : 1.

Note
Published: 01 January 2020 in Journal of Equine Science
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A neurofibroma was excised from the subcutis on the medial side of the left thigh of a 15-year-old Warmblood gelding, which had shown lameness of the left hind limb. No other source of lameness was found. Two weeks after surgery, the horse was sound at a lameness examination.

ACS Style

Riccardo Rinnovati; Socrate Xenos; Andrea Beltrame; Andrea Marigo; Giulia Forni; Maria Morini. Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse. Journal of Equine Science 2020, 31, 45 -48.

AMA Style

Riccardo Rinnovati, Socrate Xenos, Andrea Beltrame, Andrea Marigo, Giulia Forni, Maria Morini. Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse. Journal of Equine Science. 2020; 31 (3):45-48.

Chicago/Turabian Style

Riccardo Rinnovati; Socrate Xenos; Andrea Beltrame; Andrea Marigo; Giulia Forni; Maria Morini. 2020. "Subcutaneous neurofibroma as a cause of lameness in a warmblood horse: Neurofibroma in a horse." Journal of Equine Science 31, no. 3: 45-48.

Journal article
Published: 01 August 2019 in Research in Veterinary Science
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ACS Style

Noemi Romagnoli; Augusta Zannoni; Chiara Bernardini; Thomas Gobbetti; Cristiano Bombardi; Anna Maria Rambaldi; Maria Morini; Francesco Dondi; Riccardo Rinnovati; Carlotta Lambertini; Alessandro Spadari. Proteinase-activated receptor 2 distribution and expression in equine small intestine tracts following herniation through the epiploic foramen. Research in Veterinary Science 2019, 125, 434 -440.

AMA Style

Noemi Romagnoli, Augusta Zannoni, Chiara Bernardini, Thomas Gobbetti, Cristiano Bombardi, Anna Maria Rambaldi, Maria Morini, Francesco Dondi, Riccardo Rinnovati, Carlotta Lambertini, Alessandro Spadari. Proteinase-activated receptor 2 distribution and expression in equine small intestine tracts following herniation through the epiploic foramen. Research in Veterinary Science. 2019; 125 ():434-440.

Chicago/Turabian Style

Noemi Romagnoli; Augusta Zannoni; Chiara Bernardini; Thomas Gobbetti; Cristiano Bombardi; Anna Maria Rambaldi; Maria Morini; Francesco Dondi; Riccardo Rinnovati; Carlotta Lambertini; Alessandro Spadari. 2019. "Proteinase-activated receptor 2 distribution and expression in equine small intestine tracts following herniation through the epiploic foramen." Research in Veterinary Science 125, no. : 434-440.

Journal article
Published: 27 April 2018 in Veterinární Medicína
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A 7-year-old intact male Rottweiler dog was evaluated for recurrent dysphagia and regurgitation. Physical examination was unremarkable and routine blood works were within normal limits. Computed tomography revealed a defined lesion in the caudal mediastinum arising from the oesophagus. The lesion was excised using intercostal thoracotomy and the histological diagnosis was oesophageal duplication cyst. The dog recovered uneventfully and at a 3-year follow-up no clinical signs were reported. Although extremely rare, oesophageal duplication cysts should be considered in the differential diagnosis in cases of chronic regurgitation and dysphagia associated with evidence of an oesophageal lesion.

ACS Style

A. Foglia; S. Del Magno; M. Pietra; V. Cola; M. Joechler; Maria Morini; L. Pisoni. Surgical treatment of a thoracic oesophageal duplication cyst causing recurrent dysphagia in an adult dog. Veterinární Medicína 2018, 63, 175 -180.

AMA Style

A. Foglia, S. Del Magno, M. Pietra, V. Cola, M. Joechler, Maria Morini, L. Pisoni. Surgical treatment of a thoracic oesophageal duplication cyst causing recurrent dysphagia in an adult dog. Veterinární Medicína. 2018; 63 (No. 4):175-180.

Chicago/Turabian Style

A. Foglia; S. Del Magno; M. Pietra; V. Cola; M. Joechler; Maria Morini; L. Pisoni. 2018. "Surgical treatment of a thoracic oesophageal duplication cyst causing recurrent dysphagia in an adult dog." Veterinární Medicína 63, no. No. 4: 175-180.

Controlled clinical trial
Published: 03 March 2018 in Veterinary Record
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Saccharomyces boulardii is used to treat acute and chronic enteropathies in humans, but to date, no studies have evaluated the use of this yeast in dogs. The current study, a prospective non-randomised, double-blinded, placebo-controlled study, evaluated the effects of S boulardii in healthy dogs and dogs with chronic enteropathies (CE). Four healthy dogs and 20 dogs with CE were included. In healthy dogs, S boulardii was administered for 10 days. Possible short-term adverse effects were recorded, and quantitative stool cultures for yeasts were performed. In dogs with CE, S boulardii or a placebo was administered in addition to standard treatment protocols. Canine Chronic Enteropathy Clinical Activity Index, abdominal ultrasonography, gastroenteroscopy and histology were performed at the time of diagnosis and after 60 days of treatment. In healthy dogs, S boulardii reached a steady state in five days and was completely eliminated on day 4 after administration. No short-term side effects were seen. Clinical activity index, stool frequency, stool consistency and body condition score improved significantly in dogs with CE receiving S boulardii versus the placebo. In conclusion, S boulardii can be safely used in dogs with CE and seems to achieve better control of clinical signs than standard therapy alone.

ACS Style

Simona D'Angelo; Federico Fracassi; Francesca Bresciani; Roberta Galuppi; Alessia Diana; Nikolina Linta; Giuliano Bettini; Maria Morini; Marco Pietra. Effect of Saccharomyces boulardii in dogs with chronic enteropathies: double-blinded, placebo-controlled study. Veterinary Record 2018, 182, 258 -258.

AMA Style

Simona D'Angelo, Federico Fracassi, Francesca Bresciani, Roberta Galuppi, Alessia Diana, Nikolina Linta, Giuliano Bettini, Maria Morini, Marco Pietra. Effect of Saccharomyces boulardii in dogs with chronic enteropathies: double-blinded, placebo-controlled study. Veterinary Record. 2018; 182 (9):258-258.

Chicago/Turabian Style

Simona D'Angelo; Federico Fracassi; Francesca Bresciani; Roberta Galuppi; Alessia Diana; Nikolina Linta; Giuliano Bettini; Maria Morini; Marco Pietra. 2018. "Effect of Saccharomyces boulardii in dogs with chronic enteropathies: double-blinded, placebo-controlled study." Veterinary Record 182, no. 9: 258-258.

Journal article
Published: 15 February 2018 in Journal of the American Veterinary Medical Association
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ACS Style

Marika Menchetti; Maria Morini; Luciano Pisoni; Teresa Gagliardo; Filippo Cinti; Giuliano Bettini; Gualtiero Gandini. Pathology in Practice. Journal of the American Veterinary Medical Association 2018, 252, 423 -425.

AMA Style

Marika Menchetti, Maria Morini, Luciano Pisoni, Teresa Gagliardo, Filippo Cinti, Giuliano Bettini, Gualtiero Gandini. Pathology in Practice. Journal of the American Veterinary Medical Association. 2018; 252 (4):423-425.

Chicago/Turabian Style

Marika Menchetti; Maria Morini; Luciano Pisoni; Teresa Gagliardo; Filippo Cinti; Giuliano Bettini; Gualtiero Gandini. 2018. "Pathology in Practice." Journal of the American Veterinary Medical Association 252, no. 4: 423-425.

Journal article
Published: 16 November 2017 in Veterinární Medicína
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A 35-month-old female German shepherd weighing 33.2 kg was referred to our department with a 10-month history of sneezing and left nasal swelling. On clinical examination, the dog showed deformity of the left nasal plane in the absence of any cutaneous lesions or nasal discharge, and presented with nasal snoring noises during both the inspiratory and expiratory phases. The patency of nasal cavities was evaluated using the cotton swab test, and was found to be preserved only on the right side. Endoscopic, radiographic and computed tomographic examination revealed an osteoproductive lesion that distorted the nasal, maxillar and frontal bones, completely occupying the left nasal cavity and frontal sinuses, resulting in destruction of the nasal septum and invasion of the contralateral nasal cavity. Five bioptic samples of the mass were collected from the cutaneous surface using a 9G Jamshidi bone marrow bioptic instrument. Histologically, the lesion consisted of a non-encapsulated, multilobulated mass composed of dense coalescing trabeculae of well-differentiated bone, which was lined by osteogenic cells. The morphology was suggestive of nasal osteoma. Due to the large size of the mass, evidenced by computed tomography, chronic systemic nonsteroidal anti-inflammatory treatment with carprofen was proposed instead of surgery. The description of this case is useful for veterinarians, who should consider osteoma as a possible differential diagnosis for nasal tumours.

ACS Style

G. Galiazzo; M. Pietra; D. Tinto; N. Linta; Maria Morini; O. Capitani. A rare case of nasal osteoma in a dog: a case report. Veterinární Medicína 2017, 62, 614 -619.

AMA Style

G. Galiazzo, M. Pietra, D. Tinto, N. Linta, Maria Morini, O. Capitani. A rare case of nasal osteoma in a dog: a case report. Veterinární Medicína. 2017; 62 (No. 11):614-619.

Chicago/Turabian Style

G. Galiazzo; M. Pietra; D. Tinto; N. Linta; Maria Morini; O. Capitani. 2017. "A rare case of nasal osteoma in a dog: a case report." Veterinární Medicína 62, no. No. 11: 614-619.

Journal article
Published: 26 September 2017 in Polish Journal of Veterinary Sciences
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The aim of this study was to evaluate the suitability of synthetic bitch sex pheromones (Eau’ De Estrus®, Synbiotics USA) for the stimulation of the reproductive reflexes in adult male dogs. In experiment I: anoestral bitches were applied synthetic (n=6) or natural (n=6) pheromones and their attractiveness was compared to the attractiveness of bitches in natural oestrus, In experiment II: swabs socked in natural estrual discharge or Eau D’Estrus were presented to male dogs and behavioral arousal (Exp. II a) and changes in blood flow in the penile artery reflecting erection (Exp. II b) were recorded. In experiment III the time dedicated for sniffing in experimental dogs was analyzed in relation to the type of attractant presented (natural estrual discharge or Eau D’Estrus). In all three experiments we observed the signs of sexual arousal, increased blood flow in the penile artery and increased time of sniffing only with natural pheromones. No signs of excitation or changes in penis perfusion were noted after the use of artificial pheromones. Our results did not support the suitability of Eau D’Estrus for male dog sexual stimulation.

ACS Style

M. Dzięcioł; Wojciech Niżański; T. Jezierski; Antoni Szumny; E.J. Godzińska; Małgorzata Ochota; E. Stańczyk; L. Najder-Kozdrowska; M. Woszczyło; B. Pieczewska; P. Gianella; M. Pietra; P.E. Crisi; P. Famigli Bergamini; F. Fracassi; Maria Morini; A. Boari. The Efficiency of Synthetic Sex Pheromones in Sexual Arousal Stimulation in Domestic Dogs. Polish Journal of Veterinary Sciences 2017, 20, 429 -437.

AMA Style

M. Dzięcioł, Wojciech Niżański, T. Jezierski, Antoni Szumny, E.J. Godzińska, Małgorzata Ochota, E. Stańczyk, L. Najder-Kozdrowska, M. Woszczyło, B. Pieczewska, P. Gianella, M. Pietra, P.E. Crisi, P. Famigli Bergamini, F. Fracassi, Maria Morini, A. Boari. The Efficiency of Synthetic Sex Pheromones in Sexual Arousal Stimulation in Domestic Dogs. Polish Journal of Veterinary Sciences. 2017; 20 (3):429-437.

Chicago/Turabian Style

M. Dzięcioł; Wojciech Niżański; T. Jezierski; Antoni Szumny; E.J. Godzińska; Małgorzata Ochota; E. Stańczyk; L. Najder-Kozdrowska; M. Woszczyło; B. Pieczewska; P. Gianella; M. Pietra; P.E. Crisi; P. Famigli Bergamini; F. Fracassi; Maria Morini; A. Boari. 2017. "The Efficiency of Synthetic Sex Pheromones in Sexual Arousal Stimulation in Domestic Dogs." Polish Journal of Veterinary Sciences 20, no. 3: 429-437.

Journal article
Published: 01 January 2017 in Journal of Comparative Pathology
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ACS Style

M. Morini; F. Gentilini; M.E. Turba; F. Turci; R. Sirri; G. Bettini. Mutational Analysis of C-Kit and PDGFRA in Canine Gastrointestinal Stromal Tumours. Journal of Comparative Pathology 2017, 156, 117 .

AMA Style

M. Morini, F. Gentilini, M.E. Turba, F. Turci, R. Sirri, G. Bettini. Mutational Analysis of C-Kit and PDGFRA in Canine Gastrointestinal Stromal Tumours. Journal of Comparative Pathology. 2017; 156 (1):117.

Chicago/Turabian Style

M. Morini; F. Gentilini; M.E. Turba; F. Turci; R. Sirri; G. Bettini. 2017. "Mutational Analysis of C-Kit and PDGFRA in Canine Gastrointestinal Stromal Tumours." Journal of Comparative Pathology 156, no. 1: 117.

Case reports
Published: 23 June 2015 in Veterinary Dermatology
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Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune-mediated destruction of the adrenal cortex. In this case report we describe a dog with primary hypoadrenocorticism that developed generalized vitiligo. A 4-year-old spayed female cross-bred dog developed signs of Addison's disease and this was confirmed by biochemical testing; the dog was treated with fludrocortisone acetate and then desoxycorticosterone pivalate. Three months after the diagnosis, the dog developed depigmentation of the whole hair coat and of several focal areas of the skin. Histopathological findings were consistent with vitiligo. Dogs with immune-mediated disease may develop other manifestations of immune-mediated disease, including a combination of Addison's disease and vitiligo. The cause in this case was not determined.

ACS Style

Eleonora Malerba; Maria Morini; Federico Fracassi. Generalized vitiligo in a dog with primary hypoadrenocorticism. Veterinary Dermatology 2015, 26, 376 -e86.

AMA Style

Eleonora Malerba, Maria Morini, Federico Fracassi. Generalized vitiligo in a dog with primary hypoadrenocorticism. Veterinary Dermatology. 2015; 26 (5):376-e86.

Chicago/Turabian Style

Eleonora Malerba; Maria Morini; Federico Fracassi. 2015. "Generalized vitiligo in a dog with primary hypoadrenocorticism." Veterinary Dermatology 26, no. 5: 376-e86.

Case reports
Published: 02 October 2014 in Veterinary Quarterly
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ACS Style

Anna S. De Tommasi; Maria Morini; Maria E. Turba; Domenico Otranto; Giuliano Bettini. Hyperplastic cholangitis in a naturallyToxoplasma gondii-infected cat. Veterinary Quarterly 2014, 34, 229 -231.

AMA Style

Anna S. De Tommasi, Maria Morini, Maria E. Turba, Domenico Otranto, Giuliano Bettini. Hyperplastic cholangitis in a naturallyToxoplasma gondii-infected cat. Veterinary Quarterly. 2014; 34 (4):229-231.

Chicago/Turabian Style

Anna S. De Tommasi; Maria Morini; Maria E. Turba; Domenico Otranto; Giuliano Bettini. 2014. "Hyperplastic cholangitis in a naturallyToxoplasma gondii-infected cat." Veterinary Quarterly 34, no. 4: 229-231.

Journal article
Published: 01 June 2014 in Research in Veterinary Science
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Proteinase-activated receptor 2 (PAR2) is a G-protein-coupled receptor for trypsin and mast cell tryptase; it is highly expressed at the intestinal level with multiple functions, such as epithelial permeability and intestinal motility. Many proteases activate PAR2 during tissue damage, suggesting a role of the inflammatory response receptors. The aim of the study was to evaluate the distribution and expression of PAR2 in the jejunum, the ileum and the pelvic flexure, using samples collected from healthy adult horses after slaughter. Proteinase-activated receptor 2 immunoreactivity (PAR2-IR) was observed in the enterocytes, intestinal glands, the smooth muscle of the muscularis mucosae, and the longitudinal and circular muscle layers; there were no differences in the distribution of PAR2-IR in the different sections of the intestinal tract. The protein expression level showed that the relative amount of the PAR2 content in the mucosa of the intestinal tract decreased from the small to the large intestine while the PAR2 mRNA analysed showed similar values. This study provides relevant findings concerning the distribution of the PAR2 in the intestines of healthy horses and represents the starting point for evaluating the role of the PAR2 during strangulative intestinal disease and consequent systemic intestinal reperfusion/injury complications in horses in order to identify and employ antagonist PAR2 molecules.

ACS Style

Augusta Zannoni; Cristiano Bombardi; Francesco Dondi; Maria Morini; Monica Forni; Roberto Chiocchetti; Alessandro Spadari; Noemi Romagnoli. Proteinase-activated receptor 2 expression in the intestinal tract of the horse. Research in Veterinary Science 2014, 96, 464 -471.

AMA Style

Augusta Zannoni, Cristiano Bombardi, Francesco Dondi, Maria Morini, Monica Forni, Roberto Chiocchetti, Alessandro Spadari, Noemi Romagnoli. Proteinase-activated receptor 2 expression in the intestinal tract of the horse. Research in Veterinary Science. 2014; 96 (3):464-471.

Chicago/Turabian Style

Augusta Zannoni; Cristiano Bombardi; Francesco Dondi; Maria Morini; Monica Forni; Roberto Chiocchetti; Alessandro Spadari; Noemi Romagnoli. 2014. "Proteinase-activated receptor 2 expression in the intestinal tract of the horse." Research in Veterinary Science 96, no. 3: 464-471.

Journal article
Published: 01 November 2013 in Journal of Equine Veterinary Science
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Jole Mariella; Carolina Castagnetti; Angelo Peli; Maria Morini; Caterina Sorteni; Giuliano Bettini; Marco Pietra. Mucosal mRNA Cytokines’ Profile of Gastric Wall in Neonatal Foals: Comparison with Endoscopy and Histology. Journal of Equine Veterinary Science 2013, 33, 977 -983.

AMA Style

Jole Mariella, Carolina Castagnetti, Angelo Peli, Maria Morini, Caterina Sorteni, Giuliano Bettini, Marco Pietra. Mucosal mRNA Cytokines’ Profile of Gastric Wall in Neonatal Foals: Comparison with Endoscopy and Histology. Journal of Equine Veterinary Science. 2013; 33 (11):977-983.

Chicago/Turabian Style

Jole Mariella; Carolina Castagnetti; Angelo Peli; Maria Morini; Caterina Sorteni; Giuliano Bettini; Marco Pietra. 2013. "Mucosal mRNA Cytokines’ Profile of Gastric Wall in Neonatal Foals: Comparison with Endoscopy and Histology." Journal of Equine Veterinary Science 33, no. 11: 977-983.

Controlled clinical trial
Published: 01 January 2013 in American Journal of Veterinary Research
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To evaluate the pharmacokinetics and clinical efficacy of budesonide in dogs with inflammatory bowel disease (IBD). 11 dogs (mean ± SD age, 5.7 ± 3.9 years; various breeds and body weights) with moderate or severe IBD. Each dog received a controlled-release formulation of budesonide (3 mg/m(2), PO, q 24 h) for 30 days (first day of administration was day 1). The concentration of budesonide and its metabolite (16-α-hydroxyprednisolone) was measured via liquid chromatography-tandem mass spectrometry in plasma and urine samples obtained on days 1 and 8 of treatment. On those days, plasma samples were obtained before the daily budesonide administration and 0.5, 1, 2, 4, and 7 hours after drug administration, whereas urine samples were obtained after collection of the last blood sample. A clinical evaluation was performed on the dogs before onset of drug administration and on days 20 and 30 after start of drug administration. The highest plasma concentration of budesonide and 16-α-hydroxyprednisolone on day 1 was detected at 1 hour and at 2 hours after drug administration, respectively. After standardization on the basis of specific gravity, the ratio between urinary concentrations of budesonide and 16-α-hydroxyprednisolone was 0.006 and 0.012 on days 1 and 8, respectively. The clinical response was adequate in 8 of 11 dogs. Budesonide was rapidly absorbed and metabolized in dogs with IBD. The drug gradually accumulated, and there was an adequate therapeutic response and no adverse effects.

ACS Style

Marco Pietra; Federico Fracassi; Alessia Diana; Teresa Gazzotti; Giuliano Bettini; Angelo Peli; Maria Morini; Giampiero Pagliuca; Paola Roncada. Plasma concentrations and therapeutic effects of budesonide in dogs with inflammatory bowel disease. American Journal of Veterinary Research 2013, 74, 78 -83.

AMA Style

Marco Pietra, Federico Fracassi, Alessia Diana, Teresa Gazzotti, Giuliano Bettini, Angelo Peli, Maria Morini, Giampiero Pagliuca, Paola Roncada. Plasma concentrations and therapeutic effects of budesonide in dogs with inflammatory bowel disease. American Journal of Veterinary Research. 2013; 74 (1):78-83.

Chicago/Turabian Style

Marco Pietra; Federico Fracassi; Alessia Diana; Teresa Gazzotti; Giuliano Bettini; Angelo Peli; Maria Morini; Giampiero Pagliuca; Paola Roncada. 2013. "Plasma concentrations and therapeutic effects of budesonide in dogs with inflammatory bowel disease." American Journal of Veterinary Research 74, no. 1: 78-83.